Clinical trials: Benign Neoplasm, open to volunteers
Benign Colon Tumors
Comparison of Methods for Removing Large Benign Broad-based Epithelial Neoplasms of the Colon: ESD and EMR.
Benign epithelial neoplasms of the colon are a significant problem of colorectal surgery and health care not only because of their malignant potential, but also because of their prevalence among the working-age population.
- Trial name
- ESDEMR (NCT07041229)
- Testing
- EMR, ESD
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Pirogov Russian National Research Medical University
Urethral Internal Sphincter Morphology, Benign Prostatic Hyperplasia
MRI-DTI Assessment of Urethral Internal Sphincter Ring and Prostate Base Morphology
This is a single-center, observational imaging study designed to evaluate the in vivo morphology of the male urethral internal sphincter ring using magnetic resonance diffusion tensor imaging (MRI-DTI) fiber tracking and to…
- Conditions
- Urethral Internal Sphincter Morphology, Benign Prostatic Hyperplasia, Prostate Cancer
- Trial name
- NCT07694752
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Jiangsu Taizhou People's Hospital
Prostate Cancer (Diagnosis)
miRNA Panel for PCa Diagnosis
This is a single-center, prospective diagnostic accuracy trial conducted at Renji Hospital, Shanghai Jiao Tong University School of Medicine, led by a team of urology and molecular medicine researchers.
- Trial name
- NCT07755592
- Testing
- Serum microRNA panel detection for prostate lesion differentiation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- RenJi Hospital
Pancreatectomy, Distal Pancreatectomy (DP)
Laparoscopic Versus Robot-assisted Left-sided Pancreatectomy for Benign and Pre-malignant Lesions (DIPLOMA-3)
The DIPLOMA-3 trial is an international, multicenter, patient-blinded randomized controlled trial comparing laparoscopic and robot-assisted left-sided pancreatectomy.
- Conditions
- Pancreatectomy, Distal Pancreatectomy (DP), Pancreatic Neoplasms, Pancreatic Adenoma
- Trial name
- DIPLOMA-3 (NCT06939023)
- Testing
- Laparoscopic minimally invasive left-sided pancreatecomy, Robot-assisted minimally invasive left-sided pancreatecomy
- Where
- Netherlands
- Volunteers
- 256 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Central Nervous System Tumour
Neurocognitive Integrity After Proton Therapy for Brain Tumor
Radiation therapy remains a cornerstone in the management of both benign and malignant intracranial tumors, either as monotherapy or combined with surgery and/or chemotherapy.
- Trial name
- PROTON MIND (NCT07836478)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- European Institute of Oncology
Thyroid Nodules, Pulsed Field Ablation
Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.
- Trial name
- NCT07226804
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Fibroid Uterus, Metrorrhagia
A Randomized Study Comparing Subtotal vs Total Hysterectomy Long Term Outcomes
The goal of this randomized clinical trial is to assess the outcomes of total laparoscopic hysterectomy vs subtotal laparoscopic hysterectomy + mini-laparotomy for uterine extraction for benign gynecological conditions in terms…
- Conditions
- Fibroid Uterus, Metrorrhagia, Adenomyosis, Benign Gynecologic Neoplasm
- Trial name
- STORY (NCT06802198)
- Testing
- total hysterectomy, subtotal hysterectomy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Inherited Epidermolysis Bullosa, Ichthyosis
FARD (RaDiCo Cohort) (RaDiCo-FARD)
The goal of this observational study is to conduct a prospective assessment of the individual Burden of 9 rare skin diseases to assess disability in the broadest sense of the term (psychological, social, economic and physical)…
- Conditions
- Inherited Epidermolysis Bullosa, Ichthyosis, Ectodermal Dysplasia, Incontinentia Pigmenti
- Trial name
- FARD (NCT05954416)
- Where
- 15 sites in France
- Volunteers
- 900 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Kidney Tumor, Renal Benign Neoplasm
Renal Mass Biopsy, PEER, and 99mTc-sestamibi SPECT/CT for Patients With Clinically Localized Renal Tumors
The goal of this clinical trial is to better tell apart whether kidney tumors are benign (not cancer) or malignant (cancer) based on a biopsy or imaging tests and ask patients how they feel about decisions they make about…
- Conditions
- Kidney Tumor, Renal Benign Neoplasm, Renal Malignant Tumor
- Trial name
- BIOPSy (NCT05728957)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Loyola University
Colorectal Surgery, Benign or Malignant Rectal or Colon Tumors
Low Stable Pressure Pneumoperitoneum in Colorectal Surgery (CROSS STUDY)
The objective of this prospective, international cohort is to incorporate the low stable pressure (using Airseal Insufflator) approach and its associated parameters into the early rehabilitation program after colorectal surgery…
- Trial name
- CROSS (NCT06154785)
- Where
- 18 sites in Belgium, France and 6 more
- Volunteers
- 300 people
- Sponsor
- Bordeaux Colorectal Institute Academy
Salivary Gland Tumor, Benign Salivary Gland Tumor
Immune Biomarker Study for Salivary Gland Carcinoma
Salivary gland carcinomas (SGC) are rare tumors. The term SGC is not more than an umbrella for a variety of histogenetically, morphologically, and biologically distinct entities.
- Trial name
- ImmoGlandula (NCT06047236)
- Testing
- Sampling
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Lung Cancer (Diagnosis), Fragmentomics
Noninvasive Detection of Lung Nodule Malignancy Using cfDNA Fragmentomics
The goal of this observational study is to learn if cfDNA fragmentomics can noninvasively diagnose whether lung nodules are benign or malignant in adults with imaging-detected lung nodules.
- Trial name
- SHC2408 (NCT07399210)
- Testing
- This study did not include intervention between two cohorts
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Baohui Han
Breast Cancer, Nipple Discharge
A Study on Combined Low-pass Whole-genome and Methylome Testing of Bloody Nipple Discharge Specimens for Benign-Malignant Differentiation.
This is a prospective, single-center diagnostic study testing whether a new, minimally invasive analysis of nipple fluid can distinguish benign from malignant causes of pathologic nipple discharge.
- Trial name
- NCT07250204
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hubei Cancer Hospital
Benign Colorectal Neoplasm, Non-Neoplastic Anal Disorder
Impact of Dietary Fiber Supplementation on Colonic Microbiome
This clinical trial tests whether daily fiber supplementation will change the mucosal microbiome of the colon. The microbiome are microorganisms that live in the human gut. They serve a vital role in maintaining health.
- Trial name
- NCT05643859
- Testing
- Dietary Fiber, Proctoscopy or anoscopy with Biopsy, Colonoscopy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- OHSU Knight Cancer Institute
Benign Prostate Hypertrophy(BPH), Prostate Cancer (Diagnosis)
Application of Quantum Detection-Driven Artificial Intelligence Algorithms for Single-Molecule cfDNA Characterization in the Early Diagnosis of Prostate Cancer
This research project aims to develop a novel blood testing method integrating cutting-edge quantum sensing and artificial intelligence technologies to achieve precise, non-invasive early diagnosis of prostate cancer.
- Conditions
- Benign Prostate Hypertrophy(BPH), Prostate Cancer (Diagnosis), Prostate Neoplasm
- Trial name
- NCT07238959
- Testing
- Quantum Detection
- Where
- 7 sites in China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Neoplasms, Arteriovenous Malformation of Central Nervous System
RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT
The RSSearch® Registry is an international multi-year database designed to track SRS/SBRT (Stereotactic Radiosurgery/Stereotactic Body Radiation Therapy) utilization, treatment practices and outcomes to help determine, over time…
- Conditions
- Neoplasms, Arteriovenous Malformation of Central Nervous System, Trigeminal Neuralgia
- Trial name
- NCT01885299
- Testing
- SRS/SBRT
- Where
- 13 sites in United States
- Volunteers
- 50,000 people
- Sponsor
- The Radiosurgery Society
Gastric Cancer, Molecular Imaging
Novel Humanized Ferritin-Based NIR Fluorescent Probe for Identifying Sentinel Lymph Node Metastasis in Early Gastric Cancer
With the widespread adoption of early cancer screening, the proportion of early gastric cancer (EGC) in China has been gradually increasing. The primary treatments for EGC are endoscopic and surgical interventions.
- Trial name
- NCT07294638
- Testing
- VE/CX-FTn-ICG injection solution
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Liver Diseases, Liver Transplantation
Hepatic and Systemic Hemodynamic Modeling During Liver Surgery
" Despite the medical and surgical progress of the last two decades, the selection of candidates for liver surgery remains based on old principles and insufficiently sensitive to fine-tune the gesture to patient-specific…
- Trial name
- LSM (NCT05339984)
- Testing
- Partial hepatectomy (open approach), liver transplantation, Portal vein embolization
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ovarian Cancer, Ovarian Tumor
AI Analysis of CT Scans to Classify Ovarian Tumours as Benign, Borderline or Malignant Before Surgery
The goal of this observational study is to learn if a computer program can tell what type of ovarian tumour a person has from a CT scan taken before surgery. The program uses artificial intelligence (AI).
- Conditions
- Ovarian Cancer, Ovarian Tumor, Borderline Ovarian Tumor
- Trial name
- OvaClass (NCT07883551)
- Where
- 7 sites in Belgium, Netherlands
- Volunteers
- 1,300 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Lung Cancer, Solid Pulmonary Nodules
Constructing a Predictive Model for Differentiating Between Benign and Malignant Solid Pulmonary Nodules Based on Clinical and Imaging Features.
Study Objective: To comprehensively analyze the preoperative clinical and imaging characteristics of solid pulmonary nodules, investigate the risk factors associated with malignant solid pulmonary nodules, and provide a reference…
- Conditions
- Lung Cancer, Solid Pulmonary Nodules, Pulmonary Nodules
- Trial name
- NCT06685458
- Testing
- Preoperative Clinical and Imaging Feature Evaluation for Predictive Modeling
- Volunteers
- 320 people
- Sponsor
- The Third Affiliated Hospital of Kunming Medical College.