Clinical trials: Benzodiazepine Dependence
Benzodiazepine Dependence
Electroacupuncture for Tapering Off Long-term Benzodiazepine Use
This study aims to examine the efficacy of electroacupuncture for tapering benzodiazepines in long-term users. All eligible subjects will be randomized in a ratio of 1:1 to (1) Electroacupuncture combined with gradual tapering…
- Trial name
- NCT02475538
- Testing
- Electroacupuncture
- Where
- 3 sites in China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Alcoholism
Impact of a One-month Long Detoxification Diazepam Treatment on Early Alcohol Relapse
Alcohol-dependence is a medical condition that can lead to the occurrence of an alcohol withdrawal syndrome (AWS) in case of alcohol drinking cessation. Diazepam is the reference medication for preventing or treating AWS.
- Trial name
- DIAMA (NCT02242955)
- Testing
- Diazepam
- Where
- 2 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Lille
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Opiate Dependence, Drug Dependence
Treatment of Polydrug-Using Opiate Dependents During Withdrawal
Managed detoxification is a first and necessary step prior to treatment and rehabilitation. Detoxification can be a major obstacle for some patients, and the availability of managed and safe withdrawal is a prerequisite for…
- Conditions
- Opiate Dependence, Drug Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00367874
- Testing
- Buprenorphine, Valproate
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Sorlandet Hospital HF
Taking Benzodiazepines for Any Reason for 3 Months, Benzodiazepine Dependence
Promoting Benzodiazepine Cessation Through an Electronically-delivered Patient Self-management Intervention
Benzodiazepines (e.g., Ativan, Xanax) are widely prescribed medications that are used mainly to treat anxiety and sleeping difficulties.
- Trial name
- EMPOWER-ED (NCT04572750)
- Testing
- EMPOWER-ED
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Benzodiazepine Dependence, Benzodiazepine Abuse
Prevention of Benzodiazepine Misuse in Primary Care
Benzodiazepines and benzodiazepine-like hypnotics (z-drugs) are prevalent and addictive narcotics. Guidelines recommend restricted prescription of these drugs for anxiety and insomnia.
- Conditions
- Benzodiazepine Dependence, Benzodiazepine Abuse, Substance Use Disorders
- Trial name
- NCT04533230
- Testing
- Educational intervention with prescription feedback, Information on treatment guidelines
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Benzodiazepine Dependence, Benzodiazepine Dependent
Blended Care for the Discontinuation of Benzodiazepine Use
This study aims to compare two strategies performed by GPs to help patients taking benzodiazepines on a daily basis for at least six months to discontinue their use.
- Conditions
- Benzodiazepine Dependence, Benzodiazepine Dependent, Benzodiazepine Withdrawal
- Trial name
- Big Bird (NCT03937180)
- Testing
- Blended care, Usual care
- Where
- 110 sites in Belgium
- Volunteers
- 924 people
- Sponsor
- Kristien Coteur
Alcohol Dependence, Alcohol Withdrawal Syndrome
Assessment of Valproate on Ethanol Withdrawal
Alcohol use disorder, or heavy drinking, is commonly seen in patients who present to trauma centers. These patients are at risk for Alcohol Withdrawal Syndrome (AWS), which is collection of symptoms that can range from anxiety…
- Conditions
- Alcohol Dependence, Alcohol Withdrawal Syndrome, Trauma, Heavy Drinking
- Trial name
- PAVE (NCT03235531)
- Testing
- Valproate, Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- CAMC Health System
Insomnia, Quality of Life
Auricular Acupuncture and Cognitive Behavioral Therapy Treatment for Insomnia
"Auricular acupuncture and cognitive behavioral therapy in the context of insomnia and low dose dependence of benzodiazepine-like drugs and other sleep medicine with addiction risk" INTRODUCTION: Insomnia is a common health…
- Trial name
- NADA (NCT01765959)
- Testing
- Auricular acupuncture (AA), cognitive behavioral therapy (CBT)
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Drug Dependence
How to Ease the Withdrawal of Tranquilizers Among Older Consumers?
Benzodiazepines (BZD) are widely used to treat anxiety, insomnia, and depression. These drugs can have very serious side effects if they are taken over a long period of time.
- Trial name
- NCT02281175
- Testing
- Psychosocial intervention, a weekly physician intervention
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Prevention, Benzodiazepine Dependence
Electronic Deprescribing Tool for the Prevention of PIP
This study is a cluster randomized control trial aimed to measure the effectiveness of an educational knowledge transfer intervention to prescribers on the discontinuation of two targeted classes: Benzodiazepines…
- Trial name
- NCT03192514
- Testing
- Electronic Deprescribing tool
- Where
- Portugal
- Volunteers
- 280 people
- Sponsor
- University of Beira Interior
Primary Care, Health Plan Implementation
Effectiveness of a Joint General Practitioner-Pharmacist Intervention on Benzodiazepine Deprescribing in the Elderly
Benzodiazepines or related drug (BZDR) are consumed for hypnotic or anxiolytic purposes in most cases. The consequences of BZDR are multiple with an increased risk of daytime sedation, balance disorders leading to falls and…
- Conditions
- Primary Care, Health Plan Implementation, Benzodiazepine Dependence, Elderly
- Trial name
- BESTOPH-MG (NCT05765656)
- Testing
- GP - pharmacist collaboration and pharmacist motivational interviewing
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Nantes University Hospital
Anxiety, Prescription Drug Abuse and Dependency
Prescription of Benzodiazepines by General Practitioners: Characteristics of Prescribing Trend and Implementation of an Online Educational Program
Portugal has the highest benzodiazepine utilization compared to other European countries. The high utilization of benzodiazepines has been a concern due to reported side effects of long-term use and dependence.
- Trial name
- NCT04925596
- Testing
- ePrimaPrescribe online educational program, ComunicaSaudeMental online educational program
- Where
- Portugal
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Benzodiazepine Dependence
Effects of Intranasal Oxytocin in the Treatment of Benzodiazepine Withdrawal: A Pilot RCT
The goal of this clinical trial is to learn if oxytocin administered as a nasal spray will reduce withdrawal symptoms in adults during benzodiazepine tapering for 21 days. It will also learn about the safety of oxytocin.
- Trial name
- NCT06757517
- Testing
- Oxytocin nasal spray
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- St. Olavs Hospital
Chronic Insomnia, Hypnotic Dependence
Telepsychology for Benzodiazepines Withdrawal in Adults Suffering From Hypnotic-dependent Insomnia
Long-term use of benzodiazepines is a long-standing problem, but the optimal withdrawal modalities are not known. The main objective of this study is to compare the effectiveness of a psychological support versus a…
- Trial name
- NCT04751851
- Testing
- Medium duration withdrawal programme with ACT, Long duration withdrawal programme with ACT, Medium duration withdrawal programme without ACT
- Where
- Switzerland
- Volunteers
- 128 people
- Sponsor
- Association Nationale de Promotion des Connaissances sur le Sommeil
Benzodiazepine Dependence, Opioid Dependence
Gabapentin Treatment of Benzodiazepine Abuse in Methadone Maintenance Patients
The aim of this project is to study the use of gabapentin in reducing benzodiazepine abuse in methadone maintenance patients. A second aim is to study the effects of gabapentin on craving, mood, anxiety, and sleep disturbance in…
- Trial name
- NCT00420771
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- New York State Psychiatric Institute
Benzodiazepine Dependence
Gabapentin Treatment of Benzodiazepine Dependence
Benzodiazepine dependence is a growing public health problem for which very few evidenced-based treatment approaches are available.
- Trial name
- NCT01893632
- Testing
- gabapentin
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent)
An Opioid Prescribing Nudge
Analyze baseline concurrent opioid prescribing metrics at the individual prescriber level in the Duke Health System on the identified three main outcome measures.
- Conditions
- Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior
- Trial name
- OHS (NCT04069403)
- Testing
- Automated Reports on prescription patterns for their patients
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Duke University
Benzodiazepine Dependence
Baclofen for Improving Benzodiazepine Titration in Benzodiazepine Dependence
Benzodiazepines and related molecules are among the most prescribed psychotropic treatments in France and Europe. 13.4% of the French population had at least one reimbursement of benzodiazepines in 2015, which places France…
- Trial name
- BABET (NCT05935553)
- Testing
- Baclofen 30 mg, Baclofen 60 mg
- Where
- 2 sites in France
- Volunteers
- 93 people
- Sponsor
- Hospices Civils de Lyon
Benzodiazepine Dependence, Anxiety Disorders
Anxiety Lowering and Deprescribing Through Emotion Regulation
The goal of this clinical trial is to test ALDER (Anxiety Lowering and Deprescribing through Emotion Regulation), an online self-guided positive emotion intervention, in patients over the age of 65 who are candidates for…
- Conditions
- Benzodiazepine Dependence, Anxiety Disorders, Sleep Disturbance
- Trial name
- ALDER (NCT06359314)
- Testing
- ALDER
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northwestern University