Clinical trials: Benzodiazepines
Impulsivity, Active Suicidal Ideation
Impulsivity and Thought Process Disorder in Patients With Active Suicidal Ideation and Depression
This study is dedicated to achieving a better understanding of how the brain processes information. Specifically, the investigators are studying cognitive function, thought process, and impulsivity in people with and without…
- Conditions
- Impulsivity, Active Suicidal Ideation, Depression
- Trial name
- NCT01770600
- Testing
- Riperidone
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Healthy
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28
In this study we will examine where the radioactive tracer [11C]PBR28 is distributed in the body of healthy volunteers to calculate the radiation exposure to organs of the body.
- Trial name
- NCT00407693
- Testing
- [C-11]PRB28
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Anxiety, Prescription Drug Abuse and Dependency
Prescription of Benzodiazepines by General Practitioners: Characteristics of Prescribing Trend and Implementation of an Online Educational Program
Portugal has the highest benzodiazepine utilization compared to other European countries. The high utilization of benzodiazepines has been a concern due to reported side effects of long-term use and dependence.
- Trial name
- NCT04925596
- Testing
- ePrimaPrescribe online educational program, ComunicaSaudeMental online educational program
- Where
- Portugal
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Opiate Dependence, Drug Dependence
Treatment of Polydrug-Using Opiate Dependents During Withdrawal
Managed detoxification is a first and necessary step prior to treatment and rehabilitation. Detoxification can be a major obstacle for some patients, and the availability of managed and safe withdrawal is a prerequisite for…
- Conditions
- Opiate Dependence, Drug Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00367874
- Testing
- Buprenorphine, Valproate
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Sorlandet Hospital HF
Driving Behavior
Opiates and Benzodiazepines on Driving
The aim of this research is to assess drug effects (Xanax and Norco) on driving performance. Researchers will use the Alertness Memory Profiler (AMP) application to compare results to previous related studies.
- Trial name
- NCT03447353
- Testing
- Xanax 1Mg Tablet, Norco 10Mg-325Mg Tablet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Timothy L. Brown
Benzodiazepines
Remimazolam and Scoliosis Orthopedics
Spinal cord injury is one of the most dangerous complications of scoliosis orthopedic surgery, and the Stagnara awakening test has been used in orthopedic spine surgery and is considered the "gold standard" for detecting spinal…
- Trial name
- rimazolam (NCT05519371)
- Testing
- Remimazolam, Propofol
- Volunteers
- 148 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Kidney Disease (CKD)
Lorazepam and the Risk of Serious Adverse Events
This is a population-based cohort study assessing whether initiating a new outpatient prescription of a higher dose of lorazepam (>1-4 mg/day) compared to a lower dose (0.5-1 mg/day) in older adults with low kidney function (an…
- Trial name
- NCT07179978
- Testing
- Lorazepam
- Where
- Canada
- Volunteers
- 12,308 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Adverse Effects
Effects of Discontinuation of Benzodiazepine-derivative Hypnotics on Cognitive and Motor Functions in Elderly Persons
Benzodiazepines (BZDs) have been reported to cause negative impacts on motor as well as cognitive functions, which in turn could result in lethal incidents including falls especially in the elderly.
- Trial name
- NCT00707915
- Testing
- Drug: Benzodiazepine (listed out below)
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Minamihanno Hospital
Alcoholism
Impact of a One-month Long Detoxification Diazepam Treatment on Early Alcohol Relapse
Alcohol-dependence is a medical condition that can lead to the occurrence of an alcohol withdrawal syndrome (AWS) in case of alcohol drinking cessation. Diazepam is the reference medication for preventing or treating AWS.
- Trial name
- DIAMA (NCT02242955)
- Testing
- Diazepam
- Where
- 2 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Lille
Neurocysticercosis, Healthy
PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [C-11]PBR28
The purpose of this protocol is to measure peripheral benzodiazepine receptors in the brain using positron emission tomography (PET) and compare the imaging results between patients and healthy people.
- Trial name
- NCT00526916
- Testing
- [C-11]PBR28
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Schizophrenia, Schizoaffective Disorder
Clonazepam Effects on Brain Oscillations and Cognition in Schizophrenia
Cognitive deficits are some of the most prominent and disabling symptoms of schizophrenia. Evidence suggests that schizophrenia involves alterations to the functioning of a neural system under the control of a brain chemical…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- KGB (NCT03061136)
- Testing
- Clonazepam
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Surgery, Aging
De-adopting Routine Preoperative Benzodiazepines for Older Surgical Patients
Over 21 million surgical procedures take place among adults aged 65 and older in the US each year, and most older surgical patients in the US now receive benzodiazepines (e.g., midazolam, lorazepam) during anesthesia care.
- Trial name
- DROP-Benzo (NCT05436392)
- Testing
- Peer Comparison Feedback, Patient Informational Letter
- Where
- United States
- Volunteers
- 517,611 people
- Sponsor
- University of Pennsylvania
Anxiety Disease
Comparative Evaluation of Three Anxiety Control Protocols in Third Molar Extraction
The surgery for the extraction of the third molars is a procedure in Dentistry that generates a large picture of anxiety in the patient. One of the ways to try to soften this picture, are the professionals to use sedation.
- Trial name
- NCT03165500
- Testing
- Diazepam, Midazolam, Nitrous Oxide + Oxygen Gas
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Alzheimer Disease
Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease
To examine the differences in the capacity to activate microglia in patients with Alzheimer's Disease (AD) compared to age-comparable cognitively normal subjects and younger healthy controls.
- Trial name
- NCT04057807
- Testing
- LPS
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Yale University
Benzodiazepines Deprescribing
Benzodiazepines Deprescribing in Nursing Homes: Intervention Feasibility
The goal of this feasibility study is to evaluate the feasibility of a complex intervention towards benzodiazepines and Z-drugs deprescribing in older adults living in the Belgian nursing home setting.
- Trial name
- END-IT NH (NCT05929443)
- Testing
- END-IT intervention for nursing homes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Université Catholique de Louvain
Alcoholdependence, CIWA-R
Fixed-schedule Benzodiazepine Dosing vs Based on a CIWA-Ar Alcohol Protocol in Alcohol Detoxification.
Does the use of a symptom-triggered therapy (with assessment making use of a CIWA-Ar scale) decrease the total amount of benzodiazepines given to patients with alcohol dependence and are less patients still dependent on…
- Conditions
- Alcoholdependence, CIWA-R, Benzodiazepines
- Trial name
- NCT04777552
- Testing
- diazepam (or equivalence if other benzodiazepine)
- Volunteers
- 50 people
- Sponsor
- Universitair Ziekenhuis Brussel
Respiratory Failure
Sedation Management in Pediatric Patients Supported on Mechanical Ventilation
The purpose of this two-year project is to pilot test an intervention to change sedation management in pediatric patients supported on mechanical ventilation for acute respiratory failure in the pediatric intensive care unit…
- Trial name
- NCT00142766
- Testing
- Nurse Implemented Goal-Directed Comfort Algorithm
- Where
- 3 sites in United States
- Volunteers
- 245 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hypoactive Delirium
Flumazenil for Hypoactive Delirium Secondary to Benzodiazepine Exposure
Delirium within the intensive care unit (ICU) is associated with poor outcomes such as increased mortality, ICU and hospital length of stay (LOS), and time on mechanical ventilation.
- Trial name
- FLYP (NCT02899156)
- Testing
- Flumazenil
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, Davis
Primary Care, Health Plan Implementation
Effectiveness of a Joint General Practitioner-Pharmacist Intervention on Benzodiazepine Deprescribing in the Elderly
Benzodiazepines or related drug (BZDR) are consumed for hypnotic or anxiolytic purposes in most cases. The consequences of BZDR are multiple with an increased risk of daytime sedation, balance disorders leading to falls and…
- Conditions
- Primary Care, Health Plan Implementation, Benzodiazepine Dependence, Elderly
- Trial name
- BESTOPH-MG (NCT05765656)
- Testing
- GP - pharmacist collaboration and pharmacist motivational interviewing
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Nantes University Hospital
Low Back Pain
Diazepam Use With Standard Management for Acute Low Back Pain
Given the poor pain and functional outcomes that persist beyond an Emergency Department (ED) visit for musculoskeletal low back pain (LBP), we propose a clinical trial to evaluate whether combining a benzodiazepine with an NSAID…
- Trial name
- NCT02646124
- Testing
- Naproxen, Diazepam
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Montefiore Medical Center