Clinical trials: Berberine
Schizophrenia, Negative Symptoms of Schizophrenia
Berberine in Treating Negative Symptoms of Schizophrenia: Clinical Efficacy and Mechanisms
"Negative" symptoms are a major challenge for people with schizophrenia (SZ) and are a key reason why they struggle with everyday functioning.
- Trial name
- NCT07356765
- Testing
- Berberine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Anding Hospital
Safety
Safety Profile of a New Berberine Formulation with Improved Bioavailability
This study aims to evaluate important safety markers related to liver- and kidney function in healthy individuals after treatment with a new formulation, LipoMicel Berberine.
- Trial name
- Berberine Safe (NCT06732908)
- Testing
- LipoMicel Berberine
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Isura
Pre Diabetes
Effect of BGG on Glucose Metabolism and Other Markers of Metabolic Syndrome
According to the International Diabetes Federation, one in every 12 individuals is a diabetic (about 8% of the world population).
- Trial name
- Glucogold (NCT02834078)
- Testing
- BGG
- Volunteers
- 126 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Colorectal Adenoma
Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence
Berberine hydrochloride is a conventional component in Chinese medicine. In recent years, anticancer activity of berberine hydrochloride have been explored.
- Trial name
- NCT02226185
- Testing
- Berberine hydrochloride
- Where
- 7 sites in China
- Volunteers
- 1,108 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Gastritis, Peptic Ulcer
Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy
This study aims at evaluating efficacy and safety of berberine-containing quadruple therapy(berberine, lansoprazole, bismuth and amoxicillin) versus clarithromycin-containing quadruple therapy (clarithromycin,lansoprazole…
- Conditions
- Gastritis, Peptic Ulcer, Dyspepsia
- Trial name
- NCT02633930
- Testing
- Berberine, clarithromycin, Bismuth
- Where
- 2 sites in China
- Volunteers
- 566 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Cardiometabolic Syndrome
Effects of Berberine on Cardiometabolic Outcomes
Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount.
- Trial name
- NCT07541898
- Testing
- Berberine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Central Lancashire
Diverticulitis
Combination of Curcumin and Berberine Therapy in the Treatment of Post Acute Diverticulitis (SUDD)
Curcumin (Cur), an active ingredient of the Indian herb Rhizoma Curcuma Longa, has been extensively studied in the context of inflammatory diseases.
- Trial name
- NCT05596214
- Testing
- Curcumin-Berberine (coptis)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Dr. Adi Lahat
Non Alcoholic Fatty Liver, Obesity
Effect of Probiotics or Berberine in Hepatic Steatosis Markers, Cardiometabolic and Microbiotic Profile in NAFL.
Effect of oral selected Probiotics (PRO) and/or Berberine (BBR) supplementation on hepatic steatosis markers, cardiometabolic profile, and gut microbiota profile in the non-alcoholic fatty liver (NAFL) - a randomized double-blind…
- Trial name
- NCT05523024
- Testing
- Probiotic, Berberine, Probiotc and Berberine
- Where
- Poland
- Volunteers
- 140 people
- Sponsor
- Poznan University of Medical Sciences
Mixed Dyslipidemia
Bezafibrate Plus Berberine in Mixed Dyslipidemia
Dyslipidemia, is a cardiovascular risk factor of great importance whose prevalence has increased over the last decade. Part of the components of metabolic syndrome and consensus so far contemplated to increased triglycerides (TG)…
- Trial name
- NCT02548832
- Testing
- Berberine, Bezafibrate, Berberine plus Bezafibrate
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- University of Guadalajara
Gastritis, Peptic Ulcer
Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy
This study aims at evaluating efficacy and safety of berberine-containing quadruple therapy(berberine, esomeprazole, clarithromycin and amoxicillin) versus bismuth-containing quadruple therapy (bismuth,esomeprazole,clarithromycin…
- Conditions
- Gastritis, Peptic Ulcer, Dyspepsia
- Trial name
- NCT02296021
- Testing
- Berberine, Bismuth, esomeprazole
- Where
- China
- Volunteers
- 612 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Hypercholesterolemia
Long Term Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols and Berberine) in Low-moderate Risk Hypercholesterolemic Patients: a Double-blind, Placebo Controlled Study
Background: Statins are at the forefront of strategies to manage hypercholesterolemia. However, 10-15% of patients result to be intolerant to any statins, even at low daily doses and almost one- third of statin users discontinue…
- Trial name
- NCT02078167
- Testing
- nutraceutical combination (red yeast rice, policosanols and berberine)
- Volunteers
- 60 people
- Sponsor
- Comitato Etico di Area Vasta Sud Est
Type 2 Diabetes Mellitus
Effects of Berberine Hydrochloride and Bifidobacterium in Diabetes Mellitus Prevention and Treatment
The aim of this study is to assess the beneficial effects of Bifidobacterium Hydrochloride and Berberine on lowering glucose in patients with type 2 diabetes mellitus and to detect the potential mechanism.
- Trial name
- NCT02084004
- Testing
- Bifidobacterium viable pharmaceutics, Berberine Hydrochloride
- Where
- 4 sites in China
- Sponsor
- Xijing Hospital
Polycystic Ovary Syndrome
Treatment Benefits of Berberine Supplementation for Women With PCOS
Berberine is a plant alkaloid, reportedly possesses a wide range of pharmacological activities, including anti-obesity and anti-dyslipidemia.
- Trial name
- NCT05480670
- Testing
- Berberine
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Ayub Teaching Hospital
Phase I and Phase II Metabolites of Berberine
Metabolic Differences Between Dihydroberberine and Micellar Berberine
Differences in metabolites of dihydroberberine (DHB) and micellar berberine (LipoMicel®, LMB) are investigated through a randomized study involving human volunteers.
- Trial name
- NCT06202157
- Testing
- LMB, DHB
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Factors Group of Nutritional Companies Inc.
Prediabetes, Impaired Fasting Glucose
Effect of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes
Pre diabetes (PD) is a term that refers to alterations in glucose homeostasis, including impaired fasting glucose (IFG), Imparied glucose tolerance (IGT) or both, involving a higher risk to develop type 2 diabetes mellitus (T2DM)…
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT03029390
- Testing
- Berberine, Metformin
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- University of Guadalajara
Polycystic Ovary Syndrome, Berberine
Berberine and Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is the most frequent endocrine disease in female reproductive-age. Recently, increasing evidence has shown that natural plant-based products may play a role in PCOS management.
- Trial name
- NCT04932070
- Testing
- Berberine
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Diabetes
Berberine and Cinnamon in Management of Diabetes
In this randomized clinical trial, patients with diabetes will be randomly assigned to receive either Berberine, and Cinnamon supplements or placebo for 12 weeks. Then the glycemic characteristics will be compared in two groups.
- Trial name
- NCT05570357
- Testing
- Berberine+Cinnamon (TDS)
- Where
- Iran
- Volunteers
- 44 people
- Sponsor
- National Nutrition and Food Technology Institute
Berberine, Sprint Training
Berberine Supplementation, Sprint Interval Training, and Immune Function Study
The purpose of this clinical trial is to investigate the effects of a 2-week intervention involving berberine supplementation or sprint training in isolation as well as berberine combined with sprint training on well-being…
- Conditions
- Berberine, Sprint Training, Wellbeing, Anaerobic Power
- Trial name
- NCT07480018
- Testing
- Berberine, Sprint Interval Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Northern Colorado
Dyslipidemias
Clinical Study With Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiChol
To evaluate the effects of a nutraceutical containing Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiChol on lipid profile
- Trial name
- PARAF (NCT06340308)
- Testing
- Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiChol
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Pavia
Schizophrenia
Berberine Effect on Cytokine, CRP, Metabolic Disturbance as an Adjunctive Therapy in Schizophrenia Patients
The etiology and pathogenesis of schizophrenia remains unclear. Immune dysfunction hypothesis for schizophrenia has attracted increasing attention of the researchers, substantial evidences suggested the levels of C-reaction…
- Trial name
- NCT02936414
- Testing
- Berberine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tianjin Anding Hospital