Clinical trials: Berberine, open to volunteers
Drug Absorption
Effect of Gamma-cyclodextrin on the Bioavailability of Berberine
In this study, we will evaluate the relative bioavailability of Berberine (BB) from capsules containing Indian Barberry (Berberis aristate DC.) Bark and Root Extract in the blood plasma of healthy subjects after oral…
- Trial name
- NCT04918667
- Testing
- Berberine incorporated in gamma cyclodextrin, Berberine
- Where
- 4 sites in Armenia, Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- EuroPharma, Inc.
Diabetes Mellitis
Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 Diabetes
This pilot 12-week randomized open-label study compares metformin and berberine in newly diagnosed type 2 diabetes patients stratified by the TCF7L2 (rs7903146) genotype (TT vs. CC).
- Trial name
- NCT06911983
- Testing
- Metformin, Berberine
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- S.LAB (SOLOWAYS)
Type 1 Diabetes Mellitus, Autoimmune Diabetes
Effects Of Berberine Plus Inulin On Diabetes Care in Patients With LADA
The primary purpose of this study is to evaluate the effects of oral berberine (BBR) and inulin combined with insulin therapy on diabetes care in patients with LADA.
- Trial name
- NCT04698330
- Testing
- Berberine, Inulin
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Second Xiangya Hospital of Central South University
Intestinal Discomfort, Abdominal Pain/ Discomfort
Evaluation of the Synergistic Effect of Combining a Prebiotic and a Postbiotic on Intestinal Discomfort
This study aims to investigate the beneficial effects of the daily consumption of a synbiotic formulation-combining a prebiotic (Berberine, BBR) and a postbiotic (inactivated Bifidobacterium Longum, B.longum)-in adults…
- Trial name
- Synfood (NCT07420231)
- Testing
- Berberine, Bifidobacterium longum, Bifidobacterium longum and Berberine
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Université Catholique de Louvain
Chronic Endometritis
Randomized Controlled Trial of Berberine in Combination With Doxycycline in the Treatment of Chronic Endometritis
Study Subjects: Eligible patients were initially diagnosed with chronic endometritis (CE) by CD138 testing through outpatient hysteroscopy.
- Trial name
- NCT07180563
- Testing
- Participants were treated with doxycycline + berberin for chronic endometritis (intervention group)., At present, the commonly used clinical treatment for chronic endometritis is oral doxycycline
- Where
- China
- Volunteers
- 206 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Metabolic Syndrome
Cardiovascular Diseases and Diabetes Prevention Programme in Metabolic Syndrome (CDPP)
The metabolic syndrome population is at high-risk of cardiovascular diseases and diabetes. How to effectively control the risk factors of this population is the key to primary prevention of cardiovascular diseases and diabetes in…
- Trial name
- CDPP (NCT05105321)
- Testing
- Berberine, Healthy lifestyle intervention
- Where
- China
- Volunteers
- 5,200 people
- Sponsor
- Tang Yida
Diabetes-Related Complications
Study on the Molecular Mechanism of Berberine to Improve Type 2 Diabetes Mellitus Complicated With Depression
The incidence of type 2 diabetes with comorbid depression (T2DD) is notably high, characterized by prolonged disease duration and susceptibility to recurrence.
- Trial name
- SBDD (NCT06979440)
- Testing
- No intervention
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Nantong University
Polycystic Ovary Syndrome
Berberine Phytosome for Signs and Symptoms of Polycystic Ovary Syndrome (PCOS)
This multicenter, randomized, controlled clinical trial aims to evaluate the effectiveness of berberine phytosome supplementation in improving signs and symptoms associated with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07465575
- Testing
- Berberine Phytosome (Sophy®), Lifestyle Advice
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Coronary Artery Disease, Percutaneous Coronary Intervention
Anti-platelet Effect of Berberine in Patients After Percutaneous Coronary Intervention
The APLABE-PCI is a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, which is designed to assess the anti-platelet effect of berberine in approximately 64 patients receiving aspirin and…
- Trial name
- APLABE-PCI (NCT03378934)
- Testing
- Berberine, Standard treatment, Aspirin
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Peking Union Medical College Hospital
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Cardiometabolic Syndrome
Effects of Berberine on Cardiometabolic Outcomes
Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount.
- Trial name
- NCT07541898
- Testing
- Berberine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Central Lancashire
Gastric Intestinal Metaplasia
Efficacy and Safety of Berberine for Gastric Intestinal Metaplasia
The goal of this clinical trial is to investigate the efficacy of Berberine in treating gastric intestinal metaplasia in Helicobacter pylori-negative adults. It will also learn about the safety of Berberine.
- Trial name
- NCT07129460
- Testing
- Berberine hydrochloride
- Volunteers
- 204 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Colorectal Adenomas, Colorectal Cancers
Effects of Berberine on the Human Gut Microbiome
Berberine hydrochloride is a conventional component in Chinese medicine. In recent years, anticancer activity of berberine hydrochloride have been explored.
- Trial name
- NCT07519681
- Testing
- Berberine Hydrochloride
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jing-yuan Fang, MD, Ph. D
Hyperlipidemia
Study on the Sex-specific, Lipid- and Lipoprotein-lowering Effects of Berberine
The goal of this clinical trial is to learn if berberine works to affect lipids and lipoproteins in Chinese females aged 20 to 65 years with hyperlipidaemia.
- Trial name
- NCT06782646
- Testing
- Berberine
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Metabolism Disorder, Nutraceutical
A Clinical Trial to Assess the Efficacy and Tolerance of a Berberine-based Nutraceutical Formula to Aid Blood Sugar Regulation and Metabolism
This randomized, triple-blind, placebo-controlled study will evaluate the efficacy of Diaberine, a berberine-based nutraceutical, in aiding blood sugar regulation and metabolism in 80 participants over 24 weeks.
- Trial name
- NCT06700915
- Testing
- Diaberine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ultimate International, Inc.
Schizophrenia, Negative Symptoms of Schizophrenia
Berberine in Treating Negative Symptoms of Schizophrenia: Clinical Efficacy and Mechanisms
"Negative" symptoms are a major challenge for people with schizophrenia (SZ) and are a key reason why they struggle with everyday functioning.
- Trial name
- NCT07356765
- Testing
- Berberine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Anding Hospital