Clinical trials: Best Disease
Atherosclerotic Cardiovascular Disease, Subclinical Disease and/or Syndrome
Gastric Bypass Versus Best Medical Treatment on Progression of Carotid-intima Media Thickness in Type 2 Diabetes Mellitus (T2DM)
Background: Type 2 Diabetes Mellitus (T2DM) is associated with an increased burden for cardiovascular disease (CVD). Multifactorial interventions are necessary to reduce the CV risk in T2DM.
- Trial name
- EURDSS (NCT01353066)
- Testing
- Intensive Medical Treatment, IMM+Roux-en-Y Gastric Bypass (RYGBP)
- Where
- Spain
- Volunteers
- 240 people
- Sponsor
- Hospital Clinic of Barcelona
Severe Obesity
Bypass Equipoise Sleeve Trial (BEST)
This is nationwide registry-based randomised clinical multicenter trial in which patients will be randomised to gastric bypass (RYGB) or sleeve gastrectomy (SG).
- Trial name
- BEST (NCT02767505)
- Testing
- gastric bypass, Sleeve gastrectomy
- Where
- 21 sites in Norway, Sweden
- Volunteers
- 1,752 people
- Sponsor
- Göteborg University
Colorectal Neoplasms
Randomized Trial With Dendritic Cells in Patients With Metastatic Colorectal Cancer
The different alternatives used since 1996 to treat metastatic colorectal cancer (MCRC) have increased the mean survival of these patients.
- Trial name
- NCT01413295
- Testing
- Dendritic Cell Vaccine, Supportive treatment
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Cardio Vascular Disease, Cryoablation
The Best Workflow for Paroxysmal Supraventricular Tachycardia Ablation With Zero-fluoroscopy
Primary Objective: To observe, record, and analyze the workflow and guidance system efficiency of these two surgical procedures, including placement time, location, and the number of successful placements.
- Trial name
- zeroPSVT (NCT07361055)
- Testing
- Protocol A, Protocol B
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Pilonidal Sinus
A Single Center Experience in the Management of Pilonidal Disease
Sacrococcygeal pilonidal disease (PND) is a common entity affecting the skin and subcutaneous tissue of the upper portion of the natal cleft of the buttocks.
- Trial name
- NCT05892198
- Testing
- surgery
- Volunteers
- 101 people
- Sponsor
- Mansoura University
Squamous Cell Carcinoma of Esophagus
Benefit of Chemotherapy Over Best Supportive Care in Metastatic and Squamous Cell-type Esophageal Cancer.
Interest of continuing systemic chemotherapy or not , after a short initial treatment (6 weeks) in patients who are in response or stable disease("Discontinuation design ")of patients with metastatic oesophageal cancer of…
- Trial name
- E-DIS (NCT01248299)
- Testing
- FU-CDDP, LV5FU2-CDDP, FOLFOX
- Where
- 17 sites in France
- Volunteers
- 105 people
- Sponsor
- Centre Oscar Lambret
Gastrointestinal Cancer, Dietary Modification
Study of Parenteral Nutrition to Patients With Gastrointestinal Cancer
Clinical background: Weight loss is a common problem in patients suffering from gastrointestinal cancer. It is demonstrated that the prognosis for cancer patients with weight loss is worse than that for weight stable patients.
- Conditions
- Gastrointestinal Cancer, Dietary Modification, Cancer Cachexia, Quality of Life
- Trial name
- NCT02066363
- Testing
- Dietician advise, Parenteral nutrition
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- Odense University Hospital
Platinum-sensitive Ovarian Cancer, Relapsed Ovarian Cancer
OSE2101 Alone or in Combination With Pembrolizumab vs BSC in Patient With Platinum-sensitive Recurrent OC
The proposed study is an international randomized phase II, multicenter, open-label, three arms trial to assess best supportive care (BSC) vs OSE2101 and vs OSE2101 + pembrolizumab as maintenance treatment for patients with…
- Trial name
- TEDOVA (NCT04713514)
- Testing
- OSE2101, Pembrolizumab 25 MG/ML [Keytruda]
- Where
- 41 sites in Belgium, France and 1 more
- Volunteers
- 185 people
- Sponsor
- ARCAGY/ GINECO GROUP
Acute Abdomen, Bowel Obstruction
The Best Care for Abdominal Emergencies Study
This is a single-centre retrospective cohort study utilising electronic hospital records. The aim of this study is to improve care for all patients with an intestinal emergency, irrespective of whether they have surgery or not.
- Conditions
- Acute Abdomen, Bowel Obstruction, Bowel; Ischemic, Acute, Bowel Perforated
- Trial name
- BCAE (NCT04577339)
- Testing
- Laparotomy or laparoscopy
- Where
- United Kingdom
- Volunteers
- 2,500 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Pressure Ulcer
Interdisciplinary Pressure Management & Mobility Program as an Alternative to Usual Care: A Pilot Study
People with spinal cord injuries posses many factors that increase their risk of developing pressure ulcers. Not surprisingly, approximately 82% of persons with spinal cord injury (SCI) will experience a pressure ulcer at…
- Trial name
- WOUND (NCT00796042)
- Testing
- Usual care, Pressure management and Mobility program
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- University of Western Ontario, Canada
Pneumonia, Interstitial
Study Testing Convalescent Plasma vs Best Supportive Care
Currently there are no proven treatment option for COVID-19. Human convalescent plasma is an option for COVID-19 treatment and could be available from people who have recovered and can donate plasma.
- Trial name
- NCT04333251
- Testing
- high-titer anti-Sars-CoV-2 plasma, oxygen therapy
- Sponsor
- Baylor Research Institute
Acute Ischemic Stroke
Cooling Plus Best Medical Treatment Versus Best Medical Treatment Alone for Acute Ischaemic Stroke
The purpose of this study is to determine if systemic cooling to a target temperature of 34 to 35°C, started within 6 hours of symptom onset and maintained for 12 hours, improves functional outcome at 3 months in patients with…
- Trial name
- EuroHYP-1 (NCT01833312)
- Testing
- Hypothermia, Buspirone, Pethidine
- Where
- Germany
- Volunteers
- 98 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Solid Tumors, Breast Cancer
A Study To Find The Best Doses Of SU011248 (Sunitinib) And Capecitabine When These Drugs Are Administered Together
This study assesses the maximum tolerated dose, overall safety and antitumor activity of SU011248 in combination with capecitabine in patients with advanced solid tumors
- Conditions
- Solid Tumors, Breast Cancer, Neoplasms
- Trial name
- NCT00618124
- Testing
- SU011248; Capecitabine
- Where
- 3 sites in United States
- Volunteers
- 77 people
- Sponsor
- Pfizer
Prostate Cancer
Identifying the Best Follow up Approach for People Who Have Had Treatment to Cure Newly Diagnosed Prostate Cancer
Over 20,000 patients a year in the UK get surgery or radiotherapy to cure their prostate cancer. These men then undergo regular check-ups to manage potential side effects and see if cancer recurs so it can be treated quickly.
- Trial name
- FOLLOW-UP (NCT07264088)
- Testing
- Hospital based follow up, Primary care based follow up, Planned shared care follow up
- Where
- United Kingdom
- Volunteers
- 100,000 people
- Sponsor
- Imperial College London
Lumbar Spinal Stenosis
Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant
Neurogenic intermittent claudication is a specific symptom complex occurring in patients with lumbar spinal stenosis. Characteristic of this disease is the occurrence of increasing leg, buttock or groin pain with or without lower…
- Trial name
- NCT01057641
- Testing
- Spacer, physiotherapy
- Where
- 2 sites in Germany
- Volunteers
- 22 people
- Sponsor
- University of Cologne
Acute Ischemic Stroke, Basilar Artery Occlusion
Direct Endovascular Treatment Versus Bridging Treatment In Basilar Artery Occlusive Stroke
Currently, both intravenous thrombolysis (IVT) followed by endovascular treatment (EVT) and EVT alone are widely used for the treatment of acute ischemic stroke (AIS) caused by basilar artery occlusion (BAO) (AIS-BAO), but no…
- Conditions
- Acute Ischemic Stroke, Basilar Artery Occlusion, Thrombosis, Alteplase
- Trial name
- BEST-BAO (NCT05631847)
- Testing
- Endovascular treatment, Intravenous thrombolysis (Alteplase)
- Where
- 96 sites in China
- Volunteers
- 345 people
- Sponsor
- Sichuan Academy of Medical Sciences
Non-infectious Uveitis
Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis
This extension study will assess the safety and efficacy of AIN457 versus placebo for maintaining uveitis suppression when reducing systemic immunosuppression
- Trial name
- ENDURE (NCT01090310)
- Testing
- AIN457
- Where
- 35 sites in United States, Brazil and 6 more
- Volunteers
- 86 people
- Sponsor
- Novartis Pharmaceuticals
Child Behavior Problem, Child Behavior Disorders
Positive Parenting Program in Foster Care
The purpose of the study is to evaluate early implementation outcomes of a positive parenting program, Child Adult Relationship Enhancement in Primary Care (PriCARE), in the foster care setting and to assess the efficacy of…
- Conditions
- Child Behavior Problem, Child Behavior Disorders, Parenting, Foster Care
- Trial name
- NCT03910491
- Testing
- PriCARE
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Bone Sarcoma, Osteosarcoma
Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas Patients
This is a multicenter phase II study concerning patients with high-grade bone sarcoma (HGBS) without complete remission after standard treatment at diagnosis or at relapse.
- Trial name
- REGOMAIN (NCT04698785)
- Testing
- Treatment by regorafenib and best supportive care
- Where
- 16 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre Leon Berard
Asthma, Diarrhea & Vomiting
Best Strategies for Implementation of Clinical Pathways in Emergency Department Settings
An Ontario-wide study to identify best strategies to promote uptake of high quality, expert developed Clinical Pathways (CPs) within Emergency Departments.
- Trial name
- NCT01815710
- Testing
- Pediatric Asthma Clinical Pathway, Vomiting & Diarrhea Pathway
- Where
- Canada
- Volunteers
- 6,330 people
- Sponsor
- Children's Hospital of Eastern Ontario