Clinical trials: Best Disease
Pneumonia, Severe Acute Respiratory Syndrome
Best Supportive Care With or Without Low Dose Whole Lung Radiation Therapy for the Treatment of COVID-19
This phase III trial compares low dose whole lung radiation therapy to best supportive care plus physicians choice in treating patients with COVID-19 infection.
- Conditions
- Pneumonia, Severe Acute Respiratory Syndrome, Symptomatic COVID-19 Infection Laboratory-Confirmed
- Trial name
- RESCUE1-19 (NCT04433949)
- Testing
- Best Practice, Low Dose Radiation Therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Emory University
Pancreatic Cancer Non-resectable
Stereotactic Radiotherapy vs Best Supportive Care in Unfit Pancreatic Cancer Patients
SUMMARY Rationale: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, its incidence increases with age. Many patients with localized (non-metastatic) PC have significant comorbidities, advanced age or a…
- Trial name
- PANCOSAR (NCT05265663)
- Testing
- stereotactic ablative radiotherapy
- Where
- 2 sites in Netherlands
- Volunteers
- 98 people
- Sponsor
- Amsterdam UMC, location VUmc
Severe Eosinophilic Asthma
Real World Evidence of Benralizumab in Eosinophilic Severe AsThma in Russia (BEST)
Benralizumab is a humanised, afucosylated, monoclonal antibody against the interleukin (IL)-5 receptor (IL-5R) α subunit that induces direct, rapid, and near-complete depletion of eosinophils in blood, airway tissue, and bone…
- Trial name
- NCT05271526
- Where
- Russia
- Volunteers
- 3 people
- Sponsor
- AstraZeneca
Acute Heart Failure
Registry Of Best Up-titration STrategies in Acute Heart Failure
STRONG-HF showed that rapid up-titration of renin-angiotensin inhibitor (RASI), beta-blocker, and mineralocorticoid receptor antagonist (MRA) to full optimal doses within 2 weeks post-discharge from a hospital admission for acute…
- Trial name
- ROBUST-HF (NCT05865665)
- Volunteers
- 5,000 people
- Sponsor
- Heart Initiative
Non Small Cell Lung Cancer
Safety and Efficacy of Talactoferrin in Previously Treated Patients With Non-small Cell Lung Cancer
The purpose of this study is to determine whether talactoferrin can improve overall survival in patients with non-small cell lung cancer (NSCLC) who have been previously treated with two or more regimens.
- Trial name
- FORTIS-M (NCT00707304)
- Testing
- Talactoferrin
- Where
- 189 sites in United States, Australia and 21 more
- Volunteers
- 742 people
- Sponsor
- Agennix
Hepatocellular Carcinoma (HCC)
A Phase 2 Study of Brivanib in Chinese Patients With Previously Treated Advanced HCC
This is a Phase 2, Open-label, Randomized, Multicenter Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Brivanib in Patients with Previously Treated Advanced Hepatocellular Carcinoma.
- Trial name
- NCT03516071
- Testing
- Brivanib 800 mg, QD, Brivanib 400 mg, BID
- Where
- 15 sites in China
- Volunteers
- 90 people
- Sponsor
- Zai Lab (Shanghai) Co., Ltd.
Coronavirus Infections
Bevacizumab in Severe or Critical Patients With COVID-19 Pneumonia
The novel identified coronavirus (SARS-CoV-2) in 2019 causes an nationwide outbreak as well as public health crisis in China, and expands globally.
- Trial name
- BEST-CP (NCT04275414)
- Testing
- Bevacizumab Injection
- Where
- 3 sites in China, Italy
- Volunteers
- 27 people
- Sponsor
- Qilu Hospital of Shandong University
Diabetic Kidney Disease
Prevention of Microvascular Complications in Overweight Diabetics With Surgery or Best Medicine
Background: Diabetic kidney disease (DKD) is chronic and often progresses to kidney failure,heart disease and premature death. Unfortunately, the best medical therapies available for DKD today are ultimately unable to prevent its…
- Trial name
- PROMISE (NCT02011178)
- Testing
- Optimal medical treatment and surgery, Optimal medical treatment
- Where
- 2 sites in Sweden, Switzerland
- Sponsor
- Karolinska Institutet
Complications of Diabetes Mellitus
Clinical Study on Metabolic Surgery Compared to the Best Clinical Treatment in Patients With Type 2 Diabetes Mellitus
This is a prospective, open, randomized study involving 100 patients with microvascular complications of type 2 diabetes mellitus and obesity, who will undergo gastric bypass (Roux-en-Y gastric bypass ARM A) or receive best…
- Trial name
- MOMS (NCT01821508)
- Testing
- Clinical Treatment, Roux-En-Y gastric bypass surgery
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Alemão Oswaldo Cruz
Bronchiectasis
Evaluation of Medical and Nursing Management for Bronchiectasis
The purpose of this research is to retrospectively evaluate current clinical care of Bronchiectasis (non-cystic fibrosis [CF]) in adults from a multidisciplinary management perspective.
- Trial name
- NCT03550417
- Volunteers
- 65 people
- Sponsor
- The Queen Elizabeth Hospital
Colorectal Cancer, Colorectal Adenomas
Pilot Study of a National Screening Programme for Bowel Cancer in Norway
The Norwegian government has funded a pilot study of a national colorectal cancer screening programme. This implies initiation of a screening pilot in the catchment area for two hospitals in Norway.
- Trial name
- NCT01538550
- Testing
- Flexible sigmoidoscopy, iFOBT
- Where
- 2 sites in Norway
- Volunteers
- 140,000 people
- Sponsor
- Norwegian Institute of Public Health
Rheumatoid Arthritis
A Study of RoActemra/Actemra (Tocilizumab) in Combination With DMARDs Versus Current Best Practice DMARD Therapy in Patients With Rheumatoid Arthritis
This randomized, open-label, parallel-group study will assess the effect on disease remission of RoActemra/Actemra (tocilizumab) in combination with disease-modifying antirheumatic drugs (DMARDs) versus current best practice…
- Trial name
- NCT01251120
- Testing
- tocilizumab [RoActemra/Actemra], DMARD
- Where
- 6 sites in Finland
- Volunteers
- 2 people
- Sponsor
- Hoffmann-La Roche
Shoulder Adhesive Capsulitis
Best Treatment Modality of Frozen Shoulder
This study will compare between the effect of three treatment modalities of shoulder adhesive capsulitis to hilight the best technique to improve pain and range of motion outcome measures .
- Trial name
- NCT04897308
- Testing
- Local injection of shoulder joint
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Sohag University
Graft-versus-host Disease (GVHD)
A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3)
The purpose of this study is to assess the efficacy of ruxolitinib against best available therapy in participants with steroid-refractory chronic graft-versus-host disease (SR cGvHD).
- Trial name
- NCT03112603
- Testing
- Ruxolitinib, Extracorporeal photopheresis (ECP), Low-dose methotrexate (MTX)
- Where
- 191 sites in United States, Australia and 29 more
- Volunteers
- 330 people
- Sponsor
- Incyte Corporation
Mantle Cell Lymphoma (MCL)
Study to Assess Effect of Oral Venetoclax Tablet in Combination With Oral Ibrutinib Capsule on Best Overall Response of Complete Response in Adult Japanese Participants With Relapsed/Refractory Mantle Cell Lymphoma
Mantle Cell Lymphoma (MCL) is a form of Non-Hodgkin Lymphoma (NHL - cancer of the lymphatic system in blood) where cells from outer edge of the lymph nodes, called mantle zone become cancerous.
- Trial name
- NCT04477486
- Testing
- Ibrutinib, Venetoclax
- Where
- 12 sites in Japan
- Volunteers
- 13 people
- Sponsor
- AbbVie
Peripheral Artery Disease, Intermittent Claudication
Assessing Best Medical Treatment Patterns of Patients With Symptomatic Peripheral Arterial Occlusive Disease in Germany
This proposed study will be conducted to support real-world-evidence on the extent of best medical treatment for secondary prevention of patients with symptomatic peripheral arterial occlusive disease (PAOD) for prevention of…
- Conditions
- Peripheral Artery Disease, Intermittent Claudication, Critical Limb Ischemia
- Trial name
- NCT03909022
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Myofascial Pain Syndrome - Neck
Comparing Physical Therapy Interventions on Craniovertebral Angle (CVA) in Cervical Myofascial Pain Syndrome (MPS)
Myofascial pain syndrome (MPS) and radiculopathy are prevalent musculoskeletal conditions that afflict a substantial portion of the population, causing significant discomfort and impairments in daily functioning.
- Trial name
- NCT07098754
- Testing
- Dry Needling, Trigger point therapy, Maitlands' Mobilizations
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- National Orthopedic and General Hospital
Hypertension, Blood Pressure
Best Rest: Rest Time Before Blood Pressure Measurement Trial
The objectives of this study are to: 1. Determine the impact of wait time before initiating BP measurement on BP variability 2. Determine the difference in BP variability between measurements by amount of initial rest.
- Conditions
- Hypertension, Blood Pressure, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- NCT04031768
- Testing
- Timing of rest prior to blood pressure measurement
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Stability of Driving Pressure Changes During "Best Positive End Expiratory Pressure (PEEP)" Trial
The goal of this study is to better understand in changes in lung compliance as indicated by driving pressure (a non-invasive marker) following changes in positive end expiratory pressure (PEEP; a standard of care ventilator…
- Trial name
- NCT05958862
- Sponsor
- University of Alabama at Birmingham
COVID-19
A Clinical Trial of Convalescent Plasma Compared to Best Supportive Care for Treatment of Patients With Severe COVID-19
This is a randomized, prospective, multicenter, open label clinical trial of convalescent plasma compared to best supportive care for treatment of patients with severe COVID-19.
- Trial name
- CAPSID (NCT04433910)
- Testing
- Convalesscent Plasma
- Where
- 16 sites in Germany
- Volunteers
- 106 people
- Sponsor
- Deutsches Rotes Kreuz DRK-Blutspendedienst Baden-Wurttemberg-Hessen