Clinical trials: Best Disease
Faecal Incontinence
Best Surgical Technique for Optimal Lead Placement in Sacral Neuromodulation - a Comparative Cadaver Study
Sacral neuromodulation (SNM) is an established treatment option for patients with faecal incontinence. The location of the stimulating electrode is considered to be essential for treatment success.
- Trial name
- NCT04726904
- Testing
- Sacral neuromodulation in conventional implantation technique
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Medical University of Vienna
Peripheral Artery Disease
Best Practice Advisory to Initiate High-Intensity Statin Therapy in Patients With Peripheral Artery Disease
The purpose of this study is to understand how a Best Practice Advisory (BPA) for high-intensity statin therapy in patients with Peripheral Artery Disease impacts prescription rates.
- Trial name
- NCT05166187
- Testing
- Best Practice Advisory
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Vanderbilt University Medical Center
Colorectal Cancer, Metastases
Evaluating Panitumumab (ABX-EGF) Plus Best Supportive Care Versus Best Supportive Care in Patients With Metastatic Colorectal Cancer
The purpose of this study is to determine that panitumumab, using the proposed regimen, will safely increase progression free survival in patients with metastatic colorectal cancer who have failed available treatment options…
- Trial name
- NCT00113763
- Testing
- Best supportive care, Panitumumab
- Volunteers
- 463 people
- Sponsor
- Amgen
Chronic Graft Versus Host Disease
A Study to Investigate the Efficacy and Safety of Belumosudil Compared With Best Available Therapy in Participants Aged 12 Years or Older With Chronic Graft-versus-host Disease
Participants will be randomized 1:1 to receive either belumosudil or Best Available Therapy (BAT), with stratification based on baseline cGVHD severity as defined by the 2014◦NIH consensus criteria (moderate versus severe), use…
- Trial name
- NCT07771439
- Testing
- Belumosudil, Best available therapy (BAT)
- Volunteers
- 356 people
- Sponsor
- Sanofi
Metastatic Colorectal Cancer, Metastatic Colon Cancer
A Study of Efficacy and Safety of Fruquintinib (HMPL-013) in Participants With Metastatic Colorectal Cancer
This is a global, randomized, double-blind, placebo-controlled, multicenter phase 3 clinical trial to compare the efficacy and safety of fruquintinib plus best supportive care (BSC) versus placebo plus BSC in participants with…
- Trial name
- FRESCO-2 (NCT04322539)
- Testing
- Fruquintinib
- Where
- 153 sites in United States, Australia and 12 more
- Volunteers
- 691 people
- Sponsor
- Hutchison Medipharma Limited
Zygomatic Fractures
A Comparison of Three Surgical Approaches to Zygomaticomaxillary Fractures
The study is a randomized controlled clinical trial, following the Consolidated Standards of Reporting Trials (CONSORT) guidelines.
- Trial name
- NCT05695872
- Testing
- subtarsal approach, conventional transconjunctival approach, transconjunctival approach with Y- modification
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- University of Alexandria
Ischemic Stroke, Vertebral Artery Ischemia
Best Revascularisation Approach for Posterior Circulation Strokes With Isolated Vertebral Artery Occlusions
Isolated vertebral artery occlusions (VAO) account for approximately one third of posterior circulation occlusions, but have been given the least attention among posterior circulation strokes.
- Conditions
- Ischemic Stroke, Vertebral Artery Ischemia, Arterial Occlusive Diseases, Vertebrobasilar Insufficiency
- Trial name
- BRAVO (NCT05503212)
- Testing
- Conservative treatment (CT), Intravenous thrombolysis (IVT), Endovascular thrombectomy (EVT) ± intravenous thrombolysis (IVT)
- Where
- Switzerland
- Volunteers
- 682 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Urothelial Cancer
A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100)
The main purpose of this study is to compare maintenance treatment with avelumab plus best supportive care (BSC) with BSC alone, to determine if avelumab has an effect on survival in patients with locally advanced or metastatic…
- Trial name
- NCT02603432
- Testing
- Avelumab, Best Supportive Care, Following the planned interim analysis for this study: Avelumab
- Where
- 382 sites in United States, Argentina and 27 more
- Volunteers
- 700 people
- Sponsor
- Pfizer
Interstitial Lung Disease
Best Clinical Endpoints That Likely Induce Worse Prognosis in Interstitial Lung Diseases
This prospective cohort study will investigate whether progression of the interstitial lung diseases is related to specific clinical endpoints and their changes over time.
- Trial name
- BELIEVE-ILD (NCT03400839)
- Testing
- Daily physical activity levels, 6-minute walk test, Cardiopulmonary exercise testing
- Where
- Brazil
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Asthma
DESOLO - SiT Peri-Launch: A Comparison of Symbicort Single Inhaler Therapy and Conventional Best Practice for the Treatment of Persistent Asthma in Adults
The purpose of this study is to determine whether Symbicort dosed according to the Symbicort Maintenance and Reliever Therapy (SMART) concept is superior to standard asthma treatment according to the local German treatment…
- Trial name
- NCT00252863
- Testing
- Symbicort, used twice daily (b.i.d) and as needed (prn), Budesonide Turbuhaler 200 µg, Fluticasone Discus 250 µg
- Where
- 169 sites in Germany
- Volunteers
- 1,600 people
- Sponsor
- AstraZeneca
Venous Thromboembolism, Clinical Decision Support Systems
Smart Technology Facilitated Venous Thromboembolism Prophylaxis Based on Bundled Evidence-based Prevention Strategies
Venous thromboembolism (VTE) is the third leading cause of cardiovascular disease deaths globally, and its incidence is increasing over the years.
- Conditions
- Venous Thromboembolism, Clinical Decision Support Systems, Digital Health
- Trial name
- SmaVTE-BEST (NCT06353373)
- Testing
- Application of the modified DeVTEcare system
- Volunteers
- 15,626 people
- Sponsor
- Navy General Hospital, Beijing
Macular Holes
Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques
This study compares ten modern vitreoretinal surgical techniques for full-thickness macular hole repair. Participants will be randomly assigned to one of the surgical approaches during pars plana vitrectomy, using stratified…
- Trial name
- FTMH-10 (NCT07606404)
- Testing
- Pars Plana Vitrectomy (PPV)-Based Macular Hole Surgery, Autologous Platelet-Rich Plasma (PRP), Human Amniotic Membrane (hAM) Graft
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- Kazakh Eye Research Institute
Shoulder Adhesive Capsulitis
Best Treatment Modality of Frozen Shoulder
This study will compare between the effect of three treatment modalities of shoulder adhesive capsulitis to hilight the best technique to improve pain and range of motion outcome measures .
- Trial name
- NCT04897308
- Testing
- Local injection of shoulder joint
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Sohag University
Non Small Cell Lung Cancer
A Study Comparing of Two Different Chemotherapy Regimens, in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
This is a multicenter, open-label, randomized, two-arm Phase 2 study comparing pemetrexed plus best supportive care with best supportive care alone as maintenance therapy following first-line treatment with a pemetrexed-cisplatin…
- Trial name
- NCT00606021
- Testing
- pemetrexed, Best Supportive Care
- Where
- 5 sites in Egypt, Lebanon and 1 more
- Volunteers
- 106 people
- Sponsor
- Eli Lilly and Company
HIV Infections, Tuberculosis
A Study to Determine the Best Dose of Antivirals in Patients With Both TB and HIV
Because drugs used to treat TB can reduce the amount of the anti-HIV drugs that reach the sites where the virus is located, this study is designed to see whether it is necessary to use higher doses of antiviral (anti-HIV) drugs…
- Trial name
- OPTI-NNRTI (NCT00523458)
- Testing
- efavirenz or nevirapine
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Stanford University
Myelodysplastic Syndromes
An Extension to Study AZA PH GL 2003 CL 001 Allowing for Continuation of Azacitidine Treatment in Patients With Myelodysplastic Syndromes (MDS)
At the conclusion of study AZA PH GL 2003 CL 001 (NCT00071799), eligible participants could be enrolled in an optional extension phase in order to continue treatment with azacitidine until it became commercially available; the…
- Trial name
- NCT01186939
- Testing
- Azacitidine
- Where
- 22 sites in Australia, Bulgaria and 9 more
- Volunteers
- 40 people
- Sponsor
- Celgene
Facial Skin Condition
BeauSaki Bird's Nest Peptide Efficacy
The goal of this clinical trial is to learn whether BeauSaki Edible Bird's Nest Peptide Product can improve facial skin conditions in healthy adult participants.
- Trial name
- NCT07723508
- Testing
- BeauSaki Edible Bird's Nest Peptide Product
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chia Nan University of Pharmacy ＆ Science
Eating Disorders
Effectiveness of Stepped Care Versus Best Available Care for Bulimia Nervosa
This study will compare the medical and cost effectiveness of a stepped approach, including self-help and drug therapies, to the current best available care for bulimia nervosa.
- Trial name
- NCT00733525
- Testing
- Cognitive Behavioral Therapy, Fluoxetine, Guided Self-Help
- Where
- 4 sites in United States
- Volunteers
- 293 people
- Sponsor
- University of Minnesota
Cerebral Palsy
Investigating Best Practices for Children With Cerebral Palsy: A Pilot Study of Two Approaches
This project (CO-OP II) is the second in a series of three studies to validate a new treatment approach for children with cerebral palsy (CP).
- Trial name
- NCT00430131
- Testing
- Cognitive Orientation to Occupational Performance, Contemporary Treatment Approach
- Volunteers
- 18 people
- Sponsor
- University of Toronto
Age Related Macular Degeneration (AMD)
A 16 Week Evaluation of the Novartis Health Management Tool (HMT) in Age Related Macular Degeneration (AMD)
This is a prospective pilot study to evaluate the usability and applicability of a self monitoring test of visual function with the handheld Health Management Tool (HMT) to remotely monitor neovascular Age Related Macular…
- Trial name
- NCT01542866
- Testing
- Health Management Tool (HMT)
- Where
- 23 sites in United States
- Volunteers
- 160 people
- Sponsor
- Novartis Pharmaceuticals