Clinical trials: Best Disease
Ophthalmopathy
Assessing Agreement Between Acuvera Capture and Paper-Based Methods for BCVA Data Recording in Ophthalmic Trials
Study Purpose: To evaluate the level of agreement between the Acuvera Capture application and traditional paper-based methods for recording Best Corrected Visual Acuity (BCVA) in ophthalmic clinical trials.
- Trial name
- VALiCAPTURE (NCT07613580)
- Where
- 2 sites in Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- OptymEdge, LLC
Pharyngitis
Best Assessment of Sore Throat and Antibiotic Prescribing
This project aims to investigate if an organisational change of patient flow away from medical practitioners can reduce unnecessary antibiotic prescribing in patients attending with a sore throat as the main complaint.
- Trial name
- BASTA (NCT06114706)
- Testing
- Physicians assess patients, Nurses assess patients, Pharmacists assess patients
- Where
- 4 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Vastra Gotaland Region
Glioblastoma Multiforme
Study of Therapy With TransMID™ Compared to Best Standard of Care in Patients With Glioblastoma Multiforme
TransMID treatment or best standard of care for patients with advanced glioblastoma multiforme Glioblastoma multiforme (GBM) is a type of brain tumour. GBM tumours are usually treated with surgery and radiotherapy.
- Trial name
- NCT00083447
- Testing
- TransMID™
- Where
- 25 sites in United States, Australia
- Volunteers
- 323 people
- Sponsor
- Xenova Biomedix
HIV Infections
Safety Study of Once a Day ART and Opiate Substitute.
This study looks at HIV-infected subjects who are on methadone treatment and medicines for HIV.
- Trial name
- 3OD (NCT00324688)
- Testing
- Viread
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Gilead Sciences
Radiation Dermatitis
Trial Comparing Best Supportive Care to Aloe Vera Gel
Radiation therapy (RT) has been a component of breast cancer treatment for almost 100 years. Although initially used for the treatment of chest wall recurrences after mastectomy and for advanced inoperable disease, RT has evolved…
- Trial name
- NCT00876642
- Testing
- Aloe vera gel
- Where
- Brazil
- Volunteers
- 137 people
- Sponsor
- Marilia Medicine School
COVID-19
Effect of Tumor Treating Fields (TTFields, 150 kHz) Concomitant With Best Standard of Care for the Treatment of Hospitalized COVID-19 Patients and Continued Treatment Following Discharge
The study is a prospective, pilot study aimed to test the safety of Tumor Treating Fields (TTFields) concomitant with best standard of care, for the treatment of hospitalized COVID-19 patients and continued treatment after…
- Trial name
- NCT04953234
- Testing
- NovoTTF-100L
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- NovoCure GmbH
Metastatic Colorectal Carcinoma
A Study to Estimate Overall Survival in Patients Receiving Best Supportive Care for Treatment-Resistant, Metastatic Colorectal Carcinoma
The primary objective of this study is to estimate overall survival in patients only receiving best supportive care (BSC) for treatment-resistant, metastatic colorectal carcinoma.
- Trial name
- NCT03096899
- Testing
- Observational
- Where
- United States
- Sponsor
- The Rogosin Institute
Barrett's Esophagus, Esophageal Neoplasms
The Study of Barrett's Esophagus: What Are the Factors of Progression
This trial is a multi-center clinical and endoscopic outcomes project involving a single large database of patients with Barrett's Esophagus (BE).
- Trial name
- BEST (NCT00586404)
- Where
- 4 sites in United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Non-exudative (Dry) Age-related Macular Degeneration (AMD)
HELP Therapy for Dry AMD
This is an open-label, single center clinical investigation to evaluate the efficacy and safety of Heparin-induced Extracorporeal Lipoprotein Precipitation (H.E.L.P.) Therapy as a treatment for non-exudative (dry) Age-related…
- Trial name
- HELPuc (NCT01840683)
- Testing
- H.E.L.P. therapy (H.E.L.P. Plasmat Futura System)
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- B.Braun Avitum AG
Gastrointestinal Stromal Tumors
Study of Regorafenib as a 3rd-line or Beyond Treatment for Gastrointestinal Stromal Tumors (GIST)
A randomized, double-blind, placebo-controlled phase III study of regorafenib plus best supportive care versus placebo plus best supportive care for subjects with metastatic and/or unresectable gastrointestinal stromal tumors…
- Trial name
- GRID (NCT01271712)
- Testing
- Regorafenib (Stivarga, BAY73-4506), Best supportive care
- Where
- 57 sites in United States, Austria and 15 more
- Volunteers
- 199 people
- Sponsor
- Bayer
Psoriasis, Depression
Identification of the Best Self-questionnaire to Diagnose Depression in Patients With Psoriasis (DePsoVal)
Prevalence of depression shows great heterogeneity in patients with psoriasis. This could be explained by the psychometric properties of the questionnaires assessing depressive symptoms: these tests have not been developed in a…
- Trial name
- DePsoVal (NCT04013867)
- Where
- France
- Volunteers
- 289 people
- Sponsor
- University Hospital, Clermont-Ferrand
Polycythemia Vera
Study of Efficacy and Safety in Polycythemia Vera Subjects Who Are Resistant to or Intolerant of Hydroxyurea: JAK Inhibitor INC424 (INCB018424) Tablets Versus Best Available Care: (The RESPONSE Trial)
This pivotal phase III trial (CINC424B2301) is designed to compare the efficacy and safety of ruxolitinib (INC424) to Best Available Therapy (BAT) in participants with polycythemia vera (PV) who are resistant to or intolerant of…
- Trial name
- NCT01243944
- Testing
- ruxolitinib tablets, Best Available Therapy (BAT)
- Where
- 102 sites in United States, Argentina and 16 more
- Volunteers
- 222 people
- Sponsor
- Incyte Corporation
Multivessel Coronary Artery Disease
Ten-Year Outcomes of Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients With Multivessel Coronary Artery Disease
The primary objective of the BEST extended 10Y follow-up study is to compare the safety and effectiveness of coronary stent implantation using everolimus-eluting balloon-expandable stents with bypass grafting for the treatment of…
- Trial name
- BEST Extended (NCT05125367)
- Testing
- coronary stent implantation, bypass grafting
- Where
- 24 sites in China, Malaysia and 2 more
- Volunteers
- 880 people
- Sponsor
- Seung-Jung Park
Acute Ischemic Stroke
BEnefits of Stroke Treatment Delivered Using a Mobile Stroke Unit
The primary goal of this project is to carry out a trial comparing pre-hospital diagnosis and treatment of patients with stroke symptoms using a Mobile Stroke Unit (MSU) with subsequent transfer to a Comprehensive Stroke Center…
- Trial name
- BEST-MSU (NCT02190500)
- Testing
- Mobile Stroke Unit Management
- Where
- United States
- Volunteers
- 1,038 people
- Sponsor
- Memorial Hermann Health System
Neuropathic Pain
Burst Spinal Cord Stimulation for Neuropathic Pain
Recently a novel stimulation design was developed, called burst stimulation. In a non-placebo controlled pilot study burst stimulation seemed superior to tonic stimulation over a period extending more than 2 years, and even…
- Trial name
- NCT01486108
- Testing
- dorsal column stimulator
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University Hospital, Antwerp
Heart Failure, Chronic Kidney Diseases
A Clinical Trial to Define the Best Strategy for the Management of Heart Failure in Elderly Patients
Heart failure (HF) and Chronic Kidney Disease (CKD) patients are frequently not administered renin-angiotensin aldosterone system inhibitor (RAASi) therapies at recommended doses due to hyperkalaemia, despite proven mortality and…
- Trial name
- SENEKA (NCT06578078)
- Testing
- Sodium Zirconium Cyclosilicate, Standard of care treatment (RAASi therapy)
- Where
- 6 sites in Spain
- Volunteers
- 94 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Multiple Myeloma, Non-Hodgkins Lymphoma
Study of the Best Timing for Plerixafor in Autologous Hematopoietic Stem Cell Collection
The purpose of this study is to determine whether it is safe and effective to collect peripheral blood hematopoietic stem cells 16 hours rather than the usual 11 hours after administration of plerixafor.
- Trial name
- NCT01042717
- Testing
- Plerixafor
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shi, Patricia, M.D.
Parkinson Disease
Autocorrelated Rhythmic Auditory Stimulations for Parkinson's Disease Patients
Parkinson's Disease (PD) patients suffer from gait impairments responsible for falls and bad quality of life: reduced speed and stride length, randomness in stride duration variability (reduced Long-Range Autocorrelations (LRA)).
- Trial name
- NCT03716674
- Testing
- Metronome
- Volunteers
- 9 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Pancreatic Neoplasm, Gastric Neoplasm
The Role of Early Systematic Best Palliative Care Versus on Request Palliative Care Consultation During Standard Oncologic Treatment for Patients With Advanced Gastric or Pancreatic Cancers: a Randomized, Controlled, Multicenter Trial.
Title: The role of early systematic best palliative care versus on request palliative care consultation during standard oncologic treatment for patients with advanced gastric or pancreatic cancers: a randomized, controlled…
- Trial name
- NCT01996540
- Testing
- Interventional arm: Early best palliative care
- Where
- 30 sites in Italy
- Volunteers
- 394 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Granulomatous Disease, Chronic
Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995
Chronic granulomatous disease (CGD) is an inherited immune system abnormality in which bone marrow transplantation (BMT) has been shown to be curative.
- Trial name
- NCT02082353
- Where
- 44 sites in United States, Canada
- Volunteers
- 1,480 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)