Clinical trials: Best Disease
SARS-CoV 2, COVID-19
Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19
Study objective is to evaluate the efficacy of the combination of masitinib and isoquercetin in adult hospitalized patients with moderate and severe COVID-19.
- Conditions
- SARS-CoV 2, COVID-19, Coronavirus Disease 2019
- Trial name
- NCT04622865
- Testing
- Masitinib, Isoquercetin, Best Supportive Care
- Where
- 6 sites in France
- Volunteers
- 200 people
- Sponsor
- AB Science
Pregnancy, Spontaneous Abortions
Study of the Best Blastocyst Post Transfer by aCGH
An Observational, blind and prospective study of Preimplantational Aneuploidy Screening by aCGH in Trophectoderm Biopsy
- Conditions
- Pregnancy, Spontaneous Abortions, Stillbirth
- Trial name
- NCT01664546
- Testing
- Trophectoderm biopsy
- Where
- Argentina
- Volunteers
- 150 people
- Sponsor
- University of Buenos Aires
Non Metastatic Breast Cancer
Support and Rehabilitation Protocol for Non Metastatic Breast Cancer Patients in Complete Remission After Chemotherapy
Many breast cancer patients (BCP) will gain weight during chemotherapy and about 10% of them are able to find back to their initial weight after all treatments are finished.
- Trial name
- NCT01563588
- Testing
- dietaty education, physical training, physiotherapy and SPA cares
- Where
- 2 sites in France
- Volunteers
- 251 people
- Sponsor
- Centre Jean Perrin
Adverse Effects
Method of Fish Oil Administration on Patient Compliance
Many patients complain of fishy breath, upset stomach, or heartburn when taking the recommended amount of fish oil. A common recommendation made by pharmacists is to freeze the fish oil capsules to help decrease adverse…
- Trial name
- NCT01471366
- Testing
- Frozen capsule, Capsule with food, Capsule without food
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Mississippi, Oxford
Skin Ulcer Venous Stasis Chronic, Mixed Arteriovenous Leg Ulcer
Pilot Study Comparing NatroxTM Topical Oxygen Therapy to A Placebo in the Management of Non-Healing Leg Ulcers
The purpose of this study is to determine the effectiveness of the NatroxTM Topical Oxygen device versus a placebo in patients with non-healing leg ulceration in conjunction with standard best practice.
- Trial name
- NCT01913704
- Testing
- NatroxTM Device
- Where
- 2 sites in Czechia
- Sponsor
- Inotec AMD Limited
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical Hypothyroidism
Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism
The goal of this randomized controlled trial is to compare letrozole alone versus letrozole plus levothyroxine for ovulation induction in infertile women with both PCOS and subclinical hypothyroidism.
- Conditions
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical Hypothyroidism, Female Infertility
- Trial name
- NCT06041204
- Testing
- Letrozole 2.5mg, Levothyroxine 25 Mcg (0.025 Mg) Oral Tablet
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy
Prostatic Neoplasms
A Study of JNJ-101556143 With Best Supportive Care in Participants With Metastatic Prostate Cancer
The purpose of this study is to evaluate how well JNJ-101556143 plus Best Supportive Care (BSC) improves overall survival (the length of time a participant remains alive) compared with placebo plus BSC in participants with…
- Trial name
- NCT07906717
- Testing
- JNJ-101556143, Best Supportive Care
- Volunteers
- 400 people
- Sponsor
- Janssen Research & Development, LLC
Liver Cancer
Sorafenib in Liver Function Impaired Advanced Hepatocellular Carcinoma
Due to the HBV and HCV infection, about 55% hepatocellular carcinoma patients happened in China. Among them, only 10% patients can be diagnosed in early stage.
- Trial name
- NCT01932385
- Testing
- Sorafenib, Best Supportive Care
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Qingdao Central Hospital
Polycythemia Vera
Study of Efficacy and Safety in Polycythemia Vera Subjects Who Are Resistant to or Intolerant of Hydroxyurea: JAK Inhibitor INC424 (INCB018424) Tablets Versus Best Available Care: (The RESPONSE Trial)
This pivotal phase III trial (CINC424B2301) is designed to compare the efficacy and safety of ruxolitinib (INC424) to Best Available Therapy (BAT) in participants with polycythemia vera (PV) who are resistant to or intolerant of…
- Trial name
- NCT01243944
- Testing
- ruxolitinib tablets, Best Available Therapy (BAT)
- Where
- 102 sites in United States, Argentina and 16 more
- Volunteers
- 222 people
- Sponsor
- Incyte Corporation
Thyroid Function
Mothers and Babies at Yorkhill Thyroid Health Cohort
This is an observational study in pregnant mothers and their newborn babies. The rationale of the study is to examine early markers of the effects of iodine insufficiency during pregnancy on thyroid stimulating hormone (TSH) and…
- Trial name
- MABY (NCT02390128)
- Testing
- observational only
- Where
- United Kingdom
- Volunteers
- 697 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Obese, Analgesia
Dose of Magnesium Sulfate Infusion in Obese
Magnesium sulfate has been shown to be a successful tool in a large number of clinical areas. Its benefits include neuroprotection, control of eclampsia / pre-eclampsia, control of intraoperative blood pressure, decreased…
- Trial name
- NCT04645719
- Testing
- Lactate ringer group, Magnesium sulfate dose through real weight group, Magnesium sulfate dose through corrected ideal weight group
- Where
- 2 sites in Brazil
- Volunteers
- 75 people
- Sponsor
- University of Sao Paulo General Hospital
Systemic Sclerosis, Arthritis
Improvement of Hand Dysfunction by Arthritis in Systemic Sclerosis
Systemic sclerosis (SSc) is an orphan, multiorgan disease affecting the connective tissue of the skin and several internal organs.
- Trial name
- NCT01834157
- Where
- 33 sites in Belgium, Croatia and 12 more
- Volunteers
- 160 people
- Sponsor
- Prof. Laszlo Czirjak
Pilonidal Sinus Treatment, Pilonidal Sinus Disorder
Phenol or Laser: Best Minimally Invasive Treatment for Pilonidal Sinus?
Pilonidal sinus disease is a common condition. There is still ongoing research on the ideal treatment. Pilonidal sinus disease is most common in men between the ages of 20 and 30.
- Conditions
- Pilonidal Sinus Treatment, Pilonidal Sinus Disorder, Surgical Outcomes
- Trial name
- NCT06721169
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Mersin University
Stable Coronary Disease, Unstable Coronary Disease
Brazilian and Italian Evaluation of Safety Using Tacrolimus-eluting Stent With Short-term Dual Antiplatelet Regimen
To evaluate the safety and efficacy of the Janus OPTIMA Tacrolimus-Eluting Stent (Optima TES, CID) for the treatment of de novo coronary lesions when associated with short-term (two months) dual antiplatelet (aspirin +…
- Conditions
- Stable Coronary Disease, Unstable Coronary Disease, Documented Silent Ischemia
- Trial name
- BEST (NCT01122719)
- Testing
- Drug Eluting Stent
- Where
- 2 sites in Brazil, Italy
- Volunteers
- 16 people
- Sponsor
- CID - Carbostent & Implantable Devices
Concussion, Mild, Concussion, Brain
Building Emotional Self-Awareness Teletherapy (BEST)
To examine the feasibility, acceptability, and preliminary efficacy of a remotely delivered intervention for civilians and service members with mild traumatic brain injury (mTBI) who have difficulty recognizing and regulating…
- Conditions
- Concussion, Mild, Concussion, Brain, Concussion, Severe, Concussion, Intermediate
- Trial name
- BEST (NCT05623046)
- Testing
- Treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Psychotic Disorders
Cognitive Remediation and Supported Education in Psychotic Disorders
This trial aims to assess the added value of cognitive remediation therapy to supported education intervention in young adults with a psychotic disorder.
- Trial name
- REUSSIR (NCT04040829)
- Testing
- Cognitive remediation therapy (CR), Supported education (SE), Treatment as usual (TAU)
- Where
- 3 sites in Canada
- Volunteers
- 9 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec
Cancer of Prostate
Dynamic Focusing Evaluation for Prostate Cancer Treatment
Define the best acoustic parameters for the dynamic focusing HIFU transducer in the treatment of localized Prostate Cancer.
- Trial name
- FOC/DYN (NCT03632980)
- Testing
- "Ablatherm Foc/Dyn" or "Focal One" HIFU treatment
- Where
- France
- Volunteers
- 180 people
- Sponsor
- EDAP TMS S.A.
Pancreatic Neoplasm, Gastric Neoplasm
The Role of Early Systematic Best Palliative Care Versus on Request Palliative Care Consultation During Standard Oncologic Treatment for Patients With Advanced Gastric or Pancreatic Cancers: a Randomized, Controlled, Multicenter Trial.
Title: The role of early systematic best palliative care versus on request palliative care consultation during standard oncologic treatment for patients with advanced gastric or pancreatic cancers: a randomized, controlled…
- Trial name
- NCT01996540
- Testing
- Interventional arm: Early best palliative care
- Where
- 30 sites in Italy
- Volunteers
- 394 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Cesarean Section, Cardiac Output
Best Regimen for Phenylephrine Administration During Cesarean Section
During Cesarean delivery, phenylephrine is used to maintain the patient's blood pressure. Low blood pressure is the most common side effect of the spinal medication used to anesthetize the patient prior to the start of surgery.
- Conditions
- Cesarean Section, Cardiac Output, Hypotension
- Trial name
- NCT00996190
- Testing
- Phenylephrine
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Age Problem
The SUMAMOS EXCELENCIA Project: Assessment of Implementation of Best Practices in a National Health System
There is a gap between research and clinical practice, leading to variability in decision-making. Clinical audits are an effective strategy for improving implementation of best practices.
- Trial name
- NCT03725774
- Testing
- GRIP (Getting Research into Practice) model
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Teresa Moreno Casbas