Clinical trials: Best Disease
Age Problem
The SUMAMOS EXCELENCIA Project: Assessment of Implementation of Best Practices in a National Health System
There is a gap between research and clinical practice, leading to variability in decision-making. Clinical audits are an effective strategy for improving implementation of best practices.
- Trial name
- NCT03725774
- Testing
- GRIP (Getting Research into Practice) model
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Teresa Moreno Casbas
Acute Myeloid Leukemia
Reduced Intensity Conditioning Transplantation Versus Standard of Care in Acute Myeloid Leukemia
This study compares overall survival between patients with acute myeloid leukemia, who are in complete remission following initial treatment with chemotherapy and whose remission is maintained either with a transplantation of…
- Trial name
- NCT00342316
- Testing
- Reduced Intensity Conditioning Stem Cell Transplantation
- Where
- 25 sites in Australia, Canada and 7 more
- Volunteers
- 340 people
- Sponsor
- Vastra Gotaland Region
Rapid Sequence Induction
Best Hypnotic Drug Choice for Rapid Sequence Induction in the Operating Room
The best hypnotic choice to optimize the balance between good intubation condition quality and hemodynamic stability during RSI performed in the operating theatre remained to be investigated.
- Trial name
- HYPNOTIKS (NCT06733129)
- Testing
- direct IV injection, combination of Ketamine and Propofol
- Where
- 20 sites in France
- Volunteers
- 1,218 people
- Sponsor
- Nantes University Hospital
Polycystic Ovary Syndrome
Mediterranean Diet Versus Hypocaloric Diet in PCOS
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive-aged women that manifests itself with chronic anovulation, hyperandrogenism and insulin resistance.
- Trial name
- NCT02397174
- Testing
- mediterranean diet, restricted calorie, hypocaloric diet, restricted calorie
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona
Acute Myeloid Leukemia
Using Gilteritinib to Keep People With Acute Myeloid Leukemia Cancer-free After a Stem Cell Transplant
People with acute myeloid leukemia (AML) are usually treated with chemotherapy. When the cancer comes back (relapse) the next treatment is usually a stem cell transplant.
- Trial name
- NCT06734585
- Testing
- Gilteritinib
- Where
- 18 sites in Australia, Brazil and 4 more
- Volunteers
- 114 people
- Sponsor
- Astellas Pharma Singapore Pte. Ltd.
Leukemia, Myeloid, Acute
An Efficacy and Safety Study of Oral Azacitidine (CC-486) as Maintenance Therapy in Chinese Participants With Acute Myeloid Leukemia in Complete Remission
The purpose of this study is to evaluate the efficacy and safety of Oral Azacitidine (CC-486) in Chinese participants with acute myeloid leukemia in complete remission.
- Trial name
- NCT05413018
- Testing
- CC-486
- Where
- 34 sites in China
- Volunteers
- 34 people
- Sponsor
- Bristol-Myers Squibb
Inherited Ophthalmic Diseases, Hypopigmentation Disorder
National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases
Background: The eyeGENE (Registered Trademark) program is a research resource for inherited eye conditions which includes genotypic and phenotypic data, imaging, and a corresponding biobank of DNA samples from people with a…
- Conditions
- Inherited Ophthalmic Diseases, Hypopigmentation Disorder, Corneal Dystrophy, Blue-cone Monochromacy
- Trial name
- NCT06491615
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- National Eye Institute (NEI)
Cesarean Section, Cardiac Output
Best Regimen for Phenylephrine Administration During Cesarean Section
During Cesarean delivery, phenylephrine is used to maintain the patient's blood pressure. Low blood pressure is the most common side effect of the spinal medication used to anesthetize the patient prior to the start of surgery.
- Conditions
- Cesarean Section, Cardiac Output, Hypotension
- Trial name
- NCT00996190
- Testing
- Phenylephrine
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Colorectal Cancer, Metastatic Cancer
Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
RATIONALE: Hepatic arterial infusion uses a catheter to carry tumor-killing substances directly into the liver. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or…
- Trial name
- NCT00492999
- Testing
- dexamethasone, floxuridine, fluorouracil
- Where
- 5 sites in United States
- Volunteers
- 64 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Benign Paroxysmal Positional Vertigo
Evidence Based Best Care Practice for Benign Paroxysmal Positional Vertigo
The study evaluates a theory-based educational intervention and implementation strategy on the use of the Dix-Hallpike test (DHT) and Canalith Repositioning Maneuver (CRM) in a community Emergency Department (ED) setting.
- Trial name
- NCT02809599
- Testing
- DIZZTINCT
- Volunteers
- 7,635 people
- Sponsor
- University of Michigan
Non Small Cell Lung Cancer
A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer
The main purpose of this study is to evaluate how safe and effective the study drug known as abemaciclib is in participants with lung cancer.
- Trial name
- JUNIPER (NCT02152631)
- Testing
- Abemaciclib, Erlotinib
- Where
- 231 sites in United States, Argentina and 19 more
- Volunteers
- 453 people
- Sponsor
- Eli Lilly and Company
Hepatic Insufficiency, Cirrhosis, Liver
Diagnosis of Lymphohistiocytic Hemophagocytosis in Intensive Care
Patients with hepatocellular insufficiency and/or cirrhosis are at risk of developing invasive fungal infections, particularly in critical care settings.
- Trial name
- SAMICU (NCT07343037)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Hypoxemic Respiratory Failure, Ventilation, Mechanical
Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure
This observational study will analyze data already collected by the investigators as part of their routine clinical practice from patients with acute respiratory failure (ARF) treated with mechanical ventilation.
- Trial name
- TAC-EIT-20-5 (NCT07175194)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
Age-Related Macular Degeneration, Retinal Function
Ranibizumab Short- and Log-term Effects on Retinal Function in wAMD
Multifocal-electroretinoram (ERG) and microperimetry are objective criteria to asses retinal function. No information besides visual acuity exist for the development of retinal function during the course of wet AMD during therapy…
- Trial name
- LucERG (NCT01269151)
- Testing
- Lucentis (Ranibizumab)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Luebeck
Colorectal Cancer
Botensilimab + Balstilimab vs Best Supportive Care as Therapy in Chemo-refractory, Unresectable, Colorectal Adenocarcinoma
This study is being done to answer the main question of: Do patients with colorectal cancer that cannot be removed by surgery, that is treated with two new immunotherapy drugs, botensilimab and balstilimab, live longer? Other…
- Trial name
- BATTMAN (NCT07152821)
- Testing
- Best Supportive Care, Balstilimab, Botensilimab
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Canadian Cancer Trials Group
Keratoconus
Lamellar Transplant With Lyophilized Corneas
The goals of this study are to develop a lyophilization method for anterior lamellar transplants in Brasil and to make a comparative analysis among patients transplanted with lyophilized and optisol corneas
- Trial name
- NCT00409955
- Testing
- Lamellar transplant with lyophilized corneas
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of São Paulo
Arrhythmia
Trial of a Best-Practice Alert in the Electronic Medical Record to Reduce Unnecessary Telemetry Monitoring
This is a randomized trial of a best-practice alert delivered via the electronic medical record (Apex) to physicians on the Medicine service at UCSF Medical Center over a six month period.
- Trial name
- NCT02529176
- Testing
- Best-practice alert
- Volunteers
- 1,021 people
- Sponsor
- University of California, San Francisco
Neoplasms, Carcinoma, Non-Small-Cell Lung
This Study Tests the New Medicine BI 754111 Alone or in Combination With Another New Substance BI 754091 in Patients With Advanced Cancer. The Study Tests Different Doses to Find the Best Dose for Continuous Treatment.
This is a study in adults with advanced solid tumors including non-small cell lung cancer. The study tests the combination of two medicines called BI 754111 and BI 754091 that may help the immune system to fight the cancer.
- Trial name
- NCT03156114
- Testing
- Ezabenlimab, BI 754111
- Where
- 15 sites in United States, Canada and 3 more
- Volunteers
- 172 people
- Sponsor
- Boehringer Ingelheim
Arthritis
Balance Impairment and Falls Risk in People With Lower Limb Arthritis, and Can These be Improved With Exercise?
Arthritis has been reported as a risk factor for falls. Few studies have investigated the effect of balance training on balance performance in women with lower limb arthritis.
- Trial name
- NCT00527189
- Testing
- Balance Exercises
- Where
- Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Ageing Research Institute, Australia
Treatment Resistant Depression (TRD)
Treatment Resistant Depression and Vagus Nerve Stimulation
Depression is a common illness, affecting 17% of the population over the course of a lifetime. A third of depressions relapses and progresses to recurrence and resistance to treatments.
- Trial name
- DepVNS (NCT05952674)
- Testing
- Vagus Nerve Stimulation (VNS), Best Medical Treatment
- Where
- 24 sites in France
- Volunteers
- 166 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris