Clinical trials: Best Disease
Salt; Deficit (or Low), Cystic Fibrosis
Evaluation of Salt Status in Patients With Cystic Fibrosis
The results of the annual check-up will be collected to evaluate the best urinary marker for fractional sodium excretion and salt status will be correlated to clinical outcome measures.
- Trial name
- NCT04556162
- Testing
- fractional sodium excretion, risk subgroups
- Where
- Belgium
- Volunteers
- 222 people
- Sponsor
- University Hospital, Ghent
Bipolar Disorder, Multiple Mental Health Conditions
Narrative Enhancement and Cognitive Therapy for Self-Stigma in Youth
The goal of this pilot clinical trial is to assess the feasibility of conducting a full-scale study to learn if a new youth-adapted Narrative Enhancement and Cognitive Therapy (NECT-Y) reduces self-stigma in youth living with…
- Trial name
- NCT06672562
- Testing
- Narrative Enhancement and Cognitive Therapy, Usual care
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Centre for Addiction and Mental Health
Neovascular Age-related Macular Degeneration
Safety and Efficacy of ADVM-022 in Treatment-Experienced Patients With Neovascular Age-related Macular Degeneration [LUNA]
Neovascular or wet age-related macular degeneration (nAMD) is a degenerative ocular disease associated with the infiltration of abnormal blood vessels in the retina from the underlying choroid layer and is a leading cause of…
- Trial name
- NCT05536973
- Testing
- ADVM-022
- Where
- 39 sites in United States, France and 1 more
- Volunteers
- 69 people
- Sponsor
- Adverum Biotechnologies, Inc.
Vascular Malformations
Treatment of Low-flow Vascular Malformations With Bleomycin Electrosclerotherapy (BEST)
In biomedical applications, electroporation is used not only for cancer treatment but also for vaccinations, treatment of cardiac arrhythmias and, more recently, for the treatment of vascular malformations.
- Trial name
- BEST (NCT07579962)
- Testing
- Bleomycin Sulfate
- Where
- Slovenia
- Volunteers
- 140 people
- Sponsor
- Institute of Oncology Ljubljana
Intracerebral Haemorrhage
Early Minimally Invasive Image Guided Endoscopic Evacuation of Intracerebral Haemorrhage (EMINENT-ICH)
This is an open-labelled, single centre randomised controlled trial evaluating the efficacy of early minimally invasive image-guided hematoma evacuation in combination with the current best medical treatment compared to best…
- Trial name
- EMINENT-ICH (NCT05681988)
- Testing
- Early minimally invasive image guided endoscopic hematoma evacuation, Best medical treatment (BMT)
- Where
- 10 sites in Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Opioid-related Disorders, HIV Infections
Project BEST: Buprenorphine Entry Into Substance Abuse Treatment
Project BEST is a clinical project funded by the Substance Abuse and Mental Health Services Administration (SAMHSA) to increase treatment to opiate dependent patients with mental illness in New Haven, CT and to prospectively…
- Conditions
- Opioid-related Disorders, HIV Infections, Hepatitis C, Chronic, Depression
- Trial name
- NCT02583243
- Testing
- MET/CBT based individualized counseling, Buprenorphine
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Yale University
Chronic Graft-versus-host-disease
A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)
This study will be conducted to compare Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy.
- Trial name
- NCT07124078
- Testing
- INCA034176, Best available Treatment (BAT)
- Where
- 41 sites in United States, Belgium and 4 more
- Volunteers
- 60 people
- Sponsor
- Incyte Corporation
Intellectual Disabilities, Developmental Disability
Health Engagement & Access Through Learning, Training, and Health-coaching With People With Intellectual and/or Developmental Disabilities
The purpose of this study is to see if a combination of an educational curriculum and health coaching embedded within Special Olympics improves health outcomes and healthcare access compared to regular Special Olympics sport and…
- Trial name
- HEALTH 4 ME (NCT07475117)
- Testing
- Comprehensive Community Health, Regular Special Olympics programming
- Where
- United States
- Volunteers
- 1,040 people
- Sponsor
- University of Wisconsin, Madison
Eating Disorders, Bulimia
Guided Self-Help Treatment for Binge Eating Disorder
This study will determine the effectiveness of guided self-help treatment in treating individuals with binge eating disorder (BED).
- Trial name
- BEST (NCT00158340)
- Testing
- Guided self-help cognitive behavioral therapy (CBT), Usual clinical care
- Where
- 2 sites in United States
- Volunteers
- 284 people
- Sponsor
- Kaiser Permanente
Skin Ulcer Venous Stasis Chronic, Mixed Arteriovenous Leg Ulcer
Pilot Study Comparing NatroxTM Topical Oxygen Therapy to A Placebo in the Management of Non-Healing Leg Ulcers
The purpose of this study is to determine the effectiveness of the NatroxTM Topical Oxygen device versus a placebo in patients with non-healing leg ulceration in conjunction with standard best practice.
- Trial name
- NCT01913704
- Testing
- NatroxTM Device
- Where
- 2 sites in Czechia
- Sponsor
- Inotec AMD Limited
Alzheimer's Disease
Development of Therapeutic Intervention for Sleep in Alzheimer/Caregiver Dyads
This non-intervention qualitative study will use focus groups to assess the feasibility and acceptability of a proposed intervention for a future study.
- Trial name
- BEST-Sleep (NCT02506374)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Stroke, Ischemic
Triage of Patients Presenting Beyond 24 Hours With Ischemic Stroke Due to Vertebrobasilar Artery Occlusion
Endovascular thrombectomy (EVT) for posterior circulation occlusion is generally performed within a window of less than 24 hours from the time the patient was last known well (LKW).
- Trial name
- VBAO-LATE (NCT06510634)
- Testing
- Endovascular Therapy
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Tianjin Huanhu Hospital
Hearing Loss, Cytomegalovirus
The Benefits Feasibility and Acceptability of Extended Screening Testing in Newborn Babies Who Are Referred for Further Hearing Assessment
This study will look at the feasibility and acceptability of testing newborn babies who are referred after their newborn hearing screen for an infection called congenital Cytomegalovirus (cCMV).
- Trial name
- BEST (NCT01162330)
- Testing
- Screening urine and saliva tests for congenital Cytomegalovirus
- Where
- United Kingdom
- Volunteers
- 411 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Multiple Myeloma
A Study of Carfilzomib vs Best Supportive Care in Subjects With Relapsed and Refractory Multiple Myeloma
This is a Phase 3, randomized, open-label, multicenter study comparing two treatment regimens for subjects with multiple myeloma who have received all available approved treatment options and may therefore be considered…
- Trial name
- FOCUS (NCT01302392)
- Testing
- Carfilzomib, Best Supportive Care
- Where
- 68 sites in Australia, Austria and 17 more
- Volunteers
- 315 people
- Sponsor
- Amgen
Acute Coronary Syndrome, Medication Adherence
Using Automated Calls To Improve Compliance With Acute Coronary Syndrome Best Practice Guidelines
The purpose of this study is to determine whether interactive voice response (IVR) technology can be used to bring post discharge care for acute coronary syndrome (ACS) closer to best practice guidelines (BPGs).
- Trial name
- NCT01151800
- Testing
- Using IVR to maintain ACS patients on best practice guidelines
- Where
- Canada
- Volunteers
- 1,608 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Relapsing Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
This is a multi-center prospective rater-masked (blinded) randomized controlled trial of 156 participants, comparing the treatment strategy of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) to the treatment strategy…
- Conditions
- Relapsing Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
- Trial name
- BEAT-MS (NCT04047628)
- Testing
- Autologous Hematopoietic Stem Cell Transplantation, Best Available Therapy (BAT)
- Where
- 23 sites in United States
- Volunteers
- 156 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Recurrent Glioblastoma Multiforme
Effect of NovoTTF-100A in Recurrent Glioblastoma Multiforme (GBM)
The study is a randomized, controlled trial, designed to test the efficacy and safety of a new medical device, the NovoTTF-100A.
- Trial name
- NCT00379470
- Testing
- NovoTTF-100A
- Where
- 25 sites in United States, Austria and 5 more
- Volunteers
- 236 people
- Sponsor
- NovoCure Ltd.
Digestive Cancer, Metastatic Colorectal Cancer
TARGETed Therapy Drug MONITOring in DIGestive Oncology
Targeted therapy drug monitoring in digestive oncology: Dosage of plasma levels of various multikinase inhibitors (MKI) in patients treated for advanced digestive cancer (gastrointestinal stromal tumor (GIST), metastatic…
- Conditions
- Digestive Cancer, Metastatic Colorectal Cancer, Hepatocellular Carcinoma, GIST
- Trial name
- TARGETMONITO (NCT05443087)
- Testing
- Blood sampling to build population pharmacokinetics model
- Where
- 29 sites in France
- Volunteers
- 330 people
- Sponsor
- UNICANCER
COVID-19
Treatment of COVID-19 Patients With Anti-interleukin Drugs
The purpose of this study is to test the safety and effectiveness of individually or simultaneously blocking IL-6 and IL-1 versus standard of care on blood oxygenation and systemic cytokine release syndrome in patients with…
- Trial name
- COV-AID (NCT04330638)
- Testing
- Usual Care, Anakinra, Siltuximab
- Where
- 15 sites in Belgium
- Volunteers
- 342 people
- Sponsor
- University Hospital, Ghent
Chest Pain
The BEACON Registry: Best Expert Agreement for Care of Occult Myocardial Infarction (MI) Nationally
The purpose of this registry is to assess and improve the process of care and health outcomes of patients presenting to the Emergency Department with chest pain suspected to be of cardiac origin.
- Trial name
- BEACON (NCT00560248)
- Where
- United States
- Volunteers
- 1,897 people
- Sponsor
- The Cleveland Clinic