Clinical trials: Best Disease
Metastatic Colorectal Cancer (mCRC)
Evaluation of a Diagnostic Test to Identify the Best Drugs for Treatment of Metastatic Colorectal Cancer
DSEE-CRC is a top-tier Norwegian and Swedish public-private partnership for the development of µCAN, a unique patient-centric, therapy-guiding in vitro diagnostic test to improve cancer treatment outcomes for metastatic…
- Trial name
- DSEE-CRC (NCT07171554)
- Testing
- µCAN drug screen test, Standard-of-Care Therapy
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Oncosyne AS
Acute Myeloid Leukemia
A Study Comparing Allogeneic Hematopoietic Cell Transplantation Versus Best Available Standard of Care Therapy in Elderly Patients With Acute Myeloid Leukemia
A subject of major interest for researchers, clinicians, patients, and payers, is the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of these older patients with AML.
- Trial name
- ALLO-BEST (NCT04822766)
- Testing
- Hematopoietic stem cell transplantation, Best chemotherapy treatment
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension, Obesity
A Randomized, Double-Blind, Active Control Trial Comparing Effects of Telmisartan, Candesartan and Amlodipine, Alone or Plus Metformin, on Non-Diabetic, Obese Hypertensive Patients
The epidemic of obesity is associated with a considerable rise in the incidence of the metabolic syndrome, type 2 diabetes mellitus, and hypertension.
- Trial name
- HOT-ACME (NCT00538486)
- Testing
- Telmisartan plus Metformin, Telmisartan, Candesartan
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Third Military Medical University
Bacterial Vaginosis
Treatment of Bacterial Vaginosis Combined With Human Lactobacilli
The primary objectives of this study were to characterize lactobacilli of human vaginal origin and to investigate if more extended antibiotic treatment against Bacterial Vaginosis, together with adjuvant lactobacilli treatment…
- Trial name
- NCT01245322
- Testing
- lactobacilli
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Skaraborg Hospital
Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Stability of Driving Pressure Changes During "Best Positive End Expiratory Pressure (PEEP)" Trial
The goal of this study is to better understand in changes in lung compliance as indicated by driving pressure (a non-invasive marker) following changes in positive end expiratory pressure (PEEP; a standard of care ventilator…
- Trial name
- NCT05958862
- Sponsor
- University of Alabama at Birmingham
COVID-19
Acalabrutinib Study With Best Supportive Care Versus Best Supportive Care in Subjects Hospitalized With COVID-19.
CALAVI US will investigate the safety, efficacy and pharmacokinetics of acalabrutinib together with Best Supportive Care in the treatment of COVID-19.
- Trial name
- CALAVI US (NCT04380688)
- Testing
- Acalabrutinib
- Where
- 31 sites in United States
- Volunteers
- 62 people
- Sponsor
- AstraZeneca
Quality of Life, Brain Metastases
Evaluation of the Best Treatment in Terms of Quality of Life for Patients Having a Brain Metastasis
Main Goal : evaluation of quality of life for patient having a brain metastasis and allowed to have either surgery and radiosurgery of the surgical site or only hypofractionned radiosurgery on the lesion.
- Trial name
- OPTMETACER (NCT04358666)
- Testing
- surgery and focal radiosurgery of the surgical bed
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Non-small Cell Lung Cancer
Effects of Selected Vegetable and Herb Mix (SV) on Advanced Non-small Cell Lung Cancer
The primary objective of these two studies is to test the hypothesis that the daily ingestion of a dietary supplement, Selected Vegetables and Herbs Mix (SV), which consists of non-toxic botanicals containing known anti-cancer…
- Trial name
- NCT00246727
- Testing
- Selected Vegetable and Herb Mix
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Sun Farm Corporation
Parkinson's Disease
STN-Stimulation Versus Best Medical Treatment in Advanced PD
Assessment of the therapeutic effect of deep brain stimulation of the subthalamic nucleus compared with drug treatment alone in patients with advanced Parkinson's disease.
- Trial name
- NCT00196911
- Testing
- Implantation of stimulation electrodes in the STN
- Where
- 6 sites in Germany
- Volunteers
- 156 people
- Sponsor
- German Parkinson Study Group (GPS)
Type 2 Diabetes Mellitus
Beta-Cell Function and Sitagliptin Trial (BEST)
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by progressive deterioration in the function of the pancreatic beta-cells, which are the cells that produce and secrete insulin (the hormone primarily…
- Trial name
- BEST (NCT00420511)
- Testing
- Sitagliptin, metformin
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Gambling Disorder
Contingency Management as an Adjunct Treatment for Rural and Remote Disordered Gamblers
The purpose of this project is to pilot contingency management as an adjunct treatment to counselling as usual using internet delivered video-conferencing applications for remote disordered gamblers.
- Trial name
- NCT02953899
- Testing
- Contingency Management, Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Lethbridge
Acute Ischemic Stroke
EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke
Acute ischemic stroke (AIS) is one of the main causes of disability and loss of quality adjusted life years. This study is to analyze whether endovascular therapy (EVT) in addition to best medical treatment (BMT) reduces the…
- Trial name
- DISTAL (NCT05029414)
- Testing
- Endovascular Therapy
- Where
- 56 sites in Belgium, Finland and 9 more
- Volunteers
- 543 people
- Sponsor
- University Hospital, Basel, Switzerland
Retinal Disease, Bestrophinopathy
Stem Cell Models of Best Disease and Other Retinal Degenerative Diseases.
Background: Autosomal recessive bestrophinopathy (ARB) is one of 5 blinding eye diseases caused by mutations in the gene BEST1. These diseases, collectively termed "bestrophinopathies" include ARB, Best vitelliform macular…
- Conditions
- Retinal Disease, Bestrophinopathy, Best Vitelliform Macular Dystrophy, Adult Onset Vitelliform Macular Dystrophy
- Trial name
- NCT02162953
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Peripheral Arterial Disease, Critical Limb Ischemia
Exercise Rehabilitation for Patients With Critical Limb Ischemia After Revascularization
Peripheral arterial disease (PAD) affects more than 200 million people worldwide. This disease occurs with narrowing and occlusion of arteries supplying oxygenated blood to the organs and limbs.
- Trial name
- NCT03839953
- Testing
- Supervised Exercise Program, Best Medical Therapy
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
SIRS, Sepsis
Hematological Infection Score Compared to the Hospital Standard for Diagnosis of SIRS or Sepsis on ICU
CRP and PCT are not valid parameters of early infection in particularly postoperative patients. (Sanders et al., A\&A, June 2006, Vol.102; Katja et al., Shock, February 2001, Vol 15.2) Better detection systems for SIRS and sepsis…
- Trial name
- NCT01236703
- Where
- Germany
- Volunteers
- 207 people
- Sponsor
- Charite University, Berlin, Germany
Leptomeningeal Carcinomatosis, Leptomeningeal Metastases
ANG1005 in Leptomeningeal Disease From Breast Cancer
This is an open-label Phase 3 study to see if ANG1005 can prolong survival compared to a Physician Best Choice control in HER2-negative breast cancer patients with newly diagnosed leptomeningeal disease and previously treated…
- Conditions
- Leptomeningeal Carcinomatosis, Leptomeningeal Metastases, Brain Metastases, HER2-negative Breast Cancer
- Trial name
- ANGLeD (NCT03613181)
- Testing
- ANG1005, Physician's Best Choice
- Volunteers
- 150 people
- Sponsor
- Angiochem Inc
Breast Cancer
To Discuss the Best Mode for Taking Lapatinib Under the Influence of the Diet
Food can make a big difference on the bioavailability of lapatinib in breast cancer patients,and fatty food can increase the lapatinib bioavailability.By examine the steady blood drug concentration in the same individual at…
- Trial name
- NCT03075995
- Testing
- hight-fat breakfast
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Sun Yat-sen University
Non-Hodgkin Lymphoma
Identification of the Best Treatment Pathway for Patients With Relapsed/Refractory Lymphocytic B-derived Non-Hodgkin Lymphoma
Bispecific antibodies have demonstrated high efficacy in the treatment of Refractory/relapsed b-cell non-Hodgkin lymphomas. However, a non-negligible percentage of patients do not respond to therapy and/or develop significant…
- Trial name
- ASCLEPIO (NCT07614035)
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Myelodysplastic Syndromes
PREDICTive FactOR of Overall Survival Among Geriatric Assessment Tools and Disease Related Factors in Elderly Patients With High Risk Myelodysplastic Syndromes.
No prospective study was conducted in elderly patients with cancer to assess the relative value of disease-related and patient-related prognosis factors.
- Trial name
- PREDICTOR (NCT02689622)
- Testing
- research of disease-related factors, research of comorbidities, physical performance
- Where
- 31 sites in France, Monaco
- Volunteers
- 157 people
- Sponsor
- University Hospital, Toulouse
GVHD
Proof-of-concept Trial of Apraglutide in Acute Graft Versus Host Disease (aGVHD)
The aim of this trial is to assess safety and efficacy of apraglutide in subjects with steroid refractory gastrointestinal aGVHD.
- Trial name
- NCT05415410
- Testing
- Apraglutide
- Where
- 13 sites in United States, Germany and 2 more
- Volunteers
- 31 people
- Sponsor
- VectivBio AG