Clinical trials: Best Disease
Aortic Valve Stenosis, Valvular Heart Disease
CoreValve Advance-II Study: Prospective International Post-market Study
The CoreValve ADVANCE-II Study is a best practices investigation of patients implanted with the Medtronic CoreValve bioprosthesis.
- Trial name
- Advance-II (NCT01624870)
- Where
- 9 sites in Belgium, Czechia and 4 more
- Volunteers
- 200 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Autism, Children
A Realist Evaluation of Autism ServiCe Delivery (RE-ASCeD)
Diagnostic pathways for children with possible autism. Which work best, for whom, when, and at what cost? Autism is a complex neuro-behaviour condition.
- Conditions
- Autism, Children, Family, Diagnoses, Syndromes, and Conditions
- Trial name
- Re-ASCed (NCT04422483)
- Testing
- Realist evaluation
- Where
- United Kingdom
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Sussex Community NHS Foundation Trust
Respiratory Distress Syndrome, Adult
Pilot Study of Positive-End Expiratory Pressure in Acute Respiratory Distress Syndrome
Randomized controlled pilot trial in 70 patients with Acute Respiratory Distress Syndrome (ARDS) ventilated with low tidal volumes and limitation on airway pressure at 35 centimeters of water (cmH2O), to compare two different…
- Trial name
- PEEP-HUPA (NCT01119872)
- Testing
- Positive End-expiratory Pressure (PEEP)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitario Principe de Asturias
Intermittent Claudication, Peripheral Vascular Diseases
Does Neuromuscular Electrical Stimulation Improve the Absolute Walking Distance in Patients With Intermittent Claudication Compared to Best Available Treatment?
Intermittent claudication (IC) is caused by a blockage in the artery of the leg, causing muscle pain. Although some evidence of the efficacy of neuromuscular electrical stimulation (NMES) in the management of patients with IC…
- Trial name
- NESIC (NCT03446027)
- Testing
- NMES
- Where
- 11 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Ventilator Associated Pneumonia
PK of BV100 in Patients VABP Suspected or Confirmed to Be Due to CRAB
A multicenter Phase 2 study to evaluate the pharmacokinetics, efficacy, and safety of intravenous BV100 combined with Polymyxin B in adult patients with VABP suspected or confirmed to be due to CRAB
- Trial name
- NCT05685615
- Testing
- BV100 plus Polymyxin B, BAT
- Where
- 16 sites in Georgia, Greece and 1 more
- Volunteers
- 39 people
- Sponsor
- BioVersys AG
Prematurity; Extreme, Prematurity
Breastfeeding Support and Promotion Program to Improve the Health of Premature Babies (PAP-LM)
This study evaluates the effectiveness of a breastfeeding support and promotion program to increase exclusive breastfeeding rates in the preterm group.
- Trial name
- PAP-LM (NCT06653595)
- Testing
- Programme to Support Breastfeeding
- Where
- 2 sites in Spain
- Volunteers
- 162 people
- Sponsor
- University of Barcelona
Neovascular Age-related Macular Degeneration
Open-label Extension Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Neovascular ("Wet") Age-related Macular Degeneration (AMD)
The primary objective is to assess long-term safety and tolerability of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in patients with neovascular AMD.
- Trial name
- NCT00964795
- Testing
- Intravitreal Aflibercept Injection 2mg
- Where
- 124 sites in United States, Canada
- Volunteers
- 323 people
- Sponsor
- Regeneron Pharmaceuticals
Parkinson's Disease
Phase I Deep Brain Stimulation (DBS) vs. Best Medical Therapy (BMT) Trial
The goals of this study are to determine if simultaneous bilateral subthalamic nucleus stimulation or simultaneous bilateral globus pallidus stimulation is more effective in reducing symptoms of Parkinson's disease, and if deep…
- Trial name
- NCT00056563
- Testing
- Bilateral Deep Brain Stimulation, best medical therapy
- Where
- 14 sites in United States
- Volunteers
- 255 people
- Sponsor
- US Department of Veterans Affairs
Epilepsy
PuLsE 2-Observational Long-Term Effectiveness Follow-Up Study of PuLsE 1
This is a post-market, open observational long-term effectiveness follow-up study of participants with drug-resistant epilepsy with partial-onset seizures previously enrolled in a randomized controlled trial (PuLsE) comparing…
- Trial name
- PuLsE 2 (NCT01281280)
- Where
- 18 sites in Belgium, Canada and 5 more
- Volunteers
- 81 people
- Sponsor
- Cyberonics, Inc.
Cataract
A Prospective Observational Case Series of a Four-ring-haptic Acrylic One-piece IOL
To describe biocompatibility, postoperative results and complications after implantation of the Corneal Quatrix Evolutive (Corneal, Croma, Austria) intraocular lens, a hydrophilic acrylic intraocular lens (IOL) with 4-haptic…
- Trial name
- Qu01 (NCT01244373)
- Where
- Austria
- Volunteers
- 9 people
- Sponsor
- General Hospital Linz
Pre-eclampsia
New Magnesium Sulphate Protocol for Pre-eclampsia
there is a standard magnesium sulphate protocol and newer protocols for pre-eclampsia, we need to make a trial to find the best protocol
- Trial name
- NCT01846156
- Testing
- MgSO4
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Cairo University
Migraine, Tension Headache
The Prevalence of Osmophobia in Migraine and Tension-Type Headache Patients and Its Association With Migraine Symptoms Over a Period of 6 Months
The goal of this observational study is to learn about the frequency and diagnostic value of osmophobia, which is a sensitivity to smell, in people with migraine compared to those with tension-type headache.
- Trial name
- NCT07329127
- Where
- Greece
- Volunteers
- 210 people
- Sponsor
- National and Kapodistrian University of Athens
Melanoma
OH2 Injection in Melanoma
To evaluate the efficacy of OH2 injection in patients with unresectable or metastatic melanoma who have failed at least second-line standard therapy, using investigator-selected salvage chemotherapy or best supportive care (BSC)…
- Trial name
- NCT05868707
- Testing
- OH2, Salvage chemotherapy or best supportive care
- Where
- 30 sites in China
- Volunteers
- 340 people
- Sponsor
- Binhui Biopharmaceutical Co., Ltd.
Pilonidal Sinus
A Single Center Experience in the Management of Pilonidal Disease
Sacrococcygeal pilonidal disease (PND) is a common entity affecting the skin and subcutaneous tissue of the upper portion of the natal cleft of the buttocks.
- Trial name
- NCT05892198
- Testing
- surgery
- Volunteers
- 101 people
- Sponsor
- Mansoura University
Polycythemia Vera
A Clinical Trial of Bomedemstat in Participants With Polycythemia Vera (MK-3543-025).
Researchers are looking for new ways to treat polycythemia vera (PV). People with PV may receive treatment to lower the number of red blood cells in the blood, but the usual treatments may not work for everyone.
- Trial name
- NCT07722611
- Testing
- Bomedemstat, Ruxolitinib, Ropeginterferon alfa-2b
- Where
- 2 sites in United States, Israel
- Volunteers
- 380 people
- Sponsor
- Merck Sharp & Dohme LLC
Peripheral Arterial Disease
BEST SFA Pilot Study - Best Endovascular STrategy for Complex Lesions of the Superficial Femoral Artery
Prospective, multi-center 1:1 randomized trial to compare efficacy and safety of a stent-avoiding (using drug coated balloons) versus a stent-preferred (using drug eluting or interwoven stents) approach for treatment of complex…
- Trial name
- NCT03776799
- Testing
- Stent-avoiding, Stent-based
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Leipzig
Heart Failure, Heart Failure With Reduced Ejection Fraction
Building Electronic Tools To Enhance and Reinforce Cardiovascular Recommendations - Heart Failure
This is a feasibility study using a cross-over design to implement and compare a best practice alert (BPA) with an automated in-basket message to inform providers when a patient with heart failure and reduced ejection fraction…
- Trial name
- BETTER CARE-HF (NCT05077293)
- Testing
- Best Practice Alert (BPA), In-Basket Message
- Where
- United States
- Volunteers
- 596 people
- Sponsor
- NYU Langone Health
Carcinoma, Non-Small-Cell Lung
BIBW 2992 and BSC Versus Placebo and BSC in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib (LUX-LUNG 1)
This randomized, double-blind, multi-center Phase IIb/III trial will be performed in patients with NSCLC who have received previous treatment with at least one but not more than two lines of cytotoxic chemotherapy (one line must…
- Trial name
- NCT00656136
- Testing
- BIBW 2992
- Where
- 90 sites in United States, Belgium and 13 more
- Volunteers
- 585 people
- Sponsor
- Boehringer Ingelheim
Acute Coronary Syndrome, Medication Adherence
Using Automated Calls To Improve Compliance With Acute Coronary Syndrome Best Practice Guidelines
The purpose of this study is to determine whether interactive voice response (IVR) technology can be used to bring post discharge care for acute coronary syndrome (ACS) closer to best practice guidelines (BPGs).
- Trial name
- NCT01151800
- Testing
- Using IVR to maintain ACS patients on best practice guidelines
- Where
- Canada
- Volunteers
- 1,608 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Brain Injuries
Validating the MATADOC Against Best Practice Standard External Reference Standard
The purpose of this project is to further develop a standardized music-based measure used in music therapy with adults who have emerged from coma following profound brain injury, but are not able to demonstrate responsiveness to…
- Trial name
- MATADOC (NCT02959736)
- Testing
- MATADOC and CRS-R
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Temple University