Clinical trials: Best Disease
Non-Small Cell Lung Cancer
A Study of Tarceva (Erlotinib) Monotherapy in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
This study will evaluate the efficacy and safety of oral Tarceva in patients with advanced NSCLC for whom Tarceva monotherapy is considered the best therapeutic option. The anticipated time on study treatment is 3-12 months.
- Trial name
- NCT01996332
- Testing
- erlotinib [Tarceva]
- Where
- 94 sites in Spain
- Volunteers
- 1,805 people
- Sponsor
- Hoffmann-La Roche
Radionecrosis, Brain Metastases
Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases
This randomized phase II study aims to investigate whether the addition of bevacizumab to standard corticosteroid therapy results in greater improvement in symptoms and less treatment-induced symptoms compared with standard…
- Trial name
- NCT02490878
- Testing
- bevacizumab, corticosteroids
- Where
- 341 sites in United States, Canada
- Volunteers
- 19 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Pancreatic Cancer
A Multicenter Study of IBI343 Monotherapy Versus Placebo in Subjects With Previously Treated, Claudin (CLDN) 18.2-positive, Pancreatic Cancer(G-HOPE-002)
This is a study of a Multicenter, Randomized, Double-Blind, Phase III Study of IBI343 Monotherapy Plus Best Supportive Care Versus Placebo Plus Best Supportive Care in Participants with Claudin (CLDN) 18.2-Positive, Locally…
- Trial name
- NCT07066098
- Testing
- IBI343
- Where
- China
- Volunteers
- 201 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Colorectal Cancer, Metastases
Evaluating Panitumumab (ABX-EGF) Plus Best Supportive Care Versus Best Supportive Care in Patients With Metastatic Colorectal Cancer
The purpose of this study is to determine that panitumumab, using the proposed regimen, will safely increase progression free survival in patients with metastatic colorectal cancer who have failed available treatment options…
- Trial name
- NCT00113763
- Testing
- Best supportive care, Panitumumab
- Volunteers
- 463 people
- Sponsor
- Amgen
ANEMIA
Anemia Management in Chronic Kidney Disease Not on Dialysis Patients After the European Renal Best Practice (ERBP) Working Group Recommendations
The purpose of this study is to evaluate the impact of the last recommendations of the European Anemia Working Group ERBP in the anemia management in the achievement of the therapeutic goal of Hb 11-12 g/dL.
- Trial name
- ACERCA (NCT01903148)
- Where
- 29 sites in Spain
- Volunteers
- 455 people
- Sponsor
- Fundación Senefro
Oral Mucositis
A Trial Assessing Chemo Mouthpiece Device With Best Supportive Care for Symptoms of Chemotherapy-Induced Oral Mucositis
This study will compare the use of the Chemo MouthpieceTM device along with best supportive oral care to best supportive oral care alone to rate the effectiveness of Chemo MouthpieceTM in lessening symptoms associated with…
- Trial name
- NCT04595838
- Testing
- Chemo Mouthpiece, Best Supportive Care only
- Where
- 11 sites in United States
- Volunteers
- 176 people
- Sponsor
- Chemo Mouthpiece
Urothelial Carcinoma
Maintenance With Niraparib In Patients With Advanced Urothelial Cancer After 1st-line Platinum-based Chemotherapy
This is a 2-arm, prospective, randomized (2:1 ratio), open-label, multi-centre, phase II study conducted in patients affected by unresectable, locally advanced or metastatic urothelial cancer receiving niraparib plus best…
- Trial name
- NCT03945084
- Testing
- Niraparib, Best supportive care
- Where
- 20 sites in Italy
- Volunteers
- 58 people
- Sponsor
- University of Turin, Italy
Keratoconus
Lamellar Transplant With Lyophilized Corneas
The goals of this study are to develop a lyophilization method for anterior lamellar transplants in Brasil and to make a comparative analysis among patients transplanted with lyophilized and optisol corneas
- Trial name
- NCT00409955
- Testing
- Lamellar transplant with lyophilized corneas
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of São Paulo
Faecal Incontinence
Best Surgical Technique for Optimal Lead Placement in Sacral Neuromodulation - a Comparative Cadaver Study
Sacral neuromodulation (SNM) is an established treatment option for patients with faecal incontinence. The location of the stimulating electrode is considered to be essential for treatment success.
- Trial name
- NCT04726904
- Testing
- Sacral neuromodulation in conventional implantation technique
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Medical University of Vienna
Bronchiectasis
Clinical Outcomes of BronchiEctaSis in Taiwan: A Multicenter Prospective Cohort (BEST Study)
Bronchiectasis is a disease characteristic by bronchial dilatation. Bronchiectasis leads to further impairment of mucociliary clearance, causing a vicious cycle of further infection and progressive airway damage, resulting in…
- Trial name
- BEST (NCT07490704)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Relapsing Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
This is a multi-center prospective rater-masked (blinded) randomized controlled trial of 156 participants, comparing the treatment strategy of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) to the treatment strategy…
- Conditions
- Relapsing Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
- Trial name
- BEAT-MS (NCT04047628)
- Testing
- Autologous Hematopoietic Stem Cell Transplantation, Best Available Therapy (BAT)
- Where
- 23 sites in United States
- Volunteers
- 156 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Myeloma
A Comparative Clinical Study to Determine the Optimal Initial Therapy for Multiple Myeloma
This study evaluates the outcomes of patients undergoing initial therapy for multiple myeloma.
- Trial name
- NCT06151717
- Testing
- Non-Interventional Study
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Leukemia, Myeloid, Acute
An Efficacy and Safety Study of Oral Azacitidine (CC-486) as Maintenance Therapy in Chinese Participants With Acute Myeloid Leukemia in Complete Remission
The purpose of this study is to evaluate the efficacy and safety of Oral Azacitidine (CC-486) in Chinese participants with acute myeloid leukemia in complete remission.
- Trial name
- NCT05413018
- Testing
- CC-486
- Where
- 34 sites in China
- Volunteers
- 34 people
- Sponsor
- Bristol-Myers Squibb
Taenia Solium Infection
Taenia Solium Elimination Versus Control: What is the Best Way Forward for Sub-Saharan Africa?
Taenia solium taeniosis/cysticercosis is a neglected zoonotic parasitic disease complex with significant economic and public health impacts, occurring primarily in developing countries.
- Trial name
- CYSTISTOP (NCT02612896)
- Testing
- Mass drug administration, praziquantel 10mg/kg, Health education
- Where
- Zambia
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Overweight, Obesity
Connect 4 Health: An Intervention to Improve Childhood Obesity Outcomes
Health care system (HCS)-based interventions have been limited by their inattention to social and environmental barriers that impede improvement in obesity-related behaviors.
- Trial name
- NCT02124460
- Testing
- Health Coaching
- Where
- United States
- Volunteers
- 721 people
- Sponsor
- Massachusetts General Hospital
Non-Small Cell Lung Cancer
Pemetrexed and Best Supportive Care Versus Placebo and Best Supportive Care in Non-Small Cell Lung Cancer (NSCLC)
This study is a randomized Phase 3, double-blind study of maintenance pemetrexed plus best supportive care versus placebo plus best supportive care in NSCLC.
- Trial name
- NCT00102804
- Testing
- Pemetrexed, Best Supportive Care
- Where
- 73 sites in United States, Australia and 18 more
- Volunteers
- 663 people
- Sponsor
- Eli Lilly and Company
Parkinson Disease
Controlled Trial With Deep Brain Stimulation in Patients With Early Parkinson's Disease
Earlystim Study: Patients are randomized either to medical treatment or subthalamic stimulation. The observation period was 2 years. The primary outcome criterium: PDQ-39.
- Trial name
- EARLYSTIM (NCT00354133)
- Testing
- Kinetra and Soletra (neurostimulator, Medtronic), Best Medical Treatment
- Where
- 16 sites in France, Germany
- Volunteers
- 251 people
- Sponsor
- German Parkinson Study Group (GPS)
Acute Leukemia of Ambiguous Lineage, Acute Myeloid Leukemia
Randomization for the Identification of Best Treatment Intensity for Less Fit Adults With Acute Myeloid Leukemia and Myeloid Neoplasms
This clinical trial studies whether less fit adults with acute myeloid leukemia (AML) or myeloid neoplasms are willing to let a computer program decide (randomization) whether they receive lower- or higher-intensity chemotherapy.
- Conditions
- Acute Leukemia of Ambiguous Lineage, Acute Myeloid Leukemia, Myeloid Neoplasm
- Trial name
- NCT07094750
- Testing
- Biospecimen Collection, Bone Marrow Collection, Electronic Health Record Review
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Fred Hutchinson Cancer Center
Overactive Bladder
A Two-Part Study to Determine: Best Medication Formulation and Food Effect
This is a two-part study. Part 1 is designed to find the best modified release formulation of GW423753; Part 2 is designed to use the selected formulation(s) from Part 1 to find out if food affects the way the medication is…
- Trial name
- NCT00427596
- Testing
- Solabegron
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Penile Cancer
A PHASE II, RANDOMIZED STUDY TO ASSESS MAINTENANCE THERAPY WITH CEMIPLIMAB VERSUS BEST SUPPORTIVE CARE AFTER 1ST LINE PLATINUM-BASED CHEMOTHERAPY IN ADVANCED/RECURRENT PENILE CANCER
This is a phase II, randomized study which will enroll participants given 4 to 6 cycles of first-line platinum-based chemotherapy treatment for advanced penile SCC not amenable by curative surgical treatment (stages III-IV as per…
- Trial name
- BRAVA PENILE (NCT07101822)
- Testing
- Cemiplimab
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Hospital Israelita Albert Einstein