Clinical trials: Beta Blocker, active
Aortic Stenosis
Impact of Beta-blocker on Outcome Among Patients Undergoing Transcatheter Aortic Valve Replacement (B-TAVR)
This is a multi-centric, open-label, randomized trial to evaluate the safety and efficacy of temporary discontinuation of beta-blocker treatment in patients undergoing transcatheter aortic valve replacement.
- Trial name
- NCT06472934
- Testing
- Transcatheter aortic valve replacement in the absence of B-blocker treatment, Transcatheter aortic valve replacement
- Where
- 11 sites in Austria, Germany and 1 more
- Volunteers
- 498 people
- Sponsor
- University Hospital, Basel, Switzerland
Atrial Fibrillation
The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation
This is a prospective study to evaluate changes in exercise capacity and chronotropic response to exercise before and after beta-blocker dosage reduction in patients with atrial fibrillation (AF).
- Trial name
- NCT05332457
- Testing
- Reduced dosage of beta-blocker
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Heat Stress, Aging
Aging, Beta Blockers, and Thermoregulatory Responses
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.
- Trial name
- NCT06582680
- Testing
- Ambient Heat
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Myocardial Infarction
Long-term Beta-blocker Therapy After Acute Myocardial Infarction
The aim of the study is to determine whether discontinuation of β-blocker after at least 1 year of β-blocker therapy is noninferior to continuation of β-blocker in patients without heart failure (HF) or left ventricular systolic…
- Trial name
- SMART-DECISION (NCT04769362)
- Testing
- Discontinuation of β-blocker
- Where
- South Korea
- Volunteers
- 2,540 people
- Sponsor
- Samsung Medical Center
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction
BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function
The study aims to investigate whether oral betablocker (BB) therapy is superior to no such treatment following an acute myocardial infarction (AMI).
- Conditions
- Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction
- Trial name
- BETAMI (NCT03646357)
- Testing
- Non-betablocker, Betablocker
- Where
- 20 sites in Norway
- Volunteers
- 2,895 people
- Sponsor
- Oslo University Hospital
Septic Shock, Tachycardia
Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility
Several data emphasize the relation between tachycardia (>90/min) and high mortality during septic shock. The investigators previously demonstrated the high mortality associated with hypercontractility, tachycardia and the…
- Conditions
- Septic Shock, Tachycardia, Mortality During Septic Shock, Beta-blocker
- Trial name
- HyperBetashock (NCT04748796)
- Testing
- echocardiography, Landiolol
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Spontaneous Coronary Artery Dissection
Randomized Study of Beta-Blockers and Antiplatelets in Patients With Spontaneous Coronary Artery Dissection
Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary syndrome (ACS). Most patients are treated with beta-blockers (BB) and antiplatelet drugs (AP) on empiric basis.
- Trial name
- BA-SCAD (NCT04850417)
- Testing
- Beta blocker, aspirin, clopidogrel
- Volunteers
- 600 people
- Sponsor
- Spanish Society of Cardiology
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI)
Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction
To determine whether long-term treatment with oral betablocker therapy after myocardial infarction in patient with no heart failure reduces the composite outcome of recurrent MI, all-cause mortality, revascularisation with…
- Conditions
- Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI), ST Elevation Myocardial Infarction
- Trial name
- DANBLOCK (NCT03778554)
- Testing
- Metoprolol Succinate, Bisoprolol, Carvedilol
- Where
- Denmark
- Volunteers
- 2,760 people
- Sponsor
- Bispebjerg Hospital
Gastric Cancer
Beta-Blockers on the Efficacy of Neoadjuvant Immunotherapy for Gastric Cancer
Study Population:Patients with locally advanced gastric cancer complicated by hypertension, who are scheduled to undergo laparoscopic gastric cancer resection after receiving preoperative immunotherapy.
- Trial name
- BBNIGC (NCT07511894)
- Testing
- Experimental Group
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Non-obstructive Hypertrophic Cardiomyopathy
Treatment Effects of Bisoprolol and Verapamil in Symptomatic Patients With Non-obstructive Hypertrophic Cardiomyopathy
Aim: to compare the treatment effects of Bisoprolol (beta 1 receptor specific beta blocker (BB)) and Verapamil (cardio-specific calcium channel blockers (CCB)) in patients with non-obstructive hypertrophic cardiomyopathy (HCM).
- Trial name
- TEMPO II (NCT05569382)
- Testing
- Verapamil, Bisoprolol
- Where
- 4 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Morten Steen Kvistholm Jensen
Heart Failure With Reduced Ejection Fraction
Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score
The purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics.
- Trial name
- NCT07490067
- Testing
- Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Hepatocellular Carcinoma (HCC), Esophageal Varices
Endoscopic Variceal Ligation vs Carvedilol for the Prevention of First Esophageal Variceal Bleeding in Patients With HCC
The goal of this clinical trial is to evaluate whether endoscopic variceal ligation (EVL) or carvedilol is more effective at preventing the first esophageal variceal bleeding (EVB) in patients with hepatocellular carcinoma (HCC).
- Trial name
- P-HCC-CVL (NCT06594744)
- Testing
- Endoscopic variceal ligation, Carvedilol
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Colon Cancer (Stage II &Amp; III), Immunotherapy
Neoadjuvant Iparomlimab/Tuvonralimab Plus CAPEOX Versus Iparomlimab/Tuvonralimab Plus CAPEOX and Propranolol for Locally Advanced pMMR Colon Cancer: A Prospective, Single-Center, Multi-Cohort Study
The goal of this prospective, single-center, multi-cohort clinical trial is to evaluate the efficacy and safety of neoadjuvant Iparomlimab/Tuvonralimab combined with CAPEOX, with or without propranolol, in patients with locally…
- Conditions
- Colon Cancer (Stage II &Amp; III), Immunotherapy, Beta Blocker, Neoadjuvant Chemoimmunotherapy
- Trial name
- NCT07549906
- Testing
- Iparomlimab/Tuvonralimab, Capecitabine, Oxaliplatin
- Volunteers
- 45 people
- Sponsor
- Sun Yat-sen University
Atrial Fibrillation (AF), Atrial Fibrillation With Rapid Ventricular Response
Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation)
The goal of this clinical trial is to learn whether intravenous verapamil or intravenous metoprolol controls heart rate more effectively in adult patients who arrive at the emergency department with atrial fibrillation and a fast…
- Trial name
- NCT07706075
- Testing
- Verapamil Hydrochloride, Metoprolol tartrate
- Volunteers
- 120 people
- Sponsor
- Muhammad Ali Javed
Cirrhosis, Liver, Portal Hypertension
Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial.
Research has proven that large varices can be treated with beta-blockers (a type of anti-hypertensive medication) to reduce the pressure in the veins. The management of small varices is still uncertain.
- Conditions
- Cirrhosis, Liver, Portal Hypertension, Variceal Hemorrhage, Varices, Esophageal
- Trial name
- BOPPP (NCT05872698)
- Testing
- Carvedilol
- Where
- United Kingdom
- Volunteers
- 763 people
- Sponsor
- King's College Hospital NHS Trust
Septic Shock
POCUS-Guided Esmolol in Septic Shock: A Pilot RCT
The goal of this pilot clinical trial is to determine if conducting a larger study using point-of-care ultrasound (POCUS) to guide beta-blocker therapy in patients with septic shock is feasible.
- Trial name
- Epic-Beta (NCT07313605)
- Testing
- Esmolol
- Volunteers
- 100 people
- Sponsor
- John Basmaji
Heart Failure, Heart Failure, Diastolic
A Preliminary Study for INFORMED
Investigators will determine whether N-of-1 trials, as a pragmatic, participant-centered approach to medication optimization that can overcome key barriers of deprescribing, can lead to increased participant confidence regarding…
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- PRE-INFORMED (NCT05585125)
- Testing
- Beta blocker
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Weill Medical College of Cornell University
Cirrhosis, Esophageal Varices
Carvedilol Plus EVL or Not for the Primary Prevention of Esophageal Variceal Bleeding in Carvedilol Non-responders
The goal of this clinical trial is to evaluate whether carvedilol plus endoscopic variceal ligation (EVL) is more effective for the primary prevention of esophageal variceal bleeding than carvedilol alone in carvedilol…
- Trial name
- CVL-NR (NCT06594783)
- Testing
- Carvedilol plus endoscopic variceal ligation, Carvedilol alone
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Intracranial Aneurysm
Beta-blockade in Unruptured Intracranial Aneurysm
Subarachnoid haemorrhage is a devastating type of stroke, with high mortality and morbidity rate. In approximately 85% of cases, it is caused by an intracranial aneurysm rupture.
- Trial name
- BBLURAN (NCT06249802)
- Testing
- Nebivolol
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death
Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection…
- Conditions
- Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death, Ventricular Arrhythmia, Implantable Cardioverter Defibrillator (ICD)
- Trial name
- CARVTOP-ICD (NCT06964464)
- Testing
- Metoprolol Succinate, Carvedilol
- Where
- 13 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Rochester