Clinical trials: Beta Blockers
Locally Advanced Malignant Neoplasm, Breast Cancer
Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
This study is being conducted in patients with newly diagnosed breast cancer that will be undergoing chemotherapy prior to surgery - neoadjuvant chemotherapy.
- Trial name
- NCT01847001
- Testing
- Propranolol, DOT imaging, Paclitaxel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Brain Injuries, Craniocerebral Trauma
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI).
- Conditions
- Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
- Trial name
- NCT01322048
- Testing
- IV Propranolol and Per Tube Clonidine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University
Open Angle Glaucoma, Ocular Hypertension
Efficacy of Travoprost/Timolol for Uncontrolled Intraocular Pressure
The purpose of this study is to demonstrate superior intraocular pressure (IOP) control with travoprost 0.004% / timolol 0.5% compared to beta-blocker monotherapy in participants with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT02003391
- Testing
- Beta-blocker monotherapy, Travoprost 0.004% / timolol 0.5% fixed combination ophthalmic solution
- Volunteers
- 157 people
- Sponsor
- Alcon Research
Migraine Headache
Drug and Non-Drug Treatment Of Severe Migraine
The purpose of this study is to determine if the addition of preventive medication, behavior migraine management or the combination of preventive medication and behavior migraine management improves the outcome of optimal acute…
- Trial name
- TSM (NCT00910689)
- Testing
- Propranolol or nadolol, Behavioral Migraine Management (BMM), Optimal Acute Therapy
- Where
- 2 sites in United States
- Volunteers
- 232 people
- Sponsor
- Ohio University
Healthy, Pre Hypertension
Race, Natriuretic Peptides and Physiological Perturbations
The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.
- Trial name
- NCT03070184
- Testing
- Exercise capacity VO2 max determination, Standardized meals, Exercise challenge
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Autism Spectrum Disorder, Developmental Disability
Propranolol for Challenging Behaviors in Autism
Severe challenging behaviors such as aggression and self-injury can cause significant morbidity and decrease the quality of life for individuals with Autism Spectrum Disorders (ASD).
- Conditions
- Autism Spectrum Disorder, Developmental Disability, Aggression, Self-Injurious Behavior
- Trial name
- NCT04047355
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rutgers, The State University of New Jersey
Heart Failure, Heart Failure, Diastolic
Impact of Beta-blockers on Physical Function in HFpEF
The purpose of this study is to understand the impact of beta-blockers on physical function in older adults with heart failure. We will achieve this objective by conducting N-of-1 trials.
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- NCT04767061
- Testing
- Beta blockers
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Weill Medical College of Cornell University
Laminectomy
Esmolol Infusion During Laminectomy: Effect on Quality of Recovery
The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and requirements for pain…
- Trial name
- NCT01179113
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Heart Failure
Association Between Genetic Polymorphism of Beta-adrenergic Receptor and Effects of Bisoprolol in Korean Heart Failure Patients.
At present, there is some clinical data for different functional response to beta-blockers associated with beta-adrenergic receptor polymorphisms.
- Trial name
- ABBA (NCT01104558)
- Testing
- Bisoprolol
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
High Blood Pressure
The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension
High blood pressure (hypertension) is called the "silent killer" because many people do not know they have it, and do not know when it is well controlled.
- Trial name
- NCT01049009
- Testing
- Nebivolol, Metoprolol XL
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Emory University
Pre-hypertension, Hypertension
Effects of the Beta-blocker Nebivolol (Bystolic) on Subjects With High Normal Blood Pressure and/or a Family History of Hypertension
The investigators aim to evaluate subjects at high risk of future development of hypertension, those with a family history of hypertension and/or that already have high normal(SBP 120-139 mmHg or DBP 80-89 mmHg) blood pressure.
- Trial name
- NCT01202175
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Peripheral Artery Disease, Hypertension
Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure
This is a 26-week, prospective double-blind, randomized pilot trial of nebivolol versus an active control, metoprolol succinate, in patients with established lower-extremity peripheral artery disease, hypertension, and at least…
- Trial name
- ENCOMPASS (NCT01499134)
- Testing
- nebivolol, Metoprolol succinate
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Thomas Jefferson University
Heart Failure With Preserved Ejection Fraction, Hypertension
BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in HFpEF
Heart failure with preserved ejection fraction (HFpEF) is a critical public health problem. Heart failure (HF) affects over 5 million adults in the United States (US), and is a major source of morbidity, mortality, and impaired…
- Trial name
- BLOCK HFpEF (NCT04434664)
- Testing
- Amlodipine Besylate, Metoprolol Succinate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Heart Failure, Heart Failure, Diastolic
Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF
In this study, we will test the feasibility of N-of-1 trials for deprescribing beta-blockers in patients with Heart Failure with Preserved Ejection Fraction.
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- NCT04757584
- Testing
- Beta blockers
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Weill Medical College of Cornell University
Hypertension
Comparing the Effects of Two Beta Blockers,Metoprolol and Nebivolol,on Ambulatory Blood Pressure and Basal Metabolic Rate
The purpose of the study is to compare the effects of nebivolol and metoprolol on 24-hour ambulatory blood pressure characteristics and basal metabolic rates in patients with hypertension.
- Trial name
- NCT00849810
- Testing
- Metoprolol, Nebivolol
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Mississippi Medical Center
Diabetes Mellitus, Type 2
Examining Genetic Influence on Response to Beta-Blocker Medications in People With Type 2 Diabetes
Beta-blockers are medications used to treat cardiovascular disease (CVD) symptoms, including high blood pressure and chest pain.
- Trial name
- NCT00925119
- Testing
- Atenolol
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Maryland, Baltimore
Pulmonary Arterial Hypertension
Beta-blockers in Pulmonary Arterial Hypertension
The investigators will conduct a, randomized, phase 2, placebo-controlled, double-blinded, crossover trial of carvedilol in 26 PAH patients with World Health Organization functional class II or III symptoms and RV ejection…
- Trial name
- NCT02507011
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Minnesota
Long QT Syndrome, Cardiac Repolarization
Effect of Beta-blocker Therapy on QTc Response in Exercise and Recovery in Normal Subjects
Background. In congenital long QT syndrome type 1 (LQT1), episodes of ventricular tachycardia are usually triggered by exercise and can be prevented in most patients by beta-blocker therapy.
- Trial name
- NCT00588965
- Testing
- Propranolol LA
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Orthostatic Intolerance, Postural Tachycardia Syndrome
Effect of Exercise in OI
The main limitation patients with orthostatic intolerance (OI, or postural tachycardia syndrome, POTS) have to exercise is related to their increase in heart rate when standing.
- Trial name
- NCT00770484
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University
Acute Myocardial Infarction (AMI)
HMO Research Network CERT: Acute Myocardial Infarction
The primary goal of this study is to evaluate the effectiveness of direct-to-patient mailings designed to increase patient's adherence to prescribed beta-blockers following an acute myocardial infarction (AMI).
- Trial name
- NCT00211172
- Testing
- Beta-blocker adherence after an AMI
- Where
- 4 sites in United States
- Volunteers
- 836 people
- Sponsor
- Kaiser Permanente