Clinical trials: Beta Blockers
Systolic Heart Failure, Beta-blockers Intolerance
Surgical Sympathetic Blockade in Heart Failure
The investigators sought to evaluate the feasibility and safety of surgical sympathetic blockade in systolic heart failure patients and secondary to assess its cardiovascular consequences.
- Conditions
- Systolic Heart Failure, Beta-blockers Intolerance, Beta-blockers Resistance
- Trial name
- SymBlock (NCT01224899)
- Testing
- Left cervico-thoracic sympathetic blockade
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo
Side-Effect, Heart Failure
pErsonalised Nocebo Assessment of Beta-blockEr Symptoms in Heart Failure
Beta-blocker tablets are an effective treatment for heart failure that make people live longer and reduce the need to be admitted to hospital.
- Trial name
- ENABLE-HF (NCT07029906)
- Testing
- Bisoprolol 2.5 mg
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Imperial College London
Perioperative Myocardial Injury, Autonomic Dysfunction
LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery
Limiting perioperative tachycardia (aiming for a heart rate <90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing…
- Conditions
- Perioperative Myocardial Injury, Autonomic Dysfunction, Cardiovascular (CV) Risk, Major Surgery
- Trial name
- LANTA-P (NCT07168421)
- Testing
- Landiolol
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI)
Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction
To determine whether long-term treatment with oral betablocker therapy after myocardial infarction in patient with no heart failure reduces the composite outcome of recurrent MI, all-cause mortality, revascularisation with…
- Conditions
- Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI), ST Elevation Myocardial Infarction
- Trial name
- DANBLOCK (NCT03778554)
- Testing
- Metoprolol Succinate, Bisoprolol, Carvedilol
- Where
- Denmark
- Volunteers
- 2,760 people
- Sponsor
- Bispebjerg Hospital
Hypertension
Comparison of Calcium Channel Blockers and Beta Blockers on Tourniquet-induced Hypertension During Intravenous Regional Anesthesia
The investigators aimed to investigate the efficacy of calcium channel blockers and beta blockers for controlling tourniquet induced blood pressure increase in patients undergoing carpal tunnel operations with IVRA.
- Trial name
- NCT02319161
- Testing
- Calcium channel blocker and beta blocker
- Volunteers
- 50 people
- Sponsor
- Ankara University
Beta Blockers, Swallowing Disorder
The Effect of Beta-blockers in Substance P Levels and the Swallowing Function
A non-randomised, prospective study to assess the effects of beta-blockers on substance P levels and the swallowing function. The study is going to be carry out in the Gastrointestinal Physiology Laboratory of the Hospital de…
- Conditions
- Beta Blockers, Swallowing Disorder, Substance P
- Trial name
- BETASP (NCT03306134)
- Testing
- Dysphagia
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Idiopathic Pulmonary Arterial Hypertension
Beta-blockers in i-PAH
The main question of this study is: 'Is selective beta-blocker treatment safe and effective in reducing sympathetic overdrive, thereby improving RV function and remodeling in patients with iPAH?'.
- Trial name
- NCT01246037
- Testing
- Bisoprolol
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Amsterdam UMC, location VUmc
Aortic Stenosis
Effect of Bisoprolol on Progression of Aortic Stenosis
Aortic stenosis has been thought to be a degenerative process basically induced by long-lasting mechanical stress, and hemodynamic factors such as shear forces, acceleration of blood flow, hypertension and rapid heart rate might…
- Trial name
- BLAST (NCT01579058)
- Testing
- bisoprolol
- Where
- 3 sites in South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Myocardial Infarction
TREatment With Beta-blockers After myOcardial Infarction withOut Reduced Ejection fracTion"
REBOOT clinical trial will study whether long-term maintenance beta-blockers therapy results in a clinical benefit after heart attack without reduced left ventricular function.
- Trial name
- NCT03596385
- Testing
- Beta blocker
- Where
- 111 sites in Italy, Spain
- Volunteers
- 8,505 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Locally Advanced Malignant Neoplasm, Breast Cancer
Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
This study is being conducted in patients with newly diagnosed breast cancer that will be undergoing chemotherapy prior to surgery - neoadjuvant chemotherapy.
- Trial name
- NCT01847001
- Testing
- Propranolol, DOT imaging, Paclitaxel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
AMI
Influence of Beta Blockers on Prognosis in Patients With Acute Myocardial Infarction Complicated With Normal Ejection Fraction
To understand the effect of beta blockers on the prognosis of patients with acute myocardial infarction with preserved ejection fraction.
- Trial name
- NCT04485988
- Testing
- Beta blocker
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chongqing Medical University
Heart Failure, Chronic Obstructive Pulmonary Disease
Bisoprolol in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease
The principal research objectives are to demonstrate cardioselective beta-blockade using bisoprolol is not inferior to placebo with regard to pulmonary function and improves quality of life in patients with heart failure and…
- Trial name
- NCT00702156
- Testing
- Bisoprolol
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- NHS Greater Glasgow and Clyde
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Gradual Tapering or Discontinuation of Beta-Blockers After Stabilization With Mavacamten Therapy
This multicenter, randomized, open-label, parallel-group, non-inferiority trial will evaluate whether sequential tapering and discontinuation of beta-blockers is non-inferior to maintenance of the baseline stable beta-blocker…
- Trial name
- STEP-oHCM (NCT07815301)
- Testing
- Beta-Blocker Sequential Tapering and Discontinuation, Beta-Blocker Baseline Stable-Dose Maintenance
- Where
- China
- Volunteers
- 286 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Liver Cirrhosis, Hepatoma
A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol
New strategy to improve the outcomes in patients with HCC and acute variceal bleeding. NSBB added to endoscopic ligation may further reduce rebleeding in cirrhotic patients.
- Trial name
- NCT01298284
- Testing
- propranolol
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Surgery
Perioperative Effect of Atenolol on Cytokine Profiles
Studies have shown that beta-blockers such as atenolol when given in the perioperative period reduce morbidity and mortality. One study showed that atenolol given just during the surgery period, seemed to improve outcomes up to 2…
- Trial name
- NCT00202358
- Testing
- atenolol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Saini Foundation
Ascites
To Study the Effect of Nonselective Beta Blockers in Advanced Stage Liver Disease With Ascites
Cirrhosis is the leading cause of death in India and worldwide and leading causes in developed world include alcoholic liver disease, hepatitis C, and more recently, non-alcoholic fatty liver disease (NAFLD), non-alcoholic…
- Trial name
- NSBB (NCT02649335)
- Testing
- Propranolol, Endoscopic variceal ligation (EVL)
- Where
- India
- Volunteers
- 190 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Essential Hypertension
Early Metabolic Changes With Thiazide or Beta Blocker Therapy for Essential Hypertension
Can the oral glucose tolerance test detect changes after 4 weeks treatment with thiazide diuretics or beta blockers or combination of the two?
- Trial name
- NCT00380289
- Testing
- Thiazide and beta blocker
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Cambridge
Myocardial Infarction
The PACE-MI Registry Study - Outcomes of Beta-blocker Therapy After Myocardial Infarction (OBTAIN)
The purpose of the PACE-MI (OBTAIN) registry is: Analyze beta-blocker dose response effect on outcome over two years Explore gender and minority differences in beta-blocker utilization and outcomes.
- Trial name
- OBTAIN (NCT00430612)
- Where
- 23 sites in United States, Canada
- Volunteers
- 7,057 people
- Sponsor
- Northwestern University
Cardiac Amyloidosis, Heart Diseases
N-of-1 for Beta-Blockers in Cardiac Amyloidosis
The study team will generate preliminary data on whether patients with cardiac amyloidosis feel better when their beta-blocker is stopped. To achieve this objective, 20 N-of-1 trials (on vs.
- Conditions
- Cardiac Amyloidosis, Heart Diseases, TTR Cardiac Amyloidosis
- Trial name
- NCT05019027
- Testing
- Beta blocker
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Weill Medical College of Cornell University
Hepatocellular Carcinoma Recurrent, Hepatocellular Carcinoma
Association Between Pre-op Non-Selective Beta-Blockers and Hepatocellular Carcinoma Recurrence Post-Liver Transplant
The goal of this observational study is to investigate the effect of non-selective beta-blocker (NSBB) on the recurrence of hepatocellular carcinoma (HCC) following liver transplantation in patients who underwent liver…
- Trial name
- NCT06233708
- Testing
- Non-Selective Beta-Adrenoreceptor Agonists for Systemic Use
- Volunteers
- 2,092 people
- Sponsor
- Asan Medical Center