Clinical trials: Beta Endorphin
Cushing Syndrome
Modified Desmopressin (mDesmo) Using Cold-Kit for PET/CT
The incidence of Cushing syndrome (CS) is 1.2-3.2 cases per million per year, of which adrenocorticotropic Hormone (ACTH)-dependent disease comprises approximately 70-80% of cases.
- Trial name
- Ga-68 mDesmo (NCT06962202)
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Proliferative Vitreoretinopathy
Adrenocorticotropic Hormone (ACTH) for Post-op Inflammation in Proliferative Vitreoretinopathy (PVR)
This is a pilot study to measure levels of albumin and inflammatory cytokines [including Transforming Growth Factor-Beta (TGF-β) and Interleukin-1 Beta (IL-1β)] in the aqueous humor of post-operative proliferative…
- Trial name
- NCT03727776
- Testing
- Adrenocorticotropic Hormone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Johns Hopkins University
Primary Aldosteronism
Corticotropin Stimulation in Adrenal Venous Sampling for Patients With Primary Aldosteronism(ADOPA)
To compare the effect of different procedures of AVS(with or without ACTH stimulation) on the long-term outcomes of patients with PA
- Trial name
- NCT04461535
- Testing
- Adrenocorticotropic hormone
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Chongqing Medical University
Skin to Skin Contact
The Effect of Skin to Skin Contact on Postpartum Hemorrhage, Pain And Breastfeeding
The aim of this study was to determine the effect of postpartum hemorrhage, pain and onset of early breastfeeding so that the skin applied at the third stage of birth is in contact with the skin.
- Trial name
- NCT04425096
- Testing
- Skin to skin contact
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Uncontrolled Hypertension
A Study to Evaluate Cortisol Reserve in Response to Adrenocorticotropic Hormone (ACTH) Stimulation Test Following Baxdrostat Treatment Compared to Placebo in Participants With Uncontrolled Hypertension
The main purpose of this study is to assess the serum free cortisol response after ACTH stimulation test at baseline and at Week 8 in participants with uncontrolled hypertension.
- Trial name
- NCT06336356
- Testing
- Baxdrostat
- Where
- 10 sites in United States
- Volunteers
- 48 people
- Sponsor
- AstraZeneca
Obesity
Safety Study of the Inhibition of Agouti-related Protein (AgRP) for the Management of Obesity and Weight Loss
Multiple pathways including peripheral and central hormones and neurotransmitters are involved in the regulation of food intake and body weight. One of the most studied pathways involves the melanocortin receptor.
- Trial name
- NCT00779519
- Testing
- TTP435
- Where
- 12 sites in United States, Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- vTv Therapeutics
Postural Tachycardia Syndrome
Adrenocorticotropic Hormone Stimulation in Postural Orthostatic Tachycardia Syndrome (POTS)
This study is to determine different chemical levels in the blood during a low salt diet. This study will compare normal volunteers to those with Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT01764711
- Testing
- Cosyntropin administration
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Pain, Beta-endorphin
Double-blind, Randomized Controlled Study to Assess the Analgesic Effect of 2 g of Magnesium Dipyrone (Metamizol) and Changes in Plasma Beta-endorphin Immunoreactivity Values in Patients Undergoing Elective Inguinal Herniorrhaphy Under Epidural Anesthesia.
A double-blind, randomized controlled study is designed to assess the analgesic effect of a single intravenous dose of 2 g of magnesium dipyrone (metamizol) and whether the administration of the active drug will be associated…
- Conditions
- Pain, Beta-endorphin, Dipyrone, Hernia Surgery
- Trial name
- NCT04595877
- Testing
- Dipyrone administration, Pain assessment, beta-endorphin immunoreactivity
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Antonio Martín Duce
Scleritis
A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis
ATLAS study is a clinical trial to evaluate the potential role of subcutaneous adrenocorticotropic hormone (ACTH) gel in the management of non-infectious scleritis.
- Trial name
- ATLAS (NCT03465111)
- Testing
- ACTH (adrenocorticotropic hormone) gel
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Metropolitan Eye Research & Surgery Institute
Patient Admitted in Reanimation
Hydrocortisone Use After Etomidate in Intensive Care
the objective of the study is to assess the value of substitution with 200mg/24h of hydrocortisone for 48 hours for patients in intensive care who have received a single injection of etomidate
- Trial name
- NCT00862381
- Testing
- Hydrocortisone
- Where
- 2 sites in France
- Volunteers
- 106 people
- Sponsor
- University Hospital, Grenoble
Cushings Disease, Cushing Disease
Safety and Efficacy of LCI699 in Cushing's Disease Patients
This exploratory study is a proof of concept study to determine whether LCI699 can safely reduce the level of urinary free cortisol in patients with Cushing's disease.
- Trial name
- NCT01331239
- Testing
- LCI699
- Where
- 10 sites in United States, France and 2 more
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Idiopathic Membranous Nephropathy
Treatment With Synthetic ACTH in High Risk Patients With Membranous Nephropathy
The purpose of this study is to determine whether treatment with long-acting synthetic adrenocorticotropic hormone is in the treatment of patients with idiopathic membranous nephropathy and high for renal failure.
- Trial name
- ACTHiMeN (NCT00694863)
- Testing
- tetracosactide hexacetaat
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Multiple Sclerosis
Adrenocorticotropic Hormone (ACTH) Effects on Myelination in Subjects With MS
The primary objective of this study is to determine if monthly pulse doses of a three-day course ACTH (H.P. Acthar®) is more effective at recovering myelin at 12 months, as measured by myelin water fraction (MWF), in new multiple…
- Trial name
- NCT02446886
- Testing
- Adrenocorticotropic hormone (ACTH) gel (H.P. Acthar®)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Suicide, Depression
Plasma Beta-endorphin Levels and Suicidal Behavior
It is an interventional research, monocentric, which involves only minimal risks and constraints. Psychological pain is closely associated with suicidal ideation (SI) and suicidal behavior, regardless of the severity of the…
- Conditions
- Suicide, Depression, Beta Endorphin
- Trial name
- BEST (NCT06291467)
- Testing
- Blood samples, questionnaires
- Where
- France
- Volunteers
- 104 people
- Sponsor
- University Hospital, Montpellier
Multiple Sclerosis
Evaluation of the Effects of Laughter Yoga
This randomized controlled study aims to evaluate the effects of laughter yoga on pain intensity, fatigue, and beta-endorphin levels in patients with Multiple Sclerosis.
- Trial name
- NCT07524231
- Testing
- Laughter Yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Firat University
Multiple Sclerosis
Acupressure in MS Patients
This study aims to evaluate the effects of acupressure therapy on patients with Multiple Sclerosis (MS). MS is a chronic autoimmune disease affecting the central nervous system, characterized by inflammation, demyelination, and…
- Trial name
- APEX-MS (NCT06755463)
- Testing
- Self-acupressure education
- Volunteers
- 82 people
- Sponsor
- Abant Izzet Baysal University
Chronic Low-back Pain
Effectiveness of Cat-Cow Yoga in Managing Chronic Low Back Pain
A randomized control trial is planned to investigate the effectiveness of Cat-Cow yoga as a treatment for chronic low back pain CLBP.
- Trial name
- NCT04723225
- Testing
- Cat-Cow Yoga
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Cushing's Disease
Efficacy and Safety of Pasireotide Administered Monthly in Patients With Cushing's Disease
This is a randomized, double-blind, multicenter, phase III study to evaluate the safety and efficacy of 2 dosing regiments of Pasireotide long acting release (LAR) in patients with Cushing's disease.
- Trial name
- NCT01374906
- Testing
- pasireotide LAR, SOM230 LAR 30 mg, SOM230 LAR 10 mg
- Where
- 82 sites in United States, Argentina and 18 more
- Volunteers
- 150 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Nephropathy, Nephrotic Syndrome
Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN)
This is a prospective open labeled trial examining the efficacy of ACTHar Gel (porcine ACTH) on the level of proteinuria in patients with diabetic nephropathy and nephrotic range proteinuria.
- Trial name
- ACTH-NRDN (NCT01028287)
- Testing
- ACTH
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Southeast Renal Research Institute