Clinical trials: Beta-blockers
Abdominal Aortic Aneurysm Patients Under Surveillance
Effects of Beta-blockade on Cardiopulmonary Exercise Testing
A major determinant of perioperative mortality is the inability of the heart to increase its output in response to surgical stress.
- Trial name
- NCT02106286
- Testing
- Bisoprolol
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- Michelle Mossa
Intracranial Aneurysm
Beta-blockade in Unruptured Intracranial Aneurysm
Subarachnoid haemorrhage is a devastating type of stroke, with high mortality and morbidity rate. In approximately 85% of cases, it is caused by an intracranial aneurysm rupture.
- Trial name
- BBLURAN (NCT06249802)
- Testing
- Nebivolol
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Congestive Heart Failure
Study to Evaluate the Safety of Twice Daily Oral Carvedilol
The objective of this study is to evaluate the long-term safety of carvedilol in pediatric patients with chronic heart failure, who completed the Pediatric Carvedilol Study 321.
- Trial name
- NCT00129363
- Testing
- Carvedilol
- Where
- 17 sites in United States
- Volunteers
- 75 people
- Sponsor
- Shaddy, Robert, M.D.
Glaucoma, Ocular Hypertension
Assessing the Efficacy of DuoTrav as a Replacement Therapy in Glaucoma Patients in Russia
The purpose of this study is to evaluate the efficacy of changing to DuoTrav® (Travoprost 0.004%/Timolol 0.5%) from prior prostaglandin analogue or beta-blocker monotherapy in Russian glaucoma patients with open-angle glaucoma or…
- Trial name
- NCT01696383
- Testing
- Travoprost 0.004%/Timolol 0.5% Fixed Combination (DuoTrav)
- Sponsor
- Alcon Research
Heart Failure, Congestive
Effects of Carvedilol on Health Outcomes in Heart Failure
The purpose of our study was to determine if a strategy of starting a heart medication (Beta-blocker) before patients leave the hospital and then being seen by a nurse manager would reduce subsequent hospitalizations compared to…
- Trial name
- NCT00381030
- Testing
- carvedilol plus nurse management
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Denver Health and Hospital Authority
Liver Cirrhosis, Portal Hypertension.
Hemodynamic Effect of Simvastatin With Beta Blockers in Clinical Portal Hypertension
In the genesis and maintenance of PH associated with liver cirrhosis are two mechanisms that act synergistically. The first is an increase in hepatic vascular resistance, due in part to the disruption of liver structure inherent…
- Trial name
- SIMBETA (NCT01282385)
- Testing
- Simvastatin
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Heart Failure, Beta-blocker Treatment
Telephone Administered Psychotherapy for the Treatment of Depression for Veterans in Rural Areas
The purpose of this study is to examine the efficacy of telephone-administered cognitive-behavioral therapy (T-CBT) in treating major depression among veterans served by community-based outpatient clinics (CBOCs) in the Veteran�s…
- Trial name
- NCT00012974
- Testing
- GTelephone-administered Cognitive-Behavioral Therapy (T-CBT), Provider education, computer reminders, nurse case management
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- US Department of Veterans Affairs
Atrial Fibrillation, Arrhythmias, Cardiac
Beta Blockers Plus Intravenous Flecainide for Paroxysmal Atrial Fibrillation: a Real-world Chios Registry (BETAFLEC-CHIOS)
BETAFLEC-CHIOS, is a single-center registry that was initiated in the "Skylitseion" General Hospital of Chios in January 2020 and is ongoing.
- Trial name
- BETAFLEC-CHIOS (NCT04991896)
- Testing
- Flecainide Injectable Product
- Where
- Greece
- Volunteers
- 81 people
- Sponsor
- AHEPA University Hospital
ST Segment Elevation Myocardial Infarction (STEMI), Cardiogenic Shock Post Myocardial Infarction
Early Beta Blocker Administration in STEMI Patients With SCAI B Status
This study is looking at how a medication called beta-blockers (metoprolol) affects patients with a heart attack (STEMI) who are in the cardiac intensive care unit.
- Trial name
- NCT06967194
- Testing
- Metoprolol (MET), Plcacebo
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Arrhythmia, Cardiovascular Diseases
Beta-Blocker Heart Attack Trial (BHAT)
To determine whether the regular administration of the beta-blocker drug propranolol to people who had had at least one documented myocardial infarction would result in a significant reduction of mortality from all causes over…
- Conditions
- Arrhythmia, Cardiovascular Diseases, Coronary Disease, Death, Sudden, Cardiac
- Trial name
- NCT00000492
- Testing
- propranolol
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Premature Ventricular Complexes, Premature Ventricular Contraction (PVC)
Catheter Ablation Versus Anti-arrhythmic Drugs for Premature Ventricular Complexes
Premature ventricular complexes (PVCs) are extra, abnormal heart beats arising from the ventricles of the heart and are the most common ventricular arrhythmia.
- Conditions
- Premature Ventricular Complexes, Premature Ventricular Contraction (PVC), Premature Ventricular Beats
- Trial name
- CAAD-PVC (NCT07445334)
- Testing
- Catheter ablation, Medical therapy: Anti-arrhythmic drugs (AAD) and/or beta-adrenergic blocking agents (BB)
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Western Sydney Local Health District
Pulmonary Disease, Chronic Obstructive, Asthma
Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPD
Use of beta-blockers has proven beneficial in patients with hypertension, heart failure, and in people who have suffered a heart attack.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma, Adverse Effect of Beta-adrenoreceptor Antagonists
- Trial name
- NCT03370835
- Testing
- Metoprolol succinate ER, Carvedilol
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Ascites
To Study the Effect of Nonselective Beta Blockers in Advanced Stage Liver Disease With Ascites
Cirrhosis is the leading cause of death in India and worldwide and leading causes in developed world include alcoholic liver disease, hepatitis C, and more recently, non-alcoholic fatty liver disease (NAFLD), non-alcoholic…
- Trial name
- NSBB (NCT02649335)
- Testing
- Propranolol, Endoscopic variceal ligation (EVL)
- Where
- India
- Volunteers
- 190 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hypertension
Study to Evaluate Symptoms in Patients Treated With Nebivolol or Metoprolol Extended-release (ER) for Hypertension
The purpose of this study was to compare the tolerability of nebivolol to metoprolol ER in a general population of patients with mild to moderate hypertension receiving hydrochlorothiazide (HCTZ)
- Trial name
- NCT00547300
- Testing
- Metoprolol ER, Nebivolol
- Where
- 24 sites in United States
- Volunteers
- 49 people
- Sponsor
- Forest Laboratories
Cardiac Amyloidosis, Heart Diseases
N-of-1 for Beta-Blockers in Cardiac Amyloidosis
The study team will generate preliminary data on whether patients with cardiac amyloidosis feel better when their beta-blocker is stopped. To achieve this objective, 20 N-of-1 trials (on vs.
- Conditions
- Cardiac Amyloidosis, Heart Diseases, TTR Cardiac Amyloidosis
- Trial name
- NCT05019027
- Testing
- Beta blocker
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Weill Medical College of Cornell University
Heart Failure, Polygenic Score
UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent.
- Trial name
- UPBEAT (NCT07054489)
- Testing
- Beta blocker
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- David Lanfear
Chemotherapy Induced Systolic Dysfunction
Colchicine Versus Beta-blockers, Angiotensin-converting Enzyme Inhibitors, and Statins for Prevention of Chemotherapy-Induced Cardiomyopathy
BASiC-CIC Trial is a multicenter, double-blinded, randomized, placebo-controlled clinical trial to investigate whether repurposing colchicine or a combination of beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, and…
- Trial name
- BASiC-CIC (NCT06304896)
- Testing
- Carvedilol, Ramipril, Rosuvastatin
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Arab Contractors Medical Centre
Cirrhosis, Variceal Bleeding
EBL Versus EBL and Propranolol for the Prevention of Variceal Rebleeding in Pts With Previous Variceal Treatment
This study is performed to compare the efficacy and safety of EBL alone and EBL combined with propranolol in patients who were previously performed endoscopic variceal treatment.
- Trial name
- NCT00966082
- Testing
- endoscopic band ligation, endoscopic band ligation+Propranolol
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Korea University
COPD
What Influences Patient Outcome in Obstructive Airway Disease?
The aim of this observational study is to utilise the established record linkage data available in Tayside to investigate hospital admissions, exacerbations and mortality in COPD.
- Trial name
- NCT01221480
- Volunteers
- 5,977 people
- Sponsor
- University of Dundee
Diabetes Mellitus, Type 2, Hypertension
Vascular Benefits of Adding CarvedilolCR to Type2 Diabetic Patients on ACEI.
To determine whether addition of Carvedilol CR to diabetic patients with hypertension who are receiving the ACEi,Lisinopril,will provide added benefits to blood vessels when compared to treatment with Lisinopril alone.It is…
- Trial name
- NCT00430040
- Testing
- Carvedilol Controlled Release (CR), lisinopril
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University at Buffalo