Clinical trials: Bicuspid
Tooth, Nonvital
Pain Following One-visit Versus Two-visit Root Canal of Necrotic Teeth Using Protaper Next
To evaluate the incidence and severity of postoperative pain after root canal therapy of necrotic teeth in one appointment versus two appointments using Protaper next instrument.
- Trial name
- NCT02984488
- Testing
- single visits, two visits
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Regenerative Endodontic Treatment, Cleaning and Shaping Only With Proper Coronal Seal
Outcomes of Conventional Root Canal Treatment Compared to Regenerative Endodontics, and Cleaning and Shaping Only in Mature Upper First Premolars
It was to compare clinically between the success of the primary endodontic treatment, regeneration, and only cleaning and shaping in necrotic mature first premolars with apical periodontitis
- Conditions
- Regenerative Endodontic Treatment, Cleaning and Shaping Only With Proper Coronal Seal, Necrotic Mature First Premolar
- Trial name
- NCT07609732
- Testing
- cell homing, Cleaning and shaping only
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Bicuspid Aortic Valve Disease
TAVR vs SAVR in Severe Bicuspid Aortic Stenosis
The study is a multicenter, randomized superiority trial of standard of care therapies for severe aortic stenosis (AS) in patients with a bicuspid aortic valve (BAV).
- Trial name
- BELIEVERS (NCT07413965)
- Testing
- Transcatheter Aortic Valve Replacement, the open chest surgery to replace the aortic valve
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Cedars-Sinai Medical Center
Irreversible Pulpitis With Apical Periodontitis, Symptomatic Apical Periodontitis
Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars
To compare the post operative mean pain scores by administering single-dose preoperative piroxicam and prednisolone in patients of irreversible pulpitis with symptomatic apical periodontitis.
- Trial name
- NCT07281807
- Testing
- Group B: patients will be given prednisolone 20mg as premedication, piroxicam 20mg
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- RANA AHMAD
Third Molar Impaction
The Effect of Different Treatment Modalities of Class II Malocclusion on Upper Third Molars.
What is the effect of the different treatment modalities (distalization versus upper premolar extraction) of class II malocclusion on the position, inclination and incidence of impaction of the upper third molars?
- Trial name
- NCT06098885
- Testing
- extraction orthodontic treatment
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periapical Cyst
Clinical and Radiographic Characteristics and Outcomes of Guided Apicoectomy With Retrograde Mineral Trioxide Aggregate Filling for Periapical Cysts
Patients with periapical cysts associated with premolar teeth often require apical surgery when conventional endodontic treatment cannot resolve the lesion.
- Trial name
- NCT07724964
- Testing
- Guided Apicoectomy With Retrograde Mineral Trioxide Aggregate Filling
- Where
- Vietnam
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Orthodontic Appliance
Speed of Premolar Extraction Space Closure: Every Visit Replacement of Working Archwire
The aims of this trial were to assess the effect of changing 0.019X0.025-inch SS working archwire monthly on the rate of space closure, to compare the frictional resistance of unchanged and new working archwires in-vitro, and to…
- Trial name
- NCT04549987
- Testing
- Space closure without changing working archwire monthly, Space closure withchanging working archwire monthly
- Where
- Jordan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Aortic Valve Stenosis
Sizing-sTrategy of Bicuspid AoRtic Valve Stenosis With Transcatheter Self-expandable Valve
To observe the clinical outcomes of the different valve sizing strategies treating type-0 Bicuspid Aortic Stenosis (BAS) with self-expandable transcatheter aortic valve implantation (TAVI) valve, compared with those of a standard…
- Trial name
- START (NCT02541877)
- Testing
- Down sizing valve in type-0 BAS, Standard sizing valve in type-0 BAS, Standard sizing valve in TAS
- Where
- China
- Volunteers
- 159 people
- Sponsor
- Jian'an Wang,MD,PhD
Anesthesia, Local
The Anesthetic Efficacy of Lidocaine and Articaine as Buccal Injection for Maxillary Premolar Teeth Extraction.
This study Is designed as a prospective randomized, single-blinded clinical trial. To evaluate The anesthetic efficacy of articaine as a buccal Injection for maxillary premolar teeth extraction, compared to lidocaine as a buccal…
- Trial name
- NCT05951907
- Testing
- Maxillary extraction without palatal injection, Maxillary extraction with buccal and palatal injection
- Where
- Iraq
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Hypertension, Aortic Aneurysm
Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV)
Aortic stiffness is an important imaging biomarker of vascular aging. The ascending aorta is the most elastic segment, and it is excluded by reference non-invasive method carotid to femoral pulse wave velocity (PWV).
- Conditions
- Hypertension, Aortic Aneurysm, Bicuspid Aortic Valve, Marfan Syndrome
- Trial name
- InSide-CC (NCT05711693)
- Testing
- Laser doppler vibrometry (LDV), heart(cordium) carotid pulse wave velocity (ccPWV), Blood pressure and heart rate measurement, carotid to femoral PWW measurement
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Marfan Syndrome, Turner Syndrome
National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions
The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of…
- Conditions
- Marfan Syndrome, Turner Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome
- Trial name
- GenTAC (NCT01322165)
- Where
- 7 sites in United States
- Volunteers
- 3,706 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bone Loss, Vertical Alveolar Bone Loss
Bioactive Glass (Sol-gel) for Alveolar Bone Regeneration After Surgical Extraction
The purpose of the present research is to evaluate the effect of bioactive glass in bone regeneration immediately following extraction of mandibular and maxillary premolars.The hypothesis of the study assumes that this treatment…
- Conditions
- Bone Loss, Vertical Alveolar Bone Loss, Horizontal Alveolar Bone Loss
- Trial name
- NCT01878084
- Testing
- bioactive glass (sol-gel), empty extraction socket
- Where
- Egypt
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Missing Maxillary Premolar
Implant Stability Using Densah Bur Versus Expander
evaluating use of Densah bur in thin ridge enhance implant's primary stability when compared to screw expander.
- Trial name
- NCT03613415
- Testing
- Expansion
- Volunteers
- 20 people
- Sponsor
- Cairo University
Apical Periodontitis, Dental Pulp Necrosis
Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)
The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment.
- Conditions
- Apical Periodontitis, Dental Pulp Necrosis, Root Canal Infection
- Trial name
- CHITO-PRE RCT (NCT07048028)
- Testing
- Chitosan Low Molecular Weight (20-200 Mpa.S), Sodium Hypochlorite, EDTA chelating agents
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ESRA DAĞCI
Effect of Premolars Extraction on Bite Force
Analysis of Bite Force Distribution After Premolars Extraction by Using T-scan Analysis System
This study aims to assess the effect of first premolars extraction during orthodontic treatment bite force during the excursive mandibular movements using a digital occlusal analysis system.
- Trial name
- NCT07253337
- Testing
- T-scan analysis for bite force distribution
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Suez Canal University
Pulpitis
The Use of Platelet-Rich Fibrin in Partial Pulpotomy Procedure
The aim of this study is to evaluate the clinical and histological pulp responses when MTA and a combined of MTA/PRF is used as pulp-capping agents after partial pulpotomy.
- Trial name
- NCT04331964
- Testing
- partial pulpotomy
- Where
- Syria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Damascus University
Aortic Insufficiency
HAART 200 Aortic Valve Annuloplasty Trial
The HAART 200 "Aortic Annuloplasty during Bicuspid Aortic Valve Reconstruction" Trial is a prospective, non-randomized, multi-center trial to evaluate the safety and effectiveness of the HAART 200 bicuspid annuloplasty ring when…
- Trial name
- NCT02071849
- Testing
- HAART 200 Aortic Valve Annuloplasty Device
- Where
- 4 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Biostable Science & Engineering
Congenital Aortic Stenosis
Cardiac Imaging in Adults With Congenital Aortic Stenosis
The CAS study is a prospective observational cohort study investigating the effects of congenital aortic stenosis (ConAoS) on the left ventricular function and the prevalence, pattern and expanse of left ventricular hypertrophy…
- Trial name
- CAS (NCT05252351)
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Erasmus Medical Center
Orthodontic Extraction
Comparison of Rate and Amount of Orthodontic Space Closure
The goal of this clinical trial is to compare rate and amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction Primary outcome measure is…
- Trial name
- Premolar (NCT07445321)
- Testing
- Space Closure
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Non-maintainable Posterior Tooth (Molars and Premolars)
Clinical and Dimensional Outcomes of Sealing Socket Abutment Combined to Alveolar Ridge Preservation
objectives The aim of this study was to assess the implant outcomes as well as hard and soft tissue dimensional changes of immediate implant placement in posterior sites using a custom-made sealing socket abutment (SSA) combined…
- Trial name
- NCT04553146
- Testing
- Immediate implantation in posterior region with alveolar ridge preservation combined with sealing socket abutment
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Liege