Clinical trials: Bifidobacterium
Obesity, Hyperglycemia
The Effect of a Bifidobacterium and Polydextrose on Body Fat Mass
Obesity is a major problem worldwide, and it is related to abnormalities in glucose and lipid metabolism. The purpose of this study is to investigate the effect of a dietary supplement containing probiotic (Bifidobacterium…
- Conditions
- Obesity, Hyperglycemia, Insulin Resistance
- Trial name
- MetSProb (NCT01978691)
- Testing
- Bifidobacterium animalis ssp. lactis 420, Polydextrose
- Where
- 4 sites in Finland
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Danisco
Healthy
Infant Microbiota and Probiotic Intake Study
The purpose of this study is to determine if supplementing healthy term infants delivered by C-section or vaginal delivery who only consume breastmilk with a probiotic for 21 consecutive days increases levels of bacteria in…
- Trial name
- IMPRINT (NCT02457338)
- Testing
- Bifidobacterium
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Inflammation, Vaccine
WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study
The purpose of this study is to determine if adding dietary fiber, such as inulin, to a diet that does not have enough fiber would raise the levels of potentially beneficial bacteria, such as Bifidobacterium, in the gut.
- Conditions
- Inflammation, Vaccine, Intestinal Permeability, Typhoid Fever
- Trial name
- NCT04543877
- Testing
- Inulin, Maltodextrin, Ty21a Typhoid Fever Vaccine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Healhty
Human Milk Oligosaccharides, Gut Bifidobacterium, Vitamin D, and Infant Immunity
The goal of this observational study is to learn how certain natural sugar components in breast milk may be linked with vitamin D level, healthy gut bacteria, and immune markers in healthy breastfed infants.
- Trial name
- HMO-BIFIDI (NCT07570329)
- Where
- Indonesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Type 1 Diabetes Mellitus, Probiotics
Effect of Live Combined Bifidobacterium and Lactobacillus on Glycemic Control and Other Outcomes in Type 1 Diabetes
Aim Evidence of a possible connection between gut microbiota and several physiological processes linked to type 1 diabetes is increasing.
- Trial name
- NCT03556631
- Testing
- live combined Bifidobacterium and Lactobacillus Tablets
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenzhen People's Hospital
Obesity, Childhood
BIFI-OBESE: Clinical Trial in Paediatric Obesity
Obesity is a major, public health concern that affects at least 400 million individuals and is associated with severe disorders including diabetes and cancers.
- Trial name
- BIFI-OBESE (NCT03261466)
- Testing
- Bifidobacterium breve BR03 and Bifidobacterium breve B632
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
A03 - Digestive System, B03 - Bacteria
Fermented Dairy Product and Bifidobacterium Diversity
Bifidobacterium strains with potential health benefits can contribute to the gastrointestinal wellbeing. However, the ability of these strains to survive gastro-intestinal tract stress and their impact on gut microbiome remains…
- Trial name
- NCT07700381
- Testing
- 28-days consumption of Product A in 45 to 60-year-old healthy subjects, 28-days consumption of Control product in 45 to 60-year-old healthy subjects
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Maternal Obesity
Impact of B. Bifidum 900791 Intake on Breast Milk Characteristics of Obese Mothers
Human breast milk harbours a specific microbiota including bacteria from the Lactobacillus and Bifidobacterium genera, that contribute to the bacterial colonization of the infant gut in the post-natal period.
- Trial name
- NCT03913364
- Testing
- Probiotic
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Chile
Disbiosis, Abdominal Pain
Evaluation of the Beneficial Effects of a Probiotic Product in Healthy Adult Subjects.
A randomized, double-blind, placebo-controlled, cross-over trial performed at one centre in Italy to explore the ability of a multistrain probiotic mixture, to modulate markers of inflammation and intestinal barrier function and…
- Conditions
- Disbiosis, Abdominal Pain, Constipation, Diarrhea
- Trial name
- NCT03234452
- Testing
- Lactoflorene plus
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montefarmaco OTC SpA
Clostridium Difficile
Probiotics for Clostridium Difficile Infection in Older Adults
The purpose of this study is to determine whether a probiotic, when used together with standard treatment, is effective in reducing duration of symptoms and preventing recurrence of infection in older adults with a first episode…
- Trial name
- PICO (NCT01680874)
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Wisconsin, Madison
Recurrent Bacterial Vaginosis
Probiotics as an Adjunct to Antibiotics for Recurrent Bacterial Vaginosis
This randomized clinical trial aims to compare the recurrence of bacterial vaginosis (BV) in women receiving probiotics alongside antibiotic treatment versus women receiving antibiotic treatment alone.
- Trial name
- NCT07893782
- Testing
- Probiotic Combination Cap/Tab
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Nishtar Medical University
Helicobacter Pylori Infection
The Role of Probiotics in the Eradication of Helicobacter Pylori
All patients will receive quadruple eradication therapy for 10 days with Omerazole 20mg x2, Amoxicilin 1g x2, Clarithromycin 500mg x2 and Metronidazole 500mg x2. The patients will be randomised into two groups.
- Trial name
- NCT04178187
- Testing
- Caps Lactolevure
- Where
- 5 sites in Greece
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Evangelismos Hospital
Acute Radiation Enteritis
Gegen Qinlian Tang and Probiotics for Radiation Enteritis
The purpose of this clinical study is to evaluate whether Bifidobacterium Triple Viable Capsules, alone or in combination with Gegen Qinlian Decoction, can effectively prevent and treat acute radiation enteritis in patients…
- Trial name
- GQBT-RE (NCT06836960)
- Testing
- Probiotic Therapy With Gegen Qinlian Tang
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jiujiang No.1 People's Hospital
Crohn Disease
The Effects of Bifidobacterium Breve Bif195 for Small Intestinal Crohn's Disease
The purpose of this study is to investigate if the probiotic Bifidobacterium breve Bif195 (Bif195) will result in improvement in clinical outcome in patients with small intestinal Crohn's disease.
- Trial name
- NCT04842149
- Testing
- Bif195 capsules
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Hvidovre University Hospital
Dental Caries, Infectious Diseases
Bifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release Pacifier
Aims: 1. To develop a food supplement containing a health-promoting probiotic bacteria (B. lactis BB12) and xylitol to be administered with a novel soft, possibly occlusion-friendly pacifier. 2.
- Trial name
- NCT00638677
- Testing
- Sorbitol, Xylitol + BB12, Xylitol
- Where
- Finland
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Turku
Irritable Bowel Syndrome With Diarrhea, Irritable Bowel Syndrome
Safety and Efficacy of a Probiotic Supplement in IBS-D
This study aims to assess the safety and efficacy of a single probiotic strain on symptom severity in adults with diarrhea-predominant Irritable Bowel Syndrome (IBS-D).
- Trial name
- IBIS (NCT05754177)
- Testing
- Probiotic
- Where
- Slovenia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Helicobacter Pylori Infection
The Effects of a Synbiotic Addition on Eradication Therapy of Helicobacter Pylori Infection in Children
The aim of the study is to evaluate the effects of the synbiotic Bifidobacterium animalis ssp. lactis B94 plus inulin addition to the standard triple therapy on Helicobacter pylori infection eradication rates in children.
- Trial name
- NCT03165253
- Testing
- Bifidobacterium Animalis Oral Product, Amoxicillin Oral Tablet, Clarithromycin Oral Tablet
- Volunteers
- 69 people
- Sponsor
- Bulent Ecevit University
Reduction of Small Intestinal Ulceration Risk
Mapping the MoA Behind GI Protection From Bif195
The trial will investigate effects of daily intake of the bacterial strain Bif195 or placebo when co-administered to once-daily oral intake of 300 mg of Acetylsalicylic Acid (ASA).
- Trial name
- PIP-M (NCT04448847)
- Testing
- Bif195
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Recurrent Urinary Tract Infection
Study to Evaluate the Efficacy of Lactobacillus Crispatus M247 in the Prevention of Recurrent Urinary Tract Infections
This randomized, open-label, controlled clinical trial evaluates the efficacy and safety of Lactobacillus crispatus M247 (CRISPACT®) in preventing recurrent urinary tract infections (rUTIs) in women.
- Trial name
- NCT06857565
- Testing
- Lactobacillus crispatus M247, iNatal-Duo® (containing Bifidobacterium animalis subsp. lactis BB-12 and Enterococcus faecium L3)
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Oral Lichen Planus
Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus
Lichen planus is a chronic inflammatory mucocutaneous disease, which often results in oral manifestations, receiving the name of oral lichen planus (OLP).
- Trial name
- NCT03386643
- Testing
- Bifidobacterium animalis subsp. lactis HN019, Clobetasol propionate 0.05%
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo