Clinical trials: Bile Duct Disease
Primary Biliary Cholangitis, PBC
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis
The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with Primary Biliary Cholangitis (PBC), and to assess the possible…
- Trial name
- VANTAGE (NCT05050136)
- Testing
- Volixibat
- Where
- 130 sites in United States, Argentina and 13 more
- Volunteers
- 333 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Intrahepatic Cholangiocarcinoma
Contrast-Enhanced Ultrasound for the Prediction of Bile Duct Cancer Response to Radioembolization Treatment
This phase II trial tests whether contrast-enhanced ultrasound can predict the response of bile duct cancer to targeted radiotherapy (radioembolization treatment).
- Trial name
- NCT05328167
- Testing
- Perflutren Protein-Type A Microspheres, Contrast-Enhanced Ultrasound
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Thomas Jefferson University
Cholecystitis, Acute, Acute Cholangitis
Visualization of the Extrahepatic biliaRy Tree Trial
This study is a prospective randomized controlled trial evaluating the use of a fluorescent dye, indocyanine green (ICG), in the identification of important bile duct anatomy during emergent same-admission cholecystectomy.
- Conditions
- Cholecystitis, Acute, Acute Cholangitis, Gallstone Pancreatitis, Choledocholithiasis
- Trial name
- VERT (NCT04922528)
- Testing
- Laparoscopic Cholecystectomy with Fluorescent Cholangiography, Laparoscopic Cholecystectomy with White Light Imaging
- Where
- Canada
- Volunteers
- 340 people
- Sponsor
- University of British Columbia
Bile Duct Cancer
Safety of Biliary Intraductal Radiofrequency Ablation in Patients With Unresectable Extrahepatic Biliary Tract Cancer
The goal of this clinical trial is to provide evidence for the general tolerability of radiofrequency ablation (bRFA) in patients with unresectable bile duct cancer undergoing systemic palliative treatment consisting of systemic…
- Trial name
- Ablatio (NCT06274879)
- Testing
- Gemcitabin, Cisplatin and Durvalumab, Biliary Radiofrequency Ablation, Endoscopic Retrograde Cholangio-Pancreatography with stenting
- Where
- 4 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Radiation Therapy in Treating Patients With Bile Duct, Gallbladder, or Pancreatic Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Motexafin gadolinium may increase the effectiveness of radiation therapy by making tumor cells more sensitive to treatment.
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Pancreatic Cancer
- Trial name
- NCT00003411
- Testing
- motexafin gadolinium, radiation therapy
- Where
- 3 sites in United States
- Sponsor
- University of Pittsburgh
Primary Biliary Cirrhosis
Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary Cirrhosis
The University of Michigan is conducting a study investigating a potential new treatment aimed at slowing/halting progression of primary biliary cirrhosis.
- Trial name
- NCT00805805
- Testing
- Tetrathiomolybdate
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- George Brewer
Biliary Stones, Cholangiocarcinoma, Intrahepatic
Percutaneous Cholangiopancreatoscopy Registry
The Percutaneous Cholangiopancreatoscopy (PCPS) registry is an observational, multicentric, prospective, and retrospective registry of patients undergoing the percutaneous cholangiopancreatoscopy procedure at sites across the…
- Conditions
- Biliary Stones, Cholangiocarcinoma, Intrahepatic, Biliary Stricture, Cholelithiasis
- Trial name
- NCT05210322
- Testing
- Percutaneous cholangiopancreatoscopy
- Where
- United States
- Volunteers
- 679 people
- Sponsor
- Johns Hopkins University
Biliary Tract Neoplasms, Jaundice, Obstructive
Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents
Endoscopic retrograde biliary drainage (ERBD) is now widely accepted as the standard intervention for the relief of obstructive jaundice in patients with unresectable malignant biliary obstruction.
- Trial name
- NCT01315522
- Testing
- ComVi stent, Uncovered SEMS
- Where
- 3 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Inflammatory Bowel Diseases, Crohn Disease
Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE)
This is a prospective observational study collecting long-term clinical data and samples for research in pediatric inflammatory bowel disease (IBD) patients with gut inflammation and a control cohort of pediatric patients with…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- STRIDE (NCT06315179)
- Testing
- Esophagogastroduodenoscopy (EGD) with biopsy, Colonoscopy w/ biopsy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Seattle Children's Hospital
Choledochal Cyst Resection
Factors Affecting Postoperative Recovery From Common Bile Duct Cysts in Children: A Multicenter Retrospective Analysis Based on Perioperative Clinical Characteristics
This retrospective study aims to systematically analyze the factors influencing short-term rehabilitation and liver function recovery after radical surgery for pediatric common bile duct cysts, identify independent risk factors…
- Trial name
- NCT07800169
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Wuhan Children's Hospital
Cholangiocarcinoma
PCI Treatment/Gemcitabine & Chemotherapy vs Chemotherapy Alone in Patients With Inoperable Extrahepatic Bile Duct Cancer
This study will assess the safety and effectiveness of fimaporfin-induced photochemical internalisation (PCI) of gemcitabine complemented by systemic gemcitabine/cisplatin chemotherapy compared to gemcitabine/cisplatin alone, in…
- Trial name
- RELEASE (NCT04099888)
- Testing
- Fimaporfin and Gemcitabine, Gemcitabine/Cisplatin chemotherapy
- Where
- 50 sites in United States, Belgium and 12 more
- Volunteers
- 41 people
- Sponsor
- PCI Biotech AS
Extrahepatic Bile Duct Cancer, Nausea
Aprepitant in Preventing Nausea and Vomiting in Patients Undergoing Chemotherapy and Radiation Therapy for Pancreatic Cancer
This pilot clinical trial is studying how well aprepitant works in preventing nausea and vomiting in patients undergoing chemotherapy and radiation therapy for pancreatic cancer.
- Conditions
- Extrahepatic Bile Duct Cancer, Nausea, Vomiting, Stage II Pancreatic Cancer
- Trial name
- NCT01534637
- Testing
- aprepitant, gemcitabine hydrochloride, capecitabine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Primary Biliary Cirrhosis
Moexipril for Primary Biliary Cirrhosis
The blockade of angiotensin II synthesis attenuates hepatic fibrosis in different experimental models of chronic liver injury. We aimed to determine the safety and efficacy of moexipril, an angiotensin-converting enzyme (ACE)…
- Trial name
- NCT00588302
- Testing
- Moexipril
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Choledocholithiasis
A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation
Endoscopic papillary balloon dilation is as effective as sphincterotomy in treating bile duct stone. However, a need to switch to sphincterotomy is noted in about 20% of cases receiving dilation for lithotripsy.
- Trial name
- NCT00451581
- Testing
- Endoscopic papillary balloon dilation-5 minutes, Endoscopic papillary balloon dilation-1 minute
- Where
- Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital
Bile Duct Obstruction
A Study Comparing Sems Placement With and and Without Biliary Sphincterectomy in Patients With Malignant Biliary Obstruction
Background and rationale Placement of biliary self expanding metal stent (SEMS) is indicated when malignant common bile duct obstruction is encountered.
- Trial name
- NCT03628001
- Testing
- ERCP
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Istituto Clinico Humanitas
Common Bile Duct Gallstones
Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones
In recent years, endoscopic sphincterotomy and stone extraction are standard procedures for the removal of bile duct stones. After procedures, there are some complications such as stone recurrence, papillary stenosis, cholangitis…
- Trial name
- SIDEROD (NCT01425177)
- Testing
- Normal Saline Irrigation
- Where
- South Korea
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Primary Biliary Cirrhosis, Liver Inflammation
sCD163 in PBC Patients - Assessment of Disease Severity and Prognosis
Primary biliary cholangitis (PBC) is an autoimmune chronic liver disease, characterised by destruction of the small intrahepatic bile ducts.
- Trial name
- NCT02924701
- Testing
- Blood samples, fibroscan and questionaires
- Where
- Denmark
- Volunteers
- 168 people
- Sponsor
- University of Aarhus
Bile Duct Neoplasms
Covered or Uncovered Bile Duct Stents
The study is investigator initiated. Tumors that gives the narrowing of the bile ducts prevents bile from flowing from the liver to the intestine resulting in jaundice and the risk of bacterial growth in bile with severe…
- Trial name
- NCT01232101
- Testing
- covered or uncovered stents
- Where
- Sweden
- Volunteers
- 71 people
- Sponsor
- Göteborg University
Primary Sclerosing Cholangitis
A Research Study to Evaluate Safety and Efficacy of DUR-928 in Subjects With Primary Sclerosing Cholangitis (PSC)
This is a research trial testing DUR-928 (an experimental medication). The purpose of the trial is to assess whether treatment with DUR-928 has any effect on the treatment of Primary Sclerosing Cholangitis (PSC).
- Trial name
- NCT03394781
- Testing
- DUR-928
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Durect
Primary Sclerosing Cholangitis, Post- Orthotopic Liver Transplantation
Vancomycin Treatment in Recurrent PSC in Liver Transplant Patients
The purpose of the study is to investigate the safety and efficacy of oral vancomycin in patients with recurrent Primary Sclerosing Cholangitis (PSC) after liver transplantation.
- Trial name
- NCT03046901
- Testing
- Vancomycin
- Where
- United States
- Sponsor
- Ochsner Health System
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