Clinical trials: Biliary Cancers
Cholangiocarcinoma, Biliary Tract Cancer
Adjuvant Capecitabine vs Gemcitabine Plus Cisplatin in Resected Extrahepatic Cholangiocarcinoma
There is no proven adjuvant treatment after curative surgical resection in patients with cholangiocarcinoma, although previous meta-analysis suggested potential survival benefit of adjuvant chemotherapy or radiotherapy in…
- Conditions
- Cholangiocarcinoma, Biliary Tract Cancer, Adjuvant Chemotherapy, Capecitabine
- Trial name
- NCT03079427
- Testing
- Gemcitabine plus cisplatin, Capecitabine
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Asan Medical Center
Biliary Tract Cancer, Breast Cancer
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2001 in patients with advanced solid tumors.
- Conditions
- Biliary Tract Cancer, Breast Cancer, Cervical Cancer, Colon Cancer
- Trial name
- NCT06239194
- Testing
- MDX2001
- Where
- 6 sites in United States
- Volunteers
- 330 people
- Sponsor
- ModeX Therapeutics, An OPKO Health Company
Cholangiocarcinoma, Pancreatic Cancer
T-EUS for Gastrointestinal Disorders: A Multicenter Registry
The purpose of this registry is to record information and evaluate the impact of Endoscopic Ultrasound (EUS) Guided Endoscopic retrograde cholangiopancreatography (ERCP) on the management of pancreatico-biliary disorders.
- Conditions
- Cholangiocarcinoma, Pancreatic Cancer, Bile Duct Cancer, Biliary Stricture
- Trial name
- EUSERCPReg (NCT01522573)
- Testing
- EUS guided ERCP
- Where
- 2 sites in United States, Brazil
- Volunteers
- 1,000 people
- Sponsor
- Weill Medical College of Cornell University
Malignant Hepatobiliary Neoplasm
Ponatinib Hydrochloride in Treating Patients With Advanced Biliary Cancer With FGFR2 Fusions
This pilot phase II trial studies how well ponatinib hydrochloride works in treating patients with biliary cancer that has spread to other places in the body and that have alterations (fusions) in a gene known as fibroblast…
- Trial name
- NCT02265341
- Testing
- Laboratory Biomarker Analysis, Ponatinib Hydrochloride, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Platinum-Sensitive Biliary Tract Cancer
Pamiparib and Low Dose Temozolomide In Patients With Platinum Sensitive Biliary Tract Cancer
The main objective of this trial is to evaluate the activity of pamiparib plus low dose TMZ as maintenance treatment in improving progression free survival (PFS) in patients with advanced BTC who have received first line…
- Trial name
- PAMICC (NCT04796454)
- Testing
- Cisplatin, Gemcitabine, Oxaliplatin
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Gastric Cancer, Colorectal Cancer
Effect of Multi-modal Intervention Care on Cachexia in Patients With Advanced Cancer Compared to Conventional Management (MIRACLE)
Background Cancer Cachexia (CC) is a multi-factorial process characterized by progressive weight loss, muscle mass and fat tissue wasting, and adversely affecting their quality of life and survival in patients with advanced stage…
- Conditions
- Gastric Cancer, Colorectal Cancer, Pancreatic Cancer, Biliary Tract Cancer
- Trial name
- MIRACLE (NCT04907864)
- Testing
- Multi-modal intervention
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Kil Yeon Lee
Choledochal Cyst
Clinical Features and Prognosis of Asymptomatic Biliary Dilatation
This study is a multicenter, ambidirectional cohort study aiming to consecutively recruit asymptomatic biliary dilation patients incidentally discovered by imaging from 25 medical centers across China.
- Trial name
- NCT07028164
- Where
- China
- Volunteers
- 1,008 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Biliary Stricture
Confocal Endomicroscopy for Biliary Strictures -Phase I
The investigators hypothesize that the confocal endomicroscopy imaging of the biliary strictures during ERCP will differentiate between benign and malignant strictures in vivo and has increased sensitivity compared to biliary…
- Trial name
- NCT00892632
- Testing
- ERCP and Confocal imaging
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Pancreatic Cancer, Malignant Biliary Obstruction
Comparison of a Short Modified Metal Stent Versus Plastic Stent as a Bridge to Surgery in Pancreatic Cancer With Malignant Biliary Obstruction
This study is a multicenter, randomized clinical trial designed to compare the effectiveness and safety of a modified 8-mm fully covered self-expandable metal stent (FCSEMS) with a conventional plastic stent for preoperative…
- Trial name
- BRIDGE-8 (NCT07606430)
- Testing
- Modified 8-mm Fully Covered Self-Expandable Metal Stent, Plastic stent
- Volunteers
- 116 people
- Sponsor
- Soonchunhyang University Hospital
Cholangiopancreatography, Endoscopic Retrograde, Common Bile Duct Lithiasis
Quality Assessment in Endoscopic Retrograde Cholangiopancreatography(ERCP)
The investigators will prospectively collect patient and procedure-related data in an observational study in order to detect patient and procedure-related risk factors for poor outcome (i.e.
- Conditions
- Cholangiopancreatography, Endoscopic Retrograde, Common Bile Duct Lithiasis, Biliary Strictures, Bile Duct and Pancreatic Tumors
- Trial name
- QUASIE2 (NCT02698137)
- Where
- 3 sites in Croatia, Italy and 1 more
- Volunteers
- 1,843 people
- Sponsor
- Clinical Hospital Colentina
Biliary Tract Neoplasms Immunotherapy
A Phase II Study of Adjuvant Durvalumab Combined With GEMOX/GC Chemotherapy Followed by Lenvatinib Versus Capecitabine in Biliary Tract Cancer.
This study is designed as a prospective, randomized, open-label, phase II clinical trial to systematically evaluate the efficacy and safety of durvalumab combined with GEMOX/GC chemotherapy followed by lenvatinib, compared with…
- Trial name
- NCT07679399
- Testing
- Durvalumab plus GEMOX/GC chemotherapy sequentially followed by lenvatinib, Capecitabine
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Peking Union Medical College Hospital
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Gemcitabine Hydrochloride, Oxaliplatin, and Erlotinib Hydrochloride in Treating Patients With Advanced Biliary Tract Cancer, Pancreatic Cancer, Duodenal Cancer, or Ampullary Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Liver Cancer, Pancreatic Cancer
- Trial name
- NCT00987766
- Testing
- erlotinib hydrochloride, gemcitabine hydrochloride, oxaliplatin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Biliary Tract Cancer (BTC), Biliary Tract Cancer (CCA)
TRACE-BTC. Relation of Biomarkers and Patients Reported Quality of Life to Outcomes in Patients With Biliary Tract Cancer: a Real- World Cohort
Purpose of the Study: Bile duct cancers are rare and aggressive. About 250 new cases are diagnosed each year in Denmark. These cancers are difficult to detect early, so only about 20% of patients can have surgery when diagnosed.
- Conditions
- Biliary Tract Cancer (BTC), Biliary Tract Cancer (CCA), Gall Bladder Cancer, Biliary Tract Cancers (BTC)
- Trial name
- TRACE-BTC (NCT07454486)
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Aarhus University Hospital
Gallbladder Cancer
AK112 Combined With GAP Conversion Therapy for Locally Advanced Gallbladder Cancer
The goal of this clinical trial is to evaluate the efficacy and safety of AK112 combined with the GAP regimen as conversion therapy for patients with locally advanced gallbladder cancer who are initially considered unsuitable for…
- Trial name
- ICORE-GBC (NCT07767994)
- Testing
- AK112, Gemcitabine, Cisplatin
- Volunteers
- 22 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Biliary Tract Neoplasms, Pancreatic Neoplasms
The Efficacy and Safety of Trilaciclib in Bone Marrow Protection Before Chemotherapy for Advanced Bile Duct Cancer and Pancreatic Cancer
Evaluate the efficacy and safety of Trilaciclib for myeloprotection prior to chemotherapy in advanced cholangiocarcinoma or pancreatic cancer.
- Trial name
- NCT07160283
- Testing
- Bile duct cancer cohort, Pancreatic cancer cohort
- Volunteers
- 96 people
- Sponsor
- The Second Affiliated Hospital of Shandong First Medical University
Cholangiocarcinoma Cancer, Gallbladder Cancer
A Feasibility Phase II Study in the Treatment of Resected Cholangiocarcinoma, Gallbladder, Pancreatic and Ampullary Cancers
To assess the feasibility of administering induction chemotherapy with gemcitabine and docetaxel followed by concurrent radiation and continuous infusion 5FU and consolidation gemcitabine/docetaxel chemotherapy.
- Conditions
- Cholangiocarcinoma Cancer, Gallbladder Cancer, Pancreatic Cancer, Ampullary Cancer
- Trial name
- NCT00660699
- Testing
- Gemcitabine, Docetaxel, Radiation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Advanced Biliary Tract Cancers
A Phase II Exploratory Study of Sacituzumab Tirumotecan Combined With Envafolimab for TROP2-Positive Advanced Biliary Tract Cancers Previously Treated With First-Line Immunotherapy Combined With Chemotherapy.
This is a prospective, single-arm, Phase II study evaluating sacituzumab tirumotecan combined with envafolimab in patients with TROP2-positive advanced biliary tract cancers who have progressed on first-line immunochemotherapy.
- Trial name
- NCT07729033
- Testing
- Sacituzumab tirumotecan combined with envafolimab
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Gastric Cancer in Situ, Pancreatic Cancers
Biweekly SOLAR, as First-line C/T in Pts With Gastric, Pancreatic and Biliary Cancers
The primary purpose of the study is to determine the maximal tolerated dose (MTD) of Oxaliplatin in this phase I study. The secondary objectives are to determine the response rate, progression free survival, overall survival, and…
- Conditions
- Gastric Cancer in Situ, Pancreatic Cancers, Biliary Cancers
- Trial name
- SOLAR (NCT03162510)
- Testing
- Oxaliplatin, Albumin-Bound Paclitaxel /nab-Paclitaxel, S-1
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- National Health Research Institutes, Taiwan
Perihilar Cholangiocarcinoma
Biliary Drainage Plus HAIC in Locally Advanced pCCA
Biliary drainage and stent placement remains to be the main palliative treatment choice for advanced perihiliar cholangiocarcinoma (pCCA), and the life expectancy is only 4-6 months.
- Trial name
- NCT05024513
- Testing
- oxaliplatin and 5-fluorouracil, Biliary Drainage, Best Supportive Care
- Where
- China
- Volunteers
- 127 people
- Sponsor
- Peking University
Carcinoma, Intrahepatic Cholangiocarcinoma
Combination Therapy of HAIC, Surufatinib and Tislelizumab for Unresectable or Metastatic Biliary Tract Cancer
This is a single-arm, exploratory study to evaluate the efficacy and safety of HAIC in combination with surufatinib and tislelizumab in the first line treatment of patients with unresectable or metastatic biliary tract cancer
- Conditions
- Carcinoma, Intrahepatic Cholangiocarcinoma, Gallbladder Cancer, Surufatinib
- Trial name
- NCT06134193
- Testing
- HAIC, Surufatinib, Tislelizumab
- Volunteers
- 41 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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