Clinical trials: Biliary Condition, active
Biliary Atresia
Mapping Disease Pathways for Biliary Atresia
This project will primarily evaluate the developmental/genetic basis of biliary atresia, the most common cause of liver failure at birth, and which accounts of half of all liver transplants performed worldwide in children.
- Trial name
- BA (NCT03273049)
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- University of Pittsburgh
Biliary Tract Cancer
HAIC+Adebrelimab+Lenvatinib for Conversion Treatment of Potentially Resectable, Locally Advanced Biliary Tract Cancer
This is a single-arm, exploratory, phase II trial to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy combined with adebrelimab and lenvatinib for borderline resectable, locally advanced biliary tract…
- Trial name
- NCT06389500
- Testing
- Adebrelimab, Lenvatinib, Hepatic Arterial Infusion Chemotherapy
- Volunteers
- 30 people
- Sponsor
- Harbin Medical University
Jaundice, Obstructive, Cholangiopancreatography, Endoscopic Retrograde
A RCT of Low MBO Drainage Strategies
The purpose of this study is to evaluate the efficacy and safety of EUS-BD compared with ERCP-BD in low biliary obstruction caused by periampullary cancer, pancreatic cancer or low bile duct cancer.
- Conditions
- Jaundice, Obstructive, Cholangiopancreatography, Endoscopic Retrograde, Endoscopic Ultrasound-Guided Drainage
- Trial name
- NCT06196164
- Testing
- EUS-BD, ERCP-BD
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Biliary Tract Cancer (BTC)
Testing Mitazalimab in Combination With Standard Chemotherapy in Immunotherapy Resistant Advanced Biliary Tract Cancers
The goal of this clinical trial is to etablish whether adding Mitazalimab to standard chemotherapy is more effective than standard chemotherapy alone in people with advanced bile duct cancer.
- Trial name
- CROCOBIL (NCT07437287)
- Testing
- mFOLFOX regimen, Mitazalimab
- Where
- 22 sites in France
- Volunteers
- 160 people
- Sponsor
- UNICANCER
Cholelithiasis, Postoperative Pain, Laparoscopic Cholecystectomy
ESP vs Subcostal TAP Block for Analgesia After Laparoscopic Cholecystectomy
This prospective, randomized, double-blind study compares the analgesic efficacy of ultrasound-guided erector spinae plane (ESP) block and subcostal transversus abdominis plane (TAP) block in patients undergoing laparoscopic…
- Trial name
- ESP TAP (NCT07661693)
- Testing
- Erector Spinae Plane Block, Subcostal Transversus Abdominis Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Gaziantep City Hospital
Head and Neck Squamous Cell Carcinoma (HNSCC), Non-small Cell Lung Cancer (NSCLC)
A Study of MT-4561 in Patients With Various Advanced Solid Tumors
This is a First In Human (FIH), multicenter, open-label, Phase I/II study to evaluate safety, tolerability, Pharmacokinetics (PK), pharmacodynamics, and efficacy of MT-4561 in patients with advanced solid tumors.
- Conditions
- Head and Neck Squamous Cell Carcinoma (HNSCC), Non-small Cell Lung Cancer (NSCLC), Esophageal Cancer, Gastric Cancer
- Trial name
- NCT06943521
- Testing
- MT-4561
- Where
- 6 sites in United States, Japan
- Volunteers
- 27 people
- Sponsor
- Tanabe Pharma America, Inc.
Pancreatic Cancer
Preoperative Biliary Drainage in Malignant Biliary Obstruction
The first alarming symptom of a malignancy of the pancreas or periampullary tumor can be obstructive jaundice (OJ). Pancreato-duodenectomy (PD) combined with oncological treatment can provide long disease-free survival in…
- Trial name
- PEAR (NCT04847297)
- Testing
- Preoperative drainage and pancreatoduodenectomy, Pancreatoduodenectomy
- Volunteers
- 353 people
- Sponsor
- University of Pecs
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Bile Duct Carcinoma, Cholangiocarcinoma
Precision Integrated Strategies and Efficacy Evaluation for Biliary Tract Cancers: An Umbrella Platform Study
This study is a prospective, multicenter, open-label, umbrella phase II clinical trial. Based on different multigene expression profiling subtypes and potential molecular characteristics of various pathways, 8 treatment arms and…
- Trial name
- NCT07729917
- Testing
- FGFR Inhibitor, IDH1 mutation inhibitor, KRAS mutation inhibitor
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Zhejiang University
Ovarian Cancer, Cholecystolithiasis
Safety of Opportunistic Salpingectomy During Elective Laparoscopic Cholecystectomy.
The knowledge, coupled with epidemiological studies demonstrating lower ovarian cancer rates in women with a history of tubal sterilization has led to recommendations for opportunistic salpingectomy at the time of benign…
- Trial name
- NCT07642791
- Testing
- Opportunistic salpingectomy, Cholecystectomy
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
Cancer Harboring BRAF Alterations, HGG
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
The objective of this Master Protocol is to evaluate the efficacy and safety of plixorafenib in participants with BRAF altered (BRAF V600E or BRAF fusions) locally advanced or metastatic solid tumors, or recurrent or progressive…
- Conditions
- Cancer Harboring BRAF Alterations, HGG, LGG, Solid Tumors
- Trial name
- NCT05503797
- Testing
- Plixorafenib
- Where
- 70 sites in United States, Australia and 10 more
- Volunteers
- 254 people
- Sponsor
- Fore Biotherapeutics
Biliary Tract Neoplasms
Personalized Medicine for Advanced Biliary Cancer Patients
The object of this trial is to evaluate whether the introduction of a targeted therapy after 4 cycles of the current standard-of-care treatment for advanced biliary cancer is superior to continuing with the standard treatment.
- Trial name
- SAFIR-ABC10 (NCT05615818)
- Testing
- Futibatinib, Ivosidenib, Zanidatamab
- Where
- 69 sites in Belgium, France and 1 more
- Volunteers
- 800 people
- Sponsor
- UNICANCER
Choledochal Cyst
Host-Microbe Interactions in Biliary Dilatation
This study is an observational cohort study aimed at continuously enrolling patients with biliary dilatation and healthy controls.
- Trial name
- NCT07152496
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Gallstone Disease, Ultrasonic Diagnosis
Transabdominal and Laparoscopic Ultrasound in a Bariatric Setting
Every year, many patients undergo weight-loss (bariatric) surgery. While this surgery leads to significant and intended weight loss, it also increases the risk of developing gallstones or other gallbladder problems.
- Conditions
- Gallstone Disease, Ultrasonic Diagnosis, Bariatric Patients Undergoing Bariatric Surgery
- Trial name
- NCT07453186
- Testing
- Diagnostic procedures
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Advanced or Metastatic Solid Tumor, Pancreatic Ductal Adenocarcinoma
AB122 Platform Study
This is a phase 1, non-randomized open-label, multicenter platform study designed to evaluate the tolerability and safety of AB122 in patients with malignancies specified in each cohort.
- Conditions
- Advanced or Metastatic Solid Tumor, Pancreatic Ductal Adenocarcinoma, Colorectal Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT04999761
- Testing
- AB122, TAS-116, TAS-120
- Where
- 9 sites in Japan
- Volunteers
- 917 people
- Sponsor
- Taiho Pharmaceutical Co., Ltd.
Chronic Liver Disease
An Observational Study Evaluating Patients With Chronic Liver Diseases Associated With Hepatic Steatosis
Hepatic steatosis may cause inflammation and fibrosis within the liver potentially leading to end-stage liver disease cirrhosis, liver failure and death.
- Trial name
- FALL (NCT05335603)
- Where
- Denmark
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Gallstone Disease, Bariatric Surgery
ABCG8, UGT1A1 and Gallstone Disease After Bariatric Surgery
The goal of this observational genetic case-control study is to learn whether two specific genetic variants in ABCG8 and UGT1A1 are associated with gallstone disease after bariatric surgery.
- Conditions
- Gallstone Disease, Bariatric Surgery, Metabolic Surgery, Cholecystectomy
- Trial name
- NCT07702630
- Testing
- blood sampling
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Recurrent or Metastatic Solid Tumors
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
This study is designed to assess the efficacy and safety of ifinatamab deruxtecan (I-DXD) in the following tumor types: endometrial cancer (EC); head and neck squamous cell carcinoma (HNSCC); pancreatic ductal adenocarcinoma…
- Trial name
- NCT06330064
- Testing
- Ifinatamab deruxtecan
- Where
- 120 sites in United States, Argentina and 16 more
- Volunteers
- 680 people
- Sponsor
- Daiichi Sankyo
Abdominal Pain, Gallstone; Colic
RELIEF-pathway in Patients With Upper Abdominal Pain
Upper abdominal pain (UAP) is a common symptom and frequently the reason to visit the hospital. The prevalence of epigastric pain in the Dutch population is estimated to be as high as 37%.
- Conditions
- Abdominal Pain, Gallstone; Colic, Dyspepsia, Irritable Bowel Syndrome
- Trial name
- RELIEF (NCT06002516)
- Testing
- RELIEF-pathway
- Where
- Netherlands
- Volunteers
- 471 people
- Sponsor
- Radboud University Medical Center
Biliary Tract Cancer
Tuvonralimab and Iparomlimab Based Regimens for the Neoadjuvant Treatment of Biliary Tract Cancer
The goal of this clinical trial is to learn if Tuvonralimab/Iparomlimab-based neoadjuvant regimens can improve surgical and pathological outcomes in adults (≥18 years) with resectable or borderline-resectable biliary tract cancer…
- Trial name
- NCT07267078
- Testing
- Tuvonralimab/Iparomlimab combination with GEMOX chemotherapy
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Peking Union Medical College Hospital