Clinical trials: Biliary Duct Obstruction
Malignant Biliary Obstruction
The ID- RFA Trial: A Trial of Intraductal Radio-frequency Ablation (ID-RFA) Plus Biliary Stenting Versus Biliary Stenting Alone for the Treatment of Malignant Biliary Obstruction.
Cancers of the liver, pancreas and gall bladder can partially or fully block the bile duct leading to jaundice. Where these tumours are inoperable, maintaining adequate bile duct drainage is an important factor in survival, both…
- Trial name
- NCT04941924
- Testing
- Intraductal Radio-Frequency Ablation, Biliary Stent Placement
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- University Hospitals Dorset NHS Foundation Trust
Benign Biliary Strictures With Current or Prior Biliary Obstruction
Percutaneous Endoluminal Benign Biliary Laser
This study is being done to evaluate the safety and efficacy of Percutaneous transhepatic cholangioscopic (PTCS) laser incision as an ancillary therapy to traditional approaches such as balloon dilation and large drain placement…
- Trial name
- PEBBL (NCT05567003)
- Testing
- Percutaneous transhepatic cholangioscopic (PTCS) laser incision
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, Los Angeles
Biliary Tract Neoplasms, Pancreatic Carcinoma
A Prospective Study of UCAD for Diagnosing Benign or Malignant Biliary Obstruction and Follow-up
Chromosomal instability (CIN) refers to ongoing chromosome segregation errors throughout consecutive cell divisions. CIN is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic…
- Conditions
- Biliary Tract Neoplasms, Pancreatic Carcinoma, Gallbladder Cancer, Pancreatic Head Carcinoma
- Trial name
- NCT05237193
- Testing
- The level of CIN
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Biliary Neoplasms, Biliary Obstruction
Comparison of Drug Eluting Stent and Covered Metal Stent in Malignant Biliary Obstruction (MIRA III)
The purpose of this study is to compare the effectiveness and safety of Niti-S Mira-Cover III Biliary Stent with Comvi Biliary Covered Stent for the treatment of malignant biliary obstruction.
- Conditions
- Biliary Neoplasms, Biliary Obstruction, Pancreatic Neoplasms
- Trial name
- NCT02460432
- Testing
- Paclitaxel-eluting metal Stent, Covered Metal Stent
- Where
- 5 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- Taewoong Medical Co., Ltd.
Biliary Obstruction
Dormia Basket Versus Extraction Ballon in Proximally Migrated Biliary Stents
Dormia basket versus extraction ballon in proximally migrated biliary stents:A randomized controlled clinical trial
- Trial name
- NCT05634772
- Testing
- dormia basket, Extraction biliary ballon
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kafrelsheikh University
Pancreatic Carcinoma, Biliary Obstruction
Combined Stent Insertion and HIFU Ablation for Pancreatic Carcinoma With Biliary Obstruction
The purpose of this study is to compare the clinical effectiveness and long-term outcomes between patients with pancreatic carcinoma and biliary obstruction who are treated by stent insertion with or without high-intensity…
- Trial name
- HIFU (NCT03962478)
- Testing
- biliary stent and high-intensity focused ultrasound ablation system, biliary stent
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Xuzhou Central Hospital
Fragility, Biliary Obstruction
Sedation Methods in Percutaneous Transhepatic Biliary Drainage: Procedure Quality and Recovery
This prospective, randomized, single-center study aims to evaluate and compare two different sedation and analgesia regimens used during percutaneous transhepatic biliary drainage (PTBD) procedures.
- Conditions
- Fragility, Biliary Obstruction, Cholangitis, Malignancy
- Trial name
- NCT07640243
- Testing
- Remifentanil, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Ankara City Hospital Bilkent
Cholangitis
Comparisons of Intravenous Ceftriaxone With Intravenous Moxifloxacin in ERCP
Background and aims: The use of prophylactic antibiotics before endoscopic retrograde cholangiopancreatography (ERCP) is recommended by all major international gastroenterological societies, especially in the presence of an…
- Trial name
- NCT02098486
- Testing
- Moxifloxacin, ceftriaxone
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Kangbuk Samsung Hospital
Biliary Obstruction, Cholangitis
Treatment of Biliary Obstruction Using Biliary Stent With or Without Antireflux Valve
Biliary obstruction can be relieved by biliary stent. Ascending infection of biliary passage (cholangitis) causes hospitalization and obstruction of stents.
- Trial name
- NCT00990366
- Testing
- Cook´s biliary stent with an antireflux stent, normal biliary stent
- Where
- Finland
- Volunteers
- 15 people
- Sponsor
- Turku University Hospital
Pancreatic Cancer, Endoscopy
Plastic Stent Within a Lumen-Apposing Stent for Malignant Biliary Obstruction
There are doubts concerning the possible benefits derived from the insertion of double-pigtail plastic stents (DPS) within the lumen-apposing metal stents (LAMS) in the EUS-guided transmural biliary drainage (BD).
- Conditions
- Pancreatic Cancer, Endoscopy, Oncologic Disorders, Therapy Related Neoplasms
- Trial name
- LAMSpigBil (NCT04420039)
- Testing
- Endoscopic biliary transmural drainage
- Where
- 3 sites in Spain
- Volunteers
- 39 people
- Sponsor
- Hospital Universitari de Bellvitge
Bile Duct Obstruction, Extrahepatic
Ultrasound-guided Percutaneous Biliary Drainage With Primary Metal Implantation by Endoscopic Luminal Guidance
In a recently published meta-analysis (Sharaiha, Gastrointestinal Endoscopy, 2017), it is reported that percutaneous transhepatic biliary drainage (PTBD) is less clinical successful, causes more adverse events and needs more…
- Trial name
- NCT03541590
- Testing
- Percutaneous transhepatic biliary drainage
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Obstructive Jaundice, Cholangitis
Cholangioscopic Assessment of Occluded Biliary Stent and Role of Biliary Radiofrequency Ablation
Primary Objective: To document state-of- the-art multi-modality management of occluded biliary SEMS aiming to minimize number of reinterventions while providing symptom relief without procedure-related serious adverse events.
- Trial name
- NCT03133026
- Testing
- Single operator cholangioscopy, Endoscopic biliary RFA
- Where
- India
- Volunteers
- 4 people
- Sponsor
- Asian Institute of Gastroenterology, India
Biliary Obstruction
Feasibility of EUS-guided Biliary Drainage With LAMS for the Treatmentof Patients With Distal Malignant Biliary Obstruction
Distal malignant biliary obstruction results from different types of tumors including pancreatic cancer, biliary tract cancer (BTC), gallbladder cancer, and metastasis, which can lead to obstructive jaundice.
- Trial name
- SPAXUS (NCT04723199)
- Testing
- Electrocautetery LAMS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Clinico Humanitas
Gastric Outlet Obstruction, Biliary Obstruction
Prospective Registry Of Therapeutic EndoscopiC ulTrasound
This registry aims to analyze long-term outcomes of therapeutic EUS (T-EUS) procedures, as well as to describe clinical and technical variables potentially predicting clinical success or adverse events, for a better selection of…
- Conditions
- Gastric Outlet Obstruction, Biliary Obstruction, Acute Pancreatic Fluid Collection, Acute Pancreatitis With Infected Necrosis
- Trial name
- PROTECT (NCT04813055)
- Testing
- Therapeutic EUS, Percutaneous Procedures, Surgical Interventions
- Where
- Italy
- Volunteers
- 510 people
- Sponsor
- Paolo Giorgio Arcidiacono, MD
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Photodynamic Therapy in Treating Patients With Cancer of the Bile Duct, Gallbladder, or Pancreas
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. This may be effective treatment for cancer of the bile duct, gallbladder, or pancreas.
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Liver Cancer, Pancreatic Cancer
- Trial name
- NCT00003923
- Testing
- porfimer sodium
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Biliary Tract Neoplasms
Radiofrequency Ablation for Malignant Biliary Obstruction
Biliary obstruction is importantly influencing quality of life and survival of patients suffering from primary or secondary bile duct malignancies.
- Trial name
- NCT01758341
- Testing
- Endoscopic radiofrequency ablation, Endoscopic retrograde cholangiopancreatography (ERCP), HabibTM EndoHPB catheter
- Where
- Austria
- Volunteers
- 58 people
- Sponsor
- Medical University of Vienna
DISTAL MALIGNANT BILIARY OBSTRUCTION
Eus-giuded Biliary Drainage With Ec-lams vs ERCP as a Primary Intervention for Endoscopic Treatment of Patinets With Distal Malignant Biliary Obstruction
Endoscopic retrograde cholangiopancreatography (ERCP) is the gold standard for the management of jaundice in patients with distal malignant biliary obstruction.
- Trial name
- EUS-BD (NCT04099862)
- Testing
- ERCP, EUS-BD
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Istituto Clinico Humanitas
Bile Duct Neoplasm, Obstructive Jaundice
Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction
Internal biliary drainage using stent is used for malignant hilar obstruction such as cholangiocarcinoma, hepatocellular carcinoma and other malignancy including metastasis.
- Trial name
- NCT01622803
- Testing
- parallel stent, Y-stent (BONASTENT M-Hilar)
- Where
- South Korea
- Sponsor
- Samsung Medical Center
Biliary Tract Neoplasms, Pancreatic Neoplasms
Malignant Obstruction ZILVER Against Routine Therapy (MOZART I)
This study compares the 6 mm nitinol Zilver biliary endoprostheses and the 10 mm nitinol Zilver biliary endoprostheses to the 10 mm Wallstent in appropriate patients in need of palliative treatment of malignant obstructive…
- Conditions
- Biliary Tract Neoplasms, Pancreatic Neoplasms, Jaundice, Obstructive
- Trial name
- NCT00196105
- Testing
- 6 mm Nitinol Zilver Stent, 10 mm Nitinol Zilver Stent, 10 mm Stainless Steel Wallstent
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Cook Group Incorporated
Pancreatic Cancer, Pancreatic Adenocarcinoma
EUS BD vs ERCP TP for Pancreatic Cancer
This Endoscopic Ultrasound guided Biliary Drainage (EUS-BD) vs. Endoscopic Retrograde Cholangiopancreatography (ERCP-TP) trial (BILPAL) is a randomized controlled multicenter trial that will provide evidence whether or not…
- Conditions
- Pancreatic Cancer, Pancreatic Adenocarcinoma, Biliary Tract Neoplasms, Biliary Duct Obstruction
- Trial name
- BILPAL (NCT03063554)
- Testing
- Endoscopic Ultrasound Guided Biliary Drainage, ERCP
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Weill Medical College of Cornell University