Clinical trials: Biliary Duct Obstruction
Cholangiocarcinoma, Biliary Stricture
Photodynamic Therapy (PDT) for Palliation of Cholangiocarcinoma
Successful palliation of biliary obstruction is the main goal for reducing morbidity and mortality in patients with biliary disease and biliary obstruction related to cholangiocarcinoma.
- Conditions
- Cholangiocarcinoma, Biliary Stricture, Biliary Obstruction, Bile Duct Cancer
- Trial name
- NCT01755013
- Testing
- Photodynamic Therapy
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Weill Medical College of Cornell University
Malignant Bile Duct Obstruction
Sems Placement With and Without Biliary Sphincterectomy in Patients With Malignant Biliary Obstruction
Placement of biliary self expanding metal stent (SEMS) is indicated when malignant common bile duct obstruction is encountered [1].
- Trial name
- SEMS (NCT04805450)
- Testing
- ES before fully covered SEMS placement, no ES before fully covered SEMS placement
- Where
- Italy
- Volunteers
- 1,075 people
- Sponsor
- Istituto Clinico Humanitas
Liver Transplant; Complications, Biliary Duct Obstruction
Clinical Usefulness of Digital Single-operator Cholangioscopy(SpyGlass™) for Post-liver Transplant Anastomotic Stricture
Liver transplantation (LT) is an essential treatment for end-stage liver disease. Although clinical outcomes of LT recipients have markedly improved, anastomotic biliary strictures (ABS) are still occurred in 10-40% of post-LT…
- Conditions
- Liver Transplant; Complications, Biliary Duct Obstruction, Anastomosis, Obstructed
- Trial name
- NCT05065125
- Testing
- digital single-operator cholangioscopy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Biliary Obstruction Due to Common Bile Duct Stone, Malignant Bile Duct Obstruction
Needle-Knife Fistulotomy Vs. Standard Cannulation Trial
Needle-knife fistulotomy (NKF) is traditionally used to achieve biliary access when standard cannulation (SC) techniques are unsuccessful.
- Trial name
- NCT06694038
- Testing
- Needle Knife Fistulotomy, standard biliary cannulation
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Thomas Jefferson University
Biliary Obstruction, Bile Duct Stricture
UNITY-B A Prospective, Multicentric, Single-arm Study to Evaluate the Safety and Efficacy of the UNITY-B Biodegradable Balloon-Expandable Biliary Stent System in Subjects With Biliary Strictures
STUDY TYPE: Feasibility study STUDY DESIGN: Prospective, multicenter, single-arm, open-label PRIMARY OBJECTIVE The primary objective is to assess safety of the UNITY Balloon-expandable Biodegradable Biliary Stent System SECONDARY…
- Conditions
- Biliary Obstruction, Bile Duct Stricture, Bile Duct Diseases
- Trial name
- NCT04929821
- Testing
- Biliary Duct Stenting
- Where
- 6 sites in Hong Kong, India and 1 more
- Volunteers
- 100 people
- Sponsor
- QualiMed Innovative Medizinprodukte GmbH
Gallbladder Cancer, Liver Cancer
Quality Of Life in Patients With Malignant Biliary Obstruction
You may have symptoms like itching, abdominal pain, loss of appetite, fatigue, fevers and chills. The treatment you will receive to relieve the blockage is also intended to relieve symptoms and improve your quality of life.
- Conditions
- Gallbladder Cancer, Liver Cancer, Bile Duct Cancer
- Trial name
- NCT00579865
- Testing
- questionnaires
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Jaundice
A Prospective, Randomized Study Evaluating the Effect of Biliary Stenting on EAU-FNA in Patients With Suspected Malignant Biliary Obstruction
Patients who present with obstructive jaundice due to a malignant stricture often undergo a battery of tests for diagnosis, treatment options, and prognosis.
- Trial name
- NCT01514058
- Testing
- EUS-FNA first, followed by CRCP with bilinary stenting, ERCP with stent placement, followed by EUS-FNA
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University Health Sciences
Endoscopic Retrograde Cholangiopancreatography (ERCP), Choledocholithiasis
Role of Prophylactic Aggressive Hydration to Prevent Post-ERCP Pancreatitis
Endoscopic Retrograde Cholangiopancreatography, also called ERCP, is a procedure used to diagnose and treat disorders of the bile ducts and pancreas.
- Conditions
- Endoscopic Retrograde Cholangiopancreatography (ERCP), Choledocholithiasis, Bile Duct Disorder, Biliary Obstruction
- Trial name
- NCT07417020
- Testing
- Aggressive intravenous hydration with lactated Ringer's solution, Standard intravenous hydration with lactated Ringer's solution
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Lahore General Hospital
Klatskin Tumor
Single Versus Multiple Deployment of Metallic Stents for Inoperable Malignant Hilar Biliary Obstruction
In Bismuth II-IV hilar cholangiocarcinoma patients with a predicted survival of longer than 3 months, metallic stent performance is superior to plastic stenting for palliation with respect to outcomes and cost-effectiveness.
- Trial name
- NCT02166970
- Testing
- Metallic stent deployment in hilar obstruction
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Soon Chun Hyang University
Pancreatitis, Cholangitis
The Patency Period of the New Plastic Anti-reflux Biliary Stent
The aim of this study is to determine the average patency period of the new anti-reflux biliary stent on patients with malignant bile duct strictures and to determine if this stent remains patent for a longer period of time…
- Trial name
- NCT01142921
- Testing
- Anti-reflux Tannenbaum biliary stent, Ordinary Tannenbaum biliary stent
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Chinese University of Hong Kong
Resectable Pancreatic Cancer With Biliary Obstruction
A Prospective Randomized Multi-center Study for Efficacy of Metallic Biliary Stent Compared to Plastic Stent in Patients Receiving Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer
Pancreatic cancer is the eighth most common occurrence in Korea. In the United States, pancreatic cancer is expected to be the number two cause of death from cancer in 2030.
- Trial name
- NCT04911647
- Testing
- ERCP using plastic stent, ERCP using metal stent
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Yonsei University
Interventional Radiology
The Impact of Puncture Angle on Total Fluoroscopy Time Reduction During Percutaneous Biliary Drainage
The purpose of this study is to retrospectively assess the importance of initial bile duct puncture angle on total fluoroscopy time and overall efficacy during ultrasound and fluoroscopy guided percutaneous transhepatic biliary…
- Trial name
- NCT04653987
- Testing
- Percutaneous biliary drainage
- Volunteers
- 130 people
- Sponsor
- Institut za Rehabilitaciju Sokobanjska Beograd
Biliary Tract Neoplasms, Pancreatic Neoplasms
RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction
Less than 20% of patients with malignant distal bile duct (BD) obstruction (often pancreatic cancer) are suitable for resection surgery.In the rest,palliation treatment comes into focus.
- Conditions
- Biliary Tract Neoplasms, Pancreatic Neoplasms, Stent Occlusion
- Trial name
- NCT00980889
- Testing
- Steel, Nitinol
- Where
- 11 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Stockholm South General Hospital
Pancreatic Diseases, Bile Duct Obstruction
SpyGlass™ Discover Percutaneous
To document the clinical utility of percutaneous cholangiopancreatoscopy using a thin, disposable, flexible endoscope for evaluation and treatment of complex pancreaticobiliary disease in a prospective, multi-center case series
- Conditions
- Pancreatic Diseases, Bile Duct Obstruction, Bile Duct Diseases
- Trial name
- NCT04580940
- Testing
- SpyGlass™ Discover Digital System
- Where
- 7 sites in United States, Belgium and 5 more
- Volunteers
- 50 people
- Sponsor
- Boston Scientific Corporation
Choledocholithiasis With Cholecystitis With Obstruction, Choledocholithiasis With Acute and Chronic Cholecystitis
Single Setting ERCP and Laparoscopic Cholecystectomy is a Safe Procedure in Patients With Cholecysto-Choledocholithiasis
The ideal management of cholecysto-choledocholithiasis is an open cholecystectomy (OC) with the common bile duct (CBD) exploration worldwide.
- Conditions
- Choledocholithiasis With Cholecystitis With Obstruction, Choledocholithiasis With Acute and Chronic Cholecystitis, Cholelithiasis With Acute and Chronic Cholecystitis
- Trial name
- NCT04213092
- Testing
- ERCP+LC, OC+CBD
- Volunteers
- 160 people
- Sponsor
- Lumbini Medical College
Bile Duct Obstruction, Klatskin's Tumor
Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture
The overall median survival of nonresectable malignant hilar obstruction in most series has been less than 6 months. Most patients with malignant hilar obstruction present with advanced disease, making palliative endoscopic…
- Trial name
- NCT01125865
- Testing
- SEMS insertion, DLS insertion
- Where
- 4 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Soon Chun Hyang University
Biliary Obstruction, Complication of Treatment
Treatment of Postsphincterotomy Bleeding With a Novel Self-assembling Peptide Hemostatic Gel.
The aim of this observational study is to evaluate safety and efficacy of a novel self-assembling peptide hemostatic gel in reduction of bleeding after endoscopic sphincterotomy during ERCP (endoscopic retrograde…
- Trial name
- ERCPURA (NCT05886127)
- Testing
- A novel hemostatic agent (Purastat®)
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- General University Hospital, Prague
Biliary Obstruction, Biliary Stones
Evaluation of Efficacy and Safety of Goff Transpancreatic Septotomy vs. Double Wire Technique for Achieving Biliary Access in Technically Challenging ERCPs
Randomized, prospective study evaluating efficacy and safety of Goff transpancreatic septotomy vs. double wire technique for achieving biliary access in patients who fail initial cannulation at ERCP.
- Trial name
- NCT03118973
- Testing
- Goff trans-pancreatic septotomy vs. Double wire technique
- Where
- United States
- Volunteers
- 1,600 people
- Sponsor
- Subhas Banerjee
Cholangiocarcinoma, Bile Duct Obstruction
Endoscopic Biliary RFA of Malignant Bile Duct Obstruction
Endoscopic radiofrequency ablation (RFA) is a new palliation therapy for malignant bile duct obstruction. It delivers a high amount of thermal energy to target tissue and may prolong the duration of stent patency.
- Trial name
- NCT02582541
- Testing
- SEMS alone, SEMS plus radiofrequency ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Bile Duct Obstruction, Extrahepatic
Clinical Validation of an Immunocytochemistry Method Using MARS1
The sensitivity of brushing cytology used to distinguish the cause of biliary strictures is low and clinical usefulness is not secured.
- Trial name
- MARS1 (NCT04759794)
- Testing
- Cytology staining
- Where
- 5 sites in South Korea
- Volunteers
- 55 people
- Sponsor
- Gangnam Severance Hospital