Clinical trials: Biliary Stenosis
Alagille Syndrome
Characterization of Pulmonary Artery Stenoses in Alagille Syndrome - a Medical Record Review
Patients who have Alagille Syndrome (AGS) also frequently have blockages (or "stenoses") of their pulmonary arteries. Little is known about the degree or variability of these stenoses, or the effect of this disease on the right…
- Trial name
- NCT01515631
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Cholangiocarcinoma, Biliary Stenosis
Contribution of the EyeMAX™ 11Fr (Micro-Tech) Digital Single-Operator Cholangioscope With a Wide Working Channel
Background and aims Digital single-operator cholangioscopy (DSOC) enhances biliary stricture diagnosis, but the collection of quality samples can be difficult due to the small diameter of the working channel.
- Conditions
- Cholangiocarcinoma, Biliary Stenosis, Bile Duct Stones, Bile Duct Stenosis
- Trial name
- EyeMAX-CREGG (NCT06933576)
- Testing
- DSOC EyeMAX 11Fr
- Where
- 5 sites in France
- Volunteers
- 28 people
- Sponsor
- Clinique Paris-Bercy
Benign Biliary Stricture, Biliary Stricture
Kaffes Stent in the Management of Post-surgical Biliary Strictures
Post-surgical biliary strictures are common especially after cholecystectomy. Standard treatment involves the performance of multiple procedures over a 1 year period at least using several plastic stents to achieve permanent…
- Conditions
- Benign Biliary Stricture, Biliary Stricture, Cholangitis, Bile Duct Stricture
- Trial name
- NCT03716232
- Testing
- Metallic stent, Multiple plastic stents
- Where
- 3 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Biliary Stricture, Chronic Pancreatitis
Endoscopic Treatment of Biliary Stricture Caused by Chronic Pancreatitis
Benign biliary strictures can be endoscopically treated with plastic or self-expandable metal stents (SEMS). The purpose of the prospective randomized study is to compare the safety and feasibility of covered SEMS with multiple…
- Trial name
- NCT01085747
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Helsinki University Central Hospital
Primary Sclerosing Cholangitis, Liver Transplant, Complications
Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver Transplantation
This study aims to determine the efficacy of 36 months once-daily fenofibrate in preventing clinically-detectable recurrence of primary sclerosing cholangitis after liver transplantation, compared with a historical control cohort…
- Conditions
- Primary Sclerosing Cholangitis, Liver Transplant, Complications, PSC, Biliary Strictures
- Trial name
- NCT06905054
- Testing
- Fenofibrate (drug), Blood draw for the laboratory assessment, MRI using a hepatobiliary phase contrast agent (Gd-EOB-DPTA)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Biliary Stricture
Optical Frequency Domain Imaging (OFDI) for Biliary Stricture Imaging
The goal of this study is to evaluate the potential of comprehensive biliary Optical Frequency Domain Imaging (OFDI) for assessing common bile duct or common hepatic duct strictures, determining cholangiocarcinoma margins, and…
- Trial name
- NCT01439620
- Testing
- MGH Optical Frequency Domain Imaging (OFDI)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Other Specified Diseases of Biliary Tract
Comparison of the Guide-wire G-240 to a Combination of a Flexible/Hydrophil and a Nitinol Guide Wire
In ERCP practice, most often a combined use of guidewires is necessary to attain a therapeutic aim. E.g. a hyperflexible hydrophilic guidewire is changed after cannulating a stricture to a nitinol wire for improved stability with…
- Trial name
- NCT01382680
- Testing
- Guidewire
- Where
- Germany
- Volunteers
- 222 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Biliary Stricture
Factors Predicting Positive Yields on Biliary Brush Cytology During Endoscopic Retrograde Cholangiopancreatography
To determine factors associated with a positive yield of malignancy on biliary brush cytology obtained by ERCP.
- Trial name
- ERCP (NCT00894348)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The Cleveland Clinic
Primary Sclerosing Cholangitis
Short-term Stenting Versus Balloon Dilatation for Dominant Strictures in Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the biliary tract of unknown origin. Around 50% of patients develop during their disease course narrowing of the main bile duct with corresponding increase…
- Trial name
- NCT01398917
- Testing
- plastic endoprosthesis, balloon dilatation
- Where
- 4 sites in Belgium, Netherlands and 2 more
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Choledocholithiasis, Cholangiocarcinoma
Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD
When a doctor performs Endoscopic retrograde cholangiopancreatography "ERCP" (Endoscopy to examine the bile duct) a flexible tube is inserted into the mouth and into the stomach.
- Conditions
- Choledocholithiasis, Cholangiocarcinoma, Benign Stricture of Common Bile Duct
- Trial name
- NCT01673269
- Testing
- Blood culture ( aerobic and anaerobic)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Biliary Tract Disease, Bile Duct Obstruction
Endo-biliary Laser Excision of Biliary Stenoses
The biliary system normally empties into the intestines, however, some patients have biliary system narrow areas ("stenosis") that prevent the bile to drain normally.
- Trial name
- NCT02118493
- Testing
- Benign Biliary Stenosis, Laser
- Sponsor
- University of Florida
Extrahepatic Cholangiocarcinoma
Repeated Endobiliary Radiofrequency Ablation Plus Durvalumab, Gemcitabine, and Cisplatin for Unresectable Extrahepatic Cholangiocarcinoma
This international, multicenter, open-label randomized controlled trial evaluates whether repeated endobiliary radiofrequency ablation (EB-RFA) improves overall survival in patients with unresectable extrahepatic…
- Trial name
- BRAVE (NCT07235007)
- Testing
- Endobiliary Radiofrequency Ablation (EB-RFA), Plastic Biliary Stent
- Where
- 8 sites in Japan, South Korea
- Volunteers
- 120 people
- Sponsor
- Aichi Medical University
Bile Duct Neoplasms, Jaundice, Obstructive
A Single-center, Prospective Cohort Study on the Differentiation of Benign and Malignant Bile Duct Stenosis Based on Bile and Peripheral Blood cfDNA Methylation Profiles
The goal of this observational study is to detect the methylation characteristics of cfDNA in the bile and plasma of patients with bile duct stricture.
- Conditions
- Bile Duct Neoplasms, Jaundice, Obstructive, Bile Duct Diseases
- Trial name
- NCT06115655
- Testing
- cfDNA methylation detection
- Where
- China
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Pancreatic Cancer, Cholangiocarcinoma
Endoscopic Biliary Radiofrequency Ablation of Malignant Distal Common Bile Duct Strictures
Malignant bile duct obstruction is a common sequela of pancreatic cancers or distal bile duct cancers, and its development can hinder the use of chemotherapy, decrease patient quality of life, and decrease survival.
- Trial name
- NCT01721174
- Testing
- SEMS only, EBRFA and SEMS
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- Chinese University of Hong Kong
Liver Transplant Disorder, Ischemic Cholangiopathy
Endoscopic Management of Non-anastomotic Biliary Strictures Following Liver Transplantation.
The study will evaluate the results of endoscopic treatment of NON-anastomotic biliary strictures following liver transplantation
- Conditions
- Liver Transplant Disorder, Ischemic Cholangiopathy, Non-anastomotic Biliary Stricture, Biliary Stricture
- Trial name
- STEBINANSIED (NCT05761483)
- Testing
- ERCP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cholangiocarcinoma, Hilar, Biliary Stricture
Endoscopic Scissors Cutting Nasobiliary Duct VS Bilateral Plastic Stent
The purpose of this study is to explore the efficacy and safety of endoscopic scissors cutting nasobiliary ducts in the treatment of malignant hilar biliary tract stenosis
- Conditions
- Cholangiocarcinoma, Hilar, Biliary Stricture, Hilar Cholangiocarcinoma, Klatskin Tumor
- Trial name
- NCT06106750
- Testing
- Endoscopic nasobiliary duct cutting, Bilateral plastic stent
- Where
- China
- Volunteers
- 122 people
- Sponsor
- First People's Hospital of Hangzhou
Biliary Anastomotic Stenosis, Biliary Stricture
Self-expandable Metallic Stent Versus Multiple Plastic Stents in Post Orthotopic Liver Transplantation Biliary Stenosis
Biliary complications are one of the most common problems after orthotopic liver transplantation (OLT),occurring in up to 24% of patients. Anastomotic strictures have been endoscopically managed with plastic stents placement.
- Trial name
- NCT01148199
- Testing
- Self-expandable metalic stent, Multiple plastic stents
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- Hospital Israelita Albert Einstein
Living Donor Liver Transplantation
Transcystic Versus Transanastomotic Tube Drainage in Right Lobe LDLT
To evaluate the safety and effectiveness of the use of transcystic biliary drainage tube (not transanastomotic) in comparison to the usual transanastomotic biliary drainage tube.
- Trial name
- NCT01907750
- Testing
- biliary drainage tube
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Mansoura University
Biliary Strictures Post Liver Transplantation
Trial Comparing Kaffes Stent With Plastic Prosthesis in the Treatment of Anastomotic Biliary Strictures Post Orthotopic Liver Transplantation
Biliary anastomotic strictures (post liver transplantation) occur in 15-20 % of the cases. Biliary stenting using plastic prosthesis during a period of 1 year is the treatment of choice.
- Trial name
- NCT01339078
- Testing
- Plastic stenting, Kaffes stenting
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent
Bile Duct Stricture, Cholangiocarcinoma
Diagnosis of Bile Duct Strictures
The purpose of this prospective study is to compare the diagnostic utility of two techniques (brush cytology + FISH and brush cytology + free DNA analysis) in the diagnosis of biliary strictures.
- Conditions
- Bile Duct Stricture, Cholangiocarcinoma, Pancreatic Cancer, Chronic Pancreatitis
- Trial name
- NCT02000999
- Testing
- brushing of bile duct strictures for cytology
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Washington University School of Medicine