Clinical trials: Biliary Tract
Biliary Atresia
Pentoxifylline Therapy in Biliary Atresia
The purpose of this study is to determine whether pentoxifylline reduces liver damage in infants with biliary atresia.
- Trial name
- NCT01774487
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Gemcitabine and Radiation Therapy in Treating Patients With Locally Advanced Upper Gastrointestinal Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT00544193
- Testing
- gemcitabine hydrochloride, polymerase chain reaction, immunohistochemistry staining method
- Volunteers
- 16 people
- Sponsor
- City of Hope Medical Center
Advanced Biliary Tract Cancer
The Purpose of This Trial is to Determine if Regorafenib Plus Durvalumab (MEDI4736) is Safe and Effective in Treatment of Chemo Refractory Advanced Biliary Tract Cancers
The purpose of this study is to measure how effective combining Durvalumab and Regorafenib will be for participants with advance stage biliary track carcinoma who have received one line of prior treatment
- Trial name
- NCT04781192
- Testing
- Durvalumab, Regorafenib
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Kansas Medical Center
Bile Duct Obstruction
A Study Comparing Sems Placement With and and Without Biliary Sphincterectomy in Patients With Malignant Biliary Obstruction
Background and rationale Placement of biliary self expanding metal stent (SEMS) is indicated when malignant common bile duct obstruction is encountered.
- Trial name
- NCT03628001
- Testing
- ERCP
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Istituto Clinico Humanitas
Cholangiocarcinoma, Choledocholithiasis; Cholangitis
Efficacy of Fistulotomy for Biliary Cannulation
Access to the main bile duct is the first step in order to perform a therapeutic maneuver for biliary diseases. Early precut has been shown to ameliorate cannulation success rate, specially in difficult cannulation cases, when…
- Conditions
- Cholangiocarcinoma, Choledocholithiasis; Cholangitis, Pancreatic Cancer, Pancreatitis
- Trial name
- NCT04037007
- Testing
- Fistulotomy - High experienced., Fistulotomy - Low experienced., Conventional (guidewire) cannulation- High experienced
- Where
- Mexico
- Volunteers
- 320 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Cholelithiasis, Gallbladder Polyps
Fluorescence Versus Intraoperative Cholangiography in the Visualization of Biliary Tree Anatomy
The burden of iatrogenic bile duct injury (BDI), the most feared complication of laparoscopic cholecystectomy (LC), is extremely high and the repercussions on the patient's outcomes may be severe ranging from intraoperative…
- Trial name
- FLARIOC (NCT01881399)
- Testing
- Fluorescence cholangiography (da Vinci surgical system), Virtual cholangiography, Conventional IOC
- Where
- France
- Volunteers
- 66 people
- Sponsor
- IHU Strasbourg
Locally Advanced or Metastatic Adenoca of the Biliary Tract
A Study of OSI-7904L Versus 5-FU/LV as Treatment in Patients With Biliary Tract Cancer
Multi-center, randomized Phase II study to evaluate the efficacy and safety of OSI-7904Lversus 5 FU/LV in biliary tract cancer.
- Trial name
- NCT00088270
- Testing
- OSI-7904L, 5-Fluorouracil/Leucovorin
- Where
- 21 sites in United States, Belgium and 4 more
- Volunteers
- 58 people
- Sponsor
- OSI Pharmaceuticals
Extrahepatic Cholestasis
Clinical Success of Different Percutaneous Transhepatic Biliary Drainage Procedures
The clinical success of percutaneous transhepatic biliary drainage procedures (PTBDs) is usually measured by the the decrease of the serum bilirubin value. However, the bilirubin value can be biased by other disease conditions.
- Trial name
- TransHepatic (NCT05268731)
- Testing
- External plastic endoprosthesis, Combined external internal plastic endoprosthesis, Primary metal stent
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Colorectal Cancer, Esophagus Cancer
A Clinical Trial Targeting CEA Chimeric Antigen Receptor T (CAR-T) for CEA Positive Advanced Malignant Solid Tumors
This is a single-arm, open, dose-increasing phase I clinical study to explore the safety, tolerability and pharmacokinetic characteristics of the drug C-13-60 cells, and preliminarily observe the efficacy of the drug in CEA…
- Conditions
- Colorectal Cancer, Esophagus Cancer, Gastric Cancer, Pancreas Cancer
- Trial name
- NCT06043466
- Testing
- CEA-targeted CAR-T cells
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Gallbladder Malignant Neoplasm
A Case Series on Incidentally Detected Gallbladder Malignancy
A retrospective analysis of data, using the Hospital records of all the patients who underwent cholecystectomy for benign conditions at Osmania General Hospital in a year (2019).
- Trial name
- NCT05606029
- Testing
- Cholecystectomy, extended cholecystectomy
- Where
- India
- Volunteers
- 180 people
- Sponsor
- Osmania Medical College
Hepatobiliary Cancer, Pancreatic Cancer
Impact of Comprehensive Geriatric Management on Morbidity and Quality of Life in Elderly Patients Undergoing Major Hepatectomy and Pancreaticoduodenectomy for Cancer
The worldwide incidence of hepatobiliary and pancreatic (HPB) cancers is dramatically increasing especially for pancreatic cancer. Increasing age is associated with increased cancer risk.
- Trial name
- HPB70+ (NCT06999512)
- Testing
- Comprehensive Geriatric Assessment
- Where
- 12 sites in France
- Volunteers
- 526 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer of the Bile Duct
Single Agent Regorafenib in Refractory Advanced Biliary Cancers
The main purpose of this study is to see if regorafenib can help control or decrease cancer size in patients with cancer of the bile duct. Researchers also want to find out if regorafenib is safe and tolerable.
- Trial name
- NCT02115542
- Testing
- Regorafenib
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Primary Biliary Cholangitis
Study to Evaluate the Safety and Efficacy of ASC42 Tablets in Subjects With Primary Biliary Cholangitis
This study is a phase II, multicenter, randomized, double-blind, placebo-controlled, seamless adaptive design clinical study, aiming to evaluate the safety and effectiveness of three doses of ASC42 matched placebo in subjects…
- Trial name
- NCT05190523
- Testing
- ASC42 5 mg, ASC42 10 mg, ASC42 15 mg
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Gannex Pharma Co., Ltd.
Biliary Tract Cancer
Gemcitabine and Cisplatin With or Without CPI-613 as First Line Therapy for Patients With Advanced Unresectable Biliary Tract Cancer (BilT-04)
The purpose of this research study is to determine the safety and efficacy of CPI-613 (devimistat) in the treatment of advanced biliary tract cancer when used in combination with standard of care chemotherapy (gemcitabine plus…
- Trial name
- NCT04203160
- Testing
- CPI 613, Gemcitabine, Cisplatin
- Where
- 10 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Michigan Rogel Cancer Center
Primary Biliary Cirrhosis
Study of Combivir for Patients With Primary Biliary Cirrhosis
This is a proof of principal study to determine whether combination anti-viral therapy with Combivir impacts on hepatic biochemistry in patients with primary biliary cirrhosis
- Trial name
- NCT00490620
- Testing
- Combination antiviral therapy
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 59 people
- Sponsor
- University of Alberta
Acute Cholecystitis
Validation of a New Simplified Scoring System for Acute Calculous Cholecystitis
Acute calculous cholecystitis (ACC) is the second most frequent surgical condition in emergency departments. The recommended treatment is surgical treatment (ST) and the accepted mortality is <1%, but in severe and/or fragile…
- Trial name
- ACME (NCT06213740)
- Where
- Spain
- Volunteers
- 387 people
- Sponsor
- Hospital del Mar
Cholelithiasis, Cholecystitis
NOTES-Assisted Laparoscopic Cholecystectomy Surgery
This study proposes to evaluate the ability to reduce the size and number of laparoscopic incisions required to perform gall bladder removal by using flexible endoscopic instruments introduced through the mouth, into the stomach…
- Trial name
- NCT00486655
- Testing
- NOTES-Assisted Cholecystectomy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- USGI Medical
Cholangitis, Sclerosing
An Efficacy Trial of Low Dose All-trans Retinoic Acid in Patients With Primary Sclerosing Cholangitis
The purpose of this research study is to determine whether a low dose of ATRA will improve laboratory tests of liver and bile duct inflammation in patients with PSC.
- Trial name
- NCT03359174
- Testing
- All-trans retinoic acid
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Yale University
Biliary Tract Cancer
A Population-Based Case-Control Study of Biliary Tract Cancers in Shanghai, China
The key aims of this study include estimation of possible risk associated with a history of gallstones, bacterial infection for the biliary tract, other medical history, diet, use of tobacco and alcohol, obesity, reproductive…
- Trial name
- NCT00339560
- Where
- China
- Volunteers
- 2,624 people
- Sponsor
- National Cancer Institute (NCI)
Cholelithiasis, Gall Stone
Bile Composition in Healthy and Gallstones Patients
Determine differences between lithogenic and non-lithogenic bile composition.
- Conditions
- Cholelithiasis, Gall Stone, Gall Bladder Disease
- Trial name
- NCT03981315
- Testing
- Bile test, Blood test, Gall stone study
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Hospital Son Espases