Clinical trials: Bilirubinemia
Jaundice, Obstructive, Cholangiopancreatography, Endoscopic Retrograde
A RCT of Low MBO Drainage Strategies
The purpose of this study is to evaluate the efficacy and safety of EUS-BD compared with ERCP-BD in low biliary obstruction caused by periampullary cancer, pancreatic cancer or low bile duct cancer.
- Conditions
- Jaundice, Obstructive, Cholangiopancreatography, Endoscopic Retrograde, Endoscopic Ultrasound-Guided Drainage
- Trial name
- NCT06196164
- Testing
- EUS-BD, ERCP-BD
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Indirect Hyperbilirubinemia, Neonatal
COMPARISON OF ZINC AND PROBIOTICS ON NEONATES WITH INDIRECT HYPERBILIRUBINEMIA UNDERGOING PHOTOTHERAPY
Study will evaluate effects of oral zinc and probiotics supplementation in neonates who have indirect hyperbilirubinemia and are receiving phototherapy.
- Trial name
- ZIPP (NCT07102836)
- Testing
- Zinc sulfate, Probiotic lactobacillus rhamnosus GG
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Quaid-e-Azam Medical College
Neonatal Hyperbilirubinemia
The Effects of Underrunning Water Bathing and Underrunning Water Bathing-Massage Combination on Bilirubin Levels in Term Newborns With Hyperbilirubinemia
This randomized controlled study aimed to compare the effects of under running water bathing and underrunning water bathing combined with massage on bilirubin levels in term newborns receiving phototherapy.
- Trial name
- NCT07771985
- Testing
- Underrunning Water Bathing, Underrunning Water Bath + Massage Combination
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bozok University
Neonatal Jaundice, Microtia
Preventive Effect of Perinatal Oral Probiotic Supplementation (POPS) on Neonatal Jaundice
This is a randomized double-blind placebo-controlled parallel group superiority clinical trial among 94 pregnant women (47 in each group) to investigate the effect of maternal perinatal probiotic supplementation on neonatal…
- Conditions
- Neonatal Jaundice, Microtia, Pregnancy Related, Hyperbilirubinemia, Neonatal
- Trial name
- NCT06087874
- Testing
- Vivomixx®
- Where
- Hong Kong
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Neonatal Jaundice
Reliability of Transcutaneous Bilirubin Measurement According to the Skin Colour of Newborns
Neonatal jaundice is a physiological process characterized by a yellow coloration of the skin and mucous membranes linked to an increase in a pigment: bilirubin.
- Trial name
- BILICOLOR (NCT07315126)
- Testing
- Skin color assessment
- Where
- France
- Volunteers
- 510 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemolytic Disease of Newborn, Neonatal Hyperbilirubinemia
Safe Threshold to Discontinue Phototherapy in Hemolytic Disease of Newborn
We hypothesized that adopting a lower rather than a higher threshold for phototherapy discontinuation will be associated with reduced rates of rebound hyperbilirubinemia in term and late preterm neonates with hemolytic disease of…
- Trial name
- NCT04218318
- Testing
- phototherapy
- Where
- Saudi Arabia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Neonatal Hyperbilirubinemia, Phototherapy Complication
Conventional Versus LED Phototherapy and Their Effect on Lymphocytes Subsets of Full Term Neonates With Hyperbilirubinemia
The aim of this study is to investigate the influence of the use of different types of phototherapy on different lymphocytes subsets CD4 and CD8 in the treatment of hyperbilirubinemia in neonates.
- Trial name
- NCT04373980
- Testing
- phototherapy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rania Ali El-Farrash
Liver Failure
Recompensation of Exacerbated Liver Insufficiency With Hyperbilirubinemia and/or Encephalopathy and/or Renal Failure
The objective of this trial is to evaluate the impact of elimination of albumin bound substances during albumin dialysis (MARS®) on mortality and the clinical time course in patients with a recent severe clinical deterioration of…
- Trial name
- RELIEF (NCT00614146)
- Testing
- MARS device, Standard medical therapy
- Where
- 19 sites in Austria, Belgium and 7 more
- Volunteers
- 59 people
- Sponsor
- Vantive Health LLC
Hyperbilirubinemia
Effect of Intravenous Fluid Supplementation on Serum Bilirubin and Cardiorespiratory Parameters in Preterm Infants During Phototherapy
The aim of the study was to evaluate the influence of a systematic extra intravenous fluid supplementation during phototherapy in comparison to a fluid supplementation due to short term demand in preterm infants.
- Trial name
- NCT01550627
- Testing
- extra fluid/iv fluid supplementation during phototherapy, Non extra fluid
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Jena
Pancreatic Neoplasms, Biliary Tract Neoplasms
Comparing Endoscopic Based Stent Strategy Versus Bypass Surgery in Non-resectable Periampullary Cancer
Randomized study comparing endoscopic stent insertion strategy versus double-bypass surgery in non-resectable periampullary cancer
- Conditions
- Pancreatic Neoplasms, Biliary Tract Neoplasms, Duodenal Neoplasms
- Trial name
- NCT00487851
- Testing
- surgery, endoscopic strategy
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Hyperbilirubinemia, Neonatal
Effect of Probiotic Lacobacillus Reuterii on Serum Bilirubin Levels in Preterm Infants
The goal of this clinical trial is to learn about the effect of probiotic Lactobacillus reuterii on the level of serum bilirubin in moderately and late preterm infants with birth weights 1000 grams to 2499 grams who were admitted…
- Trial name
- NCT06672406
- Testing
- Lactobacillus reuterii
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Hasanuddin University
Neonatal Hyperbilirubinemia, Rebound Hyperbilirubinemia
Predictors of Rebound Hyperbilirubinemia Study
## Brief Summary Neonatal hyperbilirubinemia is one of the most common causes of neonatal hospitalization and phototherapy treatment.
- Trial name
- NCT07694635
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Haseki Training and Research Hospital
Prematurity, Low Birth Weight
Paternal Involvement in Nursing Guidance and Breastfeeding Self-Efficacy in Mothers of High-Risk Newborns
This study aims to evaluate whether a structured nursing guidance program that increases fathers' participation in the care of hospitalized high-risk newborns improves maternal outcomes compared with routine nursing care.
- Conditions
- Prematurity, Low Birth Weight, Respiratory Distress Syndrome, Newborn, Neonatal Hyperbilirubinemia
- Trial name
- NCT07834008
- Testing
- step-by-step parent education, active father participation in breastfeeding support
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Ampullary Cancer, Duodenal Cancer
Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders
Our institution performs therapeutic ERCP (Endoscopic retrograde cholangiopancreatography ), Endoscopic Ultrasound (EUS) and Interventional Endoscopy in around 1000 patients a year.
- Conditions
- Ampullary Cancer, Duodenal Cancer, Bile Duct Cancer, Bile Duct Disorders
- Trial name
- NCT01438385
- Testing
- Interventional Endoscopy
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- Weill Medical College of Cornell University
Neonatal Jaundice
Neonatal Jaundice: Knowledge, Attitudes and Practices of Mothers and Medical Trainees and Providers in and Around Ogbomosho
Determine the knowledge attitude and practices of all levels of health care providers about neonatal jaundice
- Trial name
- 4NNJ (NCT03306004)
- Testing
- Questionare
- Where
- Nigeria
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hyperbilirubinemia
High Intensity Phototherapy: Double vs. Single
Intensive phototherapy in form of double light is used worldwide in the treatment of severe neonatal hyperbilirubinemia. It has been debated if there is an upper limit on the efficiency of phototherapy.
- Trial name
- NCT02805296
- Testing
- Light irradiance
- Volunteers
- 83 people
- Sponsor
- Aalborg University Hospital
Hyperbilirubinemia, Erythroblastosis, Fetal
Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic Disease
The use of intravenous immunoglobulin G (IVIG) therapy has been reported in hyperbilirubinemia of Rh hemolytic disease but we don't have enough evidences for it.
- Trial name
- NCT00288600
- Testing
- Intravenous Immunoglobulin, Normal saline solution
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- Oswaldo Cruz Foundation
Hyperbilirubinemia
Comparative Study of Phototherapy for Hyperbilirubinemia
Hyperbilirubinemia is a common problem for term and preterm newborns in intensive care nurseries around the world. It is a condition in which there is too much bilirubin in the blood.
- Trial name
- NCT00635375
- Testing
- LED fiberoptic blanket phototherapy (BiliSoft blue LED fiberoptic blanket phototherapy), Metal halide phototherapy (Spot PT metal halide phototherapy), LED bank phototherapy (Natus neoBlue LED bank phototherapy)
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- GE Healthcare
Pancreatic Neoplasms, Cholestasis
Pharmacokinetic and Safety Study of Nab®-Paclitaxel (ABI-007) Plus Gemcitabine in Subjects With Advanced Pancreatic Cancer Who Have Cholestatic Hyperbilirubinemia
The purpose of this study is to determine the safety and pharmacokinetic profile of nab®-paclitaxel (ABI-007) plus gemcitabine in subjects with advanced pancreatic cancer who have cholestatic hyperbilirubinemia secondary to bile…
- Trial name
- NCT02267707
- Testing
- nab-paclitaxel, Gemcitabine
- Where
- 6 sites in United States, Germany
- Volunteers
- 1 people
- Sponsor
- Celgene
Neonatal Hyperbilirubinemia
Newborn Jaundice - An Investigation of Different Approaches to Light Therapy
Background Neonatal jaundice affects about 60% of full-term newborns in their first week. If untreated, it can lead to permanent brain damage. In Denmark, 2-5% of newborns require phototherapy, the standard treatment.
- Trial name
- NCT06702241
- Testing
- Continuous Phototherapy with a irradiance of 40 µW/cm2/nm from the overhead light, Continuos Phototherapy with a irradiance of 55 µW/cm2/nm from the overhead light, Continuous Phototherapy with a irradiance of 70 µW/cm2/nm from the overhead light
- Where
- 2 sites in Denmark
- Volunteers
- 116 people
- Sponsor
- Regionshospital Nordjylland