Clinical trials: Biofilm
Infections
Efficacy and Safety of Antimicrobial Durations Treatment of Infections Associated With Osteosynthesis Material
Infections associated with osteosynthesis material are among the most feared and challenging complications of trauma surgery and can lead to total function loss or limb amputation when complete recovery is to be expected without…
- Trial name
- DURATIOM (NCT05294796)
- Testing
- Short course of antibiotherapy, Long course of antibiotherapy
- Where
- 29 sites in Spain
- Volunteers
- 364 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Dental Plaque, Gum Bleed
Effect of Professional Prophylaxis on Clinical Parameters and Patient Comfort: Randomized Slipt-Mouth Clinical Trial
The goal of this clinical trial is to evaluate whether the Guided Biofilm Therapy (GBT) protocol can improve or maintain oral health and whether it provides more comfort to patients compared to a conventional protocol.
- Trial name
- NCT06936306
- Testing
- GBT, Master, scalling
- Where
- Portugal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Biofilm Removal, Gingival Abrasion
Capacity of Biofilm Removal and Gingival Abrasion After Utilization Medium and Soft Toothbrushes
This study compared the removal of dental biofilm between soft and medium toothbrushes. The patients refrained from performing mechanical or chemical plaque control for 96 hours to allow dental biofilm accumulation on the tooth…
- Trial name
- NCT01125007
- Testing
- Two kind toothbrushes
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Franciscan University Center
Wound Infection
Biofilm Correlation and Validation
This is a prospective, single-blind, controlled trial. There are two arms and 20 patients with acute or chronic wounds with clinical suspicion of biofilm (CSB+/CSB-) are allocated in each arm.
- Trial name
- NCT05196880
- Testing
- MolecuLight DX Imaging Device
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- MolecuLight Inc.
Implant Infection, Skeletal Sarcoma
Implant-Related Infections in Patients With Skeletal Sarcomas
The aim of this observational study is to gain knowledge on the microbial and immunological factors behind implant-related infections in patients with skeletal sarcoma.
- Conditions
- Implant Infection, Skeletal Sarcoma, Hip Arthritis, Prosthesis-Related Infections
- Trial name
- IRISSAR (NCT07264296)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Chronic Ulcers: Non-healing Deep Cavity Wounds (e.g., Diabetic Foot Ulcers, Arterial Ulcers, Post-surgical Wound Healing Disorders)
INJECTHEAL - Investigation of Chronic Wound Exudate and Biofilm
This prospective observational study will collect routine clinical waste material from 72 adults with chronic, non-healing wounds, including wound exudate from negative pressure therapy containers or sponges and wound…
- Trial name
- INJECTHEAL (NCT07745764)
- Testing
- standard of care
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Barbara Wolff-Winiski
Biofilms, Arterial Catheterization, Peripheral
Structural and Microbiological Characterization of Arterial Catheter Biofilm in ICU's Patients Using Optical Coherence Tomography
29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, including 7.7% to arterial catheters, with an influence on both morbility and mortality.
- Conditions
- Biofilms, Arterial Catheterization, Peripheral, Bacteremia, Tomography, Optical Coherence
- Trial name
- OCT-BIO-KTA (NCT06838598)
- Testing
- OCT-BIO-KTA cohort
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier William Morey - Chalon sur Saône
Breast Cancer, Gingivitis
Assessment of Periodontal Therapy and Biofilm Management in Breast Cancer
Objective: To evaluate the impact of chemotherapy on periodontal conditions, hematology, and salivary flow in patients with breast cancer and gingivitis, after basic periodontal therapy (BPT).
- Conditions
- Breast Cancer, Gingivitis, Periodontal
- Trial name
- BREASTCANCER (NCT06212908)
- Testing
- Basic Periodontal Therapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Prosthetic-joint Infection
A Second Trial of the Abbreviated Protocol Two-Stage Exchange
Apex-2 is a multi-site, parallel group, randomized trial. Patients will be randomly assigned in a 1:1 ratio to the Experimental Arm or the Control Arm.
- Trial name
- Apex-2 (NCT05607030)
- Testing
- VT-X7 Treatment System, Two-stage exchange arthroplasty, SOC Antibiotics
- Where
- 19 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Peri-implant Mucositis
Effectiveness of Interproximal Cleaning Devices for Biofilm Removal Around Posterior Single Implants With Peri-Implant Mucositis
This randomized clinical trial aims to evaluate and compare the efficacy of different interproximal oral hygiene devices for biofilm removal around posterior single dental implants in patients diagnosed with peri-implant…
- Trial name
- NCT07393828
- Testing
- Participants assigned to this intervention group are instructed to perform daily interproximal plaque control around implant-supported crowns using the allocated interdental oral hygiene device (inter
- Volunteers
- 75 people
- Sponsor
- Universitat Internacional de Catalunya
Peri-implant Mucositis
Incidence of Peri-implant Mucositis in Patients With Treated Periodontitis
the objective of this study is to determine the incidence of peri-implant mucositis in patients with treated periodontitis and enrolled in periodontal maintenance and to evaluate the associated risk indicators.
- Trial name
- PiM_Inc (NCT05356806)
- Testing
- Supportive periodontal and periimplant care
- Where
- Spain
- Volunteers
- 277 people
- Sponsor
- Universidad Complutense de Madrid
Treatment of Periodontitis, Guided Biofilm Therapy
Comparison of Current Subgingival Debridement Methods
Our study aimed to compare the effectiveness of current subgingival debridement methods used in the treatment of Stage 1 and Stage 2 periodontitis patients, the aesthetic condition achieved after these treatments, and the pain…
- Conditions
- Treatment of Periodontitis, Guided Biofilm Therapy, Subgingival Plaque, Subgingival Debridement
- Trial name
- NCT06835452
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Oral Rehabilitaiton, Caries
a Clinical Study.the Effect of Addition of Insoluble Antibacterial Nanoparticles(IABN) in Resin Base Provisional Cement
The effect of Antibacterial Nanoparticles, Incorporated in cement, on S.mutans in the margins of provisional restorations is going to be examined clinically by using two kinds of provisional cement 1.
- Conditions
- Oral Rehabilitaiton, Caries, Periodontitis
- Trial name
- IABN (NCT00502606)
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Dental Caries
Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model
To evaluate the effects of a clinically approved and commercially available iron oxide formulation Ferumoxytol (Feraheme®) to control cariogenic biofilms and enamel demineralization.
- Trial name
- NCT03678012
- Testing
- Ferumoxytol/Hydrogen peroxide, Hydrogen Peroxide, Water
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Prostheses-related Infections
A Castor Bean Solution for Cleaning Dentures
To evaluate the efficacy of a castor bean-based solution (Ricinus communis) for removal of complete denture biofilm, comparing it with two products available on the market (sodium hypochlorite and alkaline peroxide).
- Trial name
- ACBSFCD (NCT01732744)
- Testing
- Physiological solution, Sodium hypochlorite, Alkaline Peroxide
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Wound, Biofilm
Clinical Implications of Biofilm in Chronic Wound
Chronic wounds are important economic and health-care problem. Biofilm has been recognized as a major factor in wound chronicity, delayed healing, and persistent infections, increasing the need for frequent dressing changes…
- Conditions
- Wound, Biofilm, Chronic Pain, Quality of Life
- Trial name
- NCT05054244
- Testing
- standard wound treatment, Hyperbaric oxygenation (HBOT)
- Where
- Croatia
- Volunteers
- 140 people
- Sponsor
- University of Rijeka
Peri-implant Mucositis
Non-surgical Treatment of Peri-implant Mucositis: FMUD vs FMUD and Air-Flow Master Piezon®
The aim of the present study is to evaluate the adjunctive effect of glycine-powder air-polishing (GPAP) to full-mouth ultrasonic debridement (Fm-UD) in the treatment of peri-implant mucositis, and to determine the predictive…
- Trial name
- NCT05801315
- Testing
- Glycine powder air polishing, Full mouth ultrasonic debridement
- Where
- Italy
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Siena
Microplastics, Otitis Media With Effusion
Microplastics in Otitis Media With Effusion Material
Microplastic rate is increasing ib athmosphere. They can be found in lung, kidney, heart, even placenta. Otitis media with effusion (OME) is a clinical condition that is ver common in children.
- Conditions
- Microplastics, Otitis Media With Effusion, Biofilms
- Trial name
- NCT06316635
- Testing
- ventilation tube insertion
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kerem Kökoğlu
Halitosis
Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis
Purpose: To investigate the short-term clinical effect of curcumin-containing toothpaste on halitosis as compared to placebo and to assess potential shifts in the composition of dental biofilm associated with the use of…
- Trial name
- NCT04998617
- Testing
- Toothpaste with curcumin, Toothpaste without curcumin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic PJIs
Heraeus MicroDTTect Lyon Pilot Studyprosthetic Joint Infections (PJIs)
Prosthetic joint infections (PJIs) are one of the main causes of implant failure after joint arthroplasty. Identification of the causal organism is crucial for successful treatment.
- Trial name
- NCT04371068
- Testing
- Culture of removed prosthesis using DTT
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon