Clinical trials: Biofilm
Catheter-Related Infections, Bacteremia
Comparison of Infection Rates Among Patients Using Two Catheter Access Devices
Intravenous catheters are placed in nearly every hospitalized patient. These catheters, since they are breaks in skin integrity, are potential sources of infection that occur in the bloodstream.
- Trial name
- NCT00965198
- Where
- 2 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Emory University
Hemodialysis
Ex Vivo Microbiological Assessment of an Anti-biofilm Catheter in Acute Dialysis Application
The clinical study aims at providing data on antimicrobial efficiency and a supposed additional preventive effect on catheter-related infections of a catheter with antibacterial surface coating in comparison to standard catheters…
- Trial name
- ABBA (NCT00621114)
- Testing
- GamCath® central venous catheter, GamCath Dolphin® Protect central venous catheter
- Where
- Germany
- Volunteers
- 69 people
- Sponsor
- Vantive Health LLC
Dental Caries, Dental Plaque
Study of the Composition of Dental Plaque
This study will examine the composition of dental plaque-a naturally occurring substance that sticks to the teeth and can cause tooth decay and gum disease.
- Conditions
- Dental Caries, Dental Plaque, Periodontal Disease
- Trial name
- NCT00001726
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Denture Hygiene
Microbial Evaluation of Denture Cleaning and Overnight Storage
Clinical guidelines for denture care are available, but evidence for optimal nocturnal storage is missing. The investigators (Duyck J., Vandamme K., Teughels W.) therefore performed a study (submitted for publication) to evaluate…
- Trial name
- NCT02454413
- Testing
- denture brushing with water and soap, ultrasonic denture cleaning, cleansing tablet
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Class I Dental Caries
Clinical Evaluation of Bioactive Restorative Materials
The objectives of this study are to evaluate and compare the biofilm inhibition and re-mineralizing potential at tooth restoration interface and their 2-year clinical performance in class I cavities.The patients will be selected…
- Trial name
- NCT07003360
- Testing
- application of beautiful blukfill II shofu composite, application of Ivoclar vivadent bulkfill composite, application of Predicta bulk fill composite
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Chronic Wounds
Characterisation of Biofilm of the Chronic Wounds
In this prospective observational study, the investigators tried assess the presence of biofilm on chronic wound samples coming from a large cohort study of patients, whilst cross-referencing the clinical, bacteriological and…
- Trial name
- Biofilm Plaie (NCT02519166)
- Testing
- 1 clinical examination of the wound, 1 sample taken with the curette, 1 sample by swabbing
- Where
- 3 sites in France
- Volunteers
- 130 people
- Sponsor
- Institut Curie
Diabetic, Antibiotic Intake
Surface Roughness of a Dental Restorative Material and Biofilm Formation
In this study we intend to find out the pattern of biofilm accumulation in vivo on various surface finishings. Our intention is to prepare Polymethylmetacrylate squers on orthodontical brackets,then prepare the surface of the…
- Trial name
- NCT00256945
- Testing
- dental restorative material surface preparation
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Burns
Antimicrobial Resistance of Bacteria in Burn Patients
The purpose of this study is to test the resistance of pathogenic bacteria in infected tissues of burn patients to various antimicrobials and enzyme debriders.
- Trial name
- NCT00794742
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Texas Tech University Health Sciences Center
Sonication, Total Hip Replacement
Biofilm Investigation on Bearing Components of Explanted Hip Joint Prosthesis
In this study the investigators sonicate the bearing components of the explanted hip prosthesis which allows highly sensitive detection of in vivo biofilms (qualitatively and quantitatively).
- Conditions
- Sonication, Total Hip Replacement, Biofilm
- Trial name
- NCT02853461
- Testing
- Sonication, Microbiological analysis
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Toothbrushing, Periimplant Diseases
Manual Versus Sonic-powered Toothbrushing for Plaque Reduction in Patients with Peri-implant Mucositis
Aim: To compare the effect of manual and sonic-powered toothbrushing on biofilm control in patients with peri-implant mucositis.
- Trial name
- NCT06800625
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Hacettepe University
HIV Infection
Viral Biofilms: Hijacking T Cell Extracellular Matrix to Regulate HIV-1 Spread?
This project aims at characterizing HIV-1 viral biofilms structural and functional properties and at deciphering its role as a new viral reservoir and as a new mode of viral spread.
- Trial name
- TRANSBioHIV (NCT01895920)
- Testing
- Blood sample
- Where
- France
- Sponsor
- ANRS, Emerging Infectious Diseases
Dental Caries, Periodontitis
Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets
This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment.
- Conditions
- Dental Caries, Periodontitis, Oral Microbiome, Bacterial Transmission
- Trial name
- NCT07674888
- Testing
- Professional Dental Plaque Disruption
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Dental Plaque
Antimicrobial Photodynamic Therapy With Erythrosine and Blue Light on Dental Biofilm Bacteria
The objective of this study is to investigate the effect of Antimicrobial Photodynamic Therapy mediated by Erythrosine and blue LED in the reduction of bacteria in dental biofilm.
- Trial name
- NCT05805761
- Testing
- Conventional Treatment, Antimicrobial Photodynamic Therapy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Gingivitis, Dental Plaque
Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices
This randomized crossover study will assess how three aligner-cleaning methods affect early supragingival oral microbial ecology and periodontal health in adults using clear aligners.
- Trial name
- NCT07307716
- Testing
- Mechanical toothbrushing (fluoride toothpaste), Chlorhexidine mouthwash (0.2%), Oxygen-based cleanser
- Where
- Saudi Arabia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Tongue Coating, Oral Biofilm
Comparison of Three Tongue Cleaners for Removing Tongue Coating
This randomised three-period crossover study compared the effectiveness of three tongue-cleaning devices - a bristled tongue brush, a plastic tongue scraper and a metal tongue scraper - in removing tongue biofilm.
- Conditions
- Tongue Coating, Oral Biofilm, Oral Hygiene, Dental Plaque
- Trial name
- NCT07767721
- Testing
- Bristled tongue brush, Plastic tongue scraper, Metal tongue scraper
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Kent University
Dental Caries, Dental Plaque
The Effect of Arginine on Biofilm Composition, Architecture and Metabolism
Arginine is an adjunct to oral health care that has the potential to modulate the composition and activity of the microbial community of dental biofilms towards a health-related status without harmful effects for the resident…
- Conditions
- Dental Caries, Dental Plaque, Microbial Colonization
- Trial name
- NCT06135792
- Testing
- Arginine
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
End-Stage Renal Disease, Hemodialysis Catheter-associated Infection
A Novel Catheter Lock Solution for Treatment of Tunneled Hemodialysis Catheter-Associated Bacteremia
The primary objective is to investigate the ability of systemic intravenous antibiotic plus antibiotic/anti-biofilm (i.e. N-acetylcysteine) lock catheter technique in eradicating uncomplicated catheter associated bacteremia and…
- Trial name
- NCT00614679
- Testing
- catheter lock solution consisting of N-acetylcystein, tigecycline and heparin
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of California, San Diego
Multidrug Resistant Klebsiella Pneumoniae Infection
Phenotypic and Genotypic Detection of Biofilm Formation and Efflux Pump Activity in Multi-drug Resistant Klebsiella Pneumoniae
1. Sample: urine, pus and sputum samples. 2. Culture: the samples will be inoculated on the MacConkey agar and subcultured on eosine methylene blue agar. 3. Identification of isolates will be done by: Colony morphology.
- Trial name
- Klebsiella (NCT07541690)
- Testing
- Genotypic Detection of Biofilm Formation and Efflux Pump Activity.
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection
Joint Endoprostheses Can Succesfully Treat Disabling Osteoarthritis. However, Infection is an Important Cause of Failure. Adequate Diagnostics Remains Challenging. Combining Advanced Imaging With Next-generation Sequencing of Samples Obtained Endoscopically Should Aid in Mapping and Characterizing.
This prospective observational diagnostic study aims to improve the accuracy and timeliness of diagnosing chronic periprosthetic joint infection (PJI).
- Conditions
- Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection, Prosthetic Joint Failure of Unclear Etiology
- Trial name
- PJI MAP/DEF (NCT07494630)
- Testing
- Comprehensive Diagnostic Work-up for Suspected Chronic Periprosthetic Joint Infection
- Where
- Belgium
- Volunteers
- 174 people
- Sponsor
- University Hospital, Ghent
Catheter-Related Infections, Biofilms
Biofilm-induced Antimicrobial Resistance RIsk ERadication in Critical Care Central Venous Catheters
Central venous catheter (CVC) infections are a frequent and serious nosocomial complication in critical care, leading to increased morbidity, mortality, and costs.
- Conditions
- Catheter-Related Infections, Biofilms, Infection Prevention
- Trial name
- BARRIER (NCT07546994)
- Testing
- Microbial analysis of catheter biofilm
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes