Clinical trials: Biofilm
Bacterial Vaginosis
Optimization of Bacterial Vaginosis Treatment in Women of Reproductive Age
The purpose of this clinical trial is to study the efficacy of bovgialuronidase azoximere in the treatment and duration of recurrence-free course of bacterial vaginosis in women of reproductive age.
- Trial name
- NCT06458543
- Testing
- Longidaza, Metronidazole 500 mg
- Where
- 2 sites in Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Oral Leukoplakia
Candida Associated Cytokines in Oral Leukoplakia
This study aims to determine the correlation between candida and pro- inflammatory cytokines response in Oral Leukoplakia(OL) with antifungal therapy.
- Trial name
- NCT04712929
- Testing
- Fluconazole
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Pressure Ulcers, Pressure Ulcers Stage III
Efficacy of a Polyhexanide Biguanide-Based Gel in the Prevention of Biofilm Formation in Pressure Ulcers
INTRODUCTION: Pressure ulcers (PU) are one of the main challenges for nursing in our country. Wound bed preparation and the TIME algorithm provide essential tools for adequately treating these lesions.
- Conditions
- Pressure Ulcers, Pressure Ulcers Stage III, Pressure Ulcer Prevention, Pressure Ulcer ( Stage 2-3)
- Trial name
- EGELPUPP (NCT07391748)
- Testing
- To determine the efficacy of a gel containing polyhexanide and biguanide, alone or in combination with alginate with or without silver, in preventing biofilm in PU, in terms of healing at 4 weeks
- Volunteers
- 140 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Gingivitis, Dental Plaque
Effectiveness of Salvadora Persica Miswak in Improving Plaque Control and Gingival Health
Dental plaque is a main etiologic agent in periodontal disease. Global of Burden Disease Study 2016 ranked periodontal disease as the 11th most prevalent disease affecting 10.5% population worldwide.
- Trial name
- NCT04650685
- Testing
- The novel Salvadora persica toothbrush, The Salvadora persica (miswak) chewing stick, Standard toothbrush and toothpaste (control)
- Where
- Malaysia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Peri-implant Mucositis
Trehalose vs Glycine Air-Polishing in Peri-Implant Mucositis Treatment
This randomized controlled clinical trial investigates the effectiveness of trehalose powder compared to glycine powder when used in air-polishing during supportive therapy for peri-implant mucositis, a reversible inflammatory…
- Trial name
- TREAL-G (NCT07140146)
- Testing
- Trehalose Powder Air-Polishing, Glycine Powder Air-Polishing
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Dental Caries
Nanosilver Fluoride to Prevent Dental Biofilms Growth
This study aims to evaluate the effectiveness of nanosilver fluoride for controlling the growth of S. mutans present in dental plaque of children.
- Trial name
- NSFCT (NCT01950546)
- Testing
- nanosilver fluoride
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Dental Diseases
Investigation of Bacterial Adhesion and Bactericide Effect ex Vivo on Different Implant Restoration Materials
Investigation of bacterial adhesion and bactericide effect ex vivo on different implant restoration materials
- Trial name
- NCT04657757
- Testing
- Intraoral apparatus
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Irrigation Solution, Chronic Wound
Effectiveness and Safety of Using Prontosan to Treat Bacterial Biofilm
The goal of this prospective, multi-center, randomized, parallel-controlled, open-label clinical study is to evaluate the effectiveness and safety of Prontosan wound irrigation solution comparing with Normal Saline on the removal…
- Conditions
- Irrigation Solution, Chronic Wound, Pressure Injury, Diabetic Foot Ulcer
- Trial name
- NCT06185465
- Testing
- Prontosan Wound Irrigation Solution, Normal Saline
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- The First Hospital of Jilin University
Infections, Nosocomial, Infections, Respiratory Tract
Antibacterial Effect of Zinc Oxide Nanoparticles on Acinetobacter Baumannii Isolated From Patients With Hospital Acquired Infections in Sohag University Hospitals, Egypt
A. baumannii is known as the most frequently isolated organism in intensive care units (ICUs), causing a variety of nosocomial infections, including pneumonia, urinary tract infections (UTIs), bacteremia as well as skin and soft…
- Trial name
- NCT06628076
- Testing
- Culture specific antibiotic therapy, Antibiotic, Biofilm assessment
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Gingivitis
Frankincense and Herbal Extracts for Plaque-Induced Gingivitis: A Double-Blind RCT
Frankincense, a natural resin obtained from trees of the Boswellia genus, has been traditionally used for its medicinal properties.
- Trial name
- FHEPIG (NCT07535229)
- Testing
- Frankinscence and coconut Oil based mouthwash, Frankinscence and Thyme essence/ water based mouthwash, Chlorhexidine (0.2%)
- Where
- Oman
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Oman Dental College
Gingivitis
Efficacy of Matcha Tea on Patients With Biofilm-induced Gingivitis
1. Evaluate the salivary level of antioxidants (malondialdehyde "MDA," superoxide dismutase "SOD," and glutathione peroxidase-1 "GPX-1") by enzyme-linked immunosorbent assay test (ELISA). 2.
- Trial name
- NCT06912958
- Testing
- Drinking of matcha tea, Organic Japanese Matcha, Jade Leaf, Japan
- Where
- Iraq
- Volunteers
- 50 people
- Sponsor
- Ahmed Talib
Mouth Diseases
Salivary Bacterial Associations to Short Term Discontinuation of Self-performed Oral Hygiene
The purpose of the present investigation is to record and compare bacterial compositions in supragingival plaque samples and saliva samples in subjects discontinuing regular oral hygiene for 10 days.
- Trial name
- NCT02913235
- Testing
- Oral hygiene discontinuation group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Orthopedic Devices Associated With Misadventures, Prosthetic and Other Implants, Materials and Accessory Devices
Sterilizing Effects of the Erbium:YAG Laser Upon Metal Implants
Background: Even today, postoperative infection is the commonest complications after surgery although all aseptic precautions are taken and causes significant postoperative morbidity, mortality, prolongs hospital stay, and…
- Trial name
- NCT03226184
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Respiratory Insufficiency, Ventilator-associated Pneumonia
Biofilm Formation on Different Endotracheal Tube Materials
Three endotracheal tubes (ETTs) with different surfaces properties will be studied regarding formation and structure of the biofilm formed on those ETTs.
- Trial name
- NCT02284438
- Testing
- Endotracheal tube
- Where
- Sweden
- Volunteers
- 102 people
- Sponsor
- Region Skane
Urinary Tract Infections
Efficacy of BLASTX in Catheter Associated Bacteriuria Versus Standard of Care (SOC)
This is a 2-week, single-site, randomized study in adults requiring short-term (≤ 14 days) catheterization. Subjects will be randomized 1:1 to either the biofilm disrupting gel (BLASTX) or SOC (McKesson Jelly) lubricated…
- Trial name
- NCT03176394
- Testing
- BLASTX Gel, McKesson Jelly
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Next Science TM
Endodontic Disease
Evaluation of Antimicrobial Efficacy and Postoperative Pain After Using Silver Nanoparticles and Chitosan Nanoparticles Against Enterococcus Faecalis and Candida Albicans Biofilm
Silver nanoparticles possess unique physicochemical and biological properties in addition to their antibacterial capabilities. Similarly, zinc oxide nanoparticles have demonstrated antibacterial effects against a wide range of…
- Trial name
- NCT06172023
- Testing
- Silver Nanoparticles Irrigant, Chitosan Nanoparticles Irrigant
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Minia University
Orthodontic Aligner Material, Enamel Demineralization
Development of Biofunctional 3D-Printed Orthodontic Aligners With Antimicrobial and Remineralizing Properties
Clear orthodontic aligners are widely used due to their esthetics and patient comfort; however, prolonged wear may promote biofilm accumulation and enamel demineralization.
- Conditions
- Orthodontic Aligner Material, Enamel Demineralization, Dental Biofilm Formation, Clear Aligner Material Properties
- Trial name
- 3D-BIOALIGN (NCT07603427)
- Testing
- Modified 3D-Printed Orthodontic Aligner Resin
- Where
- Iraq
- Volunteers
- 400 people
- Sponsor
- University of Baghdad
Gingivitis, Dental Plaque
MicroRepair® ABX vs Chlorhexidine 0.12% in Gingivitis Patients
This randomized controlled clinical trial is designed to compare the adjunctive effects of two mouthwashes used after professional biofilm removal in patients with generalized plaque-induced gingivitis, a reversible inflammatory…
- Conditions
- Gingivitis, Dental Plaque, Gingival Inflammation
- Trial name
- GEM-CHX012 (NCT07088653)
- Testing
- MicroRepair ABX mouthwash, Chlorhexidine 0.12% mouthwash
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Catheter-Associated Urinary Tract Infections, Urinary Catheterization
Anti-fouling Silicone Urinary Catheter for Adults Needing Long-term Catheterisation: a Pilot and Feasibility Study
This single-centre randomised pilot and feasibility study assessed whether an anti-fouling zwitterionic silicone urinary catheter can be deployed and evaluated in frail, elderly adults who require long-term indwelling…
- Conditions
- Catheter-Associated Urinary Tract Infections, Urinary Catheterization, Biofilms
- Trial name
- NCT07759986
- Testing
- Anti-fouling zwitterionic silicone urinary catheter, Conventional silicone urinary catheter
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Wound Heal
Electroceutical Dressing Technology (EDT) Against Wound Microbial Biofilm Infection
There are currently limited treatments available that show anti-biofilm efficacy for wound infection management Biofilms account for over 80% of infections and approximately 65% of nosocomial infections caused by microorganisms…
- Trial name
- EDT BioFilm (NCT04794621)
- Testing
- Electroceutical Dressing Technology-EDThi, Adding EDTlo (Procellera®) for 3 weeks after use of EDThi
- Where
- 3 sites in United States
- Volunteers
- 112 people
- Sponsor
- Indiana University