Clinical trials: Biofilm
Gingivitis
Anti-Inflammatory Efficacy of Ginger Containing Dentifrice in the Control of Biofilm Induced Gingivitis
The goal of this clinical trial is to test efficiency of using toothpaste containing (Ginger) over a period of three month to control on gingival inflammation and plaque accumulation through measuring the clinical periodontal…
- Trial name
- NCT05868200
- Testing
- Capitano zenzero toothpaste, Colgate total toothpaste
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Chronic Wound, Venous Insufficiency
Treatment of Chronic Wound Biofilms
Chronic wounds cause significant morbidity and cost our healthcare system millions of dollars each year.Their healing is slowed by biofilms, communities of bacteria surrounded by a protective layer that stops the immune system…
- Conditions
- Chronic Wound, Venous Insufficiency, Biofilms
- Trial name
- NCT01646502
- Testing
- Esp protein, Standard wound care
- Where
- Canada
- Sponsor
- University of British Columbia
Dental Caries
Long-term Release of Fluoride Formed on Enamel by Fluoride Gel or Varnish to Biofilm Fluid
The anticaries effect of professional fluoride application has been associated with the formation of calcium fluoride-like products ("CaF2") on dental surface, which may function as a slow release fluoride reservoir.
- Trial name
- NCT02486458
- Testing
- 5% sodium fluoride varnish, 1.23% sodium fluoride acidic gel
- Where
- Brazil
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Mechanically Ventilated Patients
The Effect of Uroshield on Sputum-specimen Bacterial Growth
The investigators retrospectively register the conduct of this study after its completion.
- Trial name
- NCT06729476
- Testing
- Uroshield vibrator device
- Volunteers
- 48 people
- Sponsor
- Shaare Zedek Medical Center
Femur Fracture, Periprosthetic Fracture of Hip
Dose-Response Association Between Cerclage Wire Number and Infection Risk
The purpose of this dual-center retrospective study is to investigate the relationship between the number of metallic cerclage wires used in femoral fracture surgery and the risk of developing deep infections.
- Conditions
- Femur Fracture, Periprosthetic Fracture of Hip, Periprosthetic Fracture of the Femur, Surgical Site Infection (SSI)
- Trial name
- C-INFECT (NCT07434258)
- Testing
- 1 Metallic Cerclage Wiring, 2 metalic cerclage wire, 3 metalic cerclage wire
- Volunteers
- 148 people
- Sponsor
- Istanbul University
Candida Infection
Biofilm Formation and Antifungal Resistance in Candida Species
1. To determine the susceptibility pattern of our local isolated Candida strains which is essential for optimal management of fungal infection. 2. Detection of biofilm formation by conventional and molecular methods 3.
- Trial name
- NCT07245563
- Volunteers
- 300 people
- Sponsor
- Assiut University
Lung Diseases, Pulmonary Disease
A Study of the Safety and Tolerability of Inhaled SNSP113 in Healthy Subjects and Subjects With Stable Cystic Fibrosis
Although Cystic Fibrosis is a complex genetic disease affecting many organs, lung disease is the primary cause of mortality. The objective of this study is to determine the safety and tolerability of SNSP113 in healthy subjects…
- Conditions
- Lung Diseases, Pulmonary Disease, Cystic Fibrosis, Cystic Fibrosis Lung
- Trial name
- NCT03309358
- Testing
- Inhaled SNSP113
- Where
- 2 sites in United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Synspira, Inc.
Periprosthetic Joint Infections
Laser Disinfection in Periprosthetic Joint Infection
The eradication of biofilms from infected implants is still an unsolved challenge. The high-energy light beam of an Er:YAG laser causes rapid heating and explosive ablation of tissue.
- Trial name
- NCT06440564
- Testing
- Er:YAG Laser irradiation
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Biofilm Formation, Structural and Microbiological Characterization of Endotracheal Tube Biofilm
Structural and Microbiological Characterization of Endotracheal Tube Biofilm in Patients at Increased Risk for the Development of Ventilator-associated Pneumonia in the Intensive Care Unit
Ventilator-associated pneumonia (VAP) remains the most frequent healthcare-associated infection (HAI) in the intensive care unit (ICU) and one of the most critical risk factors associated with both significant morbidity as well…
- Conditions
- Biofilm Formation, Structural and Microbiological Characterization of Endotracheal Tube Biofilm, Ventilator-associated Pneumonia (VAP)
- Trial name
- BIOPAVIR (NCT04926493)
- Testing
- microbiological characterization
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Apical Periodontitis, Endodontic Disease
Nanozymes in Endodontics
The antimicrobial efficacy and healing potential of clinically approved ferumoxytol nanozymes versus the standard 3% NaOCl irrigant will be evaluated in adults undergoing endodontic treatment.
- Conditions
- Apical Periodontitis, Endodontic Disease, Root Canal Infection
- Trial name
- NCT07518901
- Testing
- Nanozyme treatment, Control (Standard treatment)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Pennsylvania
Tobacco Use, Periodontitis
Snuff Use, Smoking, Periodontal Health and Premature Death: 30-year Study
Snuff use and smoking associated with poor periodontal health, especially if used together.
- Trial name
- NCT03614871
- Testing
- Epidemiological study
- Volunteers
- 1,676 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Candidiasis, Biofilms
Clinical and Laboratorial Evaluation of the Desinfection Solutions in Candida Species From Total Prostheses and Palate of Total Edentulous.
This clinical study identified the Candida species from the palate and complete dentures of edentulous individuals with prostheses-related stomatitis (PRS) and evaluated the effect of disinfectant solutions for denture hygiene on…
- Conditions
- Candidiasis, Biofilms, Candida Infection
- Trial name
- NCT03203551
- Testing
- Disinfection Protocol
- Volunteers
- 108 people
- Sponsor
- University of Sao Paulo
Oral Biofilm, Periodontitis
Methodology Antiseptic Application, Influence on Oral Biofilm.
The study has the objective to compare two different methodology of application the antiseptic on the oral biofilm will be formed during 48h in situ on a specific device.
- Conditions
- Oral Biofilm, Periodontitis, Gingivitis
- Trial name
- NCT02267239
- Testing
- essential oils, immersion, Chlorhexidine, immersion, essential oils, mouthwash
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Total Laryngectomy Patients Who Use Voice Prostheses
Mixed-species Biofilms and Silicone Device Longevity
The purpose of this study is to determine whether the mix of microbial species isolated from biofilm-clogged voice prostheses is specific to each participant, whether the microbes are orally-derived and whether the presence of…
- Trial name
- NCT02507401
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Aberdeen
Healthy
Collection of Dental Plaque and Saliva for Studies of Bacterial Colonization of Teeth
This study will explore how bacteria colonize human teeth and how this process changes over the lifetime of individuals. It will include an investigation of transmission of bacteria that initiate colonization between adults and…
- Trial name
- NCT00098267
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Periodontitis, Adult
Effects of Antibiotic Therapy on the Short and Long-term Results of Periodontitis Treatments
Antibiotics are currently used in periodontology to specifically target the most pathogenic bacteria in subgingival biofilms and to improve treatments.
- Trial name
- PERIODONTITIS (NCT05065034)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Problems With Dentures
Evaluation of Sodium Hypochlorite as a Denture Cleanser
The present study tried to integrate all aspects of denture care: patient satisfaction with the treatment, denture decontamination and base material defects after decontamination processing.
- Trial name
- NCT01616355
- Testing
- Sodium hypochlorite immersion
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Pit and Fissure Sealant Retention, Dental Caries
Clinical Evaluation of the Retention of Fissure Sealants Applied Following Guided Biofilm Therapy and Conventional Polishing
This randomized split-mouth clinical trial will compare two methods of occlusal surface cleaning before pit and fissure sealant placement in children aged 6-10 years.
- Trial name
- NCT07725133
- Testing
- Device: Guided Biofilm Therapy with erythritol, Device: Conventional Polishing
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Prosthetic Joint Infection
Antibiogram and Biofilm Formation of Bacteria Causing Prosthetic Joint Infections Isolated From Assiut University Hospital
1. Setting of antibiogram in orthopedic department 2. Evaluate the production of biofilm in bacteria isolated from specimens phenotypically and genotypically.
- Trial name
- NCT05239312
- Testing
- Antimicrobial
- Volunteers
- 90 people
- Sponsor
- Assiut University
Surface Finish
Influence of Different Zirconia Surface Treatments on Biofilm Formation
The aim is to test the influence of surface finish on biofilm formation on the transmucosal part of zirconia implants in an in vivo study.
- Trial name
- Biofilm2020 (NCT04181099)
- Testing
- Implant neck surface
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Basel