Clinical trials: Biofilms
Ulcer, Skin
Acetic Acid 2% Solution for Skin Ulcers
The objective of this clinical trial is to assess the effectiveness of acetic acid in patients suffering from chronic cutaneous ulcers with biofilm.
- Trial name
- ECA-AA (NCT06297967)
- Testing
- Acetic Acid, Prontosan
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Wounds
Evaluation of Wound Biofilm in Acute and Chronic Wounds
Patients who present to a wound care center for management of their wounds will be evaluated clinically to establish if their wounds are chronic or acute. These patients will undergo standard of care management of their wounds.
- Trial name
- NCT00764348
- Testing
- no treatment
- Sponsor
- Southwest Regional Wound Care Center
Tooth Stain
Guided Biofilm Therapy Versus Conventional Polishing for Tooth Re-Staining
This study compared Guided Biofilm Therapy with conventional polishing in adults with visible extrinsic tooth staining. Each participant received Guided Biofilm Therapy on one side of the mouth and conventional polishing on the…
- Trial name
- NCT07799558
- Testing
- Guided Biofilm Therapy, Conventional Polishing
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Prosthetic Joint Infection, Prosthetic Infection
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections
The overall purpose of this clinical treatment research project is to explore novel diagnostics that can guide the treatment of infections associated to orthopaedic implants, in order to improve patient outcomes and reduce the…
- Conditions
- Prosthetic Joint Infection, Prosthetic Infection, Hip Prosthesis Infection, Knee Prosthesis Infection
- Trial name
- NCT04488458
- Testing
- MIC or MBEC+MIC based treatment algorithm
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Biofilm, Dental Plaque
Comparison of Biofilm Characteristics Between an in Situ Biofilm Model of Supragingival Plaque and Natural Teeth
The purpose of this study is to determine in situ the bacterial viability, thickness and bacterial diversity of a biofilm formed on different substrates in comparison to a naturally tooth-formed oral biofilm.
- Trial name
- NCT02769260
- Testing
- Toothbrushing
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Trauma Injury, Trauma
OCT in Open Fracture and Infected Fracture
This is a pilot prospective, observational study of patients with open or infected fracture evaluating the feasibility and acceptability of OCT, a light-based imaging modality that requires no drug or contrast agent.
- Conditions
- Trauma Injury, Trauma, Open Fracture, Fracture Infection
- Trial name
- NCT05785182
- Testing
- Open Fracture, Infected Fracture
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Healthy
Collection of Dental Plaque and Saliva for Studies of Bacterial Colonization of Teeth
This study will explore how bacteria colonize human teeth and how this process changes over the lifetime of individuals. It will include an investigation of transmission of bacteria that initiate colonization between adults and…
- Trial name
- NCT00098267
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Epilepsy, Gingivitis
Air Polishing Effect on Biological, Clinical and Patient-reported Experience Among Epileptic and Non-epileptic Children
In epileptic and non Epileptic children, the full dentition of each patient was split into four quadrants, starting from the upper right quadrant (1) and moving clockwise until the lower right quadrant (4).
- Trial name
- NCT06144034
- Testing
- Air polishing with erythritol powder, Conventional treatment
- Where
- 2 sites in Jordan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Prosthetic Joint Infection
Abbreviated Protocol for Two-Stage Exchange
Study Type: A multi-site, parallel group, randomized trial. Study Objectives: The objective is to evaluate safety and determine preliminary efficacy of VT-X7 (Vancomycin and Tobramycin Exchanged over 7 Days).
- Trial name
- APEX (NCT04662632)
- Testing
- VT-X7 Treatment System with Tobramycin Sulfate, Standard of Care, Two-stage exchange arthroplasty
- Where
- 17 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Drug Related Side Effects and Adverse Reactions, Infusion Reactions
Retrospective Kinetic Safety Evaluation of an Intravenous Micellar Excipient Platform
Protocol PICO-RWE-001: The goal of this observational study is to evaluate the kinetic safety and tolerability of an investigational intravenous micellar delivery platform.
- Trial name
- NCT07609069
- Testing
- PIV-850 (850-picometer Dual-NCE Acidic Matrix), Legacy Heterogeneous Payload (Micellar Vehicle)
- Where
- United States
- Volunteers
- 625 people
- Sponsor
- PICO IV, Inc.
Cystic Fibrosis
Use of a Biofilm Antimicrobial Susceptibility Assay to Guide Antibiotic Therapy
The purpose of this study is to determine whether choosing antibiotics based on a biofilm antimicrobial susceptibility assay rather than a conventional planktonic antimicrobial susceptibility assay to treat CF patients with…
- Trial name
- NCT00786513
- Testing
- Conventional antimicrobial susceptibility testing, Biofilm antimicrobial susceptibility testing
- Where
- 5 sites in Canada
- Volunteers
- 134 people
- Sponsor
- The Hospital for Sick Children
Dental Biofilm Accumulation
RCT: Enzyme Blend Toothpaste on Dental Biofilm Plaque Accumulation
The aim of the study is to investigate whether brushing twice a day with a toothpaste (Biofresh Clean) containing a blend of alpha-amylase and gluco-amylase improves oral health outcomes over a 14-day period.
- Trial name
- NCT07079683
- Testing
- Toothpaste Product
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Novozymes A/S
Prosthetic-joint Infection
A Second Trial of the Abbreviated Protocol Two-Stage Exchange
Apex-2 is a multi-site, parallel group, randomized trial. Patients will be randomly assigned in a 1:1 ratio to the Experimental Arm or the Control Arm.
- Trial name
- Apex-2 (NCT05607030)
- Testing
- VT-X7 Treatment System, Two-stage exchange arthroplasty, SOC Antibiotics
- Where
- 19 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Intrabony Periodontal Defect
Comparison of MIST With PRF and GBT With PRF in the Treatment of Intrabony Periodontal Defect. A Prospective RCT
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a MIST procedure combined with PRF, or GBT combined with PRF.
- Trial name
- NCT06768424
- Testing
- Guided biofilm therapy, Platelet Rich Fibrin, Minimally Invasive Surgical Technique
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Rheumatoid Arthritis, Periodontitis
Dental Prophylaxis and Rheumatoid Arthritis
This study evaluates the influence of dental prophylaxis on disease activity of Rheumatoid Arthritis. In addition to standard antirheumatic therapy, recently the question has been raised whether or not there is a supplementary…
- Conditions
- Rheumatoid Arthritis, Periodontitis, Gingivitis, Dental Prophylaxis
- Trial name
- PREPARA II (NCT03087240)
- Testing
- Dental Prophylaxis
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University Hospital Heidelberg
Peri-implantitis
Effect of Metallic Particles on the Progression of Peri-Implantitis
This observational cross-sectional study aims to investigate the presence and characteristics of metallic micro- and nanoparticles in peri-implant tissues and their potential association with peri-implantitis progression, the…
- Trial name
- NCT07792499
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Orthopedic Devices Associated With Misadventures, Prosthetic and Other Implants, Materials and Accessory Devices
Sterilizing Effects of the Erbium:YAG Laser Upon Metal Implants
Background: Even today, postoperative infection is the commonest complications after surgery although all aseptic precautions are taken and causes significant postoperative morbidity, mortality, prolongs hospital stay, and…
- Trial name
- NCT03226184
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Wounds
Collection of Samples for the Evaluation of Wound Biofilm in Acute and Chronic Wounds
The Specific Aim of examining wounds microscopically is to attempt to demonstrate the presence of biofilm in chronic wounds and to understand these populations on a cellular level.
- Trial name
- NCT00764296
- Testing
- no treatment
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Southwest Regional Wound Care Center
Poly(Lactide-co-glycolide) Sutures, Suture Resorption
Comparative Analysis of fast-and Slow-absorbable Poly(Lactose-co-glycolide) Sutures in Oral Surgery: a Randomized Controlled Trial.
This study aims to compare slow-resorbing and fast-resorbing sutures used after the surgical extraction of lower third molars. Sutures are routinely placed after wisdom tooth removal to promote hemostasis.
- Conditions
- Poly(Lactide-co-glycolide) Sutures, Suture Resorption, Third Molar Surgery
- Trial name
- NCT07498361
- Testing
- Fast absorbable sutures application, Standard absorbable sutures application
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Padova, School of Dental Medicine
Dental Plaque
Efficacy of Two Chlorhexidine Solutions to Control the Initial Subgingival Biofilm Formation
The aim of the study is to compare the effect of a suspension containing chlorhexidine and alcohol and another one containing clorhexidine with no alcohol in dynamic of the subgingival biofilm formation versus a Placebo…
- Trial name
- NCT02656251
- Testing
- 0.12% Clorhexidine with alcohol, 0.12% Clorhexidine without alcohol
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul