Clinical trials: Biologic Markers
Obesity
Effect of Low-calorie Diet and Orange Juice on Body Weight and Metabolic Parameters of Obese Subjects
This study aimed to verify if combination of a low calorie diet and orange juice consumption results in weight loss and ameliorates metabolic obesity-related biomarkers.
- Trial name
- LCD-OJ-OBESE (NCT02914249)
- Testing
- Orange juice (500 mL/d)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- São Paulo State University
Cardiovascular (CV) Risk
Democratizing Access to Cleaner Residential Air
The purpose of this research study is to determine whether the use of in-home air filtration to reduce exposure to air pollution benefits health.
- Trial name
- DACRA (NCT07629518)
- Testing
- Portable air purifiers with HEPA filtration
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Douglas Brugge
Relapse Remitting Multiple Sclerosis
Study to Assess the Effect of Ofatumumab in Treatment Naïve, Very Early RRMS Patients Benchmarked Against Healthy Controls.
This study evaluates the impact of ofatumumab in Relapsing Remitting Multiple Sclerosis (RRMS) participants that are very early in the course of their disease using clinical and magnetic resonance imaging (MRI) outcomes.
- Trial name
- AGNOS (NCT05084638)
- Testing
- Ofatumumab
- Where
- 36 sites in United States, Puerto Rico
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Psychotic Disorders, Schizophrenia
The Topical Niacin Skin Flush Test in First Episode Psychosis
The purpose of this study is to gather normative data from healthy adults and to determine a sensitive and specific cut-off value for responders and non-responders to the Niacin Skin Flush Test in a sample of first episode…
- Trial name
- NCT01324297
- Testing
- skin test
- Where
- Canada
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Herper Zoster
Biomarker Study in Patients With Herpes Zoster
Investigators performed this study to investigate the expression levels inflammatory cytokine and neurotransmitters (calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal peptide (VIP), and β-endorphin)…
- Trial name
- NCT05685797
- Testing
- Herpes zoszter (acute)with inter vention
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Keimyung University Dongsan Medical Center
Healthy
Effect on Blood Chemistry and Inflammatory Marker of Omega-3 Enriched Total Parenteral Nutrition
Fish oil is a rich source of omega-3 fatty acids, especially eicosapentanoic acid and docosahexaenoic acid, and it is not used widely in parenteral nutrition because fish oil emulsions have not been commercially available until…
- Trial name
- NCT02468713
- Testing
- Combiflex® lipid peri, Winuf® peri
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Alzheimer Disease, Early Onset, Protein; Disease
Proteomics Study of Mild Cognitive Impairment and Alzheimer's Disease
This study intends to adopt standardized and rigorous cross-sectional research, collect biological specimens (including blood, feces, urine, saliva and tongue coating) from eligible subjects, and use liquid chromatography/mass…
- Trial name
- NCT04804618
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Healthy Volunteer, Hypersensitivity Reactions
Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions
The goal of this clinical trial is to investigate biomarkers of non-IgE-mediated immediate hypersensitivity reactions during infusion of intravenous vancomycin.
- Conditions
- Healthy Volunteer, Hypersensitivity Reactions, Vancomycin
- Trial name
- NCT07605806
- Testing
- Vancomycin (IV)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD)
Alzheimer's Disease Neuroimaging Initiative 3
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD.
- Trial name
- ADNI3 (NCT02854033)
- Where
- 59 sites in United States, Canada
- Volunteers
- 1,141 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Metabolic Syndrome
Resistance Training and Metabolic Syndrome
Metabolic syndrome (MetS) is a multicomponent disorder closely linked to low grade inflammation, and cardiovascular disease (CVD).
- Trial name
- NCT02918448
- Testing
- Training group
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Coronary Syndrome, Acute, Coronary Artery Disease
A Study of Population and Sex-specific Troponin Cutoffs for Ruling Out Acute Myocardial Infarction
Acute myocardial infarction (MI) is defined as a rise and/or fall in cardiac troponins (cTn) with at least one value above the 99th percentile upper reference limit (URL) in the context of symptoms or clinical evidence of…
- Conditions
- Coronary Syndrome, Acute, Coronary Artery Disease, Myocardial Infarction
- Trial name
- DANSPOT (NCT05336435)
- Testing
- Implementation of the new population and sex-specific 99th percentile URL for cardiac troponin
- Where
- 22 sites in Denmark
- Volunteers
- 5,175 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Healthy Adult Women of Child Bearing Age
Impact of a MVM to Support Biomarkers Associated With Conception and Pregnancy in Healthy Women.
The goal of this clinical trial is to investigate the effects multivitamin (MVM) on blood biomarkers that are associated with healthy pregnancy and conception in adult women.
- Trial name
- NCT06505408
- Testing
- Multivitamin
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Perelel Inc.
Morbid Obesity
Identification of Biomarkers of Response After Bariatric Surgery in Morbidly Obese Patients
The prevalence of obesity in Spain is about 21.6%. The discouraging results provided by dietary treatment, together with the lack of funding for pharmacological treatment, have led to the progressive use of bariatric surgery…
- Trial name
- PREDI-BAR (NCT03784508)
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Healthy
Assessment of Dietary Biomarkers and Metabolic Effects After the Intake of Milk and Cheese
Dietary biomarkers are compounds in biofluids that directly reflect the intake of specific foods or food groups. Their exploration and use in the field of dietary assessments could provide an objective measure of actual intake…
- Trial name
- NCT02705560
- Testing
- Cow´s milk (3.9% fat, pasteurized), hard, yellow cheese, Soy based drink
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Healthy
Immune Health Biomarkers and Fecal Microbiota in Filipino Breastfed Infants
This will be a prospective observational study aiming to investigate immune health biomarkers and fecal microbiota in 48-60 Filipino breastfed infants from birth to 12 months of age.
- Trial name
- NCT06708559
- Testing
- Breast-fed infants
- Where
- Philippines
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure
Serum Phosphatemia Predictive Marker for AKI Diagnosis After Cardiac Surgery
Cardiac surgery associated acute kidney injury is an independent factor of morbidity and mortality . Despite its delayed elevation, serum creatinine (Cr) remains the goal standard to diagnose AKI.
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure, Complete Serum Creatinine Measure
- Trial name
- PhosphoIRA (NCT02900313)
- Testing
- cardiac surgery
- Where
- France
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Anorexia Nervosa, Anorexia Nervosa Restricting Type
Novel Targetable BIOmarkers in ANorexia NervosA
The overall aim of this present study is to evaluate Growth Differentiation Factor-15 (GDF-15) and inflammatory cytokines as a possible novel and readily treatable target for the successful therapy of Anorexia Nervosa (AN).
- Trial name
- BIOANNA (NCT05885724)
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Li-Fraumeni Syndrome, Hereditary Cancer Syndromes
Biomarker Monitoring in TP53 Mutation Carriers
Purpose This study is an 'N-of-one' observational study focusing on individuals with a hereditary predisposition to cancer due to a genetic mutation in the TP53 gene.
- Conditions
- Li-Fraumeni Syndrome, Hereditary Cancer Syndromes, TP53 Gene Germline Mutation Carrier
- Trial name
- NCT02289326
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Polycystic Kidney Disease
Early PKD Observational Cohort Study
This observational study will collect blood and urine and clinical information from individuals with early-stages of polycystic kidney disease (PKD), their unaffected siblings and normal volunteers to create a biobank, also…
- Trial name
- EPOC (NCT02936791)
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Healthy
Effects of Fish Oil and Red Wine on Oxidative Stress Biomarkers
The American Heart Association and the American College of Cardiology (AHA/ACC) recently encouraged "increased consumption of omega-3 fatty acids in the form of fish or capsule form (1 g/day) for risk reduction" and stated that…
- Trial name
- NCT00682318
- Testing
- Fish Oil, Safflower Oil, Ethanol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Carsten Skarke, MD