Clinical trials: Biologic Markers
Biomarkers
Role of Concentration of Biomarkers S100B and NSE in Serum in Mild and Moderate Head Trauma
In pediatric age groups communication difficulties very sometimes may present further obstacles in obtaining a detailed injury history and early identification of TBI symptoms.
- Trial name
- NCT02988102
- Testing
- Following S100B and NSE in head trauma
- Where
- Albania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Clinical Centre of Kosova
Parkinson Disease, Idiopathic, REM Sleep Behavior Disorder
Parkinson's Disease Biomarker Study
The primary objective of this study is to determine whether data acquired from a remote monitoring approach can reliably identify and track motor symptoms in prodromal PD and clinical PD.
- Trial name
- PDBS (NCT06812702)
- Testing
- Observational, Skin Biopsy
- Where
- 4 sites in Canada
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Ronald Postuma
Septic Arthritis, Inflammatory Arthritis
Differentiate Children Septic and Inflammatory Arthritis by Comparative Analysis
The purpose is to found new biomarker that differentiate septic arthritis and Juvenile Idiopathic Arthritis in children. Synovial liquid and blood samples with proteomic, MiRNA searching, multiplex cytokine analysis and cellular…
- Conditions
- Septic Arthritis, Inflammatory Arthritis, Children
- Trial name
- DIANE (NCT03827759)
- Where
- 5 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Depression, Anxiety
Cardiovascular Biomarkers and Quetiapine in Depression and Anxiety Patients
No suitable treatment has been identified to reverse and ideally prevent, the cardiovascular disease risk associated with depression and anxiety.
- Trial name
- NCT00951483
- Testing
- Quetiapine-XR
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Loyola University
Preeclampsia
Analysis of the Levels of HLADR+ Extracellular Vesicles in Women With Preeclampsia as a Early Potential Biomarker
Analysis of the circulating levels of placenta-derived HLA-DR+ extracellular vesicles in the first, second and third trimester of pregnancy of women with high and low risk to develop preeclampsia.
- Trial name
- NCT06873737
- Testing
- Blood samples for inflammatory markers
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dementia, Nursing Homes Residents
Sing Out Loud: A Choral Singing Program for Persons Living With Dementia
This study intends to investigate whether a singing programme for nursing home residents living with dementia can reduce the mental and physiological effects of dementia. The main questions it aims to answer are: 1.
- Trial name
- SOL (NCT06880237)
- Testing
- Singing
- Where
- Singapore
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Pancreatic Cancer Stage III, Pancreatic Cancer Stage IV
The Role of MicroRNA in the Diagnosis, Prognosis and Response to Treatment in Pancreatic Cancer
Aberrant miRNA production has been linked to a wide range of human cancers and shown to play important roles in their genesis and growth. These miRNA can be detected in the blood and tumors of patients with cancer.
- Conditions
- Pancreatic Cancer Stage III, Pancreatic Cancer Stage IV, Pancreatic Ductal Adenocarcinoma, Pancreatic Neoplasms
- Trial name
- NCT04406831
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nuvance Health
Tobacco Use Disorder, Lung Cancer
Assessing the Link Between Smoke Carcinogen Biomarkers and Lung Cancer Risk - 1
Lung cancer is the leading cause of cancer death in the United States. Currently it remains impossible to predict which smokers will get cancer. Each puff of a cigarette delivers a mixture of over 60 known carcinogens.
- Trial name
- NCT00218179
- Testing
- Non-intervention
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Systemic Lupus
Chemokine (CXCL13) as Anew Marker in Diagnosis of SLE
Systemic lupus erythematosus (SLE) is systemic autoimmune disease characterized by various immunological abnormalities, including dysregulated activation of both T and B lymphocytes with overt production of autoreactive…
- Trial name
- NCT03752983
- Testing
- blood samples
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cataract, Macular Edema
The Role of Radial Peripapillary Vessel Density in Irvine-gass Syndrome
Pseudophakic cystoid macular edema (PCME), also known as Irvine-Gass syndrome (IGS), is an accumulation of fluid in the macula that occurs after cataract surgery, with an early or late presentation (cut-off 3 months) .
- Trial name
- OCTA and PMCE (NCT06436170)
- Testing
- OCTA
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federico II University
Healthy
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 653048 BS H3PO4 Capsule Multiple Rising Doses in Healthy Male Volunteers
The objectives of the trial were to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple rising doses of BI 653048 BS H3PO4 compared with prednisolone.
- Trial name
- NCT02217631
- Testing
- BI 653048 BS H3PO4, Prednisolone low dose, Prednisolone high dose
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Epilepsy
Precision Medicine in the Treatment of Epilepsy
Primary objectives: The purpose of this study is to identify single and composite biomarkers (from neuroimaging, electrophysiological, and non-imaging biological measures), clinical measures (from cognitive, psychometric, and…
- Trial name
- BDE (NCT05450822)
- Testing
- Levetiracetam, Levetiracetam Tablets, Lamotrigine tablet
- Where
- Denmark
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Gitte Moos Knudsen
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of a Computerized Complex Instrumental Activities of Daily Living Marker (NMI)
The proposed study is designed to evaluate the performance of the ALTOIDA™ System as a tool to assist physicians in diagnosing Alzheimer's Disease (AD) in real-world clinical settings.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Memory Disorders, Cognitive Impairment
- Trial name
- AltoidaML (NCT02843529)
- Testing
- Altoida: neuropsychological, MRI, EEG and CSF biomarkers
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Altoida
COPD, Chronic Obstructive Pulmonary Disease
Study of COPD Subgroups and Biomarkers
SPIROMICS I, SPIROMICS II, and SPIROMICS III are longitudinal observational studies of Chronic Obstructive Pulmonary Disease (COPD) cohort.
- Conditions
- COPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
- Trial name
- SPIROMICS (NCT01969344)
- Where
- 14 sites in United States
- Volunteers
- 2,981 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Healthy Subjects, Pharmacokinetics
Pharmacodynamic Biomarkers to Support Biosimilar Development: PCSK9 Inhibitors
This study is designed to assess pharmacokinetics and pharmacodynamics of evolocumab and alirocumab across an appropriate dose range to inform clinical trial operating characteristics for future clinical pharmacology…
- Conditions
- Healthy Subjects, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT04189484
- Testing
- Evolocumab, Alirocumab
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Overweight and Obesity, NAFLD
Study to Evaluate the Safety and Efficacy of ASC41 in Overweight and Obese Subjects
The primary objective of this study is to evaluate the safety, tolerability and compare the pharmacokinetic parameters of ASC41, a THR beta agonist tables in overweight and obese subjects who have elevated LDL-C .
- Conditions
- Overweight and Obesity, NAFLD, Hyperlipidemia
- Trial name
- NCT04686994
- Testing
- ASC 41
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gannex Pharma Co., Ltd.
Alzheimer Disease
Digital Technology Combined With Blood Marker Screening and Diagnosis for Community Populations Based on Classification Theory: an Integrated Study
Our research hypothesis is as follows: A step - by - step screening strategy based on screening technologies can resolve the issue of insufficient efficiency in the traditional scale - based screening model.
- Trial name
- NCT07286812
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Food Habits, Self Efficacy
Edible Seaweeds and Health: Quality Biomarkers to Support Consumer Acceptance
Seaweeds have been part of the diet of Asian countries for thousands of years, but consumption by Quebecers remains unfamiliar. Because of their rich nutrients content and unique bioactive compounds, seaweeds have a great dietary…
- Trial name
- (CuisiAlg) (NCT04493944)
- Testing
- Culinary workshop
- Where
- Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Laval University
Vitamin D Deficiency, Vitamin D Insufficiency
ALPCO 25(OH) Vitamin D CLIA Kit - Fresh Versus Frozen Serum and Plasma Stability Study
This study evaluates the stability of 25-hydroxyvitamin D [25(OH)D] measurements in human serum and plasma using the ALPCO 25(OH) Vitamin D CLIA Kit.
- Conditions
- Vitamin D Deficiency, Vitamin D Insufficiency, Healthy Volunteers
- Trial name
- NCT07565064
- Testing
- ALPCO 25(OH) Vitamin D CLIA Kit
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Ataxia
RFC1 Natural History Study
This international, multi-center, multi-modal and prospective observational study aims to determine the phenotypic spectrum and the natural progression of the RFC1 repeat expansion disease, and to seek and validate digital…
- Trial name
- RFC1-NHS (NCT05177809)
- Testing
- Clinical rating scale to measure ataxia disease severity and progression
- Where
- 10 sites in Australia, Brazil and 5 more
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Matthis Synofzik
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