Clinical trials: Biologic Markers
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Diffuse Large B Cell Lymphoma
Is Trogocytosis a Predictive Marker of CAR-T Cell Response in Diffuse Large B-cell Lymphoma?
CAR-T cell therapy has improved survival in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL R/R). However, only 65% of patients achieve a complete metabolic response after this treatment.
- Trial name
- CARTROG (NCT06352242)
- Testing
- Flow cytometry analysis to determine the level of trogocytosis by effector immune cells in patients, Flow cytometry analysis to determine the level of trogocytosis by effector immune cells in volunteers
- Where
- 2 sites in France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Cognition Disorders
Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - the LEARN Study
The LEARN study a multicenter, observational study will that will evaluate the rate of cognitive change in approximately 500 clinically normal older individuals who "screen-fail" for the A4 trial on the basis of their screening…
- Trial name
- LEARN (NCT02488720)
- Where
- 40 sites in United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Sarcopenia, Age-related Muscle Loss
AI-Guided Sarcopenia Risk Assessment and Detection
Sarcopenia, the age-related decline in muscle mass and function, is a major contributor to frailty, disability, and mortality in older adults.
- Trial name
- SARC-AI (NCT07426159)
- Testing
- Personalized AI-Guided Exercise and Nutrition
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Healthy
Interactions Between Fibre and Polyphenols on Colonic Phenolic Acid Production and Biomarkers of Health ( 6 Weeks)
The investigators have studied the acute interactions of polyphenols and NDC in a single meal in a human study containing tomatoes, lovage \& onions, with and without inulin.
- Trial name
- NCT03840746
- Testing
- Tomato, onion and lovage soup (TOL), TOL soup with inulin
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Chronic Kidney Disease
Evaluation of New Markers to Assess Kidney Function
Glomerular filtration rate (GFR) is widely accepted as the best index of kidney function in health and disease, and accurate values are required for optimal clinical decision making and in large-scale epidemiologic studies and…
- Trial name
- NCT00938561
- Testing
- Inulin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Breast Neoplasms
Breast Cancer and Exercise Trial in Alberta
The Breast Cancer and Exercise Trial (BETA Trial) is a randomized controlled trial aimed at understanding what dose (or volume) of exercise will best reduce the risk for breast cancer, particularly among women who are between the…
- Trial name
- BETA (NCT01435005)
- Testing
- Moderate Volume, High Volume
- Where
- 2 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- AHS Cancer Control Alberta
Heart Failure, Acute Coronary Syndrome
Bace1as Role in Heart Failure (BACE1AS-HF)
The objective of this project is 1) to explore the clinical relevance of BACE1-AS and BACE1 as therapeutic targets and 2) to evaluate their potentiality as biomarkers in ischemic heart failure (HF).
- Trial name
- BACE1AS-HF (NCT06213493)
- Testing
- measurement of RNAs
- Where
- Italy
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Glucose Metabolism, Amino Acid Metabolism
Evaluation of Biomarkers for Predicting Macronutrient Intake
The goal of this clinical trial is to establish the relationship between macronutrient food intake and the resulting blood and intersticial fluid (ISF )levels of small molecule markers, as well as, validate wearable optical…
- Trial name
- Microdialysis (NCT06582381)
- Testing
- Meal set A, Meal set B, Meal set C
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Focal Epilepsy
TMS Combined With EEG/EMG as a Biomarker Predicting Antiepileptic Drug Response
Ιn the present study (BIOEPI), the following three hypotheses will be investigated: 1. The proposed TMS-EEG / EMG protocol (which includes software for calculating the cerebral cortex stimulation threshold) in combination with…
- Trial name
- BIOEPI (NCT05278221)
- Testing
- Software EstimLT
- Where
- Greece
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Chagas Disease
New Tools for the Diagnosis, Prognosis and Treatment Follow-up in Chagas Disease
Chagas disease is endemic to Latin America, and is of emerging importance in non-endemic countries because migration of people infected with T. cruzi. Current methods for diagnosis of T. cruzi infection are not ideal.
- Trial name
- BIOMARCHA (NCT01755377)
- Testing
- Benznidazole
- Where
- Spain
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Barcelona Centre for International Health Research
Lymphedema
Biomarkers for the Detection of Lymphatic Insufficiency
Acquired lymphedema is a disease that causes chronic swelling of the limb(s). It is frequently under-recognized or misdiagnosed.
- Trial name
- Biomarkers (NCT02375165)
- Testing
- phlebotomy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Stanford University
Inflammatory Bowel Disease (IBD), Crohn's Disease (CD)
Faecal Calprotectin as a Potential Non-invasive Inflammatory Marker in Pregnancy and Inflammatory Bowel Disease
When women with rheumatoid arthritis become pregnant 75% of them will go into remission, despite stopping medication. This phenomenon is not well understood and is not seen in other inflammatory conditions.
- Conditions
- Inflammatory Bowel Disease (IBD), Crohn's Disease (CD), Ulcerative Colitis (UC), Pregnancy
- Trial name
- PREGCAL (NCT02778464)
- Where
- United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT06700863)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Postoperative Delirium
Electroencephalographic Biomarker to Predict Postoperative Delirium
Acute post-operatory cognitive dysfunction states are one of the most important complications in older patients that underwent surgery. Among them postoperative delirium (POD) is the the most studied.
- Trial name
- NCT05992506
- Testing
- POD risk estimation using PEUMA
- Where
- 2 sites in Chile
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University of Chile
Head and Neck Cancer, Oropharyngeal Cancer
Role of Immune Activation in Response of Head and Neck Squamous Cell Carcinoma to Therapy
The purpose of this study is to investigate the role of the immune system in the response of squamous cell cancers of the head and neck to treatment that includes radiation therapy.
- Conditions
- Head and Neck Cancer, Oropharyngeal Cancer, Human Papillomavirus, Squamous Cell Cancer
- Trial name
- NCT01358097
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Heart Failure, Aortic Stenosis
The Role of Cardiac Mechanics, Biomarkers and Frailty in Aortic Stenosis
The role of cardiac mechanics, circulating biomarkers and frailty in predicting outcomes in patients with aortic stenosis after aortic valve replacement (SCRABLES -The 2-Parts Study) Part I: Observational study to characterize…
- Trial name
- SCRABLES (NCT02856620)
- Testing
- Observational only
- Where
- Canada
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Christine Henri
Tobacco Use Disorder, Nicotine Dependence
Novel Determinants and Measures of Smokeless Tobacco Use: Study 2
The research project will determine the level of nicotine in ST products that will lead to the greatest reduction in toxicant exposure
- Trial name
- NCT01067599
- Testing
- Low nicotine, Medium nicotine, High nicotine
- Where
- 2 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson's Disease
Evaluation of a Biomarker Related to the GI Tract for the Diagnosis of Parkinson's Disease
The cause of Parkinson's disease (PD) is currently unknown. Both environmental and genetic factors have been found to contribute to PD pathogenesis.
- Trial name
- NCT01904240
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Fibromyalgia
Effect of a Vegan Mediterranean Diet on Cardiometabolic Biomarkers, Functional Capacity, and Quality of Life in Patients with Fibromyalgia
This study aims to evaluate the effect of a vegan Mediterranean diet compared to a traditional Mediterranean diet on inflammatory biomarkers, functional capacity, and quality of life in patients with fibromyalgia.
- Trial name
- FIBROVEG (NCT06804460)
- Testing
- Dietary intervention
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.