Clinical trials: Biologic Markers
Carcinoma, Carcinoma, Renal Cell
Biomarkers for Angiogenesis in Renal Cell Carcinoma and Neuro-endocrine Tumours.
The primary objective of this study is to analyse the concentration dopamine and serotonin in thrombocytes of patients with renal cell carcinoma and neuro-endocrine tumours compared to the concentrations of these catecholamines…
- Conditions
- Carcinoma, Carcinoma, Renal Cell, Neuroendocrine Tumors, Carcinoid Tumor
- Trial name
- BANN (NCT01398306)
- Testing
- Blood sampling by vena punction.
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- University Medical Center Groningen
Coronary Heart Disease (CHD)
A Biorepository for Coronary Heart Disease in Qatar
Coronary heart disease (CHD) poses a major health burden in the Gulf countries. It is the leading cause of mortality and morbidity in the world and poses an enormous societal burden in the Gulf countries.
- Trial name
- QCBio (NCT03427489)
- Where
- Qatar
- Volunteers
- 2,100 people
- Sponsor
- Hamad Medical Corporation
Sepsis, Sepsis and Septic Shock
Study on the Construction and Application of Early Warning Model of Sepsis in Critically Ill Patients
The condition of sepsis patients changes rapidly, whom are often accompanied by impaired respiratory, circulatory, renal, and coagulation functions. So far, the prognosis of sepsis at home and abroad is not ideal.
- Conditions
- Sepsis, Sepsis and Septic Shock, Infection
- Trial name
- sepsis model (NCT06904001)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Alzheimer Disease, Early Onset
Novel Dementia Biomarkers
The study will investigate structural and functional characteristics of the brain of dementia patients compared to healthy controls in order to get a better insight into importance of early biomarkers for the diagnosis of…
- Trial name
- NCT04427436
- Testing
- No Intervention
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Dementia
Biomarker-Integrated Digital Guidance for Early Alzheimer's Detection (BRIDGE-AD): A Nationwide Multicenter Study
The investigators propose a stepwise screening approach. The first step involves rapid digital pre-screening of cognitive function through three components: the SCD-9 questionnaire to capture subjective cognitive complaints, a…
- Trial name
- NCT07284264
- Where
- 6 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Postoperative Complications
Biomarkers of Postoperative Complications After Cardiac Surgery
Postoperative delirium and other complications are important adverse outcomes following cardiac surgery. This study will integrate perioperative clinical information with molecular measurements to investigate factors associated…
- Trial name
- NCT07900009
- Testing
- no intervention
- Volunteers
- 300 people
- Sponsor
- Rao Sun
Chronic Pain, Inflammation
Biomarkers in Pain and Pain Treatment
The goal of this research project is to explore if levels of inflammation predict levels of comorbid mood disorders and treatment success in chronic pain patients.
- Trial name
- NCT03272893
- Testing
- Acceptance and Commitment Therapy
- Volunteers
- 90 people
- Sponsor
- Rikard Wicksell
Inflammatory Bowel Diseases
Urinary Biomarkers of Renal Injury in Inflammatory Bowel Disease
The study aims to early detection of renal injury in patients diagnosed to have inflammatory bowel disease with normal kidney function test focusing on glomerular filtration barrier injury and tubular injury and it's relation to…
- Trial name
- NCT04282577
- Testing
- urinary nephrin and alpha one microglobulin
- Volunteers
- 100 people
- Sponsor
- Assiut University
Aging Well
Rejuvant™ Safety and Biomarker Study
In this randomized, double-blind, placebo-controlled trial in adult men ages 45-65 years and postmenopausal women to age 75 years, the anti-inflammatory property of proprietary CaAKG based dietary supplements will be assessed by…
- Trial name
- NCT04821401
- Testing
- Rejuvant
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ponce De Leon Health
Osteopenia, Low Bone Density
Evaluation of the Effect of Spry Belt Treatment on Bone Turnover Marker Profile
To conduct a sham-controlled study to rigorously evaluate the effect of Spry Belt treatment on key bone turnover markers (BTMs) over a 12-week period.
- Trial name
- NCT05457036
- Testing
- Spry Belt
- Where
- 2 sites in United States
- Volunteers
- 94 people
- Sponsor
- Bone Health Technologies, Inc.
Weaning Failure, Mechanical Ventilation
The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in ICU Patients
The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in Mechanically Ventilated ICU Patients
- Conditions
- Weaning Failure, Mechanical Ventilation, Spontaneous Breathing Trial, Extubation Failure
- Trial name
- BIOMEXIC (NCT05637099)
- Where
- Netherlands
- Volunteers
- 181 people
- Sponsor
- Henrik Endeman
Mild Cognitive Impairment, Cognitive Decline
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment…
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
- Trial name
- NCT03954899
- Testing
- melatonin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Natalie Denburg
Depression
Imaging Biomarkers for TMS Treatment of Depression
The purpose of this research is to learn more about how rTMS works to reduce the symptoms of depression. This information can be used to improve the effectiveness of the treatment.
- Trial name
- NCT01900314
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Paravalvular Leak
Cardiac MRI for Post-TAVR Paravalvular Leak Assessment
The objectives of this study are to: a) evaluate and correlate the severity of paravalvular leak (PVL) assessed by both cardiac MRI and transthoracic echocardiography (TTE) after transcatheter aortic valve replacement (TAVR) with…
- Trial name
- Class-CMR (NCT03195114)
- Testing
- Multimodality Imaging and Biomarkers
- Where
- 3 sites in United States, Canada
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Atrial Fibrillation, Paroxysmal or Persistent
The SAFE Prospective Registry
Secretoneurin (SN) is a neuropeptide from the chromogranin family that influences intracellular calcium handling. SN suppresses calcium leakage from the sarcoplasmic reticulum through the ryanodine receptor.
- Trial name
- NCT05794464
- Testing
- Catheter ablation and/or electrical cardioversion
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Osteoarthritis
Identification and Characterization of the Biomarker in Synovial Fluid for Hyaluronic Acid Therapy in Osteoarthritis
The purpose of this study is to use the proteomic analysis of synovial fluid to perform the comprehensive investigation of the biomarker that will be useful to assign the tratment effectiveness of five weekly intra-articular HA…
- Trial name
- NCT01813916
- Testing
- proteomic analysis
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Myotonic Dystrophy
Development of Quantitative Muscle Imaging as a Biomarker of Disease Endpoints in Myotonic Dystrophy
Myotonic dystrophy (dystrophia myotonica; DM), the most prevalent form of muscular dystrophy in adults, is characterized by progressive myopathy, myotonia, and multi-systemic involvement.
- Trial name
- DeQoDE-DM (NCT07362875)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Gene Expression, Immunosuppression Conversion
Search for Transcriptional Biomarkers in a Conversion Protocol From Calcineurin Inhibitors to Mycophenolate Mofetil
As is well known, immunosuppressive treatment (IS) after liver transplantation has several and frequents adverse effects that limit the survival of the graft and recipients.
- Conditions
- Gene Expression, Immunosuppression Conversion, Liver Transplantation
- Trial name
- TBCP (NCT01321112)
- Testing
- conversion from CNI to MMF
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Muscular Atrophy
Biological and Functional Markers for Precision Astronautical Biomedicine
In the current study the investigators will study early biomarkers of human degradation. In 10-day horizontal bed rest the investigators will enroll 10 healthy male subjects (18-30years, BMI 20-28kg/m2).
- Trial name
- MARS-PRE (NCT04081467)
- Testing
- Bed rest
- Where
- Slovenia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Aging
The Role of Sirolimus in Preventing Functional Decline in Older Adults
Aging is associated with progressive impairment of tissue and organ function, resulting in increased susceptibility to chronic disease, frailty and disability.
- Trial name
- NCT05237687
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Irina Timofte