Clinical trials: Biological Ageing
Biological Aging
The Inspire Bio-resource Research Platform for Healthy Aging INSPIRE Platform
Since aging is a systemic (not organ-specific) phenomenon, the main objective of Inspire Bio-resource Research Platform for Healthy Aging is to build a comprehensive research platform gathering biological, clinical (including…
- Trial name
- INSPIRE (NCT04224038)
- Testing
- The Inspire Bio-resource Research Platform for Healthy Aging
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Depression, Hypertension
Biological CVD Risk Factors in Older Depressed Patients
The purpose of this study is to determine if improvements in mood will ameliorate autonomic dysregulation, HPA dysfunction and typical (e.g.
- Conditions
- Depression, Hypertension, Hypercholesterolemia
- Trial name
- NCT00318864
- Testing
- Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Female Volunteer
Relationship Between Skin Microbiome, Epigenetic Age, and Facial Features in Aging
The goal of this observational study is to evaluate the effect of age on skin microbiome.
- Trial name
- NCT07431203
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lesaffre International
Biological Aging, Healthy Aging
Multi-Modal Longevity Protocol Including Autologous Cell-Free Conditioned Media
This pilot study evaluated a multi-modal longevity protocol combining lifestyle optimisation, nutritional supplementation, and autologous cell-free conditioned media derived from peripheral blood-derived pro-regenerative cells…
- Conditions
- Biological Aging, Healthy Aging, Longevity
- Trial name
- NCT07322224
- Testing
- Multi-Modal Longevity Protocol
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- BlueBird Age Reversal SA
Healthy Aging
Vestibular Stimulation, Exercise and Light Optimization for Circadian Clock Enhancement (Velocce)
This study investigates the effects of remote interventions based on the exposure to one or more zeitgebers (i.e. adapted physical activity alone or combined with bright light exposure, or galvanic vestibular stimulation)…
- Trial name
- velocce (NCT05030389)
- Testing
- Adapted Physical Activity (APA), Bright Light Exposure (BLE), Galvanic Vestibular Stimulation (GVS)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université de Caen Normandie
Healthy
The Use of Aging Biomarkers in Saliva, Based on DNA Methylation Status in Elovl2 to Predict Biological Age
There is a big change in our understanding of aging in recent years. Recent researches has revealed clock-like patterns of epigenetic change across in humans. The aging involves a timed epigenetic reprogramming.
- Trial name
- NCT03734419
- Volunteers
- healthy volunteers welcome
- Sponsor
- HKGepitherapeutics
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Biological Aging
Sex-specific Adaptation to Resistance Training in Older Adults
In general, men and women experience differing degrees of age-related decreases in physical function, with women having a greater prevalence of functional limitations and disability.
- Trial name
- NCT03440099
- Testing
- Resistance exercise training
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Aging, Healthy
Biological Age in Health Promotion - Novel Health Technology
The purpose of this cross-sectional study is to collect relevant molecular markers of aging and measures of physiological function.
- Trial name
- BATE (NCT03680768)
- Testing
- Health Assessment
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Aging
Morning-Evening Specific Longevity Food Supplement
The use of food supplements with the aim of increasing longevity in the general population is rapidly increasing, while high-quality clinical evidence on the efficacy of comprehensive formulations and their impact on biomarkers…
- Trial name
- NCT07416396
- Testing
- Morning- and evening-specific compound food supplement, Control
- Where
- Slovenia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Healthy Aging, Lifestyle Risk Reduction
Biological Age Applied at Ubberup
In a previous study the investigators have developed a novel biological age model. Assessing biological age is the assessment of the present health status and functional capacity/physiological reserve of that person in comparison…
- Trial name
- NCT04279366
- Testing
- Lifestyle intervention
- Where
- 2 sites in Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Biological Aging
The Translational Initiative to Map Epigenetics in Aging (TIME-A)
The Translational Initiative to Map Epigenetics in Aging (TIME-A) study aims to advance our understanding of the connections between epigenetics, lifestyle, demographics, and health and aging.
- Trial name
- TIME-A (NCT05760547)
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Elysium Health
Healthy Aging, Healthspan
Sheba Healthspan Research Population (SHARP) Trial - Sheba Longevity Center Diagnostic and Intervention Protocol to Lower Biological Age in Older Adults
Background: Population aging is accelerating rapidly in Israel and worldwide, necessitating adaptation of the healthcare system and considering new approaches that serve the needs of older adult populations.
- Conditions
- Healthy Aging, Healthspan, Biological Age, Intrinsic Capacity
- Trial name
- SHARP (NCT07596576)
- Testing
- healthspan personalized protocol, Control
- Where
- Israel
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Longevity, Preventive Medicine
Tirzepatide and Organ-specific Biological Aging
The purpose of this study is to evaluate blood-based measures of organ-specific biological age, with a particular focus on the brain, and to investigate their relationship with established clinical indicators of health and their…
- Conditions
- Longevity, Preventive Medicine, Biological Ageing
- Trial name
- NCT07906041
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Atria Research and Global Health Institute (ARGHI)
Aging
Project SIRT6 Activator
The global ageing population is increasingly affected by age-related diseases, which are challenging healthcare systems. Current treatments often extend lifespan without improving healthspan.
- Trial name
- NCT07500649
- Testing
- Fucoidan
- Where
- 2 sites in Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Biological Aging
Translational Initiative to Map Epigenetics in Sleep
The primary aim of TIME-ZZZ is to explore the relationship between chronotype, incidence of depression and biological age, and whether individuals working "out-of-phase" with their chronotype are more likely to exhibit signs of…
- Trial name
- TIME-ZZZ (NCT06333301)
- Testing
- Surveys
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Elysium Health
Red Blood Cell Health, Biological Aging
Effect of Pentadecanoic Acid Supplementation on Red Blood Cell Health and Biological Aging in Healthy Older Adults
This Phase II randomized, double-blind, placebo-controlled, parallel-group study will evaluate the effects of pentadecanoic acid (C15:0) supplementation on red blood cell (RBC) health and predicted biological age in healthy…
- Conditions
- Red Blood Cell Health, Biological Aging, Healthy Aging
- Trial name
- NCT07812792
- Testing
- Pentadecanoic Acid
- Where
- Canada
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- ReCellience15, Inc
Age Over 50 Years
The Impact of Exercise Intervention on Biological and Functional Aging Through the Lens of Epigenetic Clocks
This study investigated the effects of a structured 6-month high-intensity interval training (HIIT) program on blood DNA methylation-based measures of biological ageing, physical fitness, cardiovascular function, body…
- Trial name
- NCT07799103
- Testing
- Exercise - Relative High-Intensity Interval Training (HIIT)
- Where
- Hungary
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hungarian University of Sports Science
Aging, Aging, Healthy
Emotional Well-being and Measures of Healthy Aging
This randomized control study is designed to understand the role of a positive psychology intervention (PARK: Positive Affect Regulation sKills) in biological aging and well-being.
- Conditions
- Aging, Aging, Healthy, Aging Well, Aging, Biological
- Trial name
- NCT07334106
- Testing
- Positive Emotion Skills Intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Aging, Polypharmacy
Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.
In this study, the investigators will investigate and characterize acute medical patients in order to optimize patient courses in the acute care departments, especially with regard to polypharmacy and undernourishment.
- Conditions
- Aging, Polypharmacy, Malnutrition, Inflammation
- Trial name
- FAM-CPH (NCT03052192)
- Where
- Denmark
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital