Clinical trials: Biological Aging
Obesity, Sarcopenia
Biological Effects of Weight Loss In Older, Obese Women
Obesity and sedentary lifestyle are associated with physical impairments and biological changes in older adults. Weight loss combined with exercise may reduce inflammation and may improve physical functioning in older adults who…
- Trial name
- WL+E (NCT01032733)
- Testing
- Lifestyle Counseling, Educational Control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Elderly, Sarcopenia
Human Muscle Gene Expression Profiles in Young and Old Men
To reach the goals of living longer in better medical conditions, many countries reach the same conclusion: new strategies have to be developed to avoid, or at least limit, the effects of age; this requires a better knowledge of…
- Trial name
- CERA (NCT00725166)
- Testing
- Skeletal muscle aging
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Aging
Effect of Aging on Haemostasis Parameters
Aging is an independent risk factor, without any clear explanation. The primary aim of the study is to depict the effect of aging on the coagulation fibrinolysis parameters and microparticles.
- Trial name
- NCT00299624
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hopital Lariboisière
Aging, LONGEVITY 1
Tirzepatide to Slow Biological Aging
This pilot clinical study aims to investigate the potential effects of tirzepatide on biological aging in older adults. In this novel study, 90 adults aged 55-70 years with an indication for tirzepatide weight-loss therapy will…
- Trial name
- NCT07220473
- Testing
- Zepbound
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Taurine, Aging, Biological
Effects Of Daily Taurine Intake For 6 Months On Biological Age and Body Metabolism Indicators As Well As Physical Fitness In 55-75-year-old Women And Men
The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months.
- Conditions
- Taurine, Aging, Biological, Physical Activity, Metabolic Health
- Trial name
- TauAge (NCT06613542)
- Testing
- 4g of taurine daily
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Aging, Polypharmacy
Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.
In this study, the investigators will investigate and characterize acute medical patients in order to optimize patient courses in the acute care departments, especially with regard to polypharmacy and undernourishment.
- Conditions
- Aging, Polypharmacy, Malnutrition, Inflammation
- Trial name
- FAM-CPH (NCT03052192)
- Where
- Denmark
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Aging, Mobility Disability
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.
- Trial name
- BRIO (NCT06940037)
- Testing
- Progressive Resistance Training, Health Education
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Age Over 50 Years
The Impact of Exercise Intervention on Biological and Functional Aging Through the Lens of Epigenetic Clocks
This study investigated the effects of a structured 6-month high-intensity interval training (HIIT) program on blood DNA methylation-based measures of biological ageing, physical fitness, cardiovascular function, body…
- Trial name
- NCT07799103
- Testing
- Exercise - Relative High-Intensity Interval Training (HIIT)
- Where
- Hungary
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hungarian University of Sports Science
Anti-aging
Clinical and Biological Anti-aging Efficacy of a Cosmetic Cream
The aim of the study is to determine the efficacy of the investigational product "Cream " : on skin network after 56 days of daily application on biological parameters linked to cellular communication involved in senescence on…
- Trial name
- NCT05895591
- Testing
- Anti-aging cosmetic care product
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Dermo Cosmetique
Strength Aerobic Training Elderly Lymphoma Sarcopenia Aging
Strength and Aerobic Training in Elderly Lymphoma Patients During Chemotherapy and Its Impact on Treatment Outcomes, Patients Functioning and Biological Markers of Aging
Frailty, one of geriatric syndromes, is considered a major obstacle for recovery from physiological stress. Such stress is imposed on patients with cancer by virtue of the disease itself but even more so by the treatment.
- Trial name
- NCT03100175
- Testing
- physiotherapy
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Obesity, Sarcopenia
The Effect of the DASH Diet Containing Meat on Muscle and Metabolic Health in Older Adults
Age-related changes in body composition, muscular fitness, and metabolic health resulting in the onset of obesity, sarcopenia, and chronic diseases are profound public health issues that are in need of immediate attention.
- Conditions
- Obesity, Sarcopenia, Aging
- Trial name
- NCT04127240
- Testing
- DASH diet containing daily intakes of red meat
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
PreDiabetes, Marker; Structural
Effects of Lifestyle Intervention in the Biological Aging in Prediabetes
Lifestyle modifications, including dietary changes and increased physical activity, play a crucial role in controlling complications to reduce or eliminate them.
- Trial name
- NCT06440681
- Testing
- Providing nutritional counselling, counseling on physical activity
- Volunteers
- 500 people
- Sponsor
- King Saud University
Aging Disorder
Exposome, Pollutants, Biology in the Older Subject: EXPOSAGE
Numerous factors, both individual and environmental, can influence aging, an individual's health, and their functional status. However, the understanding of the combined impact of lifestyle-related exposures (e.g., physical…
- Trial name
- EXPOSAGE (NCT07678528)
- Testing
- Exposome assessment
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Aging, Inpatients
Epidemiological Observatory on the Health Conditions of Inpatients Aged 65 or Older at the INRCA Research Hospitals
The goal of this research study is to collect clinical data, comprehensive geriatric assessment, risk factors, biological data and blood samples from inpatients aged 65 and older at the INRCA research hospitals (Italy).
- Trial name
- report-AGE (NCT01397682)
- Testing
- blood sample collection
- Where
- 4 sites in Italy
- Volunteers
- 2,250 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Biological Aging
Healthy Aging Through Time- Restricted Eating in Adults With Overweight/Obesity and Incipient Liver Disease: ENSATI
The goal of this clinical trial is to evaluate the effect of a time-restricted eating (TRE) regimen on hallmarks of aging, in comparison with traditional caloric restriction and an unrestricted diet in adults with…
- Trial name
- ENSATI (NCT05880095)
- Testing
- Unrestricted Mediterranean diet, Energy-reduced Mediterranean diet, Mediterranean diet with time-restricted eating
- Where
- Spain
- Volunteers
- 176 people
- Sponsor
- IMDEA Food
Obesity
Nantes Bariatric Surgery Cohort
While current research suggests that inflammation of adipose tissue in obesity is linked to accelerated aging, it has yet to be determined in humans how this could enhance preventative and personalized medicine for obese…
- Trial name
- NBC (NCT06625762)
- Testing
- Nantes bariatric surgery cohort
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital
Physical Activity, Biological Aging
Exercise Referral Schemes Enhanced by Self-Management Strategies to Battle Sedentary Behaviour
The increase of the elderly population leads to increased prevalence of frailty, risk for poor health outcomes, and related health and social care costs.
- Conditions
- Physical Activity, Biological Aging, Frail Older Adults, Controlled Clinical Trials, Randomized
- Trial name
- SitLESS (NCT02629666)
- Testing
- ERS and/or Self-management Strategies
- Where
- Spain
- Volunteers
- 1,360 people, healthy volunteers welcome
- Sponsor
- University Ramon Llull
Human Immunodeficiency Virus (HIV), Metabolic Dysfunction Associated Steatotic Liver Disease
Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV
This study is a pilot, open-lable, two-arm study. The investigators will enroll virally suppressed people living with HIV and obesity to evaluate the effect of tirzepatide on epigenetic aging, assessed by DNA methylation-based…
- Conditions
- Human Immunodeficiency Virus (HIV), Metabolic Dysfunction Associated Steatotic Liver Disease, Dyslipidaemia, Diabetes Mellitus
- Trial name
- NCT07707778
- Testing
- Tirzepatide
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Clinical Trial Center
Insomnia Chronic
Mindfulness Meditation and Insomnia in Alzheimer Disease Caregivers
Treatment of insomnia in caregivers is needed given that 60% of Alzheimer disease caregivers report sleep complaints, and insomnia may add to the burden of AD caregiving and contribute to morbidity and mortality risk.
- Trial name
- CARES (NCT03538574)
- Testing
- CBT-I, MAP-I
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- University of California, Los Angeles