Clinical trials: Biological Aging
Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders
Light Exposure to Treat Sleep Disruption in Older People
The purpose of this study is to test whether shifts in the timing of the biological clock to a later hour (phase delay shifts of the human circadian system) can be produced in response to four successive evenings of light…
- Conditions
- Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders, Hypersomnia
- Trial name
- NCT00427323
- Testing
- light exposure
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Aging, Aging, Healthy
Emotional Well-being and Measures of Healthy Aging
This randomized control study is designed to understand the role of a positive psychology intervention (PARK: Positive Affect Regulation sKills) in biological aging and well-being.
- Conditions
- Aging, Aging, Healthy, Aging Well, Aging, Biological
- Trial name
- NCT07334106
- Testing
- Positive Emotion Skills Intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Menopause, Estrogen Deficiency
Cardiometabolic Consequences of the Loss of Ovarian Function
The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease.
- Conditions
- Menopause, Estrogen Deficiency, Aging, Adiposity
- Trial name
- LILAC (NCT06264882)
- Testing
- Degarelix, Transdermal Estradiol Patch
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Aging
Beta Glucan 500 and Biological Age and Immune Age
The primary purpose of this study is to evaluate the effects of BWH Labs - Beta Glucan 500 on biomarkers of biological and immune age among healthy adults.
- Trial name
- NCT07104929
- Testing
- Beta Glucan
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- OvationLab
Chronic Renal Disease
Immunosenescence and Hepatitis B Virus (HBV) Vaccine Efficacy in Chronic Renal Disease Patient
The aim of this study is to investigate the role of immunosenescence in the HBV vaccination response in patients with renal insufficiency.
- Trial name
- IVVI (NCT02375711)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Biological Aging
Sex-specific Adaptation to Resistance Training in Older Adults
In general, men and women experience differing degrees of age-related decreases in physical function, with women having a greater prevalence of functional limitations and disability.
- Trial name
- NCT03440099
- Testing
- Resistance exercise training
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Non-Small Cell Lung Cancer
Cancer of the Lung And SeneScencE - Prospective Cohort 1
The main objective is to identify and assess the predictive value of ageing and senescence biomarkers (methylome, telomeres, inflammageing) and senescent cells in tissues to improve prognosis assessment older patients with…
- Trial name
- CLASSE-P1 (NCT06923618)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 385 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aging
Systemic and Topical Geroprotective Rejuvenation Assessed by START/REST Aging Clocks
This study tests whether certain medicines and a skin treatment can slow down or partly reverse the body's aging process. As people age, the activity of their genes changes in predictable ways.
- Trial name
- NCT07888595
- Testing
- Topical anti-aging peptide serum
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Frontiers in Bioscience Research Institute and Aging
Menopause, Depression
Depression, Aging, Stress and Heart Health Study
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women.
- Conditions
- Menopause, Depression, Heart Disease in Women, Stress
- Trial name
- DASHH (NCT05570721)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Motoric Cognitive Risk Syndrome, Aging Disorder
MCR Syndrome in Quebec : Results From NuAge Study
The overall objective of the proposal is to examine the epidemiology of the newly reported "motoric cognitive risk" (MCR) syndrome, which is a pre-dementia syndrome combining subjective cognitive complaint (i.e.; memory…
- Trial name
- NCT05046275
- Testing
- Data analysis
- Where
- Canada
- Volunteers
- 1,741 people
- Sponsor
- Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal
Aging
Effects of Monarda Didyma Extract Supplementation on Biological Ageing
This research aims to explore the potential benefits of supplementation of a natural ingredient, the Monarda didyma extract, to reduce / delay the biological aging of a susceptible population, thus contributing to two relevant…
- Trial name
- EMODISU (NCT05399966)
- Testing
- Monarda Didyma extract
- Where
- Italy
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Sofia Pavanello
Sleep Disturbance, Cognitive Change
Integrating Systematic Data of Medicine to Explore the Solution for Healthy Aging (ISDHA) Phase 4
This project aims to build up the comprehensive health database of geriatric medicine for middle-aged and elderly people in Taiwan.
- Conditions
- Sleep Disturbance, Cognitive Change, Aging
- Trial name
- NCT07414680
- Where
- 2 sites in Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Acute Coronary Syndromes (ACS), Iron Deficiencies
Effect of Intravenous Iron on Quality of Life in Older Patients With Acute Coronary Syndrome
The goal of this phase IV, open-label, randomized clinical trial is to evaluate whether intravenous iron improves quality of life in adults aged 65 years and older with iron deficiency after an acute coronary syndrome (ACS).
- Conditions
- Acute Coronary Syndromes (ACS), Iron Deficiencies, Elderly (People Aged 65 or More)
- Trial name
- HI-COR-65 (NCT07476859)
- Testing
- Ferric Carboxymaltose Injection [Ferinject]
- Where
- 9 sites in Spain
- Volunteers
- 538 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Aging
A Pilot Study on Reverse Aging (The REVERSE Study)
Aging can be defined as a time-dependent functional decline in physiological function, which may increase the vulnerability to diseases and eventually death.
- Trial name
- NCT07354620
- Testing
- Rapamycin (Tablets), Prolon diet
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- The Christ Hospital
Longevity, Healthy Aging
Collagen Peptides and Cellular Aging
The goal of this clinical trial is to learn if daily collagen peptide supplementation can stabilize or lengthen telomeres and improve related markers of cellular aging in adults aged 50-70 years with overweight and…
- Conditions
- Longevity, Healthy Aging, Biological Ageing
- Trial name
- NCT07456449
- Testing
- Collagen peptides
- Where
- Austria
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Aging, Mortality
Human Observatory Study
The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level.
- Conditions
- Aging, Mortality, All-cause Mortality, Life Expectancy
- Trial name
- HOS (NCT07646782)
- Testing
- Multi-Domain Ecological and Clinical Data Linkage
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Brain, Aging
Biobank and Brain Health in Bordeaux.
B cube is a new generation cohort to study the determinants and natural history of brain aging, using molecular epidemiology, in a representative sample (N=2000) of the general population from the age of 55 (the approximate age…
- Conditions
- Brain, Aging, Cognitive Aging, Immunosenescence
- Trial name
- B-cube (NCT05322343)
- Testing
- Questionnaires, Fasting blood sampling., Saliva collection and nasal or nasopharyngeal swab
- Where
- France
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
HEALTHY
Biological Aging of Skeletal Muscles in Humans
Aging affects almost all the tissues and physiological functions, and skeletal muscle is the most affected organ. The progressive decline of the weight and the muscular function linked to the aging contributes to the lack of…
- Trial name
- BioAge (NCT02675192)
- Testing
- Proof cohort : muscular assessment
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Arterial Stiffening, Aging
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
The purpose of this study is to find out why women's arteries stiffen as they go through menopause, and how this is affected by estrogen loss.
- Conditions
- Arterial Stiffening, Aging, Menopause
- Trial name
- SHAPE (NCT00608062)
- Testing
- GnRHant - Ganirelix acetate, Transdermal estradiol patch
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy
Biological Anti-aging Efficacy of a Cosmetic Night Cream
In a previous study, the cosmetic night cream RV4983A- LA3365 has proven a great efficacy in reducing the clinical signs of skin aging, as well as a great tolerance.
- Trial name
- NCT06433323
- Testing
- Anti-aging cosmetic care product
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Dermo Cosmetique