Clinical trials: Biological Aging, open to volunteers
Longevity, Preventive Medicine
Tirzepatide and Organ-specific Biological Aging
The purpose of this study is to evaluate blood-based measures of organ-specific biological age, with a particular focus on the brain, and to investigate their relationship with established clinical indicators of health and their…
- Conditions
- Longevity, Preventive Medicine, Biological Ageing
- Trial name
- NCT07906041
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Atria Research and Global Health Institute (ARGHI)
Idiopathic Infertility, Infertility Unexplained
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility
The goal of this clinical trial is to determine whether telomere profiling and other biological aging hallmarks can help identify underlying mechanisms of persistent infertility in women with post-treatment unexplained…
- Conditions
- Idiopathic Infertility, Infertility Unexplained, Infertility (IVF Patients), Infertility Assisted Reproductive Technology
- Trial name
- TECMI (NCT07404969)
- Testing
- 1. Aging Hallmarks Biomarker Profiling (Telomere-Based), 2. Integrative Botanical and Nutraceutical Intervention, 3. Natural Conception or Assisted Reproductive Technologies
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- BEYOND GENOMiX SA, AG, Ltd
Cancer, Mental Health
Healthspan Connect Programme of Research
Healthspan Connect is a new research programme designed to understand what helps people stay healthy as they age. The programme will explore how lifestyle, environment, genetics, and social factors influence healthy ageing and…
- Conditions
- Cancer, Mental Health, Ageing Well, Resilience
- Trial name
- NCT07209774
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- King's College London
Aging, Obesity & Overweight
Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock
This study examines whether routine treatment with semaglutide or tirzepatide, prescribed with lifestyle coaching in a real-world weight-management program, is associated with changes in biological age measured by the LinAge2…
- Trial name
- NCT07444073
- Testing
- Not applicable. This is an observational study.
- Where
- 2 sites in Singapore
- Volunteers
- 440 people
- Sponsor
- National University of Singapore
Aging, LONGEVITY 1
Tirzepatide to Slow Biological Aging
This pilot clinical study aims to investigate the potential effects of tirzepatide on biological aging in older adults. In this novel study, 90 adults aged 55-70 years with an indication for tirzepatide weight-loss therapy will…
- Trial name
- NCT07220473
- Testing
- Zepbound
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Healthy Aging, Anti Aging
iVS-1 Probiotic Intervention Targeting Biological Aging in Midlife Adults
This study is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effects of Bifidobacterium adolescentis (iVS-1) supplementation on biological aging markers, metabolic health, and functional…
- Trial name
- VITAL (NCT07407894)
- Testing
- Bifidobacterium adolescentis iVS-1
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Synbiotic Health
Menopause, Estrogen Deficiency
Cardiometabolic Consequences of the Loss of Ovarian Function
The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease.
- Conditions
- Menopause, Estrogen Deficiency, Aging, Adiposity
- Trial name
- LILAC (NCT06264882)
- Testing
- Degarelix, Transdermal Estradiol Patch
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity, Menopause Hot Flashes
The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity
The purpose of this study is to determine the effect of tirzepatide on vasomotor symptoms and on measures of biological aging.
- Trial name
- NCT07218445
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Aging, Aging Well
100-Year Human Aging Study
The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo…
- Conditions
- Aging, Aging Well, All-Cause Mortality, Mortality
- Trial name
- NCT07563777
- Testing
- Comprehensive Multi-System Clinical Screening
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Phenotypic Age Acceleration, Biological Aging Marker
Phenotypic Age Acceleration (PhenoAgeAccel) for Joint Prediction of Disease Risk, Mortality Risk, Life Expectancy, and Disease-Free Healthspan in Major Chronic Diseases
The goal of this observational study is to learn about the ability of Phenotypic Age Acceleration (PhenoAgeAccel) to predict four key health outcomes in Chinese people with or at risk of major chronic diseases: the risk of…
- Conditions
- Phenotypic Age Acceleration, Biological Aging Marker, Mortality Risk Prediction, Disease Risk Prediction
- Trial name
- NCT07595094
- Testing
- No Intervention (Observational Study)
- Where
- China
- Volunteers
- 2,000,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Hematological Malignancy, Leukemia
Halt Aging in Survivors of Blood Cancers
Older survivors of blood cancer are at a high risk of accelerated biological aging, which increases their risk of developing multiple aging-related conditions.
- Conditions
- Hematological Malignancy, Leukemia, Lymphoid Leukemia, Multiple Myeloma
- Trial name
- HALTAging-1 (NCT07292272)
- Testing
- Behavioral Coaching Intervention, Virtual Exercise Platform
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Nebraska
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Red Blood Cell Health, Biological Aging
Effect of Pentadecanoic Acid Supplementation on Red Blood Cell Health and Biological Aging in Healthy Older Adults
This Phase II randomized, double-blind, placebo-controlled, parallel-group study will evaluate the effects of pentadecanoic acid (C15:0) supplementation on red blood cell (RBC) health and predicted biological age in healthy…
- Conditions
- Red Blood Cell Health, Biological Aging, Healthy Aging
- Trial name
- NCT07812792
- Testing
- Pentadecanoic Acid
- Where
- Canada
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- ReCellience15, Inc
Aging
Project SIRT6 Activator
The global ageing population is increasingly affected by age-related diseases, which are challenging healthcare systems. Current treatments often extend lifespan without improving healthspan.
- Trial name
- NCT07500649
- Testing
- Fucoidan
- Where
- 2 sites in Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Biological Aging
The Translational Initiative to Map Epigenetics in Aging (TIME-A)
The Translational Initiative to Map Epigenetics in Aging (TIME-A) study aims to advance our understanding of the connections between epigenetics, lifestyle, demographics, and health and aging.
- Trial name
- TIME-A (NCT05760547)
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Elysium Health
Late-perimenopause, Menopause
Time-Restricted Eating in Combination With a Low Glycaemic Index Diet on Cognitive Function, Biological Ageing and Metabolic Health in Perimenopause and Menopause.
The goal of this randomised controlled trial is to investigate whether Time-Restricted Eating (TRE) combined with a Low Glycaemic Index Mediterranean Diet can improve cognitive function, metabolic health, and biological ageing in…
- Conditions
- Late-perimenopause, Menopause, Perimenopause
- Trial name
- NutriAge (NCT07378787)
- Testing
- Time-Restricted Low-Glycaemic Index Diet
- Where
- 2 sites in Croatia, Cyprus
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nicosia
Aging Disorder
Exposome, Pollutants, Biology in the Older Subject: EXPOSAGE
Numerous factors, both individual and environmental, can influence aging, an individual's health, and their functional status. However, the understanding of the combined impact of lifestyle-related exposures (e.g., physical…
- Trial name
- EXPOSAGE (NCT07678528)
- Testing
- Exposome assessment
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Brain, Aging
Biobank and Brain Health in Bordeaux.
B cube is a new generation cohort to study the determinants and natural history of brain aging, using molecular epidemiology, in a representative sample (N=2000) of the general population from the age of 55 (the approximate age…
- Conditions
- Brain, Aging, Cognitive Aging, Immunosenescence
- Trial name
- B-cube (NCT05322343)
- Testing
- Questionnaires, Fasting blood sampling., Saliva collection and nasal or nasopharyngeal swab
- Where
- France
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Healthy Aging, Healthspan
Sheba Healthspan Research Population (SHARP) Trial - Sheba Longevity Center Diagnostic and Intervention Protocol to Lower Biological Age in Older Adults
Background: Population aging is accelerating rapidly in Israel and worldwide, necessitating adaptation of the healthcare system and considering new approaches that serve the needs of older adult populations.
- Conditions
- Healthy Aging, Healthspan, Biological Age, Intrinsic Capacity
- Trial name
- SHARP (NCT07596576)
- Testing
- healthspan personalized protocol, Control
- Where
- Israel
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Non-Small Cell Lung Cancer
Cancer of the Lung And SeneScencE - Prospective Cohort 1
The main objective is to identify and assess the predictive value of ageing and senescence biomarkers (methylome, telomeres, inflammageing) and senescent cells in tissues to improve prognosis assessment older patients with…
- Trial name
- CLASSE-P1 (NCT06923618)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 385 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris