Clinical trials: Biological Samples
Morbid Obesity, Metabolically Healthy Obesity
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Obesity
This is a prospective, clinical, multicentre study aimed to collect biological samples and study microbiota from subjects with morbid obesity, metabolically healthy obesity and from healthy volunteers.
- Trial name
- BIOMIS-Endo (NCT04698135)
- Testing
- Biological samples collection, Questionnaire, Medical/laboratory examinations
- Where
- Italy
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Idopathic Inflammatory/Autoimmune Syndromes
Collection of Blood, Bone Marrow, Leukapheresis, and Tissue Biopsy Samples From Patients and Their Family Members for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases Laboratory Research Studies
Background: The Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) is conducting a variety of laboratory research experiments that require blood, bone marrow, urine, stool, and/or tissue samples from…
- Trial name
- NCT01200823
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Disease (Alcoholic or Not)
Evaluation of the Involvement of the Intestinal Microbiota and Choline Deficiency in the Severity of Chronic Liver Disease Explored by Analyzing Collection of Biological Samples (MICRONACH)
Chronic liver diseases are common and the two main causes in France are NAFLD (No Alcoholic Fatty Liver Disease Nonalcoholic) and ALD (alcoholic liver disease).
- Trial name
- MICRONACH (NCT02650115)
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Severe Pneumonia, Special Disease Cohort Database
Construction of Special Disease Cohort Database and Biological Sample Holographic Database of Severe Pneumonia
The incidence rate and mortality of lung infection are high worldwide. It is a common and frequently occurring disease which seriously threatens human health. Severe pneumonia accounts for 18-36% of all pneumonia.
- Conditions
- Severe Pneumonia, Special Disease Cohort Database, Holographic Library of Biological Samples
- Trial name
- NCT04882436
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Ruijin Hospital
Gynecological Cancer, Immunotherapy
Detection of Circulating Therapeutic Monoclonal Antibodies in Biological Samples of Gynecological Cancer Patients.
Quantification of anti PD-1 mAbs in cancer patients is extremely important to monitor pharmacokinetics and effectiveness of immunotherapy.
- Trial name
- IMMUNO_ASSAY (NCT06797479)
- Testing
- Blood samples for the analysis of sildenafil in plasma
- Volunteers
- 12 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Tuberculosis
Leukapheresis Sampling for Immune Responses After BCG Vaccination in BCG-naïve Healthy Adults in the US
The objective of this protocol is to obtain biological samples through leukapheresis and cryopreservation of cells for the future study, by in vitro assay, of immune responses after one dose of BCG in BCG-naïve healthy adults.
- Trial name
- NCT02413502
- Testing
- BCG
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aeras
Ganglioneuroblastoma, Localized Resectable Neuroblastoma
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma.
- Conditions
- Ganglioneuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Regional Neuroblastoma
- Trial name
- NCT00904241
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 259 sites in United States, Australia and 6 more
- Volunteers
- 10,000 people
- Sponsor
- Children's Oncology Group
Biochemical Dysfunction
Concordance of Capillary Blood Biological Samples With Conventional Venousbiological Blood Samples.
The main objectives are to evaluate the concordance between the results of natremia, kalaemia and blood sugar levels obtained 1) by capillary puncture, analysed on a delocalized resuscitation machine GEM 4000 (Werfen) and 2) by…
- Trial name
- CAPIVEIN (NCT03890146)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Pelvic Neoplasms, Endometriosis
Cohort of Patients With Pelvic Gynecological Cancer: Constitution of a Collection of Biological Samples With Radioclinical Characterization
The management of pelvic gynecological cancers (PGC) is based on the determination of extension to guide treatments. The biology of the CGP is constantly evolving and personalized medicine adapted to this biology is currently in…
- Trial name
- PELVIMASS2 (NCT03622983)
- Testing
- collection of sample and data
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Echinococcosis
Collection of Biological Samples From Patients With Echinococcosis and Implementation of a Home-made PCR Method
Echinococcosis is a zoonotic disease caused by Echinococcus species. Diagnosis currently relies on imaging, serology and microscopy, but microscopy is time-consuming, has limited sensitivity and cannot distinguish between…
- Trial name
- Echino_home (NCT07715435)
- Testing
- Collection of biological samples from echinococcosis patients for the development of a home-based PCR protocol for diagnostic use.
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Biological Samples
Analytical Impact of the Transport of Pathological Biological Material by Drone
The Hospital Group of Territory Somme Littoral Sud, through its biology sector and in partnership with the company DELIVRONE, aims to engage in the experiment of transporting biological samples by means of a drone platform.
- Trial name
- PATH-AIRCHU (NCT05887089)
- Testing
- drone transport
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Bone Infection, Joint Infection
Biological Collection From Samples From The Gut Microbiota In Patients Having A Bone Or Joint Infection Treated By A Suppressive Subcutaneous Antibiotherapy With Betalactamine (CARBAMICROBIOTA)
Optimal surgical therapy (debridement in chronic osteomyelitis; device exchange in patients with chronic prosthetic joint infection (PJI)) could be sometimes non-feasible, especially in the elderly population.
- Trial name
- NCT03550911
- Testing
- Biological Collection From Samples From The Gut Microbiota
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Hospices Civils de Lyon
Healthy Volunteers, Influenza
Cellular and Molecular Characterization of the Immune Response in Healthy NIH Employees atBaseline, and After Immunization With the H1N1 or Seasonal Influenza Vaccines
Background: Seasonal influenza is a major health problem whose impact is typically reduced by vaccination. The H1N1 (swine flu) influenza virus is an emerging pathogen that has the potential to cause devastating illness and even…
- Trial name
- NCT01191853
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Adult Rhabdomyosarcoma, Childhood Desmoplastic Small Round Cell Tumor
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma
The purpose of this study is to collect and store tumor tissue, blood, and bone marrow samples from patients with soft tissue sarcoma that will be tested in the laboratory.
- Conditions
- Adult Rhabdomyosarcoma, Childhood Desmoplastic Small Round Cell Tumor, Chordoma, Desmoid-Type Fibromatosis
- Trial name
- NCT00919269
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 247 sites in United States, Australia and 5 more
- Volunteers
- 150 people
- Sponsor
- Children's Oncology Group
Melanoma (Skin)
S9431: Studying Genes and Immune Response in Tumor Samples From Patients With Locally Advanced or Metastatic Melanoma
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00898183
- Testing
- gene expression analysis, polymorphism analysis
- Volunteers
- 91 people
- Sponsor
- SWOG Cancer Research Network
Multiple Myeloma, Plasma Cell Myeloma
S0120, Studying Blood and Bone Marrow Samples From Patients With Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, or Plasmacytoma
RATIONALE: Studying samples of blood and bone marrow in the laboratory from patients with monoclonal gammopathy of undetermined significance, multiple myeloma, or plasmacytoma may help doctors learn more about changes that occur…
- Conditions
- Multiple Myeloma, Plasma Cell Myeloma, Precancerous Condition
- Trial name
- NCT00900263
- Testing
- cytogenetic analysis, microarray analysis, biologic sample preservation procedure
- Where
- 69 sites in United States
- Volunteers
- 375 people
- Sponsor
- SWOG Cancer Research Network
Amyotrophic Lateral Sclerosis
Identification of Diagnostic And Prognostic Biomarkers From Amyotrophic Lateral Sclerosis (ALS) Skin and Adipose Samples
The purpose of the project is to obtain skin and adipose tissue samples from patients with ALS to develop new diagnostic and prognostic markers of the disease.
- Trial name
- ALS-TDI PEG (NCT01948102)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Wake Forest University Health Sciences
Healthy Volunteers
Characterization of the Innate Immune Response in Healthy NIH Employees at Baseline and After Immunization With the H1N1 Vaccine
Background: The Center for Human Immunology, Autoimmunity, and Inflammatory Diseases is conducting research investigating how the swine flu (H1N1) vaccine affects the immune system.
- Trial name
- NCT00995527
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Periodontitis, Trisomy 21
Periodontitis and Inflammation in Children With Down Syndrome/Trisomy 21: Study on Biological Samples
Since 2018, the Chicago Classification of Periodontal Diseases and Conditions, has listed Down syndrome (DS)/trisomy 21 (T21) as a systemic disease with periodontal implications.
- Trial name
- NT21 (NCT05970965)
- Testing
- Biological sampling
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction
CARdiAc Mri and BiOLogical samplEs at the Acute Phase of a Myocardial Infarction (CARAMBOLE)
ST-Segment Elevation Myocardial infarction (STEMI) corresponding to acute occlusion of cornary artery is the most severe ischemic myocardial disease and a leading cause of mortality of heart failure worldwide.
- Trial name
- CARAMBOLE (NCT06278519)
- Testing
- Blood, urinary and feces collection, Cardiac MRI, Quality of life and cognitive status questionnaire
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Poitiers University Hospital