Clinical trials: Biological Therapy
Non Small Cell Lung Cancer
A Phase 2 Study of Viagenpumatucel-L (HS-110) in Patients With Non-Small Cell Lung Cancer
Determine whether viagenpumatucel-L combined with low-dose cyclophosphamide prolongs survival in patients with NSCLC who failed 2 or 3 prior lines of therapy for incurable or metastatic disease compared with chemotherapy alone.
- Trial name
- NCT02117024
- Testing
- Viagenpumatucel-L, Metronomic Cyclophosphamide, Physician's Choice Regimen (Vinorelbine, Erlotinib, Gemcitabine, Paclitaxel, Docetaxel, Pemetrexed)
- Where
- 16 sites in United States
- Volunteers
- 66 people
- Sponsor
- Heat Biologics
Depression in Adolescence, Depressive Disorder
Clinical Effectiveness of TARA Compared to Standard Treatment for Adolescents and Young Adults With Depression
Depressive Disorders constitute an increasing global health concern and available treatments for young people have not been sufficiently effective in haltering this trend.
- Conditions
- Depression in Adolescence, Depressive Disorder, Dysthymia and Chronic Depression
- Trial name
- TARA (NCT04747340)
- Testing
- Training for Awareness Resilience and Action (TARA), Standard treatment
- Where
- 3 sites in Sweden
- Volunteers
- 136 people
- Sponsor
- Umeå University
Psoriasis
The Impact of Targeted Therapy on Microorganism in Patients With Psoriasis
Background: Psoriasis is a chronic, immunologically-mediated, inflammatory skin disease and targeted therapies e.g. tumor necrosis factor (TNF)-α and TH-17 antagonists have become increasing important agents in the management of…
- Trial name
- NCT01504113
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Perineal Wound Complications After ELAPE
Pelvic Floor Reconstruction Using Biological Mesh With Negative Pressure Wound Therapy Following ELAPE
Perineal wound healing is a significant challenge after extralevator abdominoperineal excision (ELAPE) due to a high rate of wound breakdown.
- Trial name
- NCT04033484
- Testing
- Negative Pressure Wound Therapy
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Beijing Chao Yang Hospital
Melanoma (Skin)
Vaccine Therapy With or Without Biological Therapy in Treating Patients With Metastatic Melanoma
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Biological therapies such as sargramostim and interferon alfa use different ways to stimulate the immune system and stop cancer cells from…
- Trial name
- NCT00006385
- Testing
- MART-1 antigen, gp100 antigen, incomplete Freund's adjuvant
- Where
- 32 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Unstable Angina, Coronary Atherosclerosis
Serp-1 for the Treatment of Acute Coronary Syndrome
Males and females aged 18-80 years who present with ACS (unstable angina and non ST-elevation MI) defined as one or more episodes of angina lasting at least 5 minutes in the last 24 hours before admission and greater than 0.05 mV…
- Conditions
- Unstable Angina, Coronary Atherosclerosis, Coronary Restenosis
- Trial name
- NCT00243308
- Testing
- Serine proteinase-1 (Serp-1)
- Where
- 8 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- Viron Therapeutics Inc
Hemorrhoids, Hemorrhoidal Disease
War-Drill Model Guided Treatment of Hemorrhoids With Nimsai Herbal (NAJ)
This study investigated a new understanding of hemorrhoid formation and evaluated a novel systemic treatment. For 200 years, hemorrhoids were conventionally understood as isolated swollen veins.
- Trial name
- NAJ (NCT07034820)
- Testing
- Nimsai Herbal
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Nimsai Academia
Rheumatoid Arthritis
Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic DMARDS (Disease Modifying Antirheumatic Drugs) Who Have an Inadequate Response to Anti-TNF Therapy
The purpose of this study is to summarize the safety and tolerability of abatacept during 6 months of combined treatment with one or more of the background non-biologic disease modifying anti-rheumatic drugs (DMARDs) approved for…
- Trial name
- NCT00124982
- Testing
- Abatacept, Non-biologic Disease Modifying Anti-Rheumatic Drug (DMARD), Anti-Tumor Necrosing Factor (TNF) Therapy
- Where
- 148 sites in United States, Belgium and 8 more
- Volunteers
- 1,286 people
- Sponsor
- Bristol-Myers Squibb
Hepatocellular Carcinoma, Cholangiocarcinoma
Liver and Biliary Tumor Tissue Registry
Patients having surgery to remove a liver or biliary tissue mass or having a biopsy of a mass or lesion will have a tissue sample collected and stored for future research of liver and biliary diseases.
- Trial name
- NCT02917759
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Mayo Clinic
Platelet Reactivity
Platelet Hyperreactivity Project
The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients.
- Trial name
- PHP (NCT00976196)
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- Pierre Fontana
Breast Cancer, Hormone Receptor Positive Tumor
A Neoadjuvant Study of Abemaciclib (LY2835219) in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast Cancer
The purpose of this study is to evaluate the biological effects of abemaciclib in combination with anastrozole and compare those to the effects of abemaciclib alone and anastrozole alone in the tumors of postmenopausal women with…
- Conditions
- Breast Cancer, Hormone Receptor Positive Tumor, Early-Stage Breast Carcinoma
- Trial name
- neoMONARCH (NCT02441946)
- Testing
- Abemaciclib, Loperamide, Anastrozole
- Where
- 66 sites in United States, Austria and 8 more
- Volunteers
- 224 people
- Sponsor
- Eli Lilly and Company
Psoriasis
Topical Psoriasis Study for Patients Receiving Biologic Therapy
A two-phase, single center, study of 20 subjects to assess 4 weeks of add-on therapy of Topicort® BID and 12 weeks BID on two consecutive days a week to patients with ≤5% BSA who are receiving biologic therapy for at least 24…
- Trial name
- NCT02983981
- Testing
- Topicort Topical Spray
- Volunteers
- 20 people
- Sponsor
- Psoriasis Treatment Center of Central New Jersey
ANCA Associated Vasculitis (AAV), Polyangiitis (GPA)
Comparison of a Strategy Based on Clinico-biological Monitoring Versus Pre-emptive Rituximab Treatment in Cases of ANCA Reappearance in Granulomatosis With Polyangiitis and Microscopic Polyangiitis.
The PREP-ANCA study seeks to establish a more personalized treatment strategy for ANCA-associated vasculitides by assessing the efficacy of pre-emptive rituximab administration upon ANCA repositivity in preventing relapses in…
- Conditions
- ANCA Associated Vasculitis (AAV), Polyangiitis (GPA), Microscopic Polyangiitis (MPA)
- Trial name
- PREP-ANCA (NCT07451847)
- Testing
- Rituximab
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Postpartum, Anxiety State
From Prevention to Treatment: How Biological Rhythms Can Maintain Perinatal Mental Health
Depression and anxiety are significant public health issues during pregnancy and the postnatal period, particularly affecting those in developing countries.
- Trial name
- NCT06246214
- Testing
- Blue Light Therapy, ControlLT
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Psoriasis, Condyloma Acuminata
Effect of Anti-Psoriatic Biologics on Risk of Anogenital Warts (CONDYPSO)
This study aims to assess the impact of anti-TNF-α, anti-IL-17, and anti-IL-23 biologic therapies on the risk of development or recurrence of anogenital warts (AGW) in patients with moderate to severe psoriasis.
- Conditions
- Psoriasis, Condyloma Acuminata, Biotherapies
- Trial name
- CONDYPSO (NCT07234838)
- Where
- 3 sites in Belgium
- Volunteers
- 600 people
- Sponsor
- Jonathan Krygier
Chronic Plaque Psoriasis
Skin Transcriptional Profiles In Psoriatic Patients Under Adalimumab Biotherapy
The expertise in the characterization of transcriptomics profile in lesional psoriatic skin and on the availability of innovative therapy for these patients.The investigators propose to follow the modification of the skin…
- Trial name
- CYTOPSO (NCT01872546)
- Testing
- Adalimumab Every Week
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Poitiers University Hospital
Leukemia
Chemotherapy Followed by Peripheral Stem Cell Transplantation And Biological Therapy in Treating Patients With Chronic Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing.
- Trial name
- NCT00005948
- Testing
- aldesleukin, recombinant interferon alfa, sargramostim
- Where
- 2 sites in United States
- Sponsor
- Fred Hutchinson Cancer Center
Rotator Cuff Tear, Rotator Cuff Injury
Bone Marrow Derived Stem Cells for the Treatment of Rotator Cuff Tears
The primary objective is to determine whether adjunct treatment using bone marrow aspirate concentrate (BMAC) in conjunction with arthroscopic repair of rotator cuff tears reduces retear rates compared to a control population…
- Trial name
- NCT03688308
- Testing
- Arthroscopic rotator cuff repair with bone marrow aspirate concentrate, Arthroscopic rotator cuff repair
- Where
- United States
- Sponsor
- Stanford University
Inflammatory Bowel Diseases, Crohn Disease
MOdel-Informed Precision Dosing of Ustekinumab and VEdolizumab in Inflammatory Bowel Disease
The goal of this clinical trial is to investigate if dosage of Ustekinumab (UST) and Vedolizumab (VDZ) based on Model-Informed Precision Dosing (MIPD) is equally as efficient in keeping adults with Inflammatory Bowel Disease…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- MOVE-IT (NCT06788340)
- Testing
- PK-model to decide when to dose Vedolizumab and Ustekinumab
- Where
- 6 sites in Denmark
- Volunteers
- 166 people
- Sponsor
- Odense University Hospital
Medication Adherence, Medication Nonadherence
Collaborative Nurse-pharmacist Counseling for Self-administered Biologics
The goal of this clinical trial is to learn if nurse-pharmacist counseling can improve patient knowledge and confidence and prevent side effects in patients who start a biologic medication in-office and later continue the…
- Conditions
- Medication Adherence, Medication Nonadherence, Adverse Drug Event
- Trial name
- COLLAB (NCT05798104)
- Testing
- Collaborative nurse-pharmacist counseling
- Where
- United States
- Sponsor
- Tonia Carr
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