Clinical trials: Biological Therapy
Rheumatoid Arthritis
A Study of Tocilizumab as Monotherapy or in Combination With DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis
This open-label single-arm study will evaluate the safety, tolerability and efficacy of tocilizumab [RoActemra/Actemra] in patients with moderate to severe rheumatoid arthritis who experience an inadequate clinical response to a…
- Trial name
- NCT01089023
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 9 sites in Bahrain, Iran and 3 more
- Volunteers
- 95 people
- Sponsor
- Hoffmann-La Roche
Ollier Disease, Maffucci Syndrome
Registry of Ollier Disease and Maffucci Syndrome
REM is a retrospective and prospective registry, finalized to care and research. It is articulated in main sections - strongly related and mutually dependent on each other - corresponding to different data domains: personal…
- Trial name
- ROM (NCT04134572)
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Luca Sangiorgi
COVID 19, Immunomediated Inflammatory Disease in Treatment With Biological Agents and / or Jak Inhibitors
Randomized, Controlled, Double-blind Clinical Trial Comparing the Efficacy and Safety of Chemoprophylaxis With Hydroxychloroquine in Patients Under Biological Treatment and / or JAK Inhibitors in the Prevention of SARS-CoV-2 Infection
The investigators plan to evaluate a strategy of chemoprophylaxis with hydroxyloquine (HCQ) against COVID-19 infection in patients diagnosed with an immunomediated inflammatory disease who are following a treatment with…
- Trial name
- NCT04330495
- Testing
- Hidroxicloroquina, Control group
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Ovarian Cancer, Fallopian Tube Cancer
Determinants of Age-Related Treatment Effectiveness in Ovarian Cancer
While significant progress has been made in the treatment and prognosis of ovarian cancer, this progress has mostly shown benefits for younger women.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer, Ovarian Diseases
- Trial name
- NCT02973750
- Testing
- Baseline Biopsy, Tissue Collection, Blood Draws
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Ulcerative Colitis and Crohn's Disease
Entyvio (Vedolizumab) Long Term Safety Study
The purpose of this study is to assess the long-term safety of vedolizumab versus other biologic agents in participants with Ulcerative Colitis (UC) or Crohn's Disease (CD).
- Trial name
- Entyvio PASS (NCT02674308)
- Testing
- Vedolizumab, Other Biologic Agents
- Where
- 287 sites in United States, Austria and 19 more
- Volunteers
- 5,302 people
- Sponsor
- Takeda
AIDS
Efficacy and Safety of GSK Biologicals HIV Vaccine in Antiretroviral Therapy (ART)-naïve HIV-1 Infected Persons
This study is designed to determine whether administration of the GSK Biologicals HIV vaccine 732462 can lead to a reduction in viral load, and impact on the course of human immunodeficiency virus type 1 (HIV-1) infection.
- Trial name
- NCT01218113
- Testing
- GSK Biologicals HIV Vaccine 732462
- Where
- 42 sites in United States, France and 2 more
- Volunteers
- 191 people
- Sponsor
- GlaxoSmithKline
Colorectal Cancer, Esophageal Cancer
Biological Factors in Predicting Response to Treatment in Patients With Esophageal Cancer or Rectal Cancer
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00628368
- Testing
- Gene expression analysis
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Biological Dressings
Clinical Efficacy of Bovine Freeze-dried Amniotic Membrane on Wound Healing in Laser Treatment
Bovine amniotic membrane may show better efficacy than hydrocolloid dressing.
- Trial name
- NCT01895374
- Testing
- laser treatments, amniotic membrane application, hydrocolloid application
- Where
- South Korea
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hematologic Malignancies, Solid Tumor
Impact of the Comprehensive Geriatric Assessment on the Quality of Life OF Elderly Patients
Impact of the Comprehensive Geriatric Assessment on the Quality of Life of elderly onco-hematologic patients' candidates for complex antitumoral therapies: clinical and biological correlatives
- Conditions
- Hematologic Malignancies, Solid Tumor, Elderly Patients
- Trial name
- ONCO-AGING (NCT04478916)
- Where
- Italy
- Volunteers
- 144 people
- Sponsor
- Lorenza Scotti
Melanoma (Skin)
Biological Therapy in Treating Patients With Metastatic Melanoma
RATIONALE: Biological therapies such as cellular adoptive immunotherapy use different ways to stimulate the immune system and stop cancer cells from growing.
- Trial name
- NCT00045149
- Testing
- aldesleukin, therapeutic tumor infiltrating lymphocytes
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Breast Cancer
Effect of Chemotherapy and Radiation Prior to Surgery for Triple Negative Breast Cancer
The purpose of this study is to determine whether Cisplatin when given with radiation therapy prior to surgery is effective in improving response to treatment in breast cancer patients.
- Trial name
- NCT00603408
- Testing
- Cisplatin, Radiation Therapy, Mastectomy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Washington University School of Medicine
Occult Hepatitis B, Biological Substance; Adverse Effect
Risk of Hepatitis Flare in Patients With Previous Hepatitis B Virus Exposure Amongst Patients
The purpose of this study is to study the risk of hepatitis flare in patients with previous hepatitis B virus exposure amongst patients on immunosuppressive and biological modifier therapies
- Conditions
- Occult Hepatitis B, Biological Substance; Adverse Effect, Immunosuppression
- Trial name
- NCT04356404
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- Chinese University of Hong Kong
Rheumatoid Arthritis
The Oxylipin Response as a New PrEdictive Biomarker of Patient Responsiveness to Biotherapy in Rheumatoid Arthritis (OPERA)
OPERA aims to better understand and predict the responsiveness of rheumatoid arthrits (RA) patients to biological disease modifying anti-rheumatic drugs (bDMARDs).
- Trial name
- OPERA (NCT05552105)
- Testing
- Blood test
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Rheumatoid Arthritis
An Exploratory Study of Tocilizumab in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Current Non-Biologic DMARDs and/or Anti-TNF Therapy.
This open-label, single arm study will investigate the safety, tolerability and efficacy of tocilizumab monotherapy, or combination therapy with non-biologic disease modifying antirheumatic drugs (DMARDs), in patients with severe…
- Trial name
- NCT00750880
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 282 sites in Australia, Austria and 23 more
- Volunteers
- 1,681 people
- Sponsor
- Hoffmann-La Roche
Major Depressive Disorder
Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study
This randomized 2x2 factorial intervention trial administers 8 weekly cognitive behavioral therapy (CBT) sessions (yes/no) and 4 bi-weekly active whole-body hyperthermia (WBH) sessions (yes/no) to adults aged 18 years or older…
- Trial name
- NCT07596914
- Testing
- Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Breast Cancer
Studying the Benefits of Adjuvant Sequential vs. Combined Taxane Based Chemotherapy, Followed by Different Biological Treatment Strategies in Early, HER2-positive Breast Cancer
This is an open-label, multicenter randomized controlled, Phase III study comparing the disease free survival after randomisation in patients treated with 3 cycles of Epirubicin-Fluorouracil-Cyclophosphamide (FEC)-chemotherapy…
- Trial name
- NCT00670878
- Testing
- 3 x FEC 3 x DOC / Gemcitabine, 3 x FEC 3 x DOC
- Where
- Germany
- Volunteers
- 799 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Recurrent Neuroblastoma
Biological Therapy, Sargramostim, and Isotretinoin in Treating Patients With Relapsed or Refractory Neuroblastoma
This phase II trial is studying how well hu14.18-interleukin-2 (IL2) fusion protein works when given together with sargramostim and isotretinoin in treating patients with relapsed or refractory neuroblastoma.
- Trial name
- NCT01334515
- Testing
- hu14.18-IL2 fusion protein, isotretinoin, sargramostim
- Where
- 76 sites in United States, Canada
- Volunteers
- 52 people
- Sponsor
- Children's Oncology Group
Rheumatoid Arthritis, Arthritis, Psoriatic
Golimumab Safety and Surveillance Program Using the Ingenix NHI Database
The participants included in this observational study will be drawn from a research database containing claims and enrollment data for members of a large, geographically diverse US health plan.The objective of this study is to…
- Conditions
- Rheumatoid Arthritis, Arthritis, Psoriatic, Ankylosing Spondylitis
- Trial name
- NCT01081717
- Testing
- systemic non-biological treatments, anti-TNF biologics, golimumab
- Volunteers
- 1,064 people
- Sponsor
- Janssen Biotech, Inc.
Breast Cancer, Lymphoma
Biological Therapies Following Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Advanced Breast Cancer
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill cancer cells. Filgrastim and stem cell factor may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's…
- Trial name
- NCT00005993
- Testing
- aldesleukin, filgrastim, recombinant human stem cell factor
- Sponsor
- Masonic Cancer Center, University of Minnesota
Rheumatoid Arthritis
A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid Arthritis
A Canadian study to evaluate early use of adalimumab after methotrexate failure in early rheumatoid arthritis. The study hypothesis will verify if adalimumab effectively reduces joint damage in more participants when introduced…
- Trial name
- RADAR (NCT01162421)
- Testing
- adalimumab, Methotrexate
- Volunteers
- 77 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
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