Clinical trials: Biomarker
Exercise Performance Recovery
The Effect of XSurge Supplementation on Biomarkers and Performance From High Intensity Resistance Exercise
Part one of this study will consist of baseline (BL) testing, 28 days of daily supplementation with XSurge, and an exercise protocol.
- Trial name
- NCT02442245
- Testing
- XSurge, Control: No supplementation
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Kemin Foods LC
Hemophilia A
Cartilage Biomarkers and HEAD-US Score in Severe Hemophilia A Patients Receiving FVIII Prophylaxis
Patients with severe hemophilia A often develop joint complication requiring careful monitoring. This study aimed to compare the effectiveness of standard low dose weight-based FVIII concentrates (CFCs) prophylaxis with…
- Trial name
- HEADUS_SHA8 (NCT06816953)
- Testing
- HEAD-US, Urinary carboxy-terminal cross linked telopeptide of type II collagen, Inflammatory markers
- Where
- Thailand
- Volunteers
- 19 people
- Sponsor
- Chulalongkorn University
Depressive Disorder, Treatment-Resistant
Brain Connectivity and Inflammatory Markers During Short-Term Psychotherapy for Treatment-Resistant Depression
Some adults continue to experience depression despite treatment with antidepressant medicines. This study aimed to explore relationships between depression symptoms, brain function, and blood markers of inflammation, and changes…
- Trial name
- NCT07847242
- Testing
- Short-Term Dynamic Psychotherapy, Mindfulness-Based Cognitive Therapy
- Where
- South Korea
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Korea University Ansan Hospital
Non-melanoma Skin Cancer
Topical Chemoprevention of Skin Cancer Biomarkers
This research study will test how well one topical medications work to prevent the development of non-melanoma skin cancers by reversing certain biomarkers in the skin.
- Trial name
- NCT02636569
- Testing
- topical diclofenac daily
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
Atrial Fibrillation, Recurrence
Outcome of Overweight AF Patients Following Ablation With a Potential Weight Loss Medication ( GOAL-AF )
Atrial Fibrillation (AF) is the most common abnormal heart rhythm(arrhythmia) affecting about one in 40 people in England. Patients with AF often have symptoms ranging from palpitations and breathlessness, and a small number of…
- Conditions
- Atrial Fibrillation, Recurrence, Overweight and Obesity, Liraglutide
- Trial name
- GOAL-AF (NCT05221229)
- Testing
- Liraglutide plus upstream risk factors modification advice and consultation
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University Hospital Birmingham
Chronic Inflammatory Disease, Angioedema
Deployment o the Multidisciplinary Prospective Cohort Imminent
Immune-mediated inflammatory diseases (IMIDs) most often affect young patients and have high impact on morbidity and mortality with a significant alteration in the quality of life of patients with professional, social and…
- Conditions
- Chronic Inflammatory Disease, Angioedema, Severe Asthma, Lupus
- Trial name
- IMMINeNT (NCT04334031)
- Testing
- Biobanking with genetic analysis, SF-12 questionnaire
- Where
- France
- Volunteers
- 2,200 people
- Sponsor
- University Hospital, Lille
Fatty Liver
Nonalcoholic Fatty Liver Disease in Taiwanese Children
Nonalcoholic fatty liver disease (NAFLD) is an emerging and important disease in Taiwan. However, the prevalence and clinical characteristics have not been studied well.
- Trial name
- NCT00274183
- Where
- Taiwan
- Volunteers
- 614 people
- Sponsor
- Far Eastern Memorial Hospital
Aortic Stenosis
Implantable Sensor in Aortic Stenosis
To establish the relationship between a panel of biological markers obtained from the REVEAL Linq device and exercise performance as judged by cardiopulmonary exercise testing
- Trial name
- ISAS (NCT06826183)
- Testing
- REVEAL Linq device
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Barts & The London NHS Trust
Muscle Fatigue (C23.888.592.612.612), Athletic Injuries (C26.857.500.124)
Recovery Optimization Intervention to Reduce the Risk of Injuries in Soccer Players
The goal of this clinical trial is to evaluate if recovery interventions using cold and hot water immersion can reduce the risk of injuries in amateur soccer players.
- Conditions
- Muscle Fatigue (C23.888.592.612.612), Athletic Injuries (C26.857.500.124), Recovery of Function (G11.427.698.620), Cryotherapy (E02.095.301.250)
- Trial name
- NCT06920966
- Testing
- Cold Water Immersion (CWI), Hot water immersion (HWI), Thermography-Guided Immersion (TI)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Graft-versus-host Disease
Clinical and Biomarker Study of the Efficacy of Extracorporeal Photopheresis in Graft-versus-host Disease
The aims of the study: 1. To evaluate the clinical efficacy of the use of extracorporeal photopheresis in the treatment of Graft-versus-host disease under standard clinical indications as pre-defined by the participants Centers…
- Trial name
- BIOECP_GVHD (NCT03124056)
- Testing
- Extracorporeal photopheresis
- Volunteers
- 62 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Training, Inflammation Biomarkers
The Effect of a Single Training Session on Changes in Inflammatory, Hormonal, and Metabolic Markers in Athletes
The study aims to assess the acute response of wrestlers to a single training session. Short-term changes in inflammatory, hormonal, and metabolic markers are analyzed to assess fatigue development and recovery following intense…
- Conditions
- Training, Inflammation Biomarkers, Hormone, Exercise Training
- Trial name
- NCT07264751
- Testing
- physical training
- Where
- Poland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
HER2-positive Early Breast Cancer
NeoAdjuvant Therapy With Trastuzumab-deruxtecan Versus Chemotherapy+Trastuzumab+Pertuzumab in HER2+ Early Breast Cancer
ADAPT-HER2-IV will address question of optimal neoadjuvant therapy in patients with less advanced -HER2+ EBC. ADAPT-HER2-IV is planned as a superiority trial to demonstrate higher pCR rates in both clinically relevant subgroups…
- Trial name
- ADAPTHER2-IV (NCT05704829)
- Testing
- Trastuzumab deruxtecan, Standard-of-Care
- Where
- 44 sites in Germany
- Volunteers
- 702 people
- Sponsor
- Women's Cancer Study Group GmbH
Diabetic Retinopathy, Diabetic Macular Edema (DME)
AI Prediction of Treatment Response in DME
Diabetic macular edema (DME) is a leading cause of vision loss among individuals with diabetes mellitus. Although intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is the standard treatment for…
- Trial name
- NCT07707856
- Testing
- Artificial Intelligence-Based Imaging Analysis
- Where
- Egypt
- Volunteers
- 1,284 people
- Sponsor
- Benha University
Head and Neck Squamous Cell Carcinoma
PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC
This is a multi-center, open-label, Phase 0 substudy designed to evaluate the localized pharmacodynamics (PD) of rilvegostomig, volrustomig, sabestomig, and AZD9592 within the tumor microenvironment (TME) when administered…
- Trial name
- NCT06366451
- Testing
- Rilvegostomig, Volrustomig, Sabestomig
- Where
- 7 sites in United States
- Volunteers
- 17 people
- Sponsor
- Presage Biosciences
Sepsis
Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention
The goal of this clinical trial is to determine if vancomycin dosing in children with sepsis can be improved by using updated, personalized dosing models that account for new markers of an individual's kidney function.
- Trial name
- VAST-i (NCT07084129)
- Testing
- personalized dosing adjustment of vancomycin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia
Lymphoma, T-Cell, Cutaneous
AFM13 in Relapsed/Refractory Cutaneous Lymphomas
The investigators plan to investigate AFM13 and evaluate its ability to facilitate and redirect the Natural Killer (NK) cells in eliminating CD30-positive lymphoma targets in the skin and, by inference, other organs involved by…
- Trial name
- NCT03192202
- Testing
- AFM13
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Ahmed Sawas
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
A Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Nephrologists
The purpose of this survey is to collect information for scientific research and to better understand the role of systemic inflammation in identification, treatment and management of patients with Atherosclerotic Cardiovascular…
- Conditions
- Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD), Systemic Inflammation
- Trial name
- NCT06322641
- Testing
- No treatment given
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
Brain Metastases, Neurocognitive Deficit
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
Brain metastases are a source of much morbidity and mortality in adults with primary solid malignant tumors. With improvements in systemic therapy that prolong survival but have limited central nervous system penetration…
- Conditions
- Brain Metastases, Neurocognitive Deficit, White Matter Alterations, Radiation Exposure
- Trial name
- NCT04073966
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Apical Periodontitis
N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as…
- Trial name
- NAC (NCT07262554)
- Testing
- Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Coronary Artery Disease, Atherosclerosis
Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3)
Regular endurance exercise is widely known to improve cardiovascular health and reduce the risk of heart disease. Yet several imaging studies have shown that male endurance athletes have a higher prevalence of coronary artery…
- Trial name
- MARC-3 (NCT07625488)
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center