Clinical trials: Biomechanical Phenomena
Cerebral Palsy (CP)
Cerebral Palsy: Ankle Foot Orthoses - Footwear Combinations
Ambulatory children with cerebral palsy (CP) demonstrate altered lower limb biomechanical alignment in walking (e.g. excessive hip/knee flexion or equinus during stance) and experience walking activity limitations that negatively…
- Trial name
- CP-AFOFC (NCT03756571)
- Testing
- Ankle Foot Orthoses-Footwear Combination, Traditional Solid Ankle AFO (TSAFO)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Seattle Children's Hospital
Cerebrovascular Accident
Mechanisms of Upper-Extremity Motor Recovery in Post-stroke Hemiparesis
The results of this study will provide sound, scientific evidence of physiologic mechanisms responsible for upper-extremity weakness; evidence of the processes involved in neuromuscular adaptation; and will elucidate the…
- Trial name
- NCT00125658
- Testing
- Control, Experimental
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Amputation of Arm
Interface Kinematics of Transhumeral Prosthetic Sockets Using XROMM
The purpose of this pilot study was to conduct a head-to-head comparison of two designs for transhumeral level upper limb prosthetic sockets: a traditional socket design and a socket design hypothesized to provide greater…
- Trial name
- NCT01546675
- Testing
- Skeletal Stabilization
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- US Department of Veterans Affairs
Peripheral Artery Disease
Improving Mobility in Peripheral Artery Disease Using an Ankle Foot Orthosis
This study will determine whether an ankle foot orthosis (AFO) improves walking performance in participants with PAD from its first use.
- Trial name
- NCT02902211
- Testing
- Ankle foot orthosis, Control/standard of care
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Arthropathy of Knee Joint
Improving Function After Knee Arthroplasty With Weight-Bearing Biofeedback
The purpose of this study is to determine if rehabilitation using weight-bearing biofeedback training following total knee arthroplasty (TKA) is more effective than standard rehabilitation methods in promoting weight-bearing…
- Trial name
- RELOAD (NCT01333189)
- Testing
- Weight-bearing biofeedback exercise, Standard of care exercise
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Colorado, Denver
Adult ALL, Healthy
Iterative Design of Custom Dynamic Orthoses
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. It is expected that carbon fiber braces can be designed to reduce forces in the ankle.
- Trial name
- PRMRP-Norms (NCT04800510)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Iowa
Achilles Tendon Pain
Achilles Pain Block
The purpose of this study is to better understand how the peripheral and central nervous system interact to produce the sensation of pain and motor patterns in patients with achilles tendinopathy (AT).
- Trial name
- APB (NCT03316378)
- Testing
- Ropivacaine injection
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ruth Chimenti
Bone Alteration
Micromechanical Modeling Using Low Magnitude Mechanical Stimulation
The response to a daily 10 minute session of low-magnitude mechanical stimulation (LMMS) on bone in 100 postmenopausal women ages 45-65 years will be evaluated at baseline and 12 months using high-resolution magnetic resonance…
- Trial name
- LMMS (NCT01921517)
- Testing
- Low Magnitude Mechanical Stimulation
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Myopia
Corneal Biomechanics and Corneal Reshaping Therapy
The aim of the proposed study is to investigate the predictive value of corneal biomechanical properties in corneal reshaping therapy and the role of these parameters in determining the amount of myopia reduction.
- Trial name
- NCT02719535
- Testing
- Corneal reshaping therapy
- Where
- Hong Kong
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Healthy
Using Real Time Biofeedback to Alter Running Mechanics
The purposes of this study are 1) to assess foot strike patterns initially, at six months and at one year between two groups of runners attempting to transition to a non-rearfoot strike pattern (NRFS) with and without the use of…
- Trial name
- NCT02495792
- Testing
- Biofeedback Sensor
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Keller Army Community Hospital
Diabetic Neuropathies
Effects of Foot Muscle Strengthening in Daily Activity in Diabetic Neuropathic Patients
The main objective of this trial is to investigate the effects of foot muscle strengthening in daily activity of patients with diabetic neuropathy.
- Trial name
- NCT02790931
- Testing
- Intervention Group
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- University of Sao Paulo General Hospital
Foot Injuries and Disorders
Ankle Foot Orthosis Comparative Effect
The proposed effort is designed to support evidence-based practice and optimal care by evaluating how the form, fit and function of two commercially available carbon fiber custom fit braces (Orthoses) influences outcomes…
- Trial name
- AFOCE (NCT03901053)
- Testing
- Reaktiv AFO, PhatBrace AFO
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- Jason Wilken
Athletic Injuries
Running Retraining to Minimize Braking Forces
The proposed research study aims to investigate whether a gait modification training program to decrease peak braking forces during the stance phase of running will result in a reduction in impact loading and the incidence of…
- Trial name
- NCT03302975
- Testing
- Real-time visual biofeedback during treadmill running
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Lower Extremity Pain of a Mechanical Origin
Custom Molded Foot Orthoses Effect on Foot Kinematics and Lower Extremity Electromyography During Walking and Running.
The purpose of this study was to determine the effectiveness of two types of in-shoe custom made orthotics in altering the motion of the foot and muscle activity of select muscles of the lower leg in individuals experiencing…
- Trial name
- SOLE (NCT02143947)
- Testing
- Maximal Arch Subtalar Stabilization, Full Contact Orthosis
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Quinnipiac University
Spinal Manipulation
The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy
The objective of the present study is to determine if spinal manipulations with a constant rate of force application but with different peak force and time to peak force lead to similar responses in healthy adults.
- Trial name
- NCT02550132
- Testing
- Spinal manipulation, Apparatus used to deliver spinal manipulations
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université du Québec à Trois-Rivières
Knee Osteoarthritis
Effect of Footwear on the Clinical, Functional, and Biomechanical Aspects in Elderly Women With Knee Osteoarthritis (OA)
The purpose of this study is to determine whether inexpensive, flexible and non-heeled footwear is effective in improving of clinical, functional and gait biomechanics in elderly women with knee osteoarthritis.
- Trial name
- OA (NCT01342458)
- Testing
- Flexible footwear
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- University of Sao Paulo General Hospital
Larynx Cancer, Laryngectomy; Status
Phonatory Movement of the Pharyngoesophageal Mucosa in Laryngectomy Patients
The treatment of advanced laryngeal cancer involves the removal of the entire larynx. After removal of the larynx, the pharyngoesophageal segment (PES) is created by reconstructing the soft tissue of the pharynx and oesophagus…
- Trial name
- NCT05561920
- Testing
- High-speed video endoscopy (HSV), Acoustic voice analysis, Quality of life questionnaire
- Where
- Croatia
- Volunteers
- 55 people
- Sponsor
- Osijek University Hospital
Adult ALL, Healthy
Heel Wedges and Carbon Fiber Custom Dynamic Orthoses to Control Knee Biomechanics
The proposed study evaluates the effect of medial and lateral wedges and carbon fiber custom dynamic orthoses (CDOs) on lower limb forces and motion during walking.
- Trial name
- CDOKNEEpilot (NCT05209360)
- Testing
- Medial or Lateral Wedge, Carbon Fiber Custom Dynamic Orthosis
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Adult ALL, Healthy
Effects of Malleo-Lok Stiffness on Lower Limb Mechanics
The primary purpose of this research study is to determine if the stiffness of a commercially available ankle foot orthosis (Malleo-Lok, Bio-Mechanical Composites, Des Moines IA) impacts gait biomechanics and overall joint level…
- Trial name
- MalleoLokStiff (NCT04806100)
- Testing
- Malleo-Lok
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Stroke With Hemiparesis
Study of Botulinum Toxin and Recovery of Hand Function After Stroke
The purpose of this study is to determine whether injections of botulinum toxin (commonly known as BOTOX®) into the affected hand of Stroke patients, while targeting the muscles controlling the hand, will lead to improved use of…
- Trial name
- NCT01422161
- Testing
- Botulinum Toxin commonly known as BOTOX®
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NYU Langone Health