Clinical trials: Bipolar Disorders
Bipolar Disorder
Bipolar Disorder Integrative Staging: Incorporating Biomarkers Into Progression Across Stages
Bipolar disorder (BD) is a lifelong, recurrent condition with growing evidence supporting a neuroprogressive course, entailing the need to adopt staging models to guide stage-speci c interventions.
- Trial name
- BOARDING-PASS (NCT07343739)
- Testing
- psychometric clinical assessment, biological acquisition, neuroimaging data
- Where
- Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Major Depressive Disorder, Bipolar Disorder
Brain Mechanisms of Human Motivation
This study aims to investigate reward learning across the mood disorder spectrum and to investigate the predictive validity of reward learning for subsequent symptom severity.
- Trial name
- NCT01976975
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Mood Disorders, Healthy
Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies
This study looks at the role of a specific brain chemical system in the mood and attention symptoms seen in major depression and bipolar disorders using functional brain imaging.
- Conditions
- Mood Disorders, Healthy, Unipolar Depression, Bipolar Depression
- Trial name
- NCT00055575
- Testing
- Scopolamine Nasal Spray
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Mania
Depakote ER Therapy for Mania Comorbid With Substance Abuse
The purpose of this study is to ascertain whether Depakote ER (Divalproex ER) has efficacy in the treatment of patients with bipolar disorder in the manic phase, who also have comorbid substance abuse diagnoses.
- Conditions
- Bipolar Disorder, Mania, Substance Abuse, Substance Dependence
- Trial name
- NCT00208195
- Testing
- Divalproex ER
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Creighton University
Cognitive Impairment, Bipolar Disorder
Effects of Altitude-like Cognition Training on Neuroplasticity and Cognitive Functions
The goal of this clinical trial is to investigate the effects of a three-week altitude-like cognition training intervention in healthy individuals (substudy 1) and symptomatically stable patients with mood disorders (depression…
- Conditions
- Cognitive Impairment, Bipolar Disorder, Depression
- Trial name
- ALTIBRAIN (NCT06121206)
- Testing
- Altitude-like hypoxia (12% O2), Normoxia (20% O2), Cognitive training
- Where
- Denmark
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Bipolar Disorders
Escitalopram as a Mood Stabilizer for Bipolar II Disorder
This study will investigate the efficacy of Escitalopram, a Selective Serotonin Reuptake Inhibitor (SSRI) antidepressant, in the treatment of Bipolar II Disorder.
- Trial name
- NCT00156325
- Testing
- Escitalopram (Lexapro)
- Where
- Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Bipolar Disorder, Panic Disorder
Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD
The specific aim of this study is to evaluate the efficacy, tolerability, and safety of quetiapine SR monotherapy and divalproex sodium ER monotherapy in comparison to placebo in the treatment of ambulatory bipolar disorder with…
- Conditions
- Bipolar Disorder, Panic Disorder, Generalized Anxiety Disorder
- Trial name
- NCT00579280
- Testing
- quetiapine SR, divalproex sodium ER
- Where
- 3 sites in United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Major Depressive Disorder
A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder
This study employs functional magnetic resonance imaging to compare brain activation patterns during a depressive episode in patients diagnosed with bipolar disorder, major depressive disorder, and a group of healthy control…
- Trial name
- NCT00188942
- Testing
- Fluoxetine+Olanzapine, Olanzapine, Functional Magnetic Resonance Imaging
- Where
- 2 sites in Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Psychiatric Disorder
Familial and Functional Study of Genetic Variants Identified in People With Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder or Resistant Depression
Genetic analyses conducted on patient with psychiatric disorders assessed at the expert centres resulted in the identific action of genetic variants associated with psychiatric disorders (Courtois, 2020).
- Trial name
- GENI (NCT05480826)
- Testing
- study of the transmission of genetic variants
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Bipolar Disorder Family Members
A Psychoeducation Intervention for Caregivers of Patients With Bipolar Disorder
Bipolar disorder is a debilitating chronic illness characterized by periods of elation and depression. Since deinstitutionalization of the mentally ill over 40 years ago, families have become major caregivers for patients with…
- Trial name
- NCT02446509
- Testing
- Psychoeducation, Psychoeducation - Delayed
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Conditions Influencing Health Status, Bipolar Disorders
Functional Correlates of Bipolar Disorders and Effects of the Psychoeducation. an fMRI Study
This research project follows two main objectives: 1) Assess anatomical and functional cerebral abnormalities in bipolar disorder.
- Trial name
- BIP-ED (NCT01821469)
- Testing
- psychoeducation
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Major Depression, Bipolar Disorder
Longitudinal Study of People Presenting for First Treatment of a Mood Disorder
The goal of this project is to study the course and outcome of illness in individuals who present with a first episode of depression or mania, or who have a recurrent disorder but have never received treatment.
- Trial name
- NCT01529905
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- McMaster University
Schizophrenia
Niacin Skin Flush Response in Patients With Schizophrenia
Patients with schizophrenia have abnormal skin flush response to niacin, but the niacin skin test accuracy is not well studied in these patients.
- Trial name
- NCT02458924
- Testing
- Niacin skin test
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Bipolar Disorder, Bipolar I Disorder
Emotional Proactive Processing in Bipolar Disorder
The main objective of this project is to identify behavioral specificities of the proactive emotional brain among bipolar patients, compared to healthy subjects.
- Conditions
- Bipolar Disorder, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- PROEMO_BP (NCT04561622)
- Testing
- Emotional Stroop Task
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Bipolar Disorder
Bioequivalency Study of 450 mg Lithium Carbonate Under Fed Conditions
The objective of this study was to assess the bioequivalence of two Roxane lithium carbonate 450 mg extended release tablet formulations compared to GlaxoSmithKline's Eskalith CR 450 mg extended release tablet under fed…
- Trial name
- NCT00601575
- Testing
- Lithium
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Psychosis, Schizophrenia
Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders
This clinical trial is a single center, single dose study of the acute effects of intranasal insulin on energy metabolism and cognitive function in patients with schizophrenia, schizoaffective and bipolar disorders, compared and…
- Conditions
- Psychosis, Schizophrenia, Schizo Affective Disorder, Bipolar I Disorder
- Trial name
- NCT03943537
- Testing
- Intranasal Insulin
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Unipolar Depression, Bipolar Depression
Mechanism of Action of Electroconvulsive Therapy
This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.
- Trial name
- MoA-ECT (NCT04059952)
- Testing
- Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Depression, Major Depressive Disorder
Non-invasive BCI and Application Verification for Depressed People
Major Depressive Disorder (MDD) is a serious mental illness and public health problem that poses threat to both physical and mental health.
- Conditions
- Depression, Major Depressive Disorder, Bipolar Depression
- Trial name
- NCT06417437
- Testing
- SSRI, rTMS, Neuro-Feedback
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Bipolar Disorder, Mania
Virtual Darkness as Additive Treatment in Mania
In this randomized controlled study we will investigate the effect of blue-blocking goggles or screens (virtual darkness therapy) on manic symptoms in bipolar disorder compared to placebo.
- Trial name
- VATMAN (NCT01818622)
- Testing
- Blue-blocking goggles/screens, Clear-lensed goggles
- Where
- 2 sites in Norway
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Helse Fonna