Clinical trials: Bipolar Disorders, open to volunteers
Schizophenia Disorder, Severe Mental Illness
Effect of Occupational Therapy on Psychosocial Parameters and Functioning in Individuals With Severe Mental Illness
Severe mental illness (SMI), including schizophrenia spectrum disorders and bipolar disorder, is associated with significant impairments in psychosocial functioning, daily life participation, self-efficacy, and social…
- Conditions
- Schizophenia Disorder, Severe Mental Illness, Bipolar Disorder, Nonorganic Psychosis
- Trial name
- OT-SMI (NCT07879118)
- Testing
- Occupational Therapy Group Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Biruni University
Schizophrenia Disorders, Major Depression
Non-Coding RNAs Gene Expression in Psychiatric Disorders
This study aims to investigate whether specific non-coding RNAs, molecules involved in the regulation of gene expression, are altered in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, major…
- Conditions
- Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- PsiRNA26 (NCT07649993)
- Testing
- Reverse Transcription Quantitative Polymerase Chain Reaction
- Where
- 5 sites in Italy
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Carmen Concerto
Schizophrenia, Schizoaffective Disorder
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
This study will evaluate the efficacy of valbenazine on clinician- and patient-reported outcomes in participants with TD while receiving or after stopping a VMAT2 inhibitor.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT07105111
- Testing
- Valbenazine
- Where
- 19 sites in United States
- Volunteers
- 100 people
- Sponsor
- Neurocrine Biosciences
ADHD - Attention Deficit Disorder With Hyperactivity, Bipolar Affective Disorder; Remission in
Psychophysiological Responses to Six Single-Session Self-Regulation Interventions in a Female Adult With ADHD and Stabilized Bipolar Disorder
This study aims to explore how six short, 15-minute self-regulation techniques affect the body and brain in a female adult with ADHD and stabilized bipolar disorder.
- Trial name
- NCT07437833
- Testing
- Moderate-Intensity Aerobic Exercise on Cycloergometer, Cyclic Sighing, Aromatherapy
- Where
- Poland
- Volunteers
- 1 people
- Sponsor
- Poznan University of Physical Education
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Mood Disorders, Depressive Disorder
An Innovative Master Platform for Clinical Trials in Mood Disorders
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person.
- Conditions
- Mood Disorders, Depressive Disorder, Bipolar and Related Disorders
- Trial name
- ENABLE (NCT06408012)
- Where
- 9 sites in Canada
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Schizophrenia, Psychosis
Enhancing Rehabilitation for Veterans With Serious Mental Illness
This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs).
- Conditions
- Schizophrenia, Psychosis, Serious Mental Illness, PTSD
- Trial name
- NCT06586164
- Testing
- Targeted Cognitive Training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Depressive Disorder, Bipolar Disorder
Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation in Depression
Invasive vagus nerve stimulation (VNS) is an approved treatment of treatment-resistant depression (TRD) in Europe and in USA. Because of the associated possible surgical complications as well as side effects, invasive VNS is…
- Trial name
- AddVNS (NCT07022171)
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Colon Polyp, Colon Neoplasia
Prospective Study of Using Novel Bipolar Scissors in Colorectal Endoscopic Submucosal Dissection
This study is an interventional, prospective, single-center study to evaluate the safety and effectiveness of a novel radiofrequency and microwave ablation flexible bipolar (SpydrBlade Flex, CREO Medical, UK) for colorectal ESD…
- Trial name
- NCT06715332
- Testing
- Colorectal ESD with SpydrBlade Flex
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Bipolar I Disorder, Depression, Anxiety
Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder
This is a randomized, double-blind, placebo-controlled proof-of-concept clinical trial to assess the efficacy and safety of Magnesium-vitamin B6in combination with treatment as usual for treating symptoms of depression, stress…
- Conditions
- Bipolar I Disorder, Depression, Anxiety, Stress
- Trial name
- NCT05837104
- Testing
- Magnesium vitamin B6
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mclean Hospital
The Key to Emotional Balance
The Key to Emotional Balance
This randomized controlled experimental study aimed to evaluate the effects of the Key to Emotional Balance (KBA) psychoeducational program, based on the Balance Model of Positive Psychotherapy (PPT), on indicators of emotion…
- Trial name
- NCT07208721
- Testing
- The Key to Emotional Balance
- Volunteers
- 74 people
- Sponsor
- TC Erciyes University
Bipolar I Disorder, Bipolar II Disorder
A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States.
- Trial name
- NCT06696755
- Testing
- Icalcaprant
- Where
- 33 sites in United States
- Volunteers
- 195 people
- Sponsor
- AbbVie
Schizophenia Disorder, Bipolar Disorder (BD)
Effects of Schizophrenia and Bipolar Disorder on Exercise Capacity, Pulmonary Function, and Quality of Life
This observational study aims to evaluate exercise capacity, pulmonary function, respiratory muscle strength, and quality of life in individuals diagnosed with schizophrenia and bipolar disorder.
- Trial name
- NCT07306468
- Testing
- Pulmonary Function Test, Respiratory Muscle Strength Evaluation, Quality of Life Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Mania, Bipolar Disorder
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
The purpose of this study is to evaluate the efficacy and safety of adjunctive KarXT for the treatment of mania in participants with Bipolar-I Disorder.
- Trial name
- NCT07140913
- Testing
- Xanomeline/Trospium Chloride
- Where
- 109 sites in United States, Argentina and 11 more
- Volunteers
- 424 people
- Sponsor
- Bristol-Myers Squibb
Multimorbidity, Older Adults (65 Years and Older)
Integrated Care for Older Adults With Major Depression and Physical Multimorbidity - The I-CONNECT
The goal of this clinical trial is to learn if I-CONNECT (Integrated Care for Older Adults with Major Depression and Physical Multimorbidity) can improve the health and well-being of older adults with depression or bipolar…
- Conditions
- Multimorbidity, Older Adults (65 Years and Older), Mood Disorders, Depression - Major Depressive Disorder
- Trial name
- I-CONNECT (NCT07211750)
- Testing
- integrated care intervention tailored to the needs of older adults leaving at home with mood disorders and multimorbidity in Leuven
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- KU Leuven
Bipolar Disorder
Senyo Health App - Comorbid Alcohol Use Disorder Treatment in Individuals With Bipolar Disorder Using a Telehealth Collaborative Care Platform
The purpose of this study is to examine the effectiveness of a digital integrated behavioral health (IBH) platform in improving alcohol use outcomes, including treatment retention and substance use frequency and severity in…
- Trial name
- NCT07556861
- Testing
- Senyo Health App
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Bipolar Disorder (BD), Depression - Major Depressive Disorder
Epigenetic Enhancement of Cognitive Training in Aging Mood and Schizophrenia Spectrum Disorder Populations
The aim of this clinical trial is to investigate the effects of a three-week virtual reality-based cognitive remediation training (VR-CRT) programme in combination with daily intake of a histone deacetylase inhibitor (HDACi)…
- Conditions
- Bipolar Disorder (BD), Depression - Major Depressive Disorder, Cognitive Impairment, Schizophrenia Disorders
- Trial name
- EPIC (NCT07404085)
- Testing
- Virtual Reality-based cognitive remediation therapy (VR-CRT), Virtual Reality-based control treatment (VR-CT), HDACi butyrate
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Bipolar Disorder, Schizophrenia
Immuno-Genetic, Inflammation, Retro-Virus, Environment
Immunology combined to neurobiology now offer prominent tools to yield biomarkers, so far missing in psychiatry, and to design innovative treatment approaches based on the discovery of new molecular and cellular targets.
- Trial name
- I-Give (NCT02878408)
- Testing
- Blood sampling
- Where
- 6 sites in France
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Pr. Marion Leboyer
Bipolar Disorder I or II
A Compassionate-focused Intervention for Older People with Bipolar Disorder
The aim of this study is to determine whether it is feasible to deliver a 9-session compassionate-focused therapy for older people with bipolar disorder.
- Trial name
- NCT06882590
- Testing
- Compassionate-focused therapy
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Manchester
Bipolar Disorder, Bipolar Disorder Type 1
Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder
The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar.
- Trial name
- NCT06373016
- Testing
- Glucose, Ketones
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stony Brook University